Bernard P Vaudaux | University of Lausanne (original) (raw)
Uploads
Papers by Bernard P Vaudaux
Neonatology, 2010
Access to full text and tables of contents, including tentative ones for forthcoming issues: www.... more Access to full text and tables of contents, including tentative ones for forthcoming issues: www.karger.com/neo_issues Commentary 29 Long-Term Epidemiology of Neonatal Sepsis: Benefits and Concerns. Commentary on van den Hoogen A., et al.: Long-Term Trends in the Epidemiology of Neonatal Sepsis and Antibiotic Susceptibility of Causative Agents (Neonatology 2010;97:22-28
Forum médical suisse =, Jan 28, 2009
Le contenu des textes paraissant dans la rubrique «Recommandations» n'est pas révisé par la rédac... more Le contenu des textes paraissant dans la rubrique «Recommandations» n'est pas révisé par la rédaction et est sous la responsabilité des auteurs.
Revue médicale suisse, 2008
Cette annee, nous avons resume les avances dans deux pathologies tres frequentes et deux plus rar... more Cette annee, nous avons resume les avances dans deux pathologies tres frequentes et deux plus rares : 1) la cryptorchidie est operee plus precocement sans utiliser des hormones. Ce traitement vise a assurer la fertilite et a eviter le developpement de tumeurs testiculaires. 2) Dans le traitement de la pharyngite streptococcique, les cephalosporines orales durant quatre a cinq jours, peuvent remplacer la penicilline. 3) Le carvedilol (betabloquant), le levosimendan (sensibilisateur du calcium) et le nesiritide (analogue du peptide natriuretique) permettent une approche neurohormonale a l'insuffisance cardiaque. 4) Les glucocorticoides administres tot et une prise en charge multidisciplinaire ralentissent le cours de la dystrophie musculaire de Duchenne. This article summarizes the medical progress achieved in 2 frequent and 2 rare pathologies: 1. Cryptorchidism should be operated around 12 months of age and hormonal treatment abandoned in order to maintain fertility and avoid development of testicular tumors. 2. For the treatment of streptococcal pharyngitis oral cephalosporins for 4 to 5 days are equivalent to a Penicillin treatment of 10 days. 3. Thanks to carvedilol (a beta-blocker agent), levosimendan (a calcium sensibiliser) and nesiritide (an analog to the natriuretic peptide) a new hormonal approach to cardiac failure is possible. 4. Corticosteroids allow to improve quality of live and life expectancy in Duchenne muscular dystrophy, provided treatment starts early and a multidisciplinary approach is assured
PubMed, May 2, 2018
The number of immunosuppressed travelers has exponentially increased in the past few years. This ... more The number of immunosuppressed travelers has exponentially increased in the past few years. This is a positive development as these patients, owing to much improved management, are now in a condition allowing them to plan activities abroad comparable to healthy persons. However, pre-travel consultation and vaccinations are particularly important to reduce the risks and/or the complications of travel-related diseases. Although we already published a review on this topic in 2013, the recent increase of immunosuppressive agents available in Switzerland justifies this update.
