M.-l. Pascu | University of Bucharest (original) (raw)
Papers by M.-l. Pascu
Biomicrofluidics, 2015
In this paper, laser beam resonant interaction with pendant microdroplets that are seeded with a ... more In this paper, laser beam resonant interaction with pendant microdroplets that are seeded with a laser dye (Rhodamine 6G (Rh6G)) water solution or oily Vitamin A emulsion with Rhodamine 6G solution in water is investigated through fluorescence spectra analysis. The excitation is made with the second harmonic generated beam emitted by a pulsed Nd:YAG laser system at 532 nm. The pendant microdroplets containing emulsion exhibit an enhanced fluorescence signal. This effect can be explained as being due to the scattering of light by the sub-micrometric drops of oily Vitamin A in emulsion and by the spherical geometry of the pendant droplet. The droplet acts as an optical resonator amplifying the fluorescence signal with the possibility of producing lasing effect. Here, we also investigate how Rhodamine 6G concentration, pumping laser beam energies and number of pumping laser pulses influence the fluorescence behavior. The results can be useful in optical imaging, since they can lead to the use of smaller quantities of fluorescent dyes to obtain results with the same quality.
Results of a study of molecular ions in a Cs thermoionic plasma, relying on thermoionic detection... more Results of a study of molecular ions in a Cs thermoionic plasma, relying on thermoionic detection (with detection of positive atomic or molecular ions formed in the space charge region of a Cs diode), are reported and analyzed. A complete molecular spectrum generated via absorption of two photons is obtained for the first time (Cs2 molecular bands system peaking at
Phlebology / Venous Forum of the Royal Society of Medicine, 2014
To assess the efficacy and safety of a new method of clearing varicose veins in the long term. It... more To assess the efficacy and safety of a new method of clearing varicose veins in the long term. It consists of applying the long-pulsed Nd:YAG laser following the injection of polidocanol microfoam, in two consecutive sessions, treating both legs in full in each session. Randomized, Polidocanol-controlled, blind evaluation clinical trial comparing the results between 79 legs treated with Polidocanol and 517 treated with Polidocanol + Laser. Photographs were taken preoperatively and at three months, two years and three years after treatment, as well as patient self-assessments. Polidocanol + Laser is much more effective than polidocanol microfoam in clearing venulectasias with a diameter under 4 mm (p < 0.001). After three years, clearing percentages of 89% (Class I veins), 94% (Class II veins) and 95% (Class III veins) are observed, in comparison to 15%, 18% and 17%, respectively when only polidocanol was applied. No unexpected adverse effects were found and 86% of patients stated...
Oftalmologia (Bucharest, Romania : 1990), 2004
Photodynamic therapy is an emerging method for local destruction of tissue by generating toxic ox... more Photodynamic therapy is an emerging method for local destruction of tissue by generating toxic oxygen species using light absorbed by an administered or an endogenously generated photosensitiser. It is a promising treatment for patients with cancer. More recently it has found increasing use as a method of therapy for non-cancerous illnesses. Following administration of a photosensitiser occurs an accumulation or retention in areas of cancer and disease relative to adjacent normal tissue. The photosensitiser is inactive until irradiated by light, following which cellular destruction occurs. This explanation is a good reason for the scientific and clinical interest in photodynamic therapy.
Oftalmologia (Bucharest, Romania : 1990), 2003
The photodynamic therapy (PDT) became more and more widely used in the treatment of different mal... more The photodynamic therapy (PDT) became more and more widely used in the treatment of different malignant tumors. For present studies, porphyrins and haematoporphyrin derivatives, in the conditions of N2 laser radiation, were chosen because their strong absorption along a large spectral range; this makes possible the excitation of their fluorescence at 337.1 nm, which is the wavelength of the N2 pulsed laser radiation. The photophysical and photochemical properties depend on the central metal and the peripheral substituents. Trying to find an optimal sensitizer to be used with N2 laser in photodynamic therapy (PDT), a spectroscopic study of these dyes was performed. The obtained data show that the UV radiation emitted by a N2 pulsed laser may be used for PDT application; among other dyes having interesting characteristics, Zn-TSPP and Zn-TNP in DMSO at 0.5% concentration seem to be more relevant.
