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Gratiela Pircalabioru

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Papers by Gratiela Pircalabioru

Research paper thumbnail of Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer

Frontiers in Immunology

The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea, and prot... more The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea, and protozoans, bringing to the host organism a dowry of cells and genes more numerous than its own. Among the different non-sterile cavities, the human gut harbors the most complex microbiota, with a strong impact on host homeostasis and immunostasis, being thus essential for maintaining the health condition. In this review, we outline the roles of gut microbiota in immunity, starting with the background information supporting the further presentation of the implications of gut microbiota dysbiosis in host susceptibility to infections, hypersensitivity reactions, autoimmunity, chronic inflammation, and cancer. The role of diet and antibiotics in the occurrence of dysbiosis and its pathological consequences, as well as the potential of probiotics to restore eubiosis is also discussed.

Research paper thumbnail of Cytokine profiles of HeLa and human diploid cells induced by different fractions of Vibrio parahaemolyticus cultures exposed to stress conditions

Roumanian Archives of Microbiology and Immunology, 2010

113 119 125 139 145 153 164 112 ROMANIAN ARCHIVES OF MICROBIOLOGY AND IMMUNOLOGY Aims and Scope R... more 113 119 125 139 145 153 164 112 ROMANIAN ARCHIVES OF MICROBIOLOGY AND IMMUNOLOGY Aims and Scope Romanian Archives of Microbiology and Immunoloy, an international journal dedicated to original research work, publishes papers focusing on various aspects of microbiology and immunology. Romanian Archives of Microbiology and Immunology is indexed in MEDLINE. The frequency of the Journal is currently four issues per year.

Research paper thumbnail of THE EFFECTS OF HEAT AND OSMOTIC STRESS ON VIBRIO PARAHAEMOLYTICUS SURVIVAL RATES, CELLULAR MORPHOLOGY AND TDH PRODUCTION

International journal of Advanced Biological and Biomedical Research

Research paper thumbnail of Cytokine profiles of HeLa and human diploid cells induced by different fractions of Vibrio parahaemolyticus cultures exposed to stress conditions

Roumanian archives of microbiology and immunology

Vibrio (V.) parahaemolyticus is an aquatic halophilic bacteria which produces gastroenteritis and... more Vibrio (V.) parahaemolyticus is an aquatic halophilic bacteria which produces gastroenteritis and in rare cases septicaemia after the consumption of raw or under-cooked contaminated seafood.The severity of diarrheal illness caused by this bacterium is closely related to the presence of two types of hemolysins (the thermostable direct hemolysin-TDH and TDH related hemolysin-TRH) and also of type III secretion system (TTSS) proteins. The TTSS type 1 induces a wide array of effects on infected HeLa cells such as autophagy, oncosis, cell rounding and lysis. Previous studies have shown that heat shock proteins have the ability to stimulate the production of interleukins in different cellular cultures. In our studies we have stimulated two cellular lines (HeLa and human diploid cells) with different V. parahaemolyticus culture fractions in order to observe the effect on cytokines production. Thus, the purpose of this study was to analyze the expression of IL-1, IL-2, IL-4, IL-6, IL-10 and...

Research paper thumbnail of Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer

Frontiers in Immunology

The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea, and prot... more The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea, and protozoans, bringing to the host organism a dowry of cells and genes more numerous than its own. Among the different non-sterile cavities, the human gut harbors the most complex microbiota, with a strong impact on host homeostasis and immunostasis, being thus essential for maintaining the health condition. In this review, we outline the roles of gut microbiota in immunity, starting with the background information supporting the further presentation of the implications of gut microbiota dysbiosis in host susceptibility to infections, hypersensitivity reactions, autoimmunity, chronic inflammation, and cancer. The role of diet and antibiotics in the occurrence of dysbiosis and its pathological consequences, as well as the potential of probiotics to restore eubiosis is also discussed.

Research paper thumbnail of Cytokine profiles of HeLa and human diploid cells induced by different fractions of Vibrio parahaemolyticus cultures exposed to stress conditions

Roumanian Archives of Microbiology and Immunology, 2010

113 119 125 139 145 153 164 112 ROMANIAN ARCHIVES OF MICROBIOLOGY AND IMMUNOLOGY Aims and Scope R... more 113 119 125 139 145 153 164 112 ROMANIAN ARCHIVES OF MICROBIOLOGY AND IMMUNOLOGY Aims and Scope Romanian Archives of Microbiology and Immunoloy, an international journal dedicated to original research work, publishes papers focusing on various aspects of microbiology and immunology. Romanian Archives of Microbiology and Immunology is indexed in MEDLINE. The frequency of the Journal is currently four issues per year.

Research paper thumbnail of THE EFFECTS OF HEAT AND OSMOTIC STRESS ON VIBRIO PARAHAEMOLYTICUS SURVIVAL RATES, CELLULAR MORPHOLOGY AND TDH PRODUCTION

International journal of Advanced Biological and Biomedical Research

Research paper thumbnail of Cytokine profiles of HeLa and human diploid cells induced by different fractions of Vibrio parahaemolyticus cultures exposed to stress conditions

Roumanian archives of microbiology and immunology

Vibrio (V.) parahaemolyticus is an aquatic halophilic bacteria which produces gastroenteritis and... more Vibrio (V.) parahaemolyticus is an aquatic halophilic bacteria which produces gastroenteritis and in rare cases septicaemia after the consumption of raw or under-cooked contaminated seafood.The severity of diarrheal illness caused by this bacterium is closely related to the presence of two types of hemolysins (the thermostable direct hemolysin-TDH and TDH related hemolysin-TRH) and also of type III secretion system (TTSS) proteins. The TTSS type 1 induces a wide array of effects on infected HeLa cells such as autophagy, oncosis, cell rounding and lysis. Previous studies have shown that heat shock proteins have the ability to stimulate the production of interleukins in different cellular cultures. In our studies we have stimulated two cellular lines (HeLa and human diploid cells) with different V. parahaemolyticus culture fractions in order to observe the effect on cytokines production. Thus, the purpose of this study was to analyze the expression of IL-1, IL-2, IL-4, IL-6, IL-10 and...

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