Giacomo Del Corso | Università di Bologna (original) (raw)

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Papers by Giacomo Del Corso

Research paper thumbnail of Central mucoepidermoid carcinoma in a young patient: A case report and review of the literature

Background: Central mucoepidermoid carcinoma is a rare malignant salivary neoplasm arising inside... more Background: Central mucoepidermoid carcinoma is a rare malignant salivary neoplasm arising inside the bone of the jaws. We report a rare case of central mucoepidermoid carcinoma of a 16-year-old girl arising in the maxilla. Clinical and radiological analyses were shown and discussed, as well as the surgical treatment. Methods: A left maxillectomy from the last molar to the first premolar was performed, and the site was reconstructed using a fibula free flap stabilized with titanium plates. Results: The young patient was followed up for more than 6 years, and to date no recurrence was observed. A literature review of the 11 rare previous cases was provided to guide the clinician in the diagnosis and management of this unusual glandular tumor. Conclusion: It is of immense importance to differentiate the central mucoepidermoid from other osteolytic lesion and odontogenic cysts because of his malignancy and local aggressiveness. The treatment option is the radical excision, with the evaluation of neck nodes, and radiotherapy is only recommended in the most aggressive of cases.

Research paper thumbnail of LETTER TO THE EDITOR

Research paper thumbnail of Micro RNA as Biomarkers of Head and Neck Cancers

Journal of Integrative Oncology, 2014

Research paper thumbnail of Socioeconomic status and health conditions associated with incidence of dental caries in Brazilian children

Journal of Medicine and the Person, 2015

The purpose of this study was to assess the prevalence and severity of caries in primary and perm... more The purpose of this study was to assess the prevalence and severity of caries in primary and permanent dentition and to investigate the association between disease distribution and socio-demographic conditions, oral hygiene, and dietary habits of a population of schoolchildren in three districts of Belo Horizonte, Brazil, in 2012. This study involved 753 schoolchildren, aged 3-15 years, of two socio-economic levels: a low level, in a public school and kindergarten; and a high level, in a private school. The mean decayed, missing and filled deciduous infant teeth (dmft) values in children age 6 years and decayed, missing, and filled permanent adult teeth (DMFT) at 12 years were similar between children in the public school (dmft, 1.53; DMFT, 0.56) and the private school (dmft, 1.53; DMFT, 0.28). A low DMFT is associated with the habit of cleaning teeth after eating sweet foods, when the fathers were employed at the time of the child's birth and if children started to brush their teeth earlier than 3 years of age. The data show that oral health monitoring of schoolchildren is a significant factor that can reduce dental caries, even in children from poor families. It is necessary to educate children to brush teeth before the 3 years of age, and to create prevention programs for children whose fathers are unemployed.

Research paper thumbnail of Tumor infiltration depth as predictor of nodal metastasis in early tongue squamous cell carcinoma: study on an Italian cancer population

Journal of Oral and Maxillofacial Surgery, 2015

A retrospective longitudinal study was conducted to identify the cutoff value of infiltration dep... more A retrospective longitudinal study was conducted to identify the cutoff value of infiltration depth for predicting the risk of lymph node metastasis of the neck in a well-defined population of surgically treated patients affected by stage T1 to T2 oral squamous cell carcinoma of the tongue. Sixty-seven patients were enrolled in this study. Forty-four patients (65.5%) had pN0 status and 23 (34.5%) had pN(+) status. Thirty-five positive lymph nodes were analyzed. The median follow-up for these patients was 51.4 months. The mean infiltration depth of the N-negative group was 2.4 mm; this was substantially different from the mean value observed in the N-positive group at 5.5 mm. A meaningful cutoff was identified at an infiltration depth value of 4 mm. Infiltration depth was identified as an important predictor for neck nodal status. In this specific population, mortality was associated with increasing tumor infiltration depth.

Research paper thumbnail of Mandibular reconstructions using computer-aided design/computer-aided manufacturing: A systematic review of a defect-based reconstructive algorithm

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, Jan 19, 2015

Modern planning techniques, including computer-aided design/computer-aided manufacturing (CAD-CAM... more Modern planning techniques, including computer-aided design/computer-aided manufacturing (CAD-CAM) can be used to plan reconstructive surgery, optimising aesthetic outcomes and functional rehabilitation. However, although many such applications are available, no systematic protocol yet describes the entire reconstructive procedure, which must include virtual planning, custom manufacture, and a reconstructive algorithm. We reviewed current practices in this novel field, analysed case series described in the literature, and developed a new, defect-based reconstructive algorithm. We also evaluated methods of mandibular reconstruction featuring virtual planning, the use of surgical guides, and laser printing of custom titanium bony plates to support composite free flaps, and evaluated their utility.

