Pedro Massaguer | Universidade Estadual de Campinas (original) (raw)
Papers by Pedro Massaguer
International Journal of Advances in Medical Biotechnology - IJAMB
We are close to achieving the production of a biomimetic functional skin and this advance is main... more We are close to achieving the production of a biomimetic functional skin and this advance is mainly due to the demand that is not limited to the field of regenerative medicine, the need for transplantation of this organ due to the aging of the population, but for ethical reasons related to the tests of safety and efficacy of new formulas in animal models by the cosmetic and pharmaceutical industries. The limitations involved in traditional 2D cell culture approaches and manual techniques for biomimetic generation have driven the use of innovative technologies such as 3D bioprinting. One of the main advantages of the bioprinted skin is the authenticity, scalability and reproducibility of tissues compared to conventional constructs, via precise positioning of multiple cell types and the inclusion of appendages. The models of bioprinted skins will serve as a platform for the development of new formulations, molecule testing, disease simulation, as well as an alternative to chronic woun...
International Journal of Advances in Medical Biotechnology - IJAMB
The objective of this work is to map the main actors within the Brazilian innovation system frame... more The objective of this work is to map the main actors within the Brazilian innovation system framework in the field of tissue engineering and bioprinting, and analyze the main conditioners related to entrepreneurship and innovation. While keeping as a backdrop, the history of 3D Biotechnology Solutions startup, its challenges and projects. Tissue engineering is a subcategory of regenerative medicine with the purpose of repairing or substituting, partially or completely, tissues or organs that have been affected by some disease or lesion. The conventional methods used for the production of these biomaterials via tissue engineering do not have the capacity to mimic the reality of native structures in the nano, micro and macro scales, while guaranteeing the reproducibility and scalability of the materials. Technologies such as 3D bioprinting or additive manufacturing could change the way that many diseases are treated in the medium term by replacing the damaged tissues with custom bio-s...
This article proposes a comprehensive framework for R&D and innovation project selection under un... more This article proposes a comprehensive framework for R&D and innovation project selection under uncertainty and subject
to real-world constraints applicable to the Brazilian electricity sector, using a combination of integer programming
formulation and a PROMETHEE-based method. The objective is to contribute to this domain by offering an approach
suitable for the challenges of this sector, but also applicable to other situations involving R&D and innovation investments
under similar conditions. The manuscript presents applications using real data from an electricity company. It also compares
the proposed method with similar approaches found in the literature such as PROMETHEE II and V. The application
revealed the best performance of the proposed framework in dealing with the sector’s regulatory constraints, which
emphasize the companies’ accomplishment with R&D and innovation expenditures obligations. In this way, although R&D
and innovation project selection is not a typical case of optimization, under some particular regional, sector-based or
organization boundaries this can be a better solution.
International Journal of Advances in Medical Biotechnology - IJAMB
We are close to achieving the production of a biomimetic functional skin and this advance is main... more We are close to achieving the production of a biomimetic functional skin and this advance is mainly due to the demand that is not limited to the field of regenerative medicine, the need for transplantation of this organ due to the aging of the population, but for ethical reasons related to the tests of safety and efficacy of new formulas in animal models by the cosmetic and pharmaceutical industries. The limitations involved in traditional 2D cell culture approaches and manual techniques for biomimetic generation have driven the use of innovative technologies such as 3D bioprinting. One of the main advantages of the bioprinted skin is the authenticity, scalability and reproducibility of tissues compared to conventional constructs, via precise positioning of multiple cell types and the inclusion of appendages. The models of bioprinted skins will serve as a platform for the development of new formulations, molecule testing, disease simulation, as well as an alternative to chronic woun...
International Journal of Advances in Medical Biotechnology - IJAMB
The objective of this work is to map the main actors within the Brazilian innovation system frame... more The objective of this work is to map the main actors within the Brazilian innovation system framework in the field of tissue engineering and bioprinting, and analyze the main conditioners related to entrepreneurship and innovation. While keeping as a backdrop, the history of 3D Biotechnology Solutions startup, its challenges and projects. Tissue engineering is a subcategory of regenerative medicine with the purpose of repairing or substituting, partially or completely, tissues or organs that have been affected by some disease or lesion. The conventional methods used for the production of these biomaterials via tissue engineering do not have the capacity to mimic the reality of native structures in the nano, micro and macro scales, while guaranteeing the reproducibility and scalability of the materials. Technologies such as 3D bioprinting or additive manufacturing could change the way that many diseases are treated in the medium term by replacing the damaged tissues with custom bio-s...
This article proposes a comprehensive framework for R&D and innovation project selection under un... more This article proposes a comprehensive framework for R&D and innovation project selection under uncertainty and subject
to real-world constraints applicable to the Brazilian electricity sector, using a combination of integer programming
formulation and a PROMETHEE-based method. The objective is to contribute to this domain by offering an approach
suitable for the challenges of this sector, but also applicable to other situations involving R&D and innovation investments
under similar conditions. The manuscript presents applications using real data from an electricity company. It also compares
the proposed method with similar approaches found in the literature such as PROMETHEE II and V. The application
revealed the best performance of the proposed framework in dealing with the sector’s regulatory constraints, which
emphasize the companies’ accomplishment with R&D and innovation expenditures obligations. In this way, although R&D
and innovation project selection is not a typical case of optimization, under some particular regional, sector-based or
organization boundaries this can be a better solution.