L. Soldati | Università degli Studi di Milano - State University of Milan (Italy) (original) (raw)

Papers by L. Soldati

Research paper thumbnail of Genetic polimorphisms of the citrate carriers are associated with citrate excretion and stones

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Research paper thumbnail of Free cytosolic calcium in children with idiopathic hypercalciuria

Contributions to nephrology, 1988

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Research paper thumbnail of Mineral Metabolism during a Hemofiltration Session in Children

The International Journal of Artificial Organs, 1986

We studied the effects of one session of hemofiltration on the mineral metabolism in a group of u... more We studied the effects of one session of hemofiltration on the mineral metabolism in a group of uremic children. We observed an increase of calcemia, accompained by positive calcium balance, and a decrease of plasma phosphate and PTH-MM. No substantial loss of plasma 25-OH D was found. It is concluded that hemofiltration has a positive effect on calcemia and is very effective in removing phosphate, but it acts only temporarily on PTH removal. An adequate calcium concentration must be provided in the substitution fluid.

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Research paper thumbnail of Study of Calcium Metabolism in Idiopathic Hypercalciuria by Strontium Oral Load Test

Clinical Chemistry, 1999

Calcium excretion and absorption were evaluated in hypercalciuric calcium stone formers by the st... more Calcium excretion and absorption were evaluated in hypercalciuric calcium stone formers by the study of Sr2+ excretion and absorption after an oral load. Ca2+ stone formers (n = 140) were studied, and the results were compared in the 83 of them who had idiopathic hypercalciuria and in the 57 who had Ca2+ excretion within reference values. Hypercalciuric patients showed increased renal Sr2+ clearance (CRE; 5.26 ± 0.358 vs 3.29 ± 0.277 mL/min; P <0.001), whereas Sr2+ absorption [assessed as the area under the serum concentration–time curve (AUC)] was increased at 30 and 60 min (1.53 ± 0.087 vs 1.21 ± 0.071 mmol · L−1 · min; P <0.05), but not at 240 min after the load. In hypercalciuric patients, the AUCs were positively correlated with urinary Sr2+ fractional excretion (P <0.001). Conversely, in normocalciuric patients plasma parathyroid hormone (PTH) was negatively correlated with the AUCs (P <0.01) and CRE (P <0.05), whereas 1,25-dihydroxyvitamin D plasma concentratio...

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Research paper thumbnail of Heparin inhibits cell growth in response to serum and growth factors by reducing mitogenic signalling

Cell Biology International Reports, 1990

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Research paper thumbnail of Dietary style and acid load in an Italian population of calcium kidney stone formers

Nutrition, Metabolism and Cardiovascular Diseases, 2015

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Research paper thumbnail of Plasma Membrane Ca-ATPase in Idiopathic Hypercalciuria

Contributions to Nephrology

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Research paper thumbnail of Predicting interindividual variations in antihypertensive therapy: the role of sodium transport systems and renin

Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1990

The efficacy of captopril at 75 mg/day, atenolol at 100 mg/day and canrenoate potassium at 200 mg... more The efficacy of captopril at 75 mg/day, atenolol at 100 mg/day and canrenoate potassium at 200 mg/day was compared in 42 essential hypertensive patients in randomly assigned sequences. All the drugs lowered blood pressure significantly but variations were found in the individual response. Patients who were more responsive to captopril also seemed to be more responsive to atenolol and vice versa (r = 0.75; P less than 0.0001), while the relationship between mean blood pressure reached after canrenoate potassium and that reached after atenolol or captopril was much weaker. The patients who were responsive to atenolol and captopril were considered as one group (n = 22) and compared with the 12 patients more responsive to canrenoate potassium. Before treatment, the former group had higher plasma renin activity (PRA) and lower Na,K cotransport activity across the erythrocyte membrane than the latter. These two variables, considered together as a discriminant function, correctly classifie...

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Research paper thumbnail of Renal osteodystrophy and vascular calcification

Journal of endocrinological investigation, 2009

Chronic kidney disease (CKD) is characterized by phosphate retention and reduced synthesis of 1.2... more Chronic kidney disease (CKD) is characterized by phosphate retention and reduced synthesis of 1.25(OH)2-vitamin D stimulating parathyroid hyperplasia. These changes cause a complex osteopathy, defined as renal osteodystrophy, and vascular calcification. Renal osteodystrophy increases the risk of fracture and causes deformities and disability. Vascular calcification occurs in a large proportion of hemodialysis patients and is a marker of arteriopathy. Calcifying arteriopathy induces arterial stiffness and contributes to the high cardiovascular mortality and morbidity among CKD patients. Vascular calcification results from a process of local bone formation induced by osteoblast-like cells developing in the vascular wall from resident cells. Osteoblast differentiation of resident vascular cells may be mediated by metabolic factors and may be induced by high concentrations of phosphate. Therefore, phosphate retention appears as the most detrimental factor affecting arteries in CKD patie...

