Akbar Haqi | Universiti Malaysia Sarawak (UNIMAS) (original) (raw)
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Papers by Akbar Haqi
International Journal of Pharma Medicine and Biological Sciences
Troponin complex is essentially situated on slim fiber of striated muscle and control connection ... more Troponin complex is essentially situated on slim fiber of striated muscle and control connection of slight and thick fiber and it might be affected by Triiodothyronine (T3). Unfortunately, there is limited study about regulation of T3 on troponin profile. In the present examination, we investigate and distinguish the impact of T3 to troponin proteins. Twelve male rat wistar, 12 weeks old were divided into 2 groups. Hyperthyroidism was induced by injecting T3 20-μg/100-g Body Weight (BW) for 10 days per intraperitoneal (i.p.). After sacrificed using CO2 chamber, rat soleus muscle were dissected out and stored at −80°C until use. T3 stimulated protein level of troponin I, T and and induce but not significant troponin C level in rat soleus muscle. T3 increase significantly the protein expression of Troponin I by 1,67 folds and Troponin T by 1,71 folds compare to control groups. In the other hand, we observed that T3 trend to stimulate the troponin C protein levels although not statistically significant. It seems that troponin C might less sensitive in response to T3 induction. Taken together, T3 alters troponin profile of soleus muscle which it might affect muscle performance.
Transgenics is commonly used as one of methods in biotechnology which the specific gene is being ... more Transgenics is commonly used as one of methods in biotechnology which the specific gene is being transferring from an organism to another. Then, the offspring will have novel characteristics which are able to be inherited to the next generation. Splicing gene is used to set up one or more genes of an organism into another organism. A transgenic organism is
International Journal of Pharma Medicine and Biological Sciences
Troponin complex is essentially situated on slim fiber of striated muscle and control connection ... more Troponin complex is essentially situated on slim fiber of striated muscle and control connection of slight and thick fiber and it might be affected by Triiodothyronine (T3). Unfortunately, there is limited study about regulation of T3 on troponin profile. In the present examination, we investigate and distinguish the impact of T3 to troponin proteins. Twelve male rat wistar, 12 weeks old were divided into 2 groups. Hyperthyroidism was induced by injecting T3 20-μg/100-g Body Weight (BW) for 10 days per intraperitoneal (i.p.). After sacrificed using CO2 chamber, rat soleus muscle were dissected out and stored at −80°C until use. T3 stimulated protein level of troponin I, T and and induce but not significant troponin C level in rat soleus muscle. T3 increase significantly the protein expression of Troponin I by 1,67 folds and Troponin T by 1,71 folds compare to control groups. In the other hand, we observed that T3 trend to stimulate the troponin C protein levels although not statistically significant. It seems that troponin C might less sensitive in response to T3 induction. Taken together, T3 alters troponin profile of soleus muscle which it might affect muscle performance.
Transgenics is commonly used as one of methods in biotechnology which the specific gene is being ... more Transgenics is commonly used as one of methods in biotechnology which the specific gene is being transferring from an organism to another. Then, the offspring will have novel characteristics which are able to be inherited to the next generation. Splicing gene is used to set up one or more genes of an organism into another organism. A transgenic organism is