Patrizia Giannoni | Université de Nimes (original) (raw)
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Papers by Patrizia Giannoni
Journal of Visualized Experiments, Dec 6, 2016
HAL (Le Centre pour la Communication Scientifique Directe), Oct 3, 2022
Frontiers in Aging Neuroscience
Le Centre pour la Communication Scientifique Directe - HAL - Aix-Marseille Université, Mar 13, 2013
International audienc
Le Centre pour la Communication Scientifique Directe - HAL - Université de Nantes, Jun 8, 2016
International audienc
Le Centre pour la Communication Scientifique Directe - HAL - Inria, Jun 11, 2015
International audienc
Le Centre pour la Communication Scientifique Directe - HAL - Inria, Jul 6, 2015
International audienc
SCICON2 - SETAC North America 41st Annual Meeting, Nov 15, 2020
International audienceThau lagoon (extended on 7500 hectares) is located in the south of France a... more International audienceThau lagoon (extended on 7500 hectares) is located in the south of France and is the main shellfish-farming center in the Mediterranean Sea. Around this lagoon, numerous activities such as wastewater treatment plants, harbor and vine cultivation represent a potential source of pollution. Although subject to microbiological and chemical monitoring (heavy metals), there is currently no global study realized on the contamination of air and water. This work proposes an integrated approach based on a non-target analysis by SBSE/HSSE coupled with GC-MS and a target analysis in order to identify chemical pollutants (heavy metals, 34 pharmaceuticals, 12 pesticides, 2 industrial products and 6 toxins). This monitoring was carried out during one year on 6 sampling points and on two matrices: air (non-target analysis) and water (non-target and target analysis). Concerning the targeted analysis, very low concentrations ranging from the pg/L to the ng/L were found in water. Among pollutants, most frequently found are: atrazine, its metabolites, azithromycin, clarithromycin, atenolol and sotalol at low concentrations ranging from 2.44 pg/L to 0.6 ng/L. In contrast, in non-targeted analysis, 116 different molecules were found including 77 and 79 in the air and water respectively. Only 28 molecules were common to both matrices. To access the exposure risk of workers and residents of the lagoon, we have in second approach decided to select some molecules from the non-target analysis and to quantify them. The selection was based on the toxicity of the molecules (Toxtree software) and their frequency of detection. Only the molecules found in more than 20% of sampling were conserved for the analysis. Examples of potentially dangerous susbtances included in this list are: - triethyl phosphate (organophosphorus flame-retardant and intermediate in the manufacture for pesticides), - diisobutyl phthalate (endocrine disruptor). This substance is considered of very high concern (SVHC) and its use is strictly regulated (Annex XVII of REACH1) - 2-furanmethanol. This molecule is included in the list of hazardous substances harmonised for classification and labelling in the EU (Annex VI to CLP regulation)2 and is suspected to be carcinogenic. The next step of the study will be to made analysis on the shellfishes grown in the lagoon. All of these elements will allow to trace pollutants in the Thau lagoon and to determine the potential sources of exposition and potential bioaccumulation
Le Centre pour la Communication Scientifique Directe - HAL - Université de Nantes, Mar 18, 2015
International audienc
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Le Centre pour la Communication Scientifique Directe - HAL - memSIC, Jun 14, 2017
International audienc
Réunion francophone sur la maladie d'Alzheimer, Jun 11, 2014
International audienc
Neurobiology of Disease, 2016
ACS chemical neuroscience, Jan 15, 2015
Alzheimer's disease (AD) is the most common form of dementia affecting 35 million individuals... more Alzheimer's disease (AD) is the most common form of dementia affecting 35 million individuals worldwide. Current AD treatments provide only brief symptomatic relief. It is therefore urgent to replace this symptomatic approach with a curative one. Increasing serotonin signaling as well as developing molecules that enhance serotonin concentration in the synaptic cleft have been debated as possible therapeutic strategies to slow the progression of AD. In this Viewpoint, we discuss exciting new insights regarding the modulation of serotonin signaling for AD prevention and therapy.