Chaos and Complex Systems, 2012
This paper reports the observation of the two-photon ionization of molecular cesium as a continuo... more This paper reports the observation of the two-photon ionization of molecular cesium as a continuous function of laser wavelength in the 6200-6600-Å region with a tunable dye laser having a 0.18-Cm-1 linewidth. To the author's knowledge, it serves to illustrate the first extension to neutral molecular species of the important techniques of resonant multiphoton photodetachment spectroscopy. The resulting two-photon photoionization
Biomicrofluidics, 2015
In this paper, laser beam resonant interaction with pendant microdroplets that are seeded with a ... more In this paper, laser beam resonant interaction with pendant microdroplets that are seeded with a laser dye (Rhodamine 6G (Rh6G)) water solution or oily Vitamin A emulsion with Rhodamine 6G solution in water is investigated through fluorescence spectra analysis. The excitation is made with the second harmonic generated beam emitted by a pulsed Nd:YAG laser system at 532 nm. The pendant microdroplets containing emulsion exhibit an enhanced fluorescence signal. This effect can be explained as being due to the scattering of light by the sub-micrometric drops of oily Vitamin A in emulsion and by the spherical geometry of the pendant droplet. The droplet acts as an optical resonator amplifying the fluorescence signal with the possibility of producing lasing effect. Here, we also investigate how Rhodamine 6G concentration, pumping laser beam energies and number of pumping laser pulses influence the fluorescence behavior. The results can be useful in optical imaging, since they can lead to the use of smaller quantities of fluorescent dyes to obtain results with the same quality.
Consideration is given to three types of pulsed nitrogen lasers (PNL): (1) a PNL using a Blumlein... more Consideration is given to three types of pulsed nitrogen lasers (PNL): (1) a PNL using a Blumlein line in series with the discharge tube and a thyratron in a central position with respect to the tube, (2) a PNL using a Blumlein transmission line in series with the tube and a spark gap in central position instead of the thyratron,
Journal of the European Optical Society: Rapid Publications, 2012
The interaction of distilled water droplets (volumes of 3-4 µl) with pulsed laser beams emitted a... more The interaction of distilled water droplets (volumes of 3-4 µl) with pulsed laser beams emitted at 532 nm is described. At 532 nm the distilled water absorption is very low and the interaction of a water droplet with the laser radiation is dominated by unresonant phenomena. In this case, following the collision of the laser beam with a droplet in suspended position in air, its deformations and mechanical vibrations are produced. The conditions in which the droplets lose material as a consequence of the impact with laser beams are explored. The effects produced on the droplet were studied pulse by pulse and depend on: droplet's content, beam wavelength, power and focusing, irradiation geometry and adhesion of the droplet to the capillary on which it is suspended. The laser pulses energies were varied in four steps: 0.25 mJ, 0.4 mJ, 0.7 mJ and 1 mJ. The laser pulse full time width at half maximum was 5ns and the typical beam waist diameter on the droplet was 90 µm; the beam had a relatively low divergence around the focus point. The droplet's shapes evolution is visualised by recordings performed at 10 kframes/second. Following a droplet interaction with the laser beam one may also produce at a controlled moment in time, nanodroplets propagating at high (probably supersonic) speeds and microdroplets propagating at slower speeds. One may also produce suspended droplets of smaller dimensions than the initial one as well as micro/nano gas bubbles in the suspended droplet's material/volume. In a second set of experiments the behaviour of the microdroplets of Rhodamine 6G in distilled water was recorded at high speed, at resonant interaction with similar laser pulses, and at the same power levels. The phenomena considering that the droplets contents are Newtonian liquids produced at interaction with the laser beams, are discussed.
Journal of the European Optical Society: Rapid Publications, 2013
Synchronization characteristics of two bidirectionally coupled semiconductor lasers, one operatin... more Synchronization characteristics of two bidirectionally coupled semiconductor lasers, one operating in a chaotic regime with low-frequency fluctuations and the other with free laser beam emission, were experimentally investigated. The chaotic synchronization regimes and optical spectral behavior of the coupled system were analyzed with respect to the optical spectra emitted initially by the two uncoupled lasers operated under the same feedback conditions. It was observed that the number of synchronization regimes that can be obtained and their stability depend on the similarity of spectral structures of the uncoupled lasers emissions. The dominant active laser modes of the coupled system emission coincide with the laser modes of the one or both uncoupled laser emissions, depending on the operating synchronization regime. We have associated changes in the optical spectrum of the coupled system with the synchronization regimes. The repartition of power between the active modes of a coupled system allows identification of the synchronization regime.