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Research paper thumbnail of Biofiltration and calcium-phosphate metabolism

The International journal of artificial organs, 1986

We evaluated the effect of one session of biofiltration on calcium-phosphate metabolism in four u... more We evaluated the effect of one session of biofiltration on calcium-phosphate metabolism in four uremic patients and compared the results with those of a previous traditional hemodialysis (Cuprophane membrane) session, on the same subjects. The most noteworthy results were: both total and ionized plasma calcium rose less in biofiltration; phosphate clearance and parathyroid hormone clearance were higher in biofiltration; plasma 25-OH D did not change in either dialysis technique.

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Research paper thumbnail of Progression of mineral metabolism derangements in childhood chronic renal failure

Bone and mineral, 1986

2 groups of children affected by different degrees of chronic renal failure (group 1, 55-36 ml/mi... more 2 groups of children affected by different degrees of chronic renal failure (group 1, 55-36 ml/min/1.73 m2; group 2, 35-20 ml/min/1.73 m2 of creatinine clearance) due to tubulo-interstitial disease were studied for one year. The spontaneous evolution of altered mineral metabolism at different levels of glomerular filtration rate (GFR) was aimed at. Parathyroid hormone, vitamin D metabolites and bone mineral content were evaluated. At the end of the year, only a decrease of plasma levels of 1,25(OH)2D in group 1 and a worsening of all mineral metabolism parameters in group 2 were found. The results are consistent with the hypothesis that mineral metabolism derangements progress rapidly after a certain 'threshold' of endocrinologically active renal mass is reached. The falling of plasma 1,25(OH)2D levels below a still undetermined critical value might be assumed as an index of this threshold.

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Research paper thumbnail of Determinants of bone mineral density and calcium excretionin idiopathic hypercalciuria

Background. Alterations of enteral and tubular Ca handling, bone mineral density (BMD) and erythr... more Background. Alterations of enteral and tubular Ca handling, bone mineral density (BMD) and erythrocyte membrane (Ca-Mg)ATPase have been observed in idiopathic hypercalciuria. In the present study factors affecting BMD were analysed in hypercalciuric patients. Methods. Results in 116 hypercalciuric and 109 normocalciuric idiopathic Ca stone formers were compared. Na, Ca and phosphate excretion were measured. BMD was analysed by DEXA at lumbar-spine and femoral sites. (Ca-Mg)ATPase activity was determined by coupled enzyme assay in erythrocytes. Enteral Ca absorption and tubular reabsorption were assessed using Sr oral load test in 98 hypercalciuric and 62 normocalciuric patients. Results. Lumbar-spine BMD z-score was lower in hypercalciuric than normocalciuric patients (-1.05\ub10.118 vs -0.65\ub10.114; p<0.02). Na excretion (182\ub17.2 vs 156\ub16.6 mmol/24 hours; p<0.02), phosphate excretion (28.39\ub10.985 vs 24.16\ub10.759 mmol/24 hours, p<0.001) and creatinine clearance (110\ub13.7 vs 98\ub13.5 ml/min, p<0.02) were higher in hypercalciuric patients, but only in those with BMD z-score 65-2 these three variables resulted increased. In hypercalciuric patients Sr absorption (1.38\ub10.060 vs 1.17\ub10.068 mmol\ub7L-1\ub7min-1; p<0.05) and (Ca-Mg)ATPase activity were elevated independently of BMD, while Na excretion was positively correlated with lumbar-spine BMD (r=0.258, p<0.01). Conclusions. Increase enteral calcium absorption is involved in the mechanisms of idiopathic hypercalciuria. Increased Na intake could favour bone mass preservation in hypercalciuric patients, influencing enteral absorption and urinary excretion of calcium and phosphate

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Research paper thumbnail of Tumour-associated fibroblasts contribute to neoangiogenesis in human parathyroid neoplasia