The first part of this paper reviews: (1) the spectrum of clinical features of congenital toxopla... more The first part of this paper reviews: (1) the spectrum of clinical features of congenital toxoplasmosis; (2) the natural course of fetal infection; (3) the influence of antitoxoplasma therapy on the course of the disease; (4) methods for diagnosing the toxoplasma infection and assessing the severity of the disease; (5) currently used antitoxoplasma drugs and different therapeutic regimens. The second part suggests a practical approach to the problem of congenital toxoplasma infection, including diagnostic work-up, drug therapy, and follow-up. This practical approach is modulated according to the clinical syndrome in the infant and diagnostic and therapeutic considerations in the mother
Revue médicale suisse, 2012
The hepatitis B virus is likely to induce a severe disease when the infection occurs in vulnerabl... more The hepatitis B virus is likely to induce a severe disease when the infection occurs in vulnerable individuals. For that reason, clear recommendations are issued that vaccine prevention be offered to the immunocompromised and to the infant newly born to a chronically infected mother. However, the vaccine coverage is definitely suboptimal among these patients and a fair proportion of them are only partially vaccinated. An increase in vaccine coverage is demonstrated in several studies involving dedicated nursing or medical teams. The prevention of hepatitis B infection in vulnerable patients requires a systemic and punctilious approach to such a point that one should consider letting the management of these preventive measures to dedicated nursing or medical teams
Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, 2009
The Pediatric infectious disease journal, Jun 27, 2016
INFOVAC is a network providing information about immunization issues to health professionals. The... more INFOVAC is a network providing information about immunization issues to health professionals. The aim of this study was to assess the attitude of INFOVAC subscribers towards the current Swiss immunization schedule, potential modifications, and current and hypothetical immunization practices regarding their own children. In March 2015, a web-based survey was sent to 4260 physicians and pharmacists subscribed to INFOVAC. Participation was anonymous and voluntary. The following information was obtained: 1) current immunization status of own children, 2) which immunizations would currently be accepted for a hypothetical own child and 3) attitudes towards potential modifications of the Swiss immunization schedule. Descriptive methods and multivariate models to correct for co-variables were used for data analysis. 955 valid questionnaires were received, 886/3704 (23.9%) from physicians and 69/556 (12.4%) from pharmacists. Current (>95%) and hypothetical (>99%) immunization rates wer...
Clinical Infectious Diseases, 2008
PubMed, May 8, 2013
With the increased number of international travelers and that of immunosuppressive therapies, it ... more With the increased number of international travelers and that of immunosuppressive therapies, it is usual to see immunosuppressed patients asking for advice before a trip exposing them to a certain risk of infectious diseases. The difficulty with vaccinating the immunosuppressed is twofold as risk as well as effectiveness has to be taken into account. Immune responses to vaccines are more effective if they are based on immunological memory. In other cases, antibody level determination may be useful to assess the potential for protection. Clinical cases are presented to illustrate difficulties faced by the general practitioner.
Sozial-und Praventivmedizin, 1998
Résumé• L'injection doit être strictement intramusculaire et effectuée dans le muscle deltoïd... more Résumé• L'injection doit être strictement intramusculaire et effectuée dans le muscle deltoïde.• La vaccination comporte 3 injections aux temps 0, 1 mois et 6 mois, sans rapel.• L'intervalle entre la première et la deuxième dose ne doit pas être plus court que 1 mois mais peut être plus long.• L'intervalle entre la deuxième et la troisième dose ne doit pas être plus court que 2 mois mais peut être plus long que 5 mois.• Les vaccins commercialement disponibles sont interchangeables: une immunisation commencée avec l'un peut être poursuivie avec un autre.• Le contrôle du titre d'anticorps est inutile dans le contexte d'une vaccination généralisée.SummaryThe Swiss Federal Office of Public Health and the Swiss Advisory Board on Immunisation recommended that universal vaccination against hepatitis B be introduced in January 1998. The target population for immunisation are youngsters between 11 and 15 years of age. This recommendation does not preclude ongoing selective vaccination of individuals in high risk groups, nor the routine immunisation of individuals younger or older than the target age if needed). Injections should be given in the deltoïd area and needle length is critical to ensure proper resorption of the antigen and adequate immune response. Three doses are recommended at times 0, 1 month and 6 months with no booster dose. The time interval between the second and third dose should not be shorter than 2 months but can be longer than 5 months. Vaccination initiated with one commercial brand can be completed with a different brand. The simultaneous administration of immune globulin with the initiation of vaccination and the measurement of serum antibodies after completion of vaccination are unnecessary.
