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Papers by CINZIA TALAMONTI

Frontiers in Physics, 2021

Lead halide perovskite CsPbBr3 is a wide-gap semiconductor material potentially very attractive f... more Lead halide perovskite CsPbBr3 is a wide-gap semiconductor material potentially very attractive for next generations of real-time monitors and particle detectors in high-energy physics. Here, we present the first characterization of crystalline CsPbBr3 point dosimeters with submillimeter size, under 6 MV X-photon beams used in clinical radiotherapy. Current response of the devices proved to be promising in terms of fast rise and decay times, of the same order of the X-ray beam onset and offset ones; absence of polarization effects; reproducibility to repeated irradiations; and linearity of the collected charge as a function of the absorbed dose. Comparing the measured sensitivity with the theoretical one, a charge collection distance of about 100 μm has been evaluated, of the same order of the linear dimensions of crystallites within the samples, suggesting that recombination centers are mainly placed at grain boundaries. A much higher sensitivity per unit area measured with crystal...

Zeitschrift f�r Physik C Particles and Fields, 1997

Physica Medica, 2016

Introduction The development of complex radiotherapy techniques, together with the huge workload ... more Introduction The development of complex radiotherapy techniques, together with the huge workload of linacs, requires comprehensive QA programs and the development of detectors and softwares allowing for reliable checks of the treatment delivery. Purpose The aim of this work was to study the impact in patient QA of the use of the Integral Quality Monitoring (IQM) device (iRTSystems) and the portal imaging with the software SoftDiso (Best Medical) to verify the safe and accurate delivery of the prescribed dose. Materials & methods The Anderson-Rando phantom was modified to mimic a female torso by adding two silicon gel breast implants. Standard conformal breast plans were calculated and the large area ionization chamber IQM was mounted on the accelerator gantry. PI acquired during treatments were used for in-vivo dose measurements using SoftDiso. Small errors induced on plans simulated deviation due to delivery problems and/or wrong positioning of the phantom. Results Tests showed good performances of the combined use of the devices to detect errors, which could not be highlighted during the pre-treatment QA. There’s correlation between two systems when errors due to small changes in delivered MU are induced. IQM can detect errors when field dimensions are changed of few millimetres while SoftDiso cannot, but is able to detect discrepancy on dose reconstruction with a precision of 5%. Conclusions In the clinical practice these devices can play an important role in meeting the needs of modern and upcoming radiotherapy QA, and it allows checking the correct functioning of all components in the radiotherapy chain.

Physica Medica, 2016

Aim of this work is the assessment of build-up and superficial doses of different clinical Head&a... more Aim of this work is the assessment of build-up and superficial doses of different clinical Head&Neck plans delivered with Helical TomoTherapy (HT) (Accuray, Sunnyvale, CA). Depth dose profiles and superficial dose points were measured in order to evaluate the Treatment Planning System (TPS) capability of an accurate dose modeling in regions of disequilibrium. Geometries and scattering conditions were investigated, similar to the ones generally encountered in clinical treatments. Measurements were performed with two dosimeters: Gafchromic® EBT3 films (Ashland Inc., Wayne, NJ) and a synthetic single crystal diamond detector (PTW-Frieburg microDiamond, MD). A modified version of the Alderson RANDO phantom was employed to house the detectors. A comparison with TPS data was carried out in terms of dose difference (DD) and distance-to-agreement (DTA). DD between calculated data and MD measurements are within 4% even in points with high spatial dose variation. For depth profiles, EBT3 data show a DDmax of 3.3% and DTAmax of 2.2mm, in low and high gradient regions, respectively, and compare well with MD data. EBT3 superficial points always results in measured doses lower than TPS evaluated ones, with a maximum DTA value of 1.5mm. Doses measured with the two devices are in good agreement and compare well with calculated data. The deviations found in the present work are within the reference tolerance level, suggesting that the HT TPS is capable of a precise dose estimation both in superficial regions and in correspondence with interfaces between air and PMMA.