Journal of Medicinal Chemistry, 2015
Journal of Visualized Experiments, Dec 6, 2016
HAL (Le Centre pour la Communication Scientifique Directe), Oct 3, 2022
Frontiers in Aging Neuroscience
Le Centre pour la Communication Scientifique Directe - HAL - Aix-Marseille Université, Mar 13, 2013
International audienc
Le Centre pour la Communication Scientifique Directe - HAL - Université de Nantes, Jun 8, 2016
International audienc
Le Centre pour la Communication Scientifique Directe - HAL - Inria, Jun 11, 2015
International audienc
Le Centre pour la Communication Scientifique Directe - HAL - Inria, Jul 6, 2015
International audienc
SCICON2 - SETAC North America 41st Annual Meeting, Nov 15, 2020
International audienceThau lagoon (extended on 7500 hectares) is located in the south of France a... more International audienceThau lagoon (extended on 7500 hectares) is located in the south of France and is the main shellfish-farming center in the Mediterranean Sea. Around this lagoon, numerous activities such as wastewater treatment plants, harbor and vine cultivation represent a potential source of pollution. Although subject to microbiological and chemical monitoring (heavy metals), there is currently no global study realized on the contamination of air and water. This work proposes an integrated approach based on a non-target analysis by SBSE/HSSE coupled with GC-MS and a target analysis in order to identify chemical pollutants (heavy metals, 34 pharmaceuticals, 12 pesticides, 2 industrial products and 6 toxins). This monitoring was carried out during one year on 6 sampling points and on two matrices: air (non-target analysis) and water (non-target and target analysis). Concerning the targeted analysis, very low concentrations ranging from the pg/L to the ng/L were found in water. Among pollutants, most frequently found are: atrazine, its metabolites, azithromycin, clarithromycin, atenolol and sotalol at low concentrations ranging from 2.44 pg/L to 0.6 ng/L. In contrast, in non-targeted analysis, 116 different molecules were found including 77 and 79 in the air and water respectively. Only 28 molecules were common to both matrices. To access the exposure risk of workers and residents of the lagoon, we have in second approach decided to select some molecules from the non-target analysis and to quantify them. The selection was based on the toxicity of the molecules (Toxtree software) and their frequency of detection. Only the molecules found in more than 20% of sampling were conserved for the analysis. Examples of potentially dangerous susbtances included in this list are: - triethyl phosphate (organophosphorus flame-retardant and intermediate in the manufacture for pesticides), - diisobutyl phthalate (endocrine disruptor). This substance is considered of very high concern (SVHC) and its use is strictly regulated (Annex XVII of REACH1) - 2-furanmethanol. This molecule is included in the list of hazardous substances harmonised for classification and labelling in the EU (Annex VI to CLP regulation)2 and is suspected to be carcinogenic. The next step of the study will be to made analysis on the shellfishes grown in the lagoon. All of these elements will allow to trace pollutants in the Thau lagoon and to determine the potential sources of exposition and potential bioaccumulation
Le Centre pour la Communication Scientifique Directe - HAL - Université de Nantes, Mar 18, 2015
International audienc
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Le Centre pour la Communication Scientifique Directe - HAL - memSIC, Jun 14, 2017
International audienc
Réunion francophone sur la maladie d'Alzheimer, Jun 11, 2014
International audienc
Neurobiology of Disease, 2016
ACS chemical neuroscience, Jan 15, 2015
Alzheimer's disease (AD) is the most common form of dementia affecting 35 million individuals... more Alzheimer's disease (AD) is the most common form of dementia affecting 35 million individuals worldwide. Current AD treatments provide only brief symptomatic relief. It is therefore urgent to replace this symptomatic approach with a curative one. Increasing serotonin signaling as well as developing molecules that enhance serotonin concentration in the synaptic cleft have been debated as possible therapeutic strategies to slow the progression of AD. In this Viewpoint, we discuss exciting new insights regarding the modulation of serotonin signaling for AD prevention and therapy.
Journal of Medicinal Chemistry, 2015