Research paper thumbnail of DNA methylation analysis by bisulfite next-generation sequencing for early detection of oral squamous cell carcinoma and high-grade squamous intraepithelial lesion from oral brushing

Journal of Cranio-Maxillofacial Surgery, 2015

Research paper thumbnail of Ki-67 and p53 expression in ghost cell odontogenic carcinoma: a case report and literature review

Oral and maxillofacial surgery, 2015

Ghost cell odontogenic carcinomas are rare neoplasms that arise in the maxillary bones either fro... more Ghost cell odontogenic carcinomas are rare neoplasms that arise in the maxillary bones either from a calcifying odontogenic cyst or de novo. They are aggressive locally and can metastasize. We report herein a case of a ghost cell odontogenic carcinoma arising in the mandible of a Caucasian male 86 years of age. We have described the clinical and radiographic features, histological characteristics, immunohistochemistry findings, and surgical treatment. We especially focused on how Ki-67 expression guides the treatment choice. Finally, we reviewed 32 cases described in the literature and compared them with the cases described up until 2014 to help clinicians identify the diagnostic characteristics of and select appropriate treatment modalities for ghost cell odontogenic carcinomas.

Research paper thumbnail of Jaw Cysts Diagnosed in an Italian Population Over a 20-Year Period

International Journal of Surgical Pathology, 2014

Background. Cysts of the jaws (JCs) are an important topic of oral pathology, but few epidemiolog... more Background. Cysts of the jaws (JCs) are an important topic of oral pathology, but few epidemiological data are present in the literature, in particular about the potential of recurrence. The aim of this study was to describe a case series of JCs from a single institution, evaluating the frequency, the site, the age distribution, and the percentage of recurrence of all types of JCs. Methods. All JCs present in the histological records of the Section of Anatomic Pathology of the University of Bologna at Bellaria Hospital from 1992 to 2012 were retrieved. Results. A total of 1136 jaws cysts were obtained, of which 1117 (98.3%) were odontogenic and 19 (1.7%) were nonodontogenic. About odontogenic cysts (OCs), the most frequent was the radicular cyst (538 cases), followed by parakeratinized keratocystic odontogenic tumor (pKOT, 193 cases) and dentigerous cyst (120 cases). Among pKOT, 21 out of 193 cases (10.89%) showed a recurrence after a mean time of 4.5 years (range, 1-12 years). During follow-up (mean 11 years, range 1-19 years), all 3 cases of botrioid cysts, 12 out of 46 cases of unicystic ameloblastoma (26.09%), 2 out of 20 cases of calcifying OCs (10%) and 2 out of 538 cases of radicular cyst (0.37%) showed a recurrence. Conclusion. Our study confirms that the distribution pattern of JCs in Italy is relatively similar to other studies worldwide and emphasizes the importance of recognizing the different histological types of JCs for their potential local aggressive behavior.

Research paper thumbnail of Aggressive Central Giant Cell Granuloma of the Mandible

Journal of Oral and Maxillofacial Surgery, 2010

Research paper thumbnail of Laser evaporation versus laser excision of oral leukoplakia: A retrospective study with long-term follow-up

Journal of Cranio-Maxillofacial Surgery, 2015

Objectives: The study makes a comparison between two surgical approaches for the treatment of ora... more Objectives: The study makes a comparison between two surgical approaches for the treatment of oral leukoplakia (OL) in terms of recurrence in a well-defined cohort of patients with a long-term follow-up period. Methods: The cohort consisted of 77 OL patients divided into 2 groups. Group 1: 47 patients treated with laser evaporation using a Nd:YAG laser. Group 2: 30 patients treated with a CO 2 laser for excision. Clinical and histological examinations were performed for the diagnosis of OL before treatment. We included OLs with or without dysplasia. The mean follow-up period was 60 ± 32.49 months. Results: Of the 77 patients, 22 (28.5%) showed recurrence during the follow-up period. No significant difference was found between the two treatments (c 2 ¼ 2.6; p ¼ 0.2). However, CO 2 laser excision resulted in better results than the Nd:YAG laser evaporation, considering the non-homogeneous OLs (c 2 ¼ 3.9; p ¼ 0.04) and OLs with mild dysplasia (c 2 ¼ 4.6; p ¼ 0.03). Discussion: The study makes a comparison between our results and articles from the literature, and suggests when each of the two surgical approaches is most appropriate.