Physica Medica, 2016

The aim of the study was a multicenter evaluation of MLC&... more The aim of the study was a multicenter evaluation of MLC&jaws-defined small field output factors (OF) for different linear accelerator manufacturers and for different beam energies using the latest synthetic single crystal diamond detector commercially available. The feasibility of providing an experimental OF data set, useful for on-site measurements validation, was also evaluated. This work was performed in the framework of the Italian Association of Medical Physics (AIFM) SBRT working group. The project was subdivided in two phases: in the first phase each center measured OFs using their own routine detector for nominal field sizes ranging from 10×10cm(2) to 0.6×0.6cm(2). In the second phase, the measurements were repeated in all centers using the PTW 60019 microDiamond detector. The project enrolled 30 Italian centers. Micro-ion chambers and silicon diodes were used for OF measurements in 24 and 6 centers respectively. Gafchromic films and TLDs were used for very small field OFs in 3 and 1 centers. Regarding the measurements performed with the user's detectors, OF standard deviations (SD) for field sizes down to 2×2cm(2) were in all cases <2.7%. In the second phase, a reduction of around 50% of the SD was obtained using the microDiamond detector. The measured values presented in this multicenter study provide a consistent dataset for OFs that could be a useful tool for improving dosimetric procedures in centers. The microDiamond data present a small variation among the centers confirming that this detector can contribute to improve overall accuracy in radiotherapy.

Radiotherapy and Oncology, 2014

International Journal of Radiation Oncology*Biology*Physics, 2014

Physics Letters B, 1992

The process t-,H +b, H+~x+v, x +-,hadrons +9 and its charge conjugate are investigated by seeking... more The process t-,H +b, H+~x+v, x +-,hadrons +9 and its charge conjugate are investigated by seeking an excess in number of observed x's beyond that expected from the standard model under the assumption of e-x universality. No such excess is found and new regions of the mn-mt plane are excluded for B(H+-,w) =0.5 and 1.0. In addition, the ratio of couplings of the x and e to the W is precisely measured as g'(/g'~ = 1.02 _+ 0.04 (stat.) + 0.04 (syst.).

Physics Letters B, 1998

In a preliminary version of the NA48 experiment at the CERN SPS, in which an iron-scintillator sa... more In a preliminary version of the NA48 experiment at the CERN SPS, in which an iron-scintillator sandwich calorimeter was used as a photon detector, the ratio of K L ! and K L ! decays was measured. The branching ratio BR(K L ! ;E 30 MeV)/(K L !) is found to be (2:080:17 +0:16 0:21)10 3 , where the rst error is statistical and the second systematic. The result is in agreement with theoretical predictions.

Physics Letters B, 1999

The NA48 experiment at CERN has performed a new measurement of direct CP violation, based on data... more The NA48 experiment at CERN has performed a new measurement of direct CP violation, based on data taken in 1997 by simultaneously collecting K L and K S decays into 0 0 and +. The result for the CP violating parameter Re (" 0 =") is (18:5 4:5(stat) 5:8(syst)) 10 4 .

Nuclear Physics B, 1993

The two{jet invariant mass spectrum as measured in the UA2 experiment is used to search for addit... more The two{jet invariant mass spectrum as measured in the UA2 experiment is used to search for additional heavy vector bosons decaying to two{jets. The mass of an additional W boson that couples to fermions with a V + A form is constrained to be greater than 261 GeV to the 90% condence level. A limit on the production cross section of additional W and Z bosons is given as a function of the boson mass. A limit on the production of excited quarks is also given as a function of the excited quark mass.

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2010

Proton imaging is not yet applied as a clinical routine, although its advantages have been demons... more Proton imaging is not yet applied as a clinical routine, although its advantages have been demonstrated. In the context of quality assurance in proton therapy, proton images can be used to verify the correct positioning of the patient and to control the range of protons. Proton computed tomography (pCT) is a 3D imaging method appropriate for planning and verification of

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2010

Proton radiation therapy is a precise form of cancer therapy, which requires verification of the ... more Proton radiation therapy is a precise form of cancer therapy, which requires verification of the patient position and the accurate knowledge of the dose delivered to the patient. At present in the proton treatment centre, patients are positioned with X-ray radiography and dose calculations rely on the patient's morphology and electron densities obtained by X-ray computed tomography [U. Schneider, E.