Endocrine-Related Cancer, 2014

Components of the tumour microenvironment initiate and promote cancer development. In this study,... more Components of the tumour microenvironment initiate and promote cancer development. In this study, we investigated the stromal component of parathyroid neoplasia. Immunohistochemistry for alpha-smooth muscle actin (α-SMA) showed an abundant periacinar distribution of α-SMA+ cells in normal parathyroid glands (n=3). This pattern was progressively lost in parathyroid adenomas (PAds; n=6) where α-SMA+cells were found to surround new microvessels, as observed in foetal parathyroid glands (n=2). Moreover, in atypical adenomas (n=5) and carcinomas (n=4), α-SMA+ cells disappeared from the parenchyma and accumulated in the capsula and fibrous bands. At variance with normal glands, parathyroid tumours (n=37) expressed high levels of fibroblast-activation protein (FAP) transcripts, a marker of tumour-associated fibroblasts. We analysed the ability of PAd-derived cells to activate fibroblasts using human bone-marrow mesenchymal stem cells (hBM-MSCs). PAd-derived cells induced a significant incr...

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Research paper thumbnail of Risk of nephrolithiasis in primary hyperparathyroidism is associated with two polymorphisms of the calcium-sensing receptor gene

Journal of Nephrology, 2014

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Research paper thumbnail of Plasma 25(OH)D Levels in Children on Long-Term Hemofiltration

Nephron, 2008

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Research paper thumbnail of Effects of 1,25-Dihydroxyvitamin-D3 Treatment on Mineral Balance in Children with End Stage Renal Disease Undergoing Chronic Hemofiltration

Pediatric Research, 1986

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Research paper thumbnail of Reprint of: Vitamin D receptor activation and prevention of arterial ageing

Nutrition, Metabolism and Cardiovascular Diseases, 2013

In chronic kidney disease (CKD) patients, cardiovascular (CV) morbidity and mortality rate is hig... more In chronic kidney disease (CKD) patients, cardiovascular (CV) morbidity and mortality rate is higher than in the general population, because of frequently concomitant hypertension, peripheral vascular disease, heart failure, vascular calcification (VC), diabetes and mineral bone disease. Recently, another important factor associated to CV risk in CKD has been deeply investigated: vitamin D deficiency. Vitamin D Receptors (VDRs) are present in several systems and tissues and VDR activation is associated to positive effects, resulting in better blood pressure control and prevention of diabetic nephropathy. Unfortunately, the natural, non-selective vitamin D receptor activator (VDRA), calcitriol, is associated to higher serum calcium and phosphate levels, thus worsening CV risk in CKD. Recent data showed that the selective VDRA paricalcitol might have ameliorative CV effects. The potential positive impact of the use of paricalcitol on diabetic nephropathy, cardiac disease, hypertension, and VC may open new paths in the fight against CV disease in CKD patients.

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Research paper thumbnail of Genetic diseases and molecular genetics

NDT Plus, 2011

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Research paper thumbnail of A new rat model for studying the calpain-calpastatin system

Laboratory Animals, 1995

A recombinant rat strain-Milan low-calpastatin strain (MLCS)-was derived from Milan hypertensive ... more A recombinant rat strain-Milan low-calpastatin strain (MLCS)-was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a model for studies of the calpain-calpastatin system, which is involved in important cellular mechanisms. Calpastatin polymorphism was observed in 10 different strains of laboratory rats and a single locus hypothesis is suggested as the mode of inheritance.

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Research paper thumbnail of Influence of Calcium-Sensing Receptor Gene on Urinary Calcium Excretion in Stone-Forming Patients

Journal of the American Society of Nephrology, 2002

ABSTRACT. Calcium-sensing receptor (CaSR) is a plasma membrane protein that regulates tubular rea... more ABSTRACT. Calcium-sensing receptor (CaSR) is a plasma membrane protein that regulates tubular reabsorption of Ca. To establish its role in idiopathic hypercalciuria, the association of urinary Ca excretion with the polymorphisms of CASR gene has been studied in healthy subjects and in hypercalciuric and normocalciuric Ca stone formers. CASR exon 7 single nucleotide polymorphisms (SNP), G/T at codon 986, G/A at codon 990, and C/G at codon 1011, were evaluated by PCR amplification and direct sequencing in 97 normocalciuric stone formers, 134 hypercalciuric stone formers, and 101 normocalciuric healthy controls. Four haplotypes were defined on the basis of CASR gene SNP: haplotype 1 was characterized by the most frequent sequence; haplotypes 2, 3, or 4 by the presence of a single polymorphic variant at codon 986, 990, or 1011, respectively. The relative risk of hypercalciuria was calculated with multinomial logistic regression and was significantly increased only in individuals carryin...

