Cristina Giannattasio | Università degli Studi di Milano-Bicocca (original) (raw)
Papers by Cristina Giannattasio
European Heart Journal Supplements, Dec 14, 2022
Journal of clinical hypertension (Greenwich, Conn.), 2018
Professor Alberto Zanchetti passed away on March 24, 2018 at the age of almost 92 years. He had b... more Professor Alberto Zanchetti passed away on March 24, 2018 at the age of almost 92 years. He had been in excellent physical health and with undiminished mental brilliance until a month before. Unfortunately, soon after returning from a lecture tour in Latin America he accidentally fell in his house and suffered a brain trauma that, after few weeks, led to his death.
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](Journal of Hypertension, 2017
s e265 Results: 91/188 (48%) women approached were both eligible and consented to randomisation (... more s e265 Results: 91/188 (48%) women approached were both eligible and consented to randomisation (45:46 intervention:control). Their mean age was 32y (SD 5), mean body mass index 29 kg/m 2 (SD 8), and mean baseline BP (day 1-6 postpartum) 133/86mmHg (SD 14/10 respectively). 75/91 (82%) were white British. Index of Multiple Deprivation scores were available for 88/91: 52/88 (59%) 1st/2nd quintiles, 23/88 (26%) 3rd quintile and 13/88 (15%) 4th/5th quintiles. Follow-up is complete with 82/91 (90%) retention, and 9/91 (10%) withdrawals. Considering complete cases: compliance with the trial was 403/410 (98%) scheduled follow-up visits; 36/40 (90%) participants (intervention group) submitted BP readings on at least alternate days whilst on treatment (NICE recommendation); 1075/1513 (71%) expected daily readings (on treatment) were submitted. Secondary outcome data including blood pressure will be available in early 2017 in time for presentation at the conference. Conclusions: The SNAP-HT trial will provide the fi rst randomised controlled evaluation of BP self-management postpartum. The recruitment (approximately 50% of those approached) and retention rates (90%) suggest expanding this study to a larger scale would be practicable. An early indication of the likely effi cacy will be available once analysis is complete and will be presented at the conference. BP.07.
Journal of Hypertension, 2015
In the last two decades new drugs that oppose the effects of vascular endothelial growth factor r... more In the last two decades new drugs that oppose the effects of vascular endothelial growth factor receptor (VEGFR), and thus angiogenesis, have considerably improved treatment of solid tumors. These anti-VEGFR drugs, however, are burdened by several side effects, particularly relevant on heart and vessels. Aim of this study was to analyze the changes in cardiovascular structure and function associated with use of anti-VEGFR drugs. 29 patients (27 affected by renal and 2 by thyroid cancer), received treatment with antiVEGFR drugs. Hemodynamic, non invasive arterial investigation (Pulse Wave velocity -cfPWV-, Augmentation Index-Aix- and Aortic Pressure) and echocardiography with global longitudinal strain (gLS) were performed before starting therapy (T0), after 2 (T1) and 6 weeks (T2). Oncologic outcome was determined by the assessment of the neoplastic lesions at CT scans, according to Response Evaluation Criteria in Solid Tumors Guidelines. A significant increase of both peripheral and central blood pressure (BP) was observed. We documented a significant raise of cfPWV from T0 (9.9 ± 2.5m/sec) to T1 (10.6 ± 2.3m/sec); at T2 cfPWV still increased in patients who continued treatment (10.8 ± 2.3m/sec), while decreased in patients who stopped therapy (9.8 ± 1.9m/sec). At the on-treatment CT scan (available in 22 patients) 12 patients had a stable disease (StD), 5 showed a reduction of the lesions (responders -PR-) and 5 showed a disease progression (PD). PD patients showed a lower cfPWV at T2 than StD-PR patients (cfPWV: 9.3 ± 2.8 Vs 13.3 ± 1.5 m/sec; p value 0.02). Aix at T1 was higher in PD than in StD-PR (Aix: 36 ± 2.8% Vs 24.6 ± 9.2%; p value 0.02). Anti-VEGFR treatment is associated with a marked increase in both brachial and central BP. Moreover it early induces an aortic reversible stiffening. The evidence that cfPWV and AIx changes are early and sensitive cardio-vascular effects of anti-angiogenic treatment and that disease progression is associated with a concomitant come back to pre-treatment value of cfPWV and a further increase in augmentation index, suggests their possible role on oncologic outcome.
