Alessandra Scaparrotta | Università degli Studi "G. d'Annunzio" Chieti Pescara (original) (raw)

Uploads

Papers by Alessandra Scaparrotta

Research paper thumbnail of Food protein-induced enterocolitis syndrome in children: what’s known? What’s new?

European annals of allergy and clinical immunology, 2018

Research paper thumbnail of Article URL

This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted

Research paper thumbnail of Quando inserire gli alimenti: dal passato ad oggi

L'introduzione degli alimenti solidi ha un ruolo importante nella prevenzione delle malattie ... more L'introduzione degli alimenti solidi ha un ruolo importante nella prevenzione delle malattie allergiche quali l'asma, la der-matite atopica e l'allergia alimentare. Negli ultimi anni le teorie sulla tempistica dell'introduzione dei cibi solidi hanno subito profonde variazioni; i nuovi orienta-menti supportano l'ipotesi che la ritardata introduzione degli alimenti solidi dopo i 6 mesi di età possa aumentare, anziché diminuire, il rischio di allergia. L'induzione della tolleranza avviene nel periodo critico tra il 4° ed il 6° mese; pertanto le attuali evidenze consigliano l'intro-duzione degli alimenti solidi durante questo intervallo di tempo. Introduzione Negli ultimi 30 anni è stato registrato un notevole aumento delle allergie e la dieta ha un ruolo im-portante nella prevenzione delle malattie allergiche in età pediatrica 1. Pertanto abbiamo effettuato un rapido excursus sulle più importanti linee guida che hanno dettato i nostri comportamenti nello sve...

Research paper thumbnail of Mycoplasma pneumoniae infection with rhabdomyolysis in a child

˜Le œInfezioni in medicina, 2014

We report the history of a seven year-old male boy with cough and fever, who developed rhabdomyol... more We report the history of a seven year-old male boy with cough and fever, who developed rhabdomyolysis concomitant with Mycoplasma pneumoniae infection. The association between this organism and the muscular injury is rarely described in paediatric patients. This case then thus emphasizes that even seemingly mild M. pneumoniae airway infections may be complicated by invalidating neuromuscular sequelae.

Research paper thumbnail of GRAZAX ® in the management of allergic rhinitis

R e v i e w open access to scientific and medical research

Research paper thumbnail of Pulmonary Outcomes in Children Born Extremely and Very Preterm at 11 Years of Age

Frontiers in Pediatrics

Background: There is increasing evidence of prematurity being a risk factor for long-term respira... more Background: There is increasing evidence of prematurity being a risk factor for long-term respiratory outcomes regardless the presence of bronchopulmonary dysplasia (BPD).Aim: To assess the effect of prematurity on respiratory outcomes in children born ≤32 weeks of gestational age at 11 years of age.Materials and Methods: Fifty five ex-preterm children (≤ 32 weeks of gestational age), born in Chieti between January 1, 2006 and December 31, 2007, performed lung function and diffusing capacity test (DLCO) at 11 years of age. Furthermore, allergy evaluation by skin prick test (SPT), eosinophil blood count and assessment of eosinophilic airways inflammation by exhaled nitric oxide (FeNO) were performed. The ex-preterm group was compared to an age- and sex-matched group of term children.Results: No difference for atopic and respiratory medical history was found between ex-preterm children and term controls, except for preschool wheezing that resulted more frequent in ex-preterm children....

Research paper thumbnail of What can hide a neonatal sepsis with subsequent foot amputation?

Archives of Medical Science - Civilization Diseases, 2016

Research paper thumbnail of Insulin resistance and lung function in obese asthmatic pre-pubertal children

Journal of Pediatric Endocrinology and Metabolism

Background: Recent findings have supposed that the underlying association between the increased p... more Background: Recent findings have supposed that the underlying association between the increased prevalence of both asthma and obesity may be insulin resistance (IR). Methods: Insulin and glucose serum levels were analyzed to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) for IR in 98 pre-pubertal children. Lung function and allergy status evaluation were performed. The study population was divided into four groups: (1) obese asthmatic children (ObA); (2) normal-weight asthmatic children (NwA); (3) normal-weight non-asthmatic children (Nw) and (4) obese non-asthmatic children (Ob). Results: Forced expiratory volume in 1 s (FEV1) was slightly lower in obese subjects compared with normal-weight subjects and forced vital capacity (FVC) appeared lower in asthmatics, whereas between non-asthmatics subjects, it was lower in the obese group than in the normal-weight one. The post hoc analysis revealed a statistically significant reduction in FEV1, peak expiratory...