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Research paper thumbnail of Genetic polimorphisms of the citrate carriers are associated with citrate excretion and stones

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Research paper thumbnail of Free cytosolic calcium in children with idiopathic hypercalciuria

Contributions to nephrology, 1988

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Research paper thumbnail of Mineral Metabolism during a Hemofiltration Session in Children

The International Journal of Artificial Organs, 1986

We studied the effects of one session of hemofiltration on the mineral metabolism in a group of u... more We studied the effects of one session of hemofiltration on the mineral metabolism in a group of uremic children. We observed an increase of calcemia, accompained by positive calcium balance, and a decrease of plasma phosphate and PTH-MM. No substantial loss of plasma 25-OH D was found. It is concluded that hemofiltration has a positive effect on calcemia and is very effective in removing phosphate, but it acts only temporarily on PTH removal. An adequate calcium concentration must be provided in the substitution fluid.

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Research paper thumbnail of Study of Calcium Metabolism in Idiopathic Hypercalciuria by Strontium Oral Load Test

Clinical Chemistry, 1999

Calcium excretion and absorption were evaluated in hypercalciuric calcium stone formers by the st... more Calcium excretion and absorption were evaluated in hypercalciuric calcium stone formers by the study of Sr2+ excretion and absorption after an oral load. Ca2+ stone formers (n = 140) were studied, and the results were compared in the 83 of them who had idiopathic hypercalciuria and in the 57 who had Ca2+ excretion within reference values. Hypercalciuric patients showed increased renal Sr2+ clearance (CRE; 5.26 ± 0.358 vs 3.29 ± 0.277 mL/min; P <0.001), whereas Sr2+ absorption [assessed as the area under the serum concentration–time curve (AUC)] was increased at 30 and 60 min (1.53 ± 0.087 vs 1.21 ± 0.071 mmol · L−1 · min; P <0.05), but not at 240 min after the load. In hypercalciuric patients, the AUCs were positively correlated with urinary Sr2+ fractional excretion (P <0.001). Conversely, in normocalciuric patients plasma parathyroid hormone (PTH) was negatively correlated with the AUCs (P <0.01) and CRE (P <0.05), whereas 1,25-dihydroxyvitamin D plasma concentratio...

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Research paper thumbnail of Heparin inhibits cell growth in response to serum and growth factors by reducing mitogenic signalling

Cell Biology International Reports, 1990

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Research paper thumbnail of Dietary style and acid load in an Italian population of calcium kidney stone formers

Nutrition, Metabolism and Cardiovascular Diseases, 2015

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Research paper thumbnail of Plasma Membrane Ca-ATPase in Idiopathic Hypercalciuria

Contributions to Nephrology

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Research paper thumbnail of Predicting interindividual variations in antihypertensive therapy: the role of sodium transport systems and renin

Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1990

The efficacy of captopril at 75 mg/day, atenolol at 100 mg/day and canrenoate potassium at 200 mg... more The efficacy of captopril at 75 mg/day, atenolol at 100 mg/day and canrenoate potassium at 200 mg/day was compared in 42 essential hypertensive patients in randomly assigned sequences. All the drugs lowered blood pressure significantly but variations were found in the individual response. Patients who were more responsive to captopril also seemed to be more responsive to atenolol and vice versa (r = 0.75; P less than 0.0001), while the relationship between mean blood pressure reached after canrenoate potassium and that reached after atenolol or captopril was much weaker. The patients who were responsive to atenolol and captopril were considered as one group (n = 22) and compared with the 12 patients more responsive to canrenoate potassium. Before treatment, the former group had higher plasma renin activity (PRA) and lower Na,K cotransport activity across the erythrocyte membrane than the latter. These two variables, considered together as a discriminant function, correctly classifie...

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Research paper thumbnail of Renal osteodystrophy and vascular calcification

Journal of endocrinological investigation, 2009

Chronic kidney disease (CKD) is characterized by phosphate retention and reduced synthesis of 1.2... more Chronic kidney disease (CKD) is characterized by phosphate retention and reduced synthesis of 1.25(OH)2-vitamin D stimulating parathyroid hyperplasia. These changes cause a complex osteopathy, defined as renal osteodystrophy, and vascular calcification. Renal osteodystrophy increases the risk of fracture and causes deformities and disability. Vascular calcification occurs in a large proportion of hemodialysis patients and is a marker of arteriopathy. Calcifying arteriopathy induces arterial stiffness and contributes to the high cardiovascular mortality and morbidity among CKD patients. Vascular calcification results from a process of local bone formation induced by osteoblast-like cells developing in the vascular wall from resident cells. Osteoblast differentiation of resident vascular cells may be mediated by metabolic factors and may be induced by high concentrations of phosphate. Therefore, phosphate retention appears as the most detrimental factor affecting arteries in CKD patie...