Clinical hemorheology and microcirculation, 1999
... Corresponding author: Prof. Giuseppe Mancia, Clinica Medica, Ospedale S. Gerardo, Via Donizet... more ... Corresponding author: Prof. Giuseppe Mancia, Clinica Medica, Ospedale S. Gerardo, Via Donizetti 106, Monza, Italy. Tel.: +39 039 2333357; Fax: +39 039 322274. 1386-0291/99/$8.00 © 1999 – IOS Press. ... [30] T. Jensen, K. Borch-Johnsen, A. Kofoed-Enevodsen and T ...
Journal of Hypertension, 2015
Williams-Beuren syndrome (WBS) is a genetic disorder that involves elastin gene causing cardiovas... more Williams-Beuren syndrome (WBS) is a genetic disorder that involves elastin gene causing cardiovascular abnormalities and increased risk. However, data on arterial function in these patients are only few and conflicting. Aim of this study was to evaluate dynamic behaviour of central and peripheral blood pressure (BP) and arterial stiffness parameters early in the course of WBS. We enrolled 19 WBS paediatric patients (age 13 ± 4 years) and 23 age, height and BP-matched controls (10 ± 4 years). We evaluated 24-h ambulatory BP values via an ambulatory blood pressure monitoring (ABPM) system (Mobil-O-Graph) also capable to calculate 24-h central BP and 24-h arterial stiffness parameters. Carotid-femoral PWV (cf-PWV) was assessed in all WBS individuals (Complior). BP values were similar in WBS and control, during the daytime and the night-time. The same behaviour applies to 24-h central BP. However, during the night, WBS showed heart rate values (HR; 78 ± 10 vs. 71 ± 9 bpm; P < 0.03), augmentation index (Aix; 24.6 ± 13.5% vs. 16.5 ± 8.9%; P = 0.03) and reflection magnitude (68 5.8 vs. 63.5 8.1; P = 0.02) higher than controls. The HR, Aix and reflection magnitude reduction in the day-night shift was lower in WBS than in controls. Cf-PWV in WBS children did not differ when compared with their normalized expected value. In WBS children, the higher night-time HR, Aix and reflection magnitude and their impaired physiological reduction in the day-night shift suggests an abnormal sympathetic cardiovascular control, an augmented wave reflection and an increase in small arteries resistance. These alterations possibly due to a sympathetic overactivity can be regarded as earlier hallmarks of cardiovascular dysfunction in these patients.
American Journal of Hypertension, 1988
Several studies have described the modifications of the arterial baroreceptor reflex in hypertens... more Several studies have described the modifications of the arterial baroreceptor reflex in hypertension. Whether this condition alters the other major cardiovascular reflex (ie, that originating from receptors in the cardiopulmonary region) is less well known, however. Herein we describe the importance of the inhibitory control of sympathetic vasomotor and renin influences exerted by the cardiopul monary reflex in normotensive humans as assessed by deactivating and stimulating heart and lung receptors through reductions and increases in central venous pressure respectively obtained via lower-body negative pressure and passive leg raising. Observations on this re flex obtained in experimental animal models are summa rized. Finally, we report recent evidence showing that the cardiopulmonary reflex is only slightly affected by mild or moderate essential hypertension but impaired in hypertension with left ventricular hypertrophy in a fash ion positively related to the degree of this cardiac structural alteration. This may further worsen the sever ity of hypertension. However, the impairment of the cardiopulmonary reflex is reversible with regression of hypertrophy obtained by antihypertensive treatment which is thus beneficial for cardiovascular homeostasis.