Research paper thumbnail of Central mucoepidermoid carcinoma in a young patient: A case report and review of the literature

Background: Central mucoepidermoid carcinoma is a rare malignant salivary neoplasm arising inside... more Background: Central mucoepidermoid carcinoma is a rare malignant salivary neoplasm arising inside the bone of the jaws. We report a rare case of central mucoepidermoid carcinoma of a 16-year-old girl arising in the maxilla. Clinical and radiological analyses were shown and discussed, as well as the surgical treatment. Methods: A left maxillectomy from the last molar to the first premolar was performed, and the site was reconstructed using a fibula free flap stabilized with titanium plates. Results: The young patient was followed up for more than 6 years, and to date no recurrence was observed. A literature review of the 11 rare previous cases was provided to guide the clinician in the diagnosis and management of this unusual glandular tumor. Conclusion: It is of immense importance to differentiate the central mucoepidermoid from other osteolytic lesion and odontogenic cysts because of his malignancy and local aggressiveness. The treatment option is the radical excision, with the evaluation of neck nodes, and radiotherapy is only recommended in the most aggressive of cases.

Research paper thumbnail of LETTER TO THE EDITOR

Research paper thumbnail of Micro RNA as Biomarkers of Head and Neck Cancers

Journal of Integrative Oncology, 2014

Research paper thumbnail of Socioeconomic status and health conditions associated with incidence of dental caries in Brazilian children

Journal of Medicine and the Person, 2015

The purpose of this study was to assess the prevalence and severity of caries in primary and perm... more The purpose of this study was to assess the prevalence and severity of caries in primary and permanent dentition and to investigate the association between disease distribution and socio-demographic conditions, oral hygiene, and dietary habits of a population of schoolchildren in three districts of Belo Horizonte, Brazil, in 2012. This study involved 753 schoolchildren, aged 3-15 years, of two socio-economic levels: a low level, in a public school and kindergarten; and a high level, in a private school. The mean decayed, missing and filled deciduous infant teeth (dmft) values in children age 6 years and decayed, missing, and filled permanent adult teeth (DMFT) at 12 years were similar between children in the public school (dmft, 1.53; DMFT, 0.56) and the private school (dmft, 1.53; DMFT, 0.28). A low DMFT is associated with the habit of cleaning teeth after eating sweet foods, when the fathers were employed at the time of the child's birth and if children started to brush their teeth earlier than 3 years of age. The data show that oral health monitoring of schoolchildren is a significant factor that can reduce dental caries, even in children from poor families. It is necessary to educate children to brush teeth before the 3 years of age, and to create prevention programs for children whose fathers are unemployed.

Research paper thumbnail of Tumor infiltration depth as predictor of nodal metastasis in early tongue squamous cell carcinoma: study on an Italian cancer population

Journal of Oral and Maxillofacial Surgery, 2015

A retrospective longitudinal study was conducted to identify the cutoff value of infiltration dep... more A retrospective longitudinal study was conducted to identify the cutoff value of infiltration depth for predicting the risk of lymph node metastasis of the neck in a well-defined population of surgically treated patients affected by stage T1 to T2 oral squamous cell carcinoma of the tongue. Sixty-seven patients were enrolled in this study. Forty-four patients (65.5%) had pN0 status and 23 (34.5%) had pN(+) status. Thirty-five positive lymph nodes were analyzed. The median follow-up for these patients was 51.4 months. The mean infiltration depth of the N-negative group was 2.4 mm; this was substantially different from the mean value observed in the N-positive group at 5.5 mm. A meaningful cutoff was identified at an infiltration depth value of 4 mm. Infiltration depth was identified as an important predictor for neck nodal status. In this specific population, mortality was associated with increasing tumor infiltration depth.

Research paper thumbnail of Mandibular reconstructions using computer-aided design/computer-aided manufacturing: A systematic review of a defect-based reconstructive algorithm

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, Jan 19, 2015

Modern planning techniques, including computer-aided design/computer-aided manufacturing (CAD-CAM... more Modern planning techniques, including computer-aided design/computer-aided manufacturing (CAD-CAM) can be used to plan reconstructive surgery, optimising aesthetic outcomes and functional rehabilitation. However, although many such applications are available, no systematic protocol yet describes the entire reconstructive procedure, which must include virtual planning, custom manufacture, and a reconstructive algorithm. We reviewed current practices in this novel field, analysed case series described in the literature, and developed a new, defect-based reconstructive algorithm. We also evaluated methods of mandibular reconstruction featuring virtual planning, the use of surgical guides, and laser printing of custom titanium bony plates to support composite free flaps, and evaluated their utility.