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Research paper thumbnail of Biofiltration and calcium-phosphate metabolism

The International journal of artificial organs, 1986

We evaluated the effect of one session of biofiltration on calcium-phosphate metabolism in four u... more We evaluated the effect of one session of biofiltration on calcium-phosphate metabolism in four uremic patients and compared the results with those of a previous traditional hemodialysis (Cuprophane membrane) session, on the same subjects. The most noteworthy results were: both total and ionized plasma calcium rose less in biofiltration; phosphate clearance and parathyroid hormone clearance were higher in biofiltration; plasma 25-OH D did not change in either dialysis technique.

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Research paper thumbnail of Progression of mineral metabolism derangements in childhood chronic renal failure

Bone and mineral, 1986

2 groups of children affected by different degrees of chronic renal failure (group 1, 55-36 ml/mi... more 2 groups of children affected by different degrees of chronic renal failure (group 1, 55-36 ml/min/1.73 m2; group 2, 35-20 ml/min/1.73 m2 of creatinine clearance) due to tubulo-interstitial disease were studied for one year. The spontaneous evolution of altered mineral metabolism at different levels of glomerular filtration rate (GFR) was aimed at. Parathyroid hormone, vitamin D metabolites and bone mineral content were evaluated. At the end of the year, only a decrease of plasma levels of 1,25(OH)2D in group 1 and a worsening of all mineral metabolism parameters in group 2 were found. The results are consistent with the hypothesis that mineral metabolism derangements progress rapidly after a certain 'threshold' of endocrinologically active renal mass is reached. The falling of plasma 1,25(OH)2D levels below a still undetermined critical value might be assumed as an index of this threshold.

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Research paper thumbnail of Determinants of bone mineral density and calcium excretionin idiopathic hypercalciuria

Background. Alterations of enteral and tubular Ca handling, bone mineral density (BMD) and erythr... more Background. Alterations of enteral and tubular Ca handling, bone mineral density (BMD) and erythrocyte membrane (Ca-Mg)ATPase have been observed in idiopathic hypercalciuria. In the present study factors affecting BMD were analysed in hypercalciuric patients. Methods. Results in 116 hypercalciuric and 109 normocalciuric idiopathic Ca stone formers were compared. Na, Ca and phosphate excretion were measured. BMD was analysed by DEXA at lumbar-spine and femoral sites. (Ca-Mg)ATPase activity was determined by coupled enzyme assay in erythrocytes. Enteral Ca absorption and tubular reabsorption were assessed using Sr oral load test in 98 hypercalciuric and 62 normocalciuric patients. Results. Lumbar-spine BMD z-score was lower in hypercalciuric than normocalciuric patients (-1.05\ub10.118 vs -0.65\ub10.114; p<0.02). Na excretion (182\ub17.2 vs 156\ub16.6 mmol/24 hours; p<0.02), phosphate excretion (28.39\ub10.985 vs 24.16\ub10.759 mmol/24 hours, p<0.001) and creatinine clearance (110\ub13.7 vs 98\ub13.5 ml/min, p<0.02) were higher in hypercalciuric patients, but only in those with BMD z-score 65-2 these three variables resulted increased. In hypercalciuric patients Sr absorption (1.38\ub10.060 vs 1.17\ub10.068 mmol\ub7L-1\ub7min-1; p<0.05) and (Ca-Mg)ATPase activity were elevated independently of BMD, while Na excretion was positively correlated with lumbar-spine BMD (r=0.258, p<0.01). Conclusions. Increase enteral calcium absorption is involved in the mechanisms of idiopathic hypercalciuria. Increased Na intake could favour bone mass preservation in hypercalciuric patients, influencing enteral absorption and urinary excretion of calcium and phosphate

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Research paper thumbnail of Tumour-associated fibroblasts contribute to neoangiogenesis in human parathyroid neoplasia