Hypertension, 1988
Cardiopulmonary receptors modulate renin release in several animals species. However, their invol... more Cardiopulmonary receptors modulate renin release in several animals species. However, their involvement in reflex control of this humoral substance in humans is controversial. Furthermore, no information is available on the alteration of this control in hypertension. We studied the modulation of plasma renin activity (radioimmunoassay) in 12 normotensive subjects and in 12 age-matched subjects with untreated hypertension of mild or moderate degree. Cardiopulmonary receptors were stimulated by increasing central venous pressure (right atrial catheter) and cardiac volume (echocardiographic measurement) through passive leg raising and deactivated by reducing central venous pressure and cardiac volume through lower body negative pressure. The stimuli were maintained for 20 to 30 minutes, and their degree was set to avoid changes in blood pressure (indirect or direct measurements) and heart rate, thus avoiding involvement of arterial baroreceptors. In normotensive subjects, deactivation ...
Echocardiography, 2008
Background: Chronic aortic regurgitation (AR) is a form of volume overload inducing left ventricl... more Background: Chronic aortic regurgitation (AR) is a form of volume overload inducing left ventricle (LV) dilatation. Myocardial fibrosis, apoptosis, progressive LV dilatation, and eventually LV dysfunction are seen with the progression of disease. The aim of the study was to assess the relation between LV geometry and LV systolic and diastolic functions in patients with chronic severe AR. Methods: The study population consisted of 88 patients with chronic severe AR and 42 healthy controls. The LV ejection fraction (LVEF) was calculated. Subjects were divided as Group I (controls, n = 42), Group II (LVEF > 50%, n = 47), and Group III (LVEF < 50%, n = 41). Transmitral early and late diastolic velocities and deceleration time were measured. The annular systolic (Sa) and diastolic (Ea and Aa) velocities were recorded. Diastolic function was classified as normal, impaired relaxation (IR), pseudonormalization (PN), and restrictive pattern (RP). Results: The LVEF was similar in Group ...
The American Journal of Cardiology, 1992
The baroreceptor-heart rate reflex in human is impaired 2 days after a myocardiai infarction but ... more The baroreceptor-heart rate reflex in human is impaired 2 days after a myocardiai infarction but it improves 10 days after the acute coronary event. This study investigated whether (1) the baroreceptor-heart rate reflex improvement takes the reflex back to normal, and (2) the cardiopulmonary reflex is affected by myocardial infarction. In subjects studied 8 to 11 days after a transmurai anterior or inferior myocardiai infarction the baroreceptor-heart rate reflex sensitivity (slope of the linear regression between negative neck chamber pressures and lengthenings in RR interval) was similar to that seen in control subjects (-6.2 f 0.8 vs-6.0 f 0.6 ms/mm Hg, mean f SEM) and did not change when reassessed 10 days later. In contrast, the cardiopulmonary reflex sensitivity (changes in forearm vascular resistance induced by changing central venous pressure through nonhypotensive lower body suction and leg raising) was markedly less in subjects studied 8 to 11 days after myocardiai infarction than in control subjects; the reduction amounted to 58.1 f 8% (p <O.Ol). The cardiopulmonary reflex sensitivity greatly improved when reassessed 28 to 45 days later. Thus, the baroreflex is normal about 10 days after myocardiai infarction. This condition markedly impairs the cardtopulmonary reflex, but the impairment is also transient.