Letters in Drug Design & Discovery, 2010
Letters in Drug Design and Discovery, 2011
Physical Chemistry of Interfaces and Nanomaterials IX, 2010
The multiple resistances to treatment, developed by bacteria and malignant tumors require finding... more The multiple resistances to treatment, developed by bacteria and malignant tumors require finding alternatives to the existing medicines and treatment procedures. One of them is strengthening the effects of cytostatics by improving the delivery method. Such a method is represented by the use of medicines as micro/nano-droplets. This method can reduce the substance consumption by generating drug micro-droplets incorporated in
International Journal of Pharmaceutics, 2015
Foam sclerotherapy is a widely used method to treat varicose veins disease. It is easy to use and... more Foam sclerotherapy is a widely used method to treat varicose veins disease. It is easy to use and apply, affordable, and has high efficiency that depends on foam stability upon injection. Since sclerotherapy is usually applied in a medical doctor's office, one of the most employed methods to generate foam is based on the Tessari technique which uses pumping cycles of liquid and air in-and-out of a double syringe system. Finally, the produced foam exits through a small orifice ($2 mm) at the output of a three-way valve. The present work shows results regarding the factors that may influence foam stability (liquid to air ratio, type of connector, syringe diameter, number of pumping cycles, etc.) of a commonly used sclerosing agent (polidocanol). Furthermore, an effort is made to evaluate the effect of adding different substances on the stability of polidocanol foams (0.5% w/w) by altering the surface tension or/and the bulk and interfacial rheological properties of the fluids. It is shown that adding small concentrations of nonionic surfactants can increase foam stability with just a very small variation of the mean bubbles size.
Letters in Drug Design & Discovery, 2012
ABSTRACT Literature reports show numerous studies concerning the occurrence, evolution, detection... more ABSTRACT Literature reports show numerous studies concerning the occurrence, evolution, detection and removal of, generically, pharmaceutical pollutants in/from environment. The current report is focused on the Phenothiazines class, in particular on Thioridazine (Thr). We discuss the time evolution of the absorption spectra of Thioridazine HCl solutions in ultra-pure water considering the racemic mixture and the two enantiomers: Thioridazine (-) and Thioridazine (+); the utilized concentration range was 10 -5M-10 -3M, and the temperature/light conditions were: 4°C in dark, 22°C in dark and 22°C in daylight. The 10-5M Thr solutions were exposed at 266nm Nd:YAG pulsed laser radiation for time intervals between (1 - 3)h with the average pulse energy on the sample of 0.263mJ. Another irradiation experiment has involved Thr solutions at 5x10 -2M, which were irradiated for time intervals between (1 - 30)min with 355nm Nd:YAG pulsed laser beam of average pulse energy on the sample 1.45mJ. The stability studies based on the absorption spectra measurements were conducted after exposure to the laser beams. The photodegradation processes of Thr are discussed.
The study of the photosensitiser properties of the cytostatics drugs was made since their effects... more The study of the photosensitiser properties of the cytostatics drugs was made since their effects cou ld be enhanced by exposure to UV radiation at different doses. Fluorouracil (FU) solutions 2.5x10-4M in natural saline and sodium hydroxide, irradiated with optical beams emitted by N2 laser and UV Hg classic lamp, were used. The FU was chosen due to its s
Journal of Physics E: Scientific Instruments, 1988
The design and operational characteristics of a high repetition rate TEA CO2 laser are described.... more The design and operational characteristics of a high repetition rate TEA CO2 laser are described. The laser operates at variable pulse repetition frequencies up to 100 Hz. Stable operation is obtained in a closed cycle which includes a gas mixture regenerator. Energies of up to 10 J/pulse are obtained in pulses having 25 MW peak powers. Average powers as high
Physical Chemistry of Interfaces and Nanomaterials X, 2011
One of the alternatives to the existing medicines and treatment procedures in fighting multi drug... more One of the alternatives to the existing medicines and treatment procedures in fighting multi drug resistance (MDR) is strengthening the effects of medicines by modifying their molecular structures through exposure to laser radiation. A method associated with this, is the generation of micro-droplets which contain medicines solutions; the droplets are utilized/produced as vectors to transport the medicines to targets. In
The increase/modification of the Cisplatinum therapeutic index by neoplastic tissue exposure to o... more The increase/modification of the Cisplatinum therapeutic index by neoplastic tissue exposure to optical radiation emitted between 400-2000 nm was studied; Cisplatinumum molecules do not absorb between 400 nm-2 &amp;amp;amp;amp;amp;square;m. Doppler ultrasonography indicates that, following exposure, the living tissue local micro-vascularisation increases in a controlled and reversible way. The increase in the Cisplatinum therapeutic index may be produced by accelerating the
Biomicrofluidics, 2015
In this paper, laser beam resonant interaction with pendant microdroplets that are seeded with a ... more In this paper, laser beam resonant interaction with pendant microdroplets that are seeded with a laser dye (Rhodamine 6G (Rh6G)) water solution or oily Vitamin A emulsion with Rhodamine 6G solution in water is investigated through fluorescence spectra analysis. The excitation is made with the second harmonic generated beam emitted by a pulsed Nd:YAG laser system at 532 nm. The pendant microdroplets containing emulsion exhibit an enhanced fluorescence signal. This effect can be explained as being due to the scattering of light by the sub-micrometric drops of oily Vitamin A in emulsion and by the spherical geometry of the pendant droplet. The droplet acts as an optical resonator amplifying the fluorescence signal with the possibility of producing lasing effect. Here, we also investigate how Rhodamine 6G concentration, pumping laser beam energies and number of pumping laser pulses influence the fluorescence behavior. The results can be useful in optical imaging, since they can lead to the use of smaller quantities of fluorescent dyes to obtain results with the same quality.
