Craig Hutton | University of Melbourne (original) (raw)
Papers by Craig Hutton
Journal of Neuroscience, 2010
Alzheimer&amp... more Alzheimer's disease (AD) is the most common age-related dementia. Unfortunately due to a lack of validated biomarkers definitive diagnosis relies on the histological demonstration of amyloid-beta (Abeta) plaques and tau neurofibrillary tangles. Abeta processing is implicated in AD progression and many therapeutic strategies target various aspects of this biology. While Abeta deposition is the most prominent feature of AD, oligomeric forms of Abeta have been implicated as the toxic species inducing the neuronal dysfunction. Currently there are no methods allowing routine monitoring of levels of such species in living populations. We have used surface enhanced laser desorption ionization time of flight (SELDI-TOF) mass spectrometry incorporating antibody capture to investigate whether the cellular membrane-containing fraction of blood provides a new source of biomarkers. There are significant differences in the mass spectra profiles of AD compared with HC subjects, with significantly higher levels of Abeta monomer and dimer in the blood of AD subjects. Furthermore, levels of these species correlated with clinical markers of AD including brain Abeta burden, cognitive impairment and brain atrophy. These results indicate that fundamental biochemical events relevant to AD can be monitored in blood, and that the species detected may be useful clinical biomarkers for AD.
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The Journal of Organic Chemistry, 1997
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The Journal of Organic Chemistry, 2007
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eLife, Jan 19, 2016
Metabolic reprogramming toward aerobic glycolysis unavoidably induces methylglyoxal (MG) formatio... more Metabolic reprogramming toward aerobic glycolysis unavoidably induces methylglyoxal (MG) formation in cancer cells. MG mediates the glycation of proteins to form advanced glycation end products (AGEs). We have recently demonstrated that MG-induced AGEs are a common feature of breast cancer. Little is known regarding the impact of MG-mediated carbonyl stress on tumor progression. Breast tumors with MG stress presented with high nuclear YAP, a key transcriptional co-activator regulating tumor growth and invasion. Elevated MG levels resulted in sustained YAP nuclear localization/activity that could be reverted using Carnosine, a scavenger for MG. MG treatment affected Hsp90 chaperone activity and decreased its binding to LATS1, a key kinase of the Hippo pathway. Cancer cells with high MG stress showed enhanced growth and metastatic potential in vivo. These findings reinforce the cumulative evidence pointing to hyperglycemia as a risk factor for cancer incidence and bring renewed intere...
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Z Kristallogr, 1993
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Chemical Communications, 2009
Covalently cross-linked homodimeric Abeta peptides have been prepared by solid-phase peptide synt... more Covalently cross-linked homodimeric Abeta peptides have been prepared by solid-phase peptide synthesis by exploiting 'site-site interactions', and exhibit substantially increased oligomerisation and fibrillisation properties compared with the corresponding monomers.
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J Org Chem, 1991
4-(Bromomethyl)-2-(methylthio)pyrimidine (26): yield 30%; an unstable oil; 'H NMR 6 2.62 (8,... more 4-(Bromomethyl)-2-(methylthio)pyrimidine (26): yield 30%; an unstable oil; 'H NMR 6 2.62 (8, Me), 4.40 (8, CH2Br), 7.17 (d, J = 5 Hz, 5H), 8.68 (d, J = 5 Hz, 6-H); HRMS m/z (M+) calcd 217.9514, obsd 217.9521. 5-Bromo-4-(bromomethyl)-2-(methylthio)pyrimidine (27): yield ...
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Amino Acids, 2006
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Tetrahedron Letters, 1990
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Z Kristallogr, 1995
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Org Biomol Chem, 2005
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Z Kristallogr, 1996
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Z Kristallogr, 1996
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Z Kristallogr, 1996
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The Journal of organic chemistry, Jan 16, 2015
Total synthesis of the highly functionalized cyclic peptide natural product, ustiloxin D, has bee... more Total synthesis of the highly functionalized cyclic peptide natural product, ustiloxin D, has been achieved in a convergent manner. Our strategy incorporates an asymmetric allylic alkylation to construct the tert-alkyl aryl ether linkage between the dopa and isoleucine residues. The elaborated β-hydroxydopa derivative is rapidly converted to a linear tripeptide through an ammonia-Ugi reaction. Subsequent cyclization and global deprotection affords ustiloxin D in six steps from a known β-hydroxydopa derivative.
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Acta Crystallographica Section F-structural Biology and Crystallization Communications - ACTA CRYSTALLOGR F-STRUCT BIO, 2010
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ChemInform, 2015
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ChemInform, 2007
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ChemInform, 2013
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ChemInform, 2005
ABSTRACT The dopa–sulfinylnorvaline component of ustiloxins A and B has been prepared using an Ev... more ABSTRACT The dopa–sulfinylnorvaline component of ustiloxins A and B has been prepared using an Evans salen–Al-catalysed aldol reaction with a 6-mercaptoisovanillin derivative, followed by incorporation of the norvaline group and asymmetric oxidation of the resulting sulfide to give the corresponding sulfoxide.