American Heart Journal, 1989
Journal of Hypertension, 2011
Hypertension, Dec 1, 2011
See Editorial Commentary, pp 991-993 Abstract-Obesity is associated with a higher risk of develop... more See Editorial Commentary, pp 991-993 Abstract-Obesity is associated with a higher risk of developing diabetes mellitus (DM), hypertension (HT), and left ventricular hypertrophy (LVH). The present study assessed in the general population the impact of body weight and visceral obesity on the development of alterations in glucose metabolism and cardiac structure, as well as of elevation in blood pressure. In 1412 subjects randomly selected and representative of the general population of Monza, we assessed twice (in 1990/1991 and 2000/2001) body mass index (BMI); waist circumference; office, home, and 24-hour ambulatory (24-hour) blood pressure, fasting glycemia, and left ventricular mass (echocardiography). New-onset high-risk conditions were DM; impaired fasting glucose; office, home, and 24-hour HT; and LVH. The incidence of new-onset DM; impaired fasting glucose; office, home, and 24-hour HT; and LVH increased progressively from the quintile with the lowest to the quintile with the highest BMI values. Adjusting for confounders, the risk of developing new-onset DM; impaired fasting glucose; office, home, and 24-hour HT; and LVH increased significantly for an increase of 1 kg/m 2 of BMI and 1 cm of waist circumference (
European Heart Journal Supplements
Background MessengerRNA (mRNA) COVID–19 vaccination has been associated with a higher–than–expect... more Background MessengerRNA (mRNA) COVID–19 vaccination has been associated with a higher–than–expected occurrence of acute myocarditis. Scarce information is available on mid–term prognosis and changes in cardiac function, volumes, and tissue characterization on cardiac magnetic resonance (CMR). Methods Retrospective, multicenter study including patients with a definite diagnosis of acute myocarditis within 30 days from mRNA COVID–19 vaccination. The diagnosis is based on endomyocardial biopsy (EMB) or autopsy or by the coexistence of positive biomarkers (troponin >99th upper reference limit or elevated creatine kinase myocardial band [CK–MB]) and cardiac MRI findings consistent with AM according to the 2018 updated Lake Louise Criteria. Results 77 patients (median age 25 years [IQR 20–35], 15% female) were included and followed–up for 147 days [IQR 74–215]. Follow–up CMR was available in n=49 patients and showed no changes in biventricular ejection fraction (EF) as compared to CMR ...
European society of hypertension, 2010
European Heart Journal Supplements, Dec 14, 2022
Journal of clinical hypertension (Greenwich, Conn.), 2018
Professor Alberto Zanchetti passed away on March 24, 2018 at the age of almost 92 years. He had b... more Professor Alberto Zanchetti passed away on March 24, 2018 at the age of almost 92 years. He had been in excellent physical health and with undiminished mental brilliance until a month before. Unfortunately, soon after returning from a lecture tour in Latin America he accidentally fell in his house and suffered a brain trauma that, after few weeks, led to his death.
Journal of Hypertension, 2017
s e265 Results: 91/188 (48%) women approached were both eligible and consented to randomisation (... more s e265 Results: 91/188 (48%) women approached were both eligible and consented to randomisation (45:46 intervention:control). Their mean age was 32y (SD 5), mean body mass index 29 kg/m 2 (SD 8), and mean baseline BP (day 1-6 postpartum) 133/86mmHg (SD 14/10 respectively). 75/91 (82%) were white British. Index of Multiple Deprivation scores were available for 88/91: 52/88 (59%) 1st/2nd quintiles, 23/88 (26%) 3rd quintile and 13/88 (15%) 4th/5th quintiles. Follow-up is complete with 82/91 (90%) retention, and 9/91 (10%) withdrawals. Considering complete cases: compliance with the trial was 403/410 (98%) scheduled follow-up visits; 36/40 (90%) participants (intervention group) submitted BP readings on at least alternate days whilst on treatment (NICE recommendation); 1075/1513 (71%) expected daily readings (on treatment) were submitted. Secondary outcome data including blood pressure will be available in early 2017 in time for presentation at the conference. Conclusions: The SNAP-HT trial will provide the fi rst randomised controlled evaluation of BP self-management postpartum. The recruitment (approximately 50% of those approached) and retention rates (90%) suggest expanding this study to a larger scale would be practicable. An early indication of the likely effi cacy will be available once analysis is complete and will be presented at the conference. BP.07.