Results of a study of molecular ions in a Cs thermoionic plasma, relying on thermoionic detection... more Results of a study of molecular ions in a Cs thermoionic plasma, relying on thermoionic detection (with detection of positive atomic or molecular ions formed in the space charge region of a Cs diode), are reported and analyzed. A complete molecular spectrum generated via absorption of two photons is obtained for the first time (Cs2 molecular bands system peaking at
Phlebology / Venous Forum of the Royal Society of Medicine, 2014
To assess the efficacy and safety of a new method of clearing varicose veins in the long term. It... more To assess the efficacy and safety of a new method of clearing varicose veins in the long term. It consists of applying the long-pulsed Nd:YAG laser following the injection of polidocanol microfoam, in two consecutive sessions, treating both legs in full in each session. Randomized, Polidocanol-controlled, blind evaluation clinical trial comparing the results between 79 legs treated with Polidocanol and 517 treated with Polidocanol + Laser. Photographs were taken preoperatively and at three months, two years and three years after treatment, as well as patient self-assessments. Polidocanol + Laser is much more effective than polidocanol microfoam in clearing venulectasias with a diameter under 4 mm (p < 0.001). After three years, clearing percentages of 89% (Class I veins), 94% (Class II veins) and 95% (Class III veins) are observed, in comparison to 15%, 18% and 17%, respectively when only polidocanol was applied. No unexpected adverse effects were found and 86% of patients stated...
Oftalmologia (Bucharest, Romania : 1990), 2004
Photodynamic therapy is an emerging method for local destruction of tissue by generating toxic ox... more Photodynamic therapy is an emerging method for local destruction of tissue by generating toxic oxygen species using light absorbed by an administered or an endogenously generated photosensitiser. It is a promising treatment for patients with cancer. More recently it has found increasing use as a method of therapy for non-cancerous illnesses. Following administration of a photosensitiser occurs an accumulation or retention in areas of cancer and disease relative to adjacent normal tissue. The photosensitiser is inactive until irradiated by light, following which cellular destruction occurs. This explanation is a good reason for the scientific and clinical interest in photodynamic therapy.
Oftalmologia (Bucharest, Romania : 1990), 2003
The photodynamic therapy (PDT) became more and more widely used in the treatment of different mal... more The photodynamic therapy (PDT) became more and more widely used in the treatment of different malignant tumors. For present studies, porphyrins and haematoporphyrin derivatives, in the conditions of N2 laser radiation, were chosen because their strong absorption along a large spectral range; this makes possible the excitation of their fluorescence at 337.1 nm, which is the wavelength of the N2 pulsed laser radiation. The photophysical and photochemical properties depend on the central metal and the peripheral substituents. Trying to find an optimal sensitizer to be used with N2 laser in photodynamic therapy (PDT), a spectroscopic study of these dyes was performed. The obtained data show that the UV radiation emitted by a N2 pulsed laser may be used for PDT application; among other dyes having interesting characteristics, Zn-TSPP and Zn-TNP in DMSO at 0.5% concentration seem to be more relevant.