Frontiers in Physics, 2021

Lead halide perovskite CsPbBr3 is a wide-gap semiconductor material potentially very attractive f... more Lead halide perovskite CsPbBr3 is a wide-gap semiconductor material potentially very attractive for next generations of real-time monitors and particle detectors in high-energy physics. Here, we present the first characterization of crystalline CsPbBr3 point dosimeters with submillimeter size, under 6 MV X-photon beams used in clinical radiotherapy. Current response of the devices proved to be promising in terms of fast rise and decay times, of the same order of the X-ray beam onset and offset ones; absence of polarization effects; reproducibility to repeated irradiations; and linearity of the collected charge as a function of the absorbed dose. Comparing the measured sensitivity with the theoretical one, a charge collection distance of about 100 μm has been evaluated, of the same order of the linear dimensions of crystallites within the samples, suggesting that recombination centers are mainly placed at grain boundaries. A much higher sensitivity per unit area measured with crystal...

Zeitschrift f�r Physik C Particles and Fields, 1997

Physica Medica, 2016

Introduction The development of complex radiotherapy techniques, together with the huge workload ... more Introduction The development of complex radiotherapy techniques, together with the huge workload of linacs, requires comprehensive QA programs and the development of detectors and softwares allowing for reliable checks of the treatment delivery. Purpose The aim of this work was to study the impact in patient QA of the use of the Integral Quality Monitoring (IQM) device (iRTSystems) and the portal imaging with the software SoftDiso (Best Medical) to verify the safe and accurate delivery of the prescribed dose. Materials & methods The Anderson-Rando phantom was modified to mimic a female torso by adding two silicon gel breast implants. Standard conformal breast plans were calculated and the large area ionization chamber IQM was mounted on the accelerator gantry. PI acquired during treatments were used for in-vivo dose measurements using SoftDiso. Small errors induced on plans simulated deviation due to delivery problems and/or wrong positioning of the phantom. Results Tests showed good performances of the combined use of the devices to detect errors, which could not be highlighted during the pre-treatment QA. There’s correlation between two systems when errors due to small changes in delivered MU are induced. IQM can detect errors when field dimensions are changed of few millimetres while SoftDiso cannot, but is able to detect discrepancy on dose reconstruction with a precision of 5%. Conclusions In the clinical practice these devices can play an important role in meeting the needs of modern and upcoming radiotherapy QA, and it allows checking the correct functioning of all components in the radiotherapy chain.

Physica Medica, 2016

Aim of this work is the assessment of build-up and superficial doses of different clinical Head&a... more Aim of this work is the assessment of build-up and superficial doses of different clinical Head&Neck plans delivered with Helical TomoTherapy (HT) (Accuray, Sunnyvale, CA). Depth dose profiles and superficial dose points were measured in order to evaluate the Treatment Planning System (TPS) capability of an accurate dose modeling in regions of disequilibrium. Geometries and scattering conditions were investigated, similar to the ones generally encountered in clinical treatments. Measurements were performed with two dosimeters: Gafchromic® EBT3 films (Ashland Inc., Wayne, NJ) and a synthetic single crystal diamond detector (PTW-Frieburg microDiamond, MD). A modified version of the Alderson RANDO phantom was employed to house the detectors. A comparison with TPS data was carried out in terms of dose difference (DD) and distance-to-agreement (DTA). DD between calculated data and MD measurements are within 4% even in points with high spatial dose variation. For depth profiles, EBT3 data show a DDmax of 3.3% and DTAmax of 2.2mm, in low and high gradient regions, respectively, and compare well with MD data. EBT3 superficial points always results in measured doses lower than TPS evaluated ones, with a maximum DTA value of 1.5mm. Doses measured with the two devices are in good agreement and compare well with calculated data. The deviations found in the present work are within the reference tolerance level, suggesting that the HT TPS is capable of a precise dose estimation both in superficial regions and in correspondence with interfaces between air and PMMA.