Journal of Hypertension, 2015
In the last two decades new drugs that oppose the effects of vascular endothelial growth factor r... more In the last two decades new drugs that oppose the effects of vascular endothelial growth factor receptor (VEGFR), and thus angiogenesis, have considerably improved treatment of solid tumors. These anti-VEGFR drugs, however, are burdened by several side effects, particularly relevant on heart and vessels. Aim of this study was to analyze the changes in cardiovascular structure and function associated with use of anti-VEGFR drugs. 29 patients (27 affected by renal and 2 by thyroid cancer), received treatment with antiVEGFR drugs. Hemodynamic, non invasive arterial investigation (Pulse Wave velocity -cfPWV-, Augmentation Index-Aix- and Aortic Pressure) and echocardiography with global longitudinal strain (gLS) were performed before starting therapy (T0), after 2 (T1) and 6 weeks (T2). Oncologic outcome was determined by the assessment of the neoplastic lesions at CT scans, according to Response Evaluation Criteria in Solid Tumors Guidelines. A significant increase of both peripheral and central blood pressure (BP) was observed. We documented a significant raise of cfPWV from T0 (9.9 ± 2.5m/sec) to T1 (10.6 ± 2.3m/sec); at T2 cfPWV still increased in patients who continued treatment (10.8 ± 2.3m/sec), while decreased in patients who stopped therapy (9.8 ± 1.9m/sec). At the on-treatment CT scan (available in 22 patients) 12 patients had a stable disease (StD), 5 showed a reduction of the lesions (responders -PR-) and 5 showed a disease progression (PD). PD patients showed a lower cfPWV at T2 than StD-PR patients (cfPWV: 9.3 ± 2.8 Vs 13.3 ± 1.5 m/sec; p value 0.02). Aix at T1 was higher in PD than in StD-PR (Aix: 36 ± 2.8% Vs 24.6 ± 9.2%; p value 0.02). Anti-VEGFR treatment is associated with a marked increase in both brachial and central BP. Moreover it early induces an aortic reversible stiffening. The evidence that cfPWV and AIx changes are early and sensitive cardio-vascular effects of anti-angiogenic treatment and that disease progression is associated with a concomitant come back to pre-treatment value of cfPWV and a further increase in augmentation index, suggests their possible role on oncologic outcome.
Clinical hemorheology and microcirculation, 1999
... Corresponding author: Prof. Giuseppe Mancia, Clinica Medica, Ospedale S. Gerardo, Via Donizet... more ... Corresponding author: Prof. Giuseppe Mancia, Clinica Medica, Ospedale S. Gerardo, Via Donizetti 106, Monza, Italy. Tel.: +39 039 2333357; Fax: +39 039 322274. 1386-0291/99/$8.00 © 1999 – IOS Press. ... [30] T. Jensen, K. Borch-Johnsen, A. Kofoed-Enevodsen and T ...
Journal of Hypertension, 2015
Williams-Beuren syndrome (WBS) is a genetic disorder that involves elastin gene causing cardiovas... more Williams-Beuren syndrome (WBS) is a genetic disorder that involves elastin gene causing cardiovascular abnormalities and increased risk. However, data on arterial function in these patients are only few and conflicting. Aim of this study was to evaluate dynamic behaviour of central and peripheral blood pressure (BP) and arterial stiffness parameters early in the course of WBS. We enrolled 19 WBS paediatric patients (age 13 ± 4 years) and 23 age, height and BP-matched controls (10 ± 4 years). We evaluated 24-h ambulatory BP values via an ambulatory blood pressure monitoring (ABPM) system (Mobil-O-Graph) also capable to calculate 24-h central BP and 24-h arterial stiffness parameters. Carotid-femoral PWV (cf-PWV) was assessed in all WBS individuals (Complior). BP values were similar in WBS and control, during the daytime and the night-time. The same behaviour applies to 24-h central BP. However, during the night, WBS showed heart rate values (HR; 78 ± 10 vs. 71 ± 9 bpm; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.03), augmentation index (Aix; 24.6 ± 13.5% vs. 16.5 ± 8.9%; P = 0.03) and reflection magnitude (68 5.8 vs. 63.5 8.1; P = 0.02) higher than controls. The HR, Aix and reflection magnitude reduction in the day-night shift was lower in WBS than in controls. Cf-PWV in WBS children did not differ when compared with their normalized expected value. In WBS children, the higher night-time HR, Aix and reflection magnitude and their impaired physiological reduction in the day-night shift suggests an abnormal sympathetic cardiovascular control, an augmented wave reflection and an increase in small arteries resistance. These alterations possibly due to a sympathetic overactivity can be regarded as earlier hallmarks of cardiovascular dysfunction in these patients.