Chaos and Complex Systems, 2012
This paper reports the observation of the two-photon ionization of molecular cesium as a continuo... more This paper reports the observation of the two-photon ionization of molecular cesium as a continuous function of laser wavelength in the 6200-6600-Å region with a tunable dye laser having a 0.18-Cm-1 linewidth. To the author's knowledge, it serves to illustrate the first extension to neutral molecular species of the important techniques of resonant multiphoton photodetachment spectroscopy. The resulting two-photon photoionization
Biomicrofluidics, 2015
In this paper, laser beam resonant interaction with pendant microdroplets that are seeded with a ... more In this paper, laser beam resonant interaction with pendant microdroplets that are seeded with a laser dye (Rhodamine 6G (Rh6G)) water solution or oily Vitamin A emulsion with Rhodamine 6G solution in water is investigated through fluorescence spectra analysis. The excitation is made with the second harmonic generated beam emitted by a pulsed Nd:YAG laser system at 532 nm. The pendant microdroplets containing emulsion exhibit an enhanced fluorescence signal. This effect can be explained as being due to the scattering of light by the sub-micrometric drops of oily Vitamin A in emulsion and by the spherical geometry of the pendant droplet. The droplet acts as an optical resonator amplifying the fluorescence signal with the possibility of producing lasing effect. Here, we also investigate how Rhodamine 6G concentration, pumping laser beam energies and number of pumping laser pulses influence the fluorescence behavior. The results can be useful in optical imaging, since they can lead to the use of smaller quantities of fluorescent dyes to obtain results with the same quality.
Consideration is given to three types of pulsed nitrogen lasers (PNL): (1) a PNL using a Blumlein... more Consideration is given to three types of pulsed nitrogen lasers (PNL): (1) a PNL using a Blumlein line in series with the discharge tube and a thyratron in a central position with respect to the tube, (2) a PNL using a Blumlein transmission line in series with the tube and a spark gap in central position instead of the thyratron,
Journal of the European Optical Society: Rapid Publications, 2012
The interaction of distilled water droplets (volumes of 3-4 µl) with pulsed laser beams emitted a... more The interaction of distilled water droplets (volumes of 3-4 µl) with pulsed laser beams emitted at 532 nm is described. At 532 nm the distilled water absorption is very low and the interaction of a water droplet with the laser radiation is dominated by unresonant phenomena. In this case, following the collision of the laser beam with a droplet in suspended position in air, its deformations and mechanical vibrations are produced. The conditions in which the droplets lose material as a consequence of the impact with laser beams are explored. The effects produced on the droplet were studied pulse by pulse and depend on: droplet's content, beam wavelength, power and focusing, irradiation geometry and adhesion of the droplet to the capillary on which it is suspended. The laser pulses energies were varied in four steps: 0.25 mJ, 0.4 mJ, 0.7 mJ and 1 mJ. The laser pulse full time width at half maximum was 5ns and the typical beam waist diameter on the droplet was 90 µm; the beam had a relatively low divergence around the focus point. The droplet's shapes evolution is visualised by recordings performed at 10 kframes/second. Following a droplet interaction with the laser beam one may also produce at a controlled moment in time, nanodroplets propagating at high (probably supersonic) speeds and microdroplets propagating at slower speeds. One may also produce suspended droplets of smaller dimensions than the initial one as well as micro/nano gas bubbles in the suspended droplet's material/volume. In a second set of experiments the behaviour of the microdroplets of Rhodamine 6G in distilled water was recorded at high speed, at resonant interaction with similar laser pulses, and at the same power levels. The phenomena considering that the droplets contents are Newtonian liquids produced at interaction with the laser beams, are discussed.
Journal of the European Optical Society: Rapid Publications, 2013
Synchronization characteristics of two bidirectionally coupled semiconductor lasers, one operatin... more Synchronization characteristics of two bidirectionally coupled semiconductor lasers, one operating in a chaotic regime with low-frequency fluctuations and the other with free laser beam emission, were experimentally investigated. The chaotic synchronization regimes and optical spectral behavior of the coupled system were analyzed with respect to the optical spectra emitted initially by the two uncoupled lasers operated under the same feedback conditions. It was observed that the number of synchronization regimes that can be obtained and their stability depend on the similarity of spectral structures of the uncoupled lasers emissions. The dominant active laser modes of the coupled system emission coincide with the laser modes of the one or both uncoupled laser emissions, depending on the operating synchronization regime. We have associated changes in the optical spectrum of the coupled system with the synchronization regimes. The repartition of power between the active modes of a coupled system allows identification of the synchronization regime.