Research paper thumbnail of Role of THRB, ARG1, and ADRB2 Genetic Variants on Bronchodilators Response in Asthmatic Children

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Research paper thumbnail of An underestimated cause of chronic cough: The protracted bacterial bronchitis

Annals of Thoracic Medicine

Research paper thumbnail of Potential Teratogenic Effects of Clomiphene Citrate

Research paper thumbnail of Usefulness of molecular diagnosis in egg allergic children

Archives of Medical Science, 2016

Research paper thumbnail of Pediatric Lower Respiratory Infections Cover OMICS Group Design team

ABSTRACT http://www.esciencecentral.org/ebooks/pediatric-lower/

Research paper thumbnail of Recombinant Allergens in Diagnosis and Therapy of Allergic Diseases

The component-resolved diagnosis use in routine clinical and laboratory practice has increased in... more The component-resolved diagnosis use in routine clinical and laboratory practice has increased in recent years. Recombinant allergens can be produced with high purity by using controlled procedures, obtaining molecules with known molecular, immunologic, and biological characteristics; they can help clinicians to treat patients with multiple pollen sensitisations. Recombinant allergens are useful in respiratory allergies such as: grass pollen, birch pollen, parietaria pollen, olive pollen, and dermatophagoides in food allergies, especially milk, eggs and peanuts. Recombinant allergens constitute an important tool in diagnosis and therapy of allergic diseases, which allows a better characterisation of the allergic patient.

Research paper thumbnail of Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis

Drug Design, Development and Therapy, 2015

Research paper thumbnail of Hormonal influences in women with epilepsy

A Practical Management Handbook, 2014

Research paper thumbnail of Bronchial hyperresponsiveness to mannitol, airway inflammation and Asthma Control Test in atopic asthmatic children

Archives of Medical Science, 2016

Research paper thumbnail of The role of ADMA, SDMA, arginine and NO in pediatric bronchial asthma

Background: Data published regarding asymmetric dimethylargi- nine (ADMA), symmetric dimethylargi... more Background: Data published regarding asymmetric dimethylargi- nine (ADMA), symmetric dimethylarginine (SDMA), arginine (ARG) and nitric oxide (NO) in pediatric bronchial asthma are limited. Many questions remain open about serum concentration of these substances in asthmatic and healthy subjects. The aim of this study was to evaluate ADMA, SDMA, ARG and NO concentration in pediatric asthmatic stable patients respect to control healthy subjects.
Subjects and Methods: We enrolled 60 subjects (50 asthmatics and 10 healthy) underwent complete clinical visit, baseline respiratory function test, respiratory inflammation markers, atopic status, and biochemical analyses.
Statistical analysis: The statistical significance of the different concentrations between the two groups was studied using one- way analysis of variance (ANOVA). A p value <0.05 was considered statistical significant.
Results: The mean plasma ADMA (0.58 vs 0.68 mmol/L), SDMA (0.40 vs 0.45 mmol/L) and ARG (52.2 vs 74.13 mmol/L) was significantly lower (p < 0.001) in the asthmatic patients respect the control group. The mean plasma concentration of NO was significantly higher in the asthmatic subjects respect to control group (4.2 vs 9.18 mmol/L – p < 0.001).
Conclusion: Our study confirms that low serum concentrations of ADMA, SDMA, ARG and high concentration of NO are associated with bronchial asthma. ADMA, SDMA and ARG levels are increased in asthma and indicated an important role in airway disease through NO metabolism.

Research paper thumbnail of A strange rash with "gloves and socks" distribution

Archives of medical science : AMS, Jan 12, 2015

The papular-purpuric gloves and socks syndrome (PPGSS) is a new acral dermatosis first described ... more The papular-purpuric gloves and socks syndrome (PPGSS) is a new acral dermatosis first described in adults in 1990 and successively described in some children . Pruritic and painful edema and erythema are the characteristic features, with subsequent acral petechiae localized to the distal upper and lower extremities as gloves and socks distribution. Sometimes, it is associated with mucosal lesions and systemic symptoms such as fever, asthenia and lymphadenopathy .

Research paper thumbnail of A strange rash- Scaparrotta et al

The papular-purpuric gloves and socks syndrome (PPGSS) is a new acral dermatosis first described ... more The papular-purpuric gloves and socks syndrome (PPGSS) is a new acral dermatosis first described in adults in 1990 and successively described in some children . Pruritic and painful edema and erythema are the characteristic features, with subsequent acral petechiae localized to the distal upper and lower extremities as gloves and socks distribution. Sometimes, it is associated with mucosal lesions and systemic symptoms such as fever, asthenia and lymphadenopathy .