Endocrine-Related Cancer, 2014

Components of the tumour microenvironment initiate and promote cancer development. In this study,... more Components of the tumour microenvironment initiate and promote cancer development. In this study, we investigated the stromal component of parathyroid neoplasia. Immunohistochemistry for alpha-smooth muscle actin (α-SMA) showed an abundant periacinar distribution of α-SMA+ cells in normal parathyroid glands (n=3). This pattern was progressively lost in parathyroid adenomas (PAds; n=6) where α-SMA+cells were found to surround new microvessels, as observed in foetal parathyroid glands (n=2). Moreover, in atypical adenomas (n=5) and carcinomas (n=4), α-SMA+ cells disappeared from the parenchyma and accumulated in the capsula and fibrous bands. At variance with normal glands, parathyroid tumours (n=37) expressed high levels of fibroblast-activation protein (FAP) transcripts, a marker of tumour-associated fibroblasts. We analysed the ability of PAd-derived cells to activate fibroblasts using human bone-marrow mesenchymal stem cells (hBM-MSCs). PAd-derived cells induced a significant incr...

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Research paper thumbnail of Risk of nephrolithiasis in primary hyperparathyroidism is associated with two polymorphisms of the calcium-sensing receptor gene

Journal of Nephrology, 2014

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Research paper thumbnail of Plasma 25(OH)D Levels in Children on Long-Term Hemofiltration

Nephron, 2008

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Research paper thumbnail of Effects of 1,25-Dihydroxyvitamin-D3 Treatment on Mineral Balance in Children with End Stage Renal Disease Undergoing Chronic Hemofiltration

Pediatric Research, 1986

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Reprint of: Vitamin D receptor activation and prevention of arterial ageing

Nutrition, Metabolism and Cardiovascular Diseases, 2013

In chronic kidney disease (CKD) patients, cardiovascular (CV) morbidity and mortality rate is hig... more In chronic kidney disease (CKD) patients, cardiovascular (CV) morbidity and mortality rate is higher than in the general population, because of frequently concomitant hypertension, peripheral vascular disease, heart failure, vascular calcification (VC), diabetes and mineral bone disease. Recently, another important factor associated to CV risk in CKD has been deeply investigated: vitamin D deficiency. Vitamin D Receptors (VDRs) are present in several systems and tissues and VDR activation is associated to positive effects, resulting in better blood pressure control and prevention of diabetic nephropathy. Unfortunately, the natural, non-selective vitamin D receptor activator (VDRA), calcitriol, is associated to higher serum calcium and phosphate levels, thus worsening CV risk in CKD. Recent data showed that the selective VDRA paricalcitol might have ameliorative CV effects. The potential positive impact of the use of paricalcitol on diabetic nephropathy, cardiac disease, hypertension, and VC may open new paths in the fight against CV disease in CKD patients.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Genetic diseases and molecular genetics

NDT Plus, 2011

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Research paper thumbnail of A new rat model for studying the calpain-calpastatin system

Laboratory Animals, 1995

A recombinant rat strain-Milan low-calpastatin strain (MLCS)-was derived from Milan hypertensive ... more A recombinant rat strain-Milan low-calpastatin strain (MLCS)-was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a model for studies of the calpain-calpastatin system, which is involved in important cellular mechanisms. Calpastatin polymorphism was observed in 10 different strains of laboratory rats and a single locus hypothesis is suggested as the mode of inheritance.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Influence of Calcium-Sensing Receptor Gene on Urinary Calcium Excretion in Stone-Forming Patients

Journal of the American Society of Nephrology, 2002

ABSTRACT. Calcium-sensing receptor (CaSR) is a plasma membrane protein that regulates tubular rea... more ABSTRACT. Calcium-sensing receptor (CaSR) is a plasma membrane protein that regulates tubular reabsorption of Ca. To establish its role in idiopathic hypercalciuria, the association of urinary Ca excretion with the polymorphisms of CASR gene has been studied in healthy subjects and in hypercalciuric and normocalciuric Ca stone formers. CASR exon 7 single nucleotide polymorphisms (SNP), G/T at codon 986, G/A at codon 990, and C/G at codon 1011, were evaluated by PCR amplification and direct sequencing in 97 normocalciuric stone formers, 134 hypercalciuric stone formers, and 101 normocalciuric healthy controls. Four haplotypes were defined on the basis of CASR gene SNP: haplotype 1 was characterized by the most frequent sequence; haplotypes 2, 3, or 4 by the presence of a single polymorphic variant at codon 986, 990, or 1011, respectively. The relative risk of hypercalciuria was calculated with multinomial logistic regression and was significantly increased only in individuals carryin...

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