PubMed, Sep 27, 2006
The incidence of tick-borne encephalitis (TBE) has more than doubled in Switzerland in recent yea... more The incidence of tick-borne encephalitis (TBE) has more than doubled in Switzerland in recent years. In the French part of Switzerland several patients seem to have acquired the infection outside of known endemic foci. Thirty patients with TBE living or having acquired the infection in the French speaking part of Switzerland between 2000 and 2005 were identified. For one patient it wasn't possible to obtain precise information about the place of acquisition of the infection and 16 patients were infected in known endemic foci. Among the 13 remaining patients, 6 were infected on the southern shores of the lake of Neuchâtel and 7 in the plaine of Orbe. We conclude that there are new foci of TBE in the northern regions of the canton of Vaud. Vaccination should be proposed to the population at risk of these regions. In addition it is important that persons with outdoor activities in this regions respect the preventive
Revue médicale suisse, 2018
The number of immunosuppressed travelers has exponentially increased in the past few years. This ... more The number of immunosuppressed travelers has exponentially increased in the past few years. This is a positive development as these patients, owing to much improved management, are now in a condition allowing them to plan activities abroad comparable to healthy persons. However, pre-travel consultation and vaccinations are particularly important to reduce the risks and/or the complications of travel-related diseases. Although we already published a review on this topic in 2013, the recent increase of immunosuppressive agents available in Switzerland justifies this update.
Sozial-und Praventivmedizin, 1998
Journal de Pédiatrie et de Puériculture, Dec 1, 1991
ABSTRACT
International Journal of Pediatric Otorhinolaryngology, Feb 1, 2014
Juvenile-onset recurrent respiratory papillomatosis (JORRP) is an HPV-related neoplasm affecting ... more Juvenile-onset recurrent respiratory papillomatosis (JORRP) is an HPV-related neoplasm affecting primarily the larynx. JORRP often requires repeated surgical debridement, which yield variable but generally moderate remission periods. We report the case of a 6-year-old boy with severe course JORRP since the age of 2, requiring tracheostomy, that underwent prolonged remission and was decannulated some months after administration of the HPV vaccine. The post-exposure use for the anti-HPV vaccine in JORRP is a topic of capital interest but still poorly characterized. Some published cases suggest a potential post-exposure role of the vaccine in JORRP, but prospective multicentric trials are still needed.
Neonatology, 2010
Access to full text and tables of contents, including tentative ones for forthcoming issues: www.... more Access to full text and tables of contents, including tentative ones for forthcoming issues: www.karger.com/neo_issues Commentary 29 Long-Term Epidemiology of Neonatal Sepsis: Benefits and Concerns. Commentary on van den Hoogen A., et al.: Long-Term Trends in the Epidemiology of Neonatal Sepsis and Antibiotic Susceptibility of Causative Agents (Neonatology 2010;97:22-28
Forum médical suisse =, Jan 28, 2009
Le contenu des textes paraissant dans la rubrique «Recommandations» n'est pas révisé par la rédac... more Le contenu des textes paraissant dans la rubrique «Recommandations» n'est pas révisé par la rédaction et est sous la responsabilité des auteurs.
Revue médicale suisse, 2008
Cette annee, nous avons resume les avances dans deux pathologies tres frequentes et deux plus rar... more Cette annee, nous avons resume les avances dans deux pathologies tres frequentes et deux plus rares : 1) la cryptorchidie est operee plus precocement sans utiliser des hormones. Ce traitement vise a assurer la fertilite et a eviter le developpement de tumeurs testiculaires. 2) Dans le traitement de la pharyngite streptococcique, les cephalosporines orales durant quatre a cinq jours, peuvent remplacer la penicilline. 3) Le carvedilol (betabloquant), le levosimendan (sensibilisateur du calcium) et le nesiritide (analogue du peptide natriuretique) permettent une approche neurohormonale a l'insuffisance cardiaque. 4) Les glucocorticoides administres tot et une prise en charge multidisciplinaire ralentissent le cours de la dystrophie musculaire de Duchenne. This article summarizes the medical progress achieved in 2 frequent and 2 rare pathologies: 1. Cryptorchidism should be operated around 12 months of age and hormonal treatment abandoned in order to maintain fertility and avoid development of testicular tumors. 2. For the treatment of streptococcal pharyngitis oral cephalosporins for 4 to 5 days are equivalent to a Penicillin treatment of 10 days. 3. Thanks to carvedilol (a beta-blocker agent), levosimendan (a calcium sensibiliser) and nesiritide (an analog to the natriuretic peptide) a new hormonal approach to cardiac failure is possible. 4. Corticosteroids allow to improve quality of live and life expectancy in Duchenne muscular dystrophy, provided treatment starts early and a multidisciplinary approach is assured
PubMed, May 2, 2018
The number of immunosuppressed travelers has exponentially increased in the past few years. This ... more The number of immunosuppressed travelers has exponentially increased in the past few years. This is a positive development as these patients, owing to much improved management, are now in a condition allowing them to plan activities abroad comparable to healthy persons. However, pre-travel consultation and vaccinations are particularly important to reduce the risks and/or the complications of travel-related diseases. Although we already published a review on this topic in 2013, the recent increase of immunosuppressive agents available in Switzerland justifies this update.