Research paper thumbnail of Food protein-induced enterocolitis syndrome in children: what’s known? What’s new?

European annals of allergy and clinical immunology, 2018

Research paper thumbnail of Article URL

This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted

Research paper thumbnail of Quando inserire gli alimenti: dal passato ad oggi

L'introduzione degli alimenti solidi ha un ruolo importante nella prevenzione delle malattie ... more L'introduzione degli alimenti solidi ha un ruolo importante nella prevenzione delle malattie allergiche quali l'asma, la der-matite atopica e l'allergia alimentare. Negli ultimi anni le teorie sulla tempistica dell'introduzione dei cibi solidi hanno subito profonde variazioni; i nuovi orienta-menti supportano l'ipotesi che la ritardata introduzione degli alimenti solidi dopo i 6 mesi di età possa aumentare, anziché diminuire, il rischio di allergia. L'induzione della tolleranza avviene nel periodo critico tra il 4° ed il 6° mese; pertanto le attuali evidenze consigliano l'intro-duzione degli alimenti solidi durante questo intervallo di tempo. Introduzione Negli ultimi 30 anni è stato registrato un notevole aumento delle allergie e la dieta ha un ruolo im-portante nella prevenzione delle malattie allergiche in età pediatrica 1. Pertanto abbiamo effettuato un rapido excursus sulle più importanti linee guida che hanno dettato i nostri comportamenti nello sve...

Research paper thumbnail of Mycoplasma pneumoniae infection with rhabdomyolysis in a child

˜Le œInfezioni in medicina, 2014

We report the history of a seven year-old male boy with cough and fever, who developed rhabdomyol... more We report the history of a seven year-old male boy with cough and fever, who developed rhabdomyolysis concomitant with Mycoplasma pneumoniae infection. The association between this organism and the muscular injury is rarely described in paediatric patients. This case then thus emphasizes that even seemingly mild M. pneumoniae airway infections may be complicated by invalidating neuromuscular sequelae.

Research paper thumbnail of GRAZAX ® in the management of allergic rhinitis

R e v i e w open access to scientific and medical research

Research paper thumbnail of Pulmonary Outcomes in Children Born Extremely and Very Preterm at 11 Years of Age

Frontiers in Pediatrics

Background: There is increasing evidence of prematurity being a risk factor for long-term respira... more Background: There is increasing evidence of prematurity being a risk factor for long-term respiratory outcomes regardless the presence of bronchopulmonary dysplasia (BPD).Aim: To assess the effect of prematurity on respiratory outcomes in children born ≤32 weeks of gestational age at 11 years of age.Materials and Methods: Fifty five ex-preterm children (≤ 32 weeks of gestational age), born in Chieti between January 1, 2006 and December 31, 2007, performed lung function and diffusing capacity test (DLCO) at 11 years of age. Furthermore, allergy evaluation by skin prick test (SPT), eosinophil blood count and assessment of eosinophilic airways inflammation by exhaled nitric oxide (FeNO) were performed. The ex-preterm group was compared to an age- and sex-matched group of term children.Results: No difference for atopic and respiratory medical history was found between ex-preterm children and term controls, except for preschool wheezing that resulted more frequent in ex-preterm children....

Research paper thumbnail of What can hide a neonatal sepsis with subsequent foot amputation?

Archives of Medical Science - Civilization Diseases, 2016

Research paper thumbnail of Insulin resistance and lung function in obese asthmatic pre-pubertal children

Journal of Pediatric Endocrinology and Metabolism

Background: Recent findings have supposed that the underlying association between the increased p... more Background: Recent findings have supposed that the underlying association between the increased prevalence of both asthma and obesity may be insulin resistance (IR). Methods: Insulin and glucose serum levels were analyzed to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) for IR in 98 pre-pubertal children. Lung function and allergy status evaluation were performed. The study population was divided into four groups: (1) obese asthmatic children (ObA); (2) normal-weight asthmatic children (NwA); (3) normal-weight non-asthmatic children (Nw) and (4) obese non-asthmatic children (Ob). Results: Forced expiratory volume in 1 s (FEV1) was slightly lower in obese subjects compared with normal-weight subjects and forced vital capacity (FVC) appeared lower in asthmatics, whereas between non-asthmatics subjects, it was lower in the obese group than in the normal-weight one. The post hoc analysis revealed a statistically significant reduction in FEV1, peak expiratory...