Research paper thumbnail of DNA methylation analysis by bisulfite next-generation sequencing for early detection of oral squamous cell carcinoma and high-grade squamous intraepithelial lesion from oral brushing

Journal of Cranio-Maxillofacial Surgery, 2015

Research paper thumbnail of Ki-67 and p53 expression in ghost cell odontogenic carcinoma: a case report and literature review

Oral and maxillofacial surgery, 2015

Ghost cell odontogenic carcinomas are rare neoplasms that arise in the maxillary bones either fro... more Ghost cell odontogenic carcinomas are rare neoplasms that arise in the maxillary bones either from a calcifying odontogenic cyst or de novo. They are aggressive locally and can metastasize. We report herein a case of a ghost cell odontogenic carcinoma arising in the mandible of a Caucasian male 86 years of age. We have described the clinical and radiographic features, histological characteristics, immunohistochemistry findings, and surgical treatment. We especially focused on how Ki-67 expression guides the treatment choice. Finally, we reviewed 32 cases described in the literature and compared them with the cases described up until 2014 to help clinicians identify the diagnostic characteristics of and select appropriate treatment modalities for ghost cell odontogenic carcinomas.

Research paper thumbnail of Jaw Cysts Diagnosed in an Italian Population Over a 20-Year Period

International Journal of Surgical Pathology, 2014

Background. Cysts of the jaws (JCs) are an important topic of oral pathology, but few epidemiolog... more Background. Cysts of the jaws (JCs) are an important topic of oral pathology, but few epidemiological data are present in the literature, in particular about the potential of recurrence. The aim of this study was to describe a case series of JCs from a single institution, evaluating the frequency, the site, the age distribution, and the percentage of recurrence of all types of JCs. Methods. All JCs present in the histological records of the Section of Anatomic Pathology of the University of Bologna at Bellaria Hospital from 1992 to 2012 were retrieved. Results. A total of 1136 jaws cysts were obtained, of which 1117 (98.3%) were odontogenic and 19 (1.7%) were nonodontogenic. About odontogenic cysts (OCs), the most frequent was the radicular cyst (538 cases), followed by parakeratinized keratocystic odontogenic tumor (pKOT, 193 cases) and dentigerous cyst (120 cases). Among pKOT, 21 out of 193 cases (10.89%) showed a recurrence after a mean time of 4.5 years (range, 1-12 years). During follow-up (mean 11 years, range 1-19 years), all 3 cases of botrioid cysts, 12 out of 46 cases of unicystic ameloblastoma (26.09%), 2 out of 20 cases of calcifying OCs (10%) and 2 out of 538 cases of radicular cyst (0.37%) showed a recurrence. Conclusion. Our study confirms that the distribution pattern of JCs in Italy is relatively similar to other studies worldwide and emphasizes the importance of recognizing the different histological types of JCs for their potential local aggressive behavior.

Research paper thumbnail of Aggressive Central Giant Cell Granuloma of the Mandible

Journal of Oral and Maxillofacial Surgery, 2010

Research paper thumbnail of Laser evaporation versus laser excision of oral leukoplakia: A retrospective study with long-term follow-up

Journal of Cranio-Maxillofacial Surgery, 2015

Objectives: The study makes a comparison between two surgical approaches for the treatment of ora... more Objectives: The study makes a comparison between two surgical approaches for the treatment of oral leukoplakia (OL) in terms of recurrence in a well-defined cohort of patients with a long-term follow-up period. Methods: The cohort consisted of 77 OL patients divided into 2 groups. Group 1: 47 patients treated with laser evaporation using a Nd:YAG laser. Group 2: 30 patients treated with a CO 2 laser for excision. Clinical and histological examinations were performed for the diagnosis of OL before treatment. We included OLs with or without dysplasia. The mean follow-up period was 60 ± 32.49 months. Results: Of the 77 patients, 22 (28.5%) showed recurrence during the follow-up period. No significant difference was found between the two treatments (c 2 ¼ 2.6; p ¼ 0.2). However, CO 2 laser excision resulted in better results than the Nd:YAG laser evaporation, considering the non-homogeneous OLs (c 2 ¼ 3.9; p ¼ 0.04) and OLs with mild dysplasia (c 2 ¼ 4.6; p ¼ 0.03). Discussion: The study makes a comparison between our results and articles from the literature, and suggests when each of the two surgical approaches is most appropriate.