The first part of this paper reviews: (1) the spectrum of clinical features of congenital toxopla... more The first part of this paper reviews: (1) the spectrum of clinical features of congenital toxoplasmosis; (2) the natural course of fetal infection; (3) the influence of antitoxoplasma therapy on the course of the disease; (4) methods for diagnosing the toxoplasma infection and assessing the severity of the disease; (5) currently used antitoxoplasma drugs and different therapeutic regimens. The second part suggests a practical approach to the problem of congenital toxoplasma infection, including diagnostic work-up, drug therapy, and follow-up. This practical approach is modulated according to the clinical syndrome in the infant and diagnostic and therapeutic considerations in the mother
Revue médicale suisse, 2012
The hepatitis B virus is likely to induce a severe disease when the infection occurs in vulnerabl... more The hepatitis B virus is likely to induce a severe disease when the infection occurs in vulnerable individuals. For that reason, clear recommendations are issued that vaccine prevention be offered to the immunocompromised and to the infant newly born to a chronically infected mother. However, the vaccine coverage is definitely suboptimal among these patients and a fair proportion of them are only partially vaccinated. An increase in vaccine coverage is demonstrated in several studies involving dedicated nursing or medical teams. The prevention of hepatitis B infection in vulnerable patients requires a systemic and punctilious approach to such a point that one should consider letting the management of these preventive measures to dedicated nursing or medical teams
Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, 2009
The Pediatric infectious disease journal, Jun 27, 2016
INFOVAC is a network providing information about immunization issues to health professionals. The... more INFOVAC is a network providing information about immunization issues to health professionals. The aim of this study was to assess the attitude of INFOVAC subscribers towards the current Swiss immunization schedule, potential modifications, and current and hypothetical immunization practices regarding their own children. In March 2015, a web-based survey was sent to 4260 physicians and pharmacists subscribed to INFOVAC. Participation was anonymous and voluntary. The following information was obtained: 1) current immunization status of own children, 2) which immunizations would currently be accepted for a hypothetical own child and 3) attitudes towards potential modifications of the Swiss immunization schedule. Descriptive methods and multivariate models to correct for co-variables were used for data analysis. 955 valid questionnaires were received, 886/3704 (23.9%) from physicians and 69/556 (12.4%) from pharmacists. Current (>95%) and hypothetical (>99%) immunization rates wer...
Clinical Infectious Diseases, 2008
PubMed, May 8, 2013
With the increased number of international travelers and that of immunosuppressive therapies, it ... more With the increased number of international travelers and that of immunosuppressive therapies, it is usual to see immunosuppressed patients asking for advice before a trip exposing them to a certain risk of infectious diseases. The difficulty with vaccinating the immunosuppressed is twofold as risk as well as effectiveness has to be taken into account. Immune responses to vaccines are more effective if they are based on immunological memory. In other cases, antibody level determination may be useful to assess the potential for protection. Clinical cases are presented to illustrate difficulties faced by the general practitioner.