Research paper thumbnail of Role of THRB, ARG1, and ADRB2 Genetic Variants on Bronchodilators Response in Asthmatic Children

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Research paper thumbnail of An underestimated cause of chronic cough: The protracted bacterial bronchitis

Annals of Thoracic Medicine

Research paper thumbnail of Potential Teratogenic Effects of Clomiphene Citrate

Research paper thumbnail of Usefulness of molecular diagnosis in egg allergic children

Archives of Medical Science, 2016

Research paper thumbnail of Pediatric Lower Respiratory Infections Cover OMICS Group Design team

ABSTRACT http://www.esciencecentral.org/ebooks/pediatric-lower/

Research paper thumbnail of Recombinant Allergens in Diagnosis and Therapy of Allergic Diseases

The component-resolved diagnosis use in routine clinical and laboratory practice has increased in... more The component-resolved diagnosis use in routine clinical and laboratory practice has increased in recent years. Recombinant allergens can be produced with high purity by using controlled procedures, obtaining molecules with known molecular, immunologic, and biological characteristics; they can help clinicians to treat patients with multiple pollen sensitisations. Recombinant allergens are useful in respiratory allergies such as: grass pollen, birch pollen, parietaria pollen, olive pollen, and dermatophagoides in food allergies, especially milk, eggs and peanuts. Recombinant allergens constitute an important tool in diagnosis and therapy of allergic diseases, which allows a better characterisation of the allergic patient.

Research paper thumbnail of Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis

Drug Design, Development and Therapy, 2015

Research paper thumbnail of Hormonal influences in women with epilepsy

A Practical Management Handbook, 2014

Research paper thumbnail of Bronchial hyperresponsiveness to mannitol, airway inflammation and Asthma Control Test in atopic asthmatic children

Archives of Medical Science, 2016

Research paper thumbnail of The role of ADMA, SDMA, arginine and NO in pediatric bronchial asthma

Background: Data published regarding asymmetric dimethylargi- nine (ADMA), symmetric dimethylargi... more Background: Data published regarding asymmetric dimethylargi- nine (ADMA), symmetric dimethylarginine (SDMA), arginine (ARG) and nitric oxide (NO) in pediatric bronchial asthma are limited. Many questions remain open about serum concentration of these substances in asthmatic and healthy subjects. The aim of this study was to evaluate ADMA, SDMA, ARG and NO concentration in pediatric asthmatic stable patients respect to control healthy subjects.
Subjects and Methods: We enrolled 60 subjects (50 asthmatics and 10 healthy) underwent complete clinical visit, baseline respiratory function test, respiratory inflammation markers, atopic status, and biochemical analyses.
Statistical analysis: The statistical significance of the different concentrations between the two groups was studied using one- way analysis of variance (ANOVA). A p value <0.05 was considered statistical significant.
Results: The mean plasma ADMA (0.58 vs 0.68 mmol/L), SDMA (0.40 vs 0.45 mmol/L) and ARG (52.2 vs 74.13 mmol/L) was significantly lower (p < 0.001) in the asthmatic patients respect the control group. The mean plasma concentration of NO was significantly higher in the asthmatic subjects respect to control group (4.2 vs 9.18 mmol/L – p < 0.001).
Conclusion: Our study confirms that low serum concentrations of ADMA, SDMA, ARG and high concentration of NO are associated with bronchial asthma. ADMA, SDMA and ARG levels are increased in asthma and indicated an important role in airway disease through NO metabolism.

Research paper thumbnail of A strange rash with "gloves and socks" distribution

Archives of medical science : AMS, Jan 12, 2015

The papular-purpuric gloves and socks syndrome (PPGSS) is a new acral dermatosis first described ... more The papular-purpuric gloves and socks syndrome (PPGSS) is a new acral dermatosis first described in adults in 1990 and successively described in some children . Pruritic and painful edema and erythema are the characteristic features, with subsequent acral petechiae localized to the distal upper and lower extremities as gloves and socks distribution. Sometimes, it is associated with mucosal lesions and systemic symptoms such as fever, asthenia and lymphadenopathy .

Research paper thumbnail of A strange rash- Scaparrotta et al

The papular-purpuric gloves and socks syndrome (PPGSS) is a new acral dermatosis first described ... more The papular-purpuric gloves and socks syndrome (PPGSS) is a new acral dermatosis first described in adults in 1990 and successively described in some children . Pruritic and painful edema and erythema are the characteristic features, with subsequent acral petechiae localized to the distal upper and lower extremities as gloves and socks distribution. Sometimes, it is associated with mucosal lesions and systemic symptoms such as fever, asthenia and lymphadenopathy .