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Journal of Neuroscience, 2010
Alzheimer&amp... more Alzheimer's disease (AD) is the most common age-related dementia. Unfortunately due to a lack of validated biomarkers definitive diagnosis relies on the histological demonstration of amyloid-beta (Abeta) plaques and tau neurofibrillary tangles. Abeta processing is implicated in AD progression and many therapeutic strategies target various aspects of this biology. While Abeta deposition is the most prominent feature of AD, oligomeric forms of Abeta have been implicated as the toxic species inducing the neuronal dysfunction. Currently there are no methods allowing routine monitoring of levels of such species in living populations. We have used surface enhanced laser desorption ionization time of flight (SELDI-TOF) mass spectrometry incorporating antibody capture to investigate whether the cellular membrane-containing fraction of blood provides a new source of biomarkers. There are significant differences in the mass spectra profiles of AD compared with HC subjects, with significantly higher levels of Abeta monomer and dimer in the blood of AD subjects. Furthermore, levels of these species correlated with clinical markers of AD including brain Abeta burden, cognitive impairment and brain atrophy. These results indicate that fundamental biochemical events relevant to AD can be monitored in blood, and that the species detected may be useful clinical biomarkers for AD.
Bookmarks Related papers MentionsView impact
The Journal of Organic Chemistry, 1997
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The Journal of Organic Chemistry, 2007
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eLife, Jan 19, 2016
Metabolic reprogramming toward aerobic glycolysis unavoidably induces methylglyoxal (MG) formatio... more Metabolic reprogramming toward aerobic glycolysis unavoidably induces methylglyoxal (MG) formation in cancer cells. MG mediates the glycation of proteins to form advanced glycation end products (AGEs). We have recently demonstrated that MG-induced AGEs are a common feature of breast cancer. Little is known regarding the impact of MG-mediated carbonyl stress on tumor progression. Breast tumors with MG stress presented with high nuclear YAP, a key transcriptional co-activator regulating tumor growth and invasion. Elevated MG levels resulted in sustained YAP nuclear localization/activity that could be reverted using Carnosine, a scavenger for MG. MG treatment affected Hsp90 chaperone activity and decreased its binding to LATS1, a key kinase of the Hippo pathway. Cancer cells with high MG stress showed enhanced growth and metastatic potential in vivo. These findings reinforce the cumulative evidence pointing to hyperglycemia as a risk factor for cancer incidence and bring renewed intere...
Bookmarks Related papers MentionsView impact
Z Kristallogr, 1993
Bookmarks Related papers MentionsView impact
Chemical Communications, 2009
Covalently cross-linked homodimeric Abeta peptides have been prepared by solid-phase peptide synt... more Covalently cross-linked homodimeric Abeta peptides have been prepared by solid-phase peptide synthesis by exploiting 'site-site interactions', and exhibit substantially increased oligomerisation and fibrillisation properties compared with the corresponding monomers.
Bookmarks Related papers MentionsView impact
J Org Chem, 1991
4-(Bromomethyl)-2-(methylthio)pyrimidine (26): yield 30%; an unstable oil; 'H NMR 6 2.62 (8,... more 4-(Bromomethyl)-2-(methylthio)pyrimidine (26): yield 30%; an unstable oil; 'H NMR 6 2.62 (8, Me), 4.40 (8, CH2Br), 7.17 (d, J = 5 Hz, 5H), 8.68 (d, J = 5 Hz, 6-H); HRMS m/z (M+) calcd 217.9514, obsd 217.9521. 5-Bromo-4-(bromomethyl)-2-(methylthio)pyrimidine (27): yield ...
Bookmarks Related papers MentionsView impact
Amino Acids, 2006
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Tetrahedron Letters, 1990
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Z Kristallogr, 1995
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Org Biomol Chem, 2005
Bookmarks Related papers MentionsView impact
Z Kristallogr, 1996
Bookmarks Related papers MentionsView impact
Z Kristallogr, 1996
Bookmarks Related papers MentionsView impact
Z Kristallogr, 1996
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The Journal of organic chemistry, Jan 16, 2015
Total synthesis of the highly functionalized cyclic peptide natural product, ustiloxin D, has bee... more Total synthesis of the highly functionalized cyclic peptide natural product, ustiloxin D, has been achieved in a convergent manner. Our strategy incorporates an asymmetric allylic alkylation to construct the tert-alkyl aryl ether linkage between the dopa and isoleucine residues. The elaborated β-hydroxydopa derivative is rapidly converted to a linear tripeptide through an ammonia-Ugi reaction. Subsequent cyclization and global deprotection affords ustiloxin D in six steps from a known β-hydroxydopa derivative.
Bookmarks Related papers MentionsView impact
Acta Crystallographica Section F-structural Biology and Crystallization Communications - ACTA CRYSTALLOGR F-STRUCT BIO, 2010
Bookmarks Related papers MentionsView impact
ChemInform, 2015
Bookmarks Related papers MentionsView impact
ChemInform, 2007
Skip to Main Content. ...
Bookmarks Related papers MentionsView impact
ChemInform, 2013
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ChemInform, 2005
ABSTRACT The dopa–sulfinylnorvaline component of ustiloxins A and B has been prepared using an Ev... more ABSTRACT The dopa–sulfinylnorvaline component of ustiloxins A and B has been prepared using an Evans salen–Al-catalysed aldol reaction with a 6-mercaptoisovanillin derivative, followed by incorporation of the norvaline group and asymmetric oxidation of the resulting sulfide to give the corresponding sulfoxide.
Bookmarks Related papers MentionsView impact