Physica Medica, 2016

The aim of the study was a multicenter evaluation of MLC&... more The aim of the study was a multicenter evaluation of MLC&jaws-defined small field output factors (OF) for different linear accelerator manufacturers and for different beam energies using the latest synthetic single crystal diamond detector commercially available. The feasibility of providing an experimental OF data set, useful for on-site measurements validation, was also evaluated. This work was performed in the framework of the Italian Association of Medical Physics (AIFM) SBRT working group. The project was subdivided in two phases: in the first phase each center measured OFs using their own routine detector for nominal field sizes ranging from 10×10cm(2) to 0.6×0.6cm(2). In the second phase, the measurements were repeated in all centers using the PTW 60019 microDiamond detector. The project enrolled 30 Italian centers. Micro-ion chambers and silicon diodes were used for OF measurements in 24 and 6 centers respectively. Gafchromic films and TLDs were used for very small field OFs in 3 and 1 centers. Regarding the measurements performed with the user's detectors, OF standard deviations (SD) for field sizes down to 2×2cm(2) were in all cases <2.7%. In the second phase, a reduction of around 50% of the SD was obtained using the microDiamond detector. The measured values presented in this multicenter study provide a consistent dataset for OFs that could be a useful tool for improving dosimetric procedures in centers. The microDiamond data present a small variation among the centers confirming that this detector can contribute to improve overall accuracy in radiotherapy.

Radiotherapy and Oncology, 2014

International Journal of Radiation Oncology*Biology*Physics, 2014

Physics Letters B, 1992

The process t-,H +b, H+~x+v, x +-,hadrons +9 and its charge conjugate are investigated by seeking... more The process t-,H +b, H+~x+v, x +-,hadrons +9 and its charge conjugate are investigated by seeking an excess in number of observed x's beyond that expected from the standard model under the assumption of e-x universality. No such excess is found and new regions of the mn-mt plane are excluded for B(H+-,w) =0.5 and 1.0. In addition, the ratio of couplings of the x and e to the W is precisely measured as g'(/g'~ = 1.02 _+ 0.04 (stat.) + 0.04 (syst.).

Physics Letters B, 1998

In a preliminary version of the NA48 experiment at the CERN SPS, in which an iron-scintillator sa... more In a preliminary version of the NA48 experiment at the CERN SPS, in which an iron-scintillator sandwich calorimeter was used as a photon detector, the ratio of K L ! and K L ! decays was measured. The branching ratio BR(K L ! ;E 30 MeV)/(K L !) is found to be (2:080:17 +0:16 0:21)10 3 , where the rst error is statistical and the second systematic. The result is in agreement with theoretical predictions.

Physics Letters B, 1999

The NA48 experiment at CERN has performed a new measurement of direct CP violation, based on data... more The NA48 experiment at CERN has performed a new measurement of direct CP violation, based on data taken in 1997 by simultaneously collecting K L and K S decays into 0 0 and +. The result for the CP violating parameter Re (" 0 =") is (18:5 4:5(stat) 5:8(syst)) 10 4 .

Nuclear Physics B, 1993

The two{jet invariant mass spectrum as measured in the UA2 experiment is used to search for addit... more The two{jet invariant mass spectrum as measured in the UA2 experiment is used to search for additional heavy vector bosons decaying to two{jets. The mass of an additional W boson that couples to fermions with a V + A form is constrained to be greater than 261 GeV to the 90% condence level. A limit on the production cross section of additional W and Z bosons is given as a function of the boson mass. A limit on the production of excited quarks is also given as a function of the excited quark mass.

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2010

Proton imaging is not yet applied as a clinical routine, although its advantages have been demons... more Proton imaging is not yet applied as a clinical routine, although its advantages have been demonstrated. In the context of quality assurance in proton therapy, proton images can be used to verify the correct positioning of the patient and to control the range of protons. Proton computed tomography (pCT) is a 3D imaging method appropriate for planning and verification of

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2010

Proton radiation therapy is a precise form of cancer therapy, which requires verification of the ... more Proton radiation therapy is a precise form of cancer therapy, which requires verification of the patient position and the accurate knowledge of the dose delivered to the patient. At present in the proton treatment centre, patients are positioned with X-ray radiography and dose calculations rely on the patient's morphology and electron densities obtained by X-ray computed tomography [U. Schneider, E.