Sozial-und Praventivmedizin, 1998
Résumé• L'injection doit être strictement intramusculaire et effectuée dans le muscle deltoïd... more Résumé• L'injection doit être strictement intramusculaire et effectuée dans le muscle deltoïde.• La vaccination comporte 3 injections aux temps 0, 1 mois et 6 mois, sans rapel.• L'intervalle entre la première et la deuxième dose ne doit pas être plus court que 1 mois mais peut être plus long.• L'intervalle entre la deuxième et la troisième dose ne doit pas être plus court que 2 mois mais peut être plus long que 5 mois.• Les vaccins commercialement disponibles sont interchangeables: une immunisation commencée avec l'un peut être poursuivie avec un autre.• Le contrôle du titre d'anticorps est inutile dans le contexte d'une vaccination généralisée.SummaryThe Swiss Federal Office of Public Health and the Swiss Advisory Board on Immunisation recommended that universal vaccination against hepatitis B be introduced in January 1998. The target population for immunisation are youngsters between 11 and 15 years of age. This recommendation does not preclude ongoing selective vaccination of individuals in high risk groups, nor the routine immunisation of individuals younger or older than the target age if needed). Injections should be given in the deltoïd area and needle length is critical to ensure proper resorption of the antigen and adequate immune response. Three doses are recommended at times 0, 1 month and 6 months with no booster dose. The time interval between the second and third dose should not be shorter than 2 months but can be longer than 5 months. Vaccination initiated with one commercial brand can be completed with a different brand. The simultaneous administration of immune globulin with the initiation of vaccination and the measurement of serum antibodies after completion of vaccination are unnecessary.
PubMed, Sep 27, 2006
The incidence of tick-borne encephalitis (TBE) has more than doubled in Switzerland in recent yea... more The incidence of tick-borne encephalitis (TBE) has more than doubled in Switzerland in recent years. In the French part of Switzerland several patients seem to have acquired the infection outside of known endemic foci. Thirty patients with TBE living or having acquired the infection in the French speaking part of Switzerland between 2000 and 2005 were identified. For one patient it wasn't possible to obtain precise information about the place of acquisition of the infection and 16 patients were infected in known endemic foci. Among the 13 remaining patients, 6 were infected on the southern shores of the lake of Neuchâtel and 7 in the plaine of Orbe. We conclude that there are new foci of TBE in the northern regions of the canton of Vaud. Vaccination should be proposed to the population at risk of these regions. In addition it is important that persons with outdoor activities in this regions respect the preventive
Revue médicale suisse, 2018
The number of immunosuppressed travelers has exponentially increased in the past few years. This ... more The number of immunosuppressed travelers has exponentially increased in the past few years. This is a positive development as these patients, owing to much improved management, are now in a condition allowing them to plan activities abroad comparable to healthy persons. However, pre-travel consultation and vaccinations are particularly important to reduce the risks and/or the complications of travel-related diseases. Although we already published a review on this topic in 2013, the recent increase of immunosuppressive agents available in Switzerland justifies this update.
Sozial-und Praventivmedizin, 1998
Journal de Pédiatrie et de Puériculture, Dec 1, 1991
ABSTRACT
International Journal of Pediatric Otorhinolaryngology, Feb 1, 2014
Juvenile-onset recurrent respiratory papillomatosis (JORRP) is an HPV-related neoplasm affecting ... more Juvenile-onset recurrent respiratory papillomatosis (JORRP) is an HPV-related neoplasm affecting primarily the larynx. JORRP often requires repeated surgical debridement, which yield variable but generally moderate remission periods. We report the case of a 6-year-old boy with severe course JORRP since the age of 2, requiring tracheostomy, that underwent prolonged remission and was decannulated some months after administration of the HPV vaccine. The post-exposure use for the anti-HPV vaccine in JORRP is a topic of capital interest but still poorly characterized. Some published cases suggest a potential post-exposure role of the vaccine in JORRP, but prospective multicentric trials are still needed.