Letters in Drug Design & Discovery, 2010
Letters in Drug Design and Discovery, 2011
Physical Chemistry of Interfaces and Nanomaterials IX, 2010
The multiple resistances to treatment, developed by bacteria and malignant tumors require finding... more The multiple resistances to treatment, developed by bacteria and malignant tumors require finding alternatives to the existing medicines and treatment procedures. One of them is strengthening the effects of cytostatics by improving the delivery method. Such a method is represented by the use of medicines as micro/nano-droplets. This method can reduce the substance consumption by generating drug micro-droplets incorporated in
International Journal of Pharmaceutics, 2015
Foam sclerotherapy is a widely used method to treat varicose veins disease. It is easy to use and... more Foam sclerotherapy is a widely used method to treat varicose veins disease. It is easy to use and apply, affordable, and has high efficiency that depends on foam stability upon injection. Since sclerotherapy is usually applied in a medical doctor's office, one of the most employed methods to generate foam is based on the Tessari technique which uses pumping cycles of liquid and air in-and-out of a double syringe system. Finally, the produced foam exits through a small orifice ($2 mm) at the output of a three-way valve. The present work shows results regarding the factors that may influence foam stability (liquid to air ratio, type of connector, syringe diameter, number of pumping cycles, etc.) of a commonly used sclerosing agent (polidocanol). Furthermore, an effort is made to evaluate the effect of adding different substances on the stability of polidocanol foams (0.5% w/w) by altering the surface tension or/and the bulk and interfacial rheological properties of the fluids. It is shown that adding small concentrations of nonionic surfactants can increase foam stability with just a very small variation of the mean bubbles size.
Letters in Drug Design & Discovery, 2012
ABSTRACT Literature reports show numerous studies concerning the occurrence, evolution, detection... more ABSTRACT Literature reports show numerous studies concerning the occurrence, evolution, detection and removal of, generically, pharmaceutical pollutants in/from environment. The current report is focused on the Phenothiazines class, in particular on Thioridazine (Thr). We discuss the time evolution of the absorption spectra of Thioridazine HCl solutions in ultra-pure water considering the racemic mixture and the two enantiomers: Thioridazine (-) and Thioridazine (+); the utilized concentration range was 10 -5M-10 -3M, and the temperature/light conditions were: 4°C in dark, 22°C in dark and 22°C in daylight. The 10-5M Thr solutions were exposed at 266nm Nd:YAG pulsed laser radiation for time intervals between (1 - 3)h with the average pulse energy on the sample of 0.263mJ. Another irradiation experiment has involved Thr solutions at 5x10 -2M, which were irradiated for time intervals between (1 - 30)min with 355nm Nd:YAG pulsed laser beam of average pulse energy on the sample 1.45mJ. The stability studies based on the absorption spectra measurements were conducted after exposure to the laser beams. The photodegradation processes of Thr are discussed.
The study of the photosensitiser properties of the cytostatics drugs was made since their effects... more The study of the photosensitiser properties of the cytostatics drugs was made since their effects cou ld be enhanced by exposure to UV radiation at different doses. Fluorouracil (FU) solutions 2.5x10-4M in natural saline and sodium hydroxide, irradiated with optical beams emitted by N2 laser and UV Hg classic lamp, were used. The FU was chosen due to its s
Journal of Physics E: Scientific Instruments, 1988
The design and operational characteristics of a high repetition rate TEA CO2 laser are described.... more The design and operational characteristics of a high repetition rate TEA CO2 laser are described. The laser operates at variable pulse repetition frequencies up to 100 Hz. Stable operation is obtained in a closed cycle which includes a gas mixture regenerator. Energies of up to 10 J/pulse are obtained in pulses having 25 MW peak powers. Average powers as high
Physical Chemistry of Interfaces and Nanomaterials X, 2011
One of the alternatives to the existing medicines and treatment procedures in fighting multi drug... more One of the alternatives to the existing medicines and treatment procedures in fighting multi drug resistance (MDR) is strengthening the effects of medicines by modifying their molecular structures through exposure to laser radiation. A method associated with this, is the generation of micro-droplets which contain medicines solutions; the droplets are utilized/produced as vectors to transport the medicines to targets. In
The increase/modification of the Cisplatinum therapeutic index by neoplastic tissue exposure to o... more The increase/modification of the Cisplatinum therapeutic index by neoplastic tissue exposure to optical radiation emitted between 400-2000 nm was studied; Cisplatinumum molecules do not absorb between 400 nm-2 &amp;amp;amp;amp;amp;square;m. Doppler ultrasonography indicates that, following exposure, the living tissue local micro-vascularisation increases in a controlled and reversible way. The increase in the Cisplatinum therapeutic index may be produced by accelerating the