American Journal of Hypertension, 1988
Several studies have described the modifications of the arterial baroreceptor reflex in hypertens... more Several studies have described the modifications of the arterial baroreceptor reflex in hypertension. Whether this condition alters the other major cardiovascular reflex (ie, that originating from receptors in the cardiopulmonary region) is less well known, however. Herein we describe the importance of the inhibitory control of sympathetic vasomotor and renin influences exerted by the cardiopul monary reflex in normotensive humans as assessed by deactivating and stimulating heart and lung receptors through reductions and increases in central venous pressure respectively obtained via lower-body negative pressure and passive leg raising. Observations on this re flex obtained in experimental animal models are summa rized. Finally, we report recent evidence showing that the cardiopulmonary reflex is only slightly affected by mild or moderate essential hypertension but impaired in hypertension with left ventricular hypertrophy in a fash ion positively related to the degree of this cardiac structural alteration. This may further worsen the sever ity of hypertension. However, the impairment of the cardiopulmonary reflex is reversible with regression of hypertrophy obtained by antihypertensive treatment which is thus beneficial for cardiovascular homeostasis.
Hypertension, 1988
Cardiopulmonary receptors modulate renin release in several animals species. However, their invol... more Cardiopulmonary receptors modulate renin release in several animals species. However, their involvement in reflex control of this humoral substance in humans is controversial. Furthermore, no information is available on the alteration of this control in hypertension. We studied the modulation of plasma renin activity (radioimmunoassay) in 12 normotensive subjects and in 12 age-matched subjects with untreated hypertension of mild or moderate degree. Cardiopulmonary receptors were stimulated by increasing central venous pressure (right atrial catheter) and cardiac volume (echocardiographic measurement) through passive leg raising and deactivated by reducing central venous pressure and cardiac volume through lower body negative pressure. The stimuli were maintained for 20 to 30 minutes, and their degree was set to avoid changes in blood pressure (indirect or direct measurements) and heart rate, thus avoiding involvement of arterial baroreceptors. In normotensive subjects, deactivation ...
Echocardiography, 2008
Background: Chronic aortic regurgitation (AR) is a form of volume overload inducing left ventricl... more Background: Chronic aortic regurgitation (AR) is a form of volume overload inducing left ventricle (LV) dilatation. Myocardial fibrosis, apoptosis, progressive LV dilatation, and eventually LV dysfunction are seen with the progression of disease. The aim of the study was to assess the relation between LV geometry and LV systolic and diastolic functions in patients with chronic severe AR. Methods: The study population consisted of 88 patients with chronic severe AR and 42 healthy controls. The LV ejection fraction (LVEF) was calculated. Subjects were divided as Group I (controls, n = 42), Group II (LVEF > 50%, n = 47), and Group III (LVEF < 50%, n = 41). Transmitral early and late diastolic velocities and deceleration time were measured. The annular systolic (Sa) and diastolic (Ea and Aa) velocities were recorded. Diastolic function was classified as normal, impaired relaxation (IR), pseudonormalization (PN), and restrictive pattern (RP). Results: The LVEF was similar in Group ...
The American Journal of Cardiology, 1992
The baroreceptor-heart rate reflex in human is impaired 2 days after a myocardiai infarction but ... more The baroreceptor-heart rate reflex in human is impaired 2 days after a myocardiai infarction but it improves 10 days after the acute coronary event. This study investigated whether (1) the baroreceptor-heart rate reflex improvement takes the reflex back to normal, and (2) the cardiopulmonary reflex is affected by myocardial infarction. In subjects studied 8 to 11 days after a transmurai anterior or inferior myocardiai infarction the baroreceptor-heart rate reflex sensitivity (slope of the linear regression between negative neck chamber pressures and lengthenings in RR interval) was similar to that seen in control subjects (-6.2 f 0.8 vs-6.0 f 0.6 ms/mm Hg, mean f SEM) and did not change when reassessed 10 days later. In contrast, the cardiopulmonary reflex sensitivity (changes in forearm vascular resistance induced by changing central venous pressure through nonhypotensive lower body suction and leg raising) was markedly less in subjects studied 8 to 11 days after myocardiai infarction than in control subjects; the reduction amounted to 58.1 f 8% (p <O.Ol). The cardiopulmonary reflex sensitivity greatly improved when reassessed 28 to 45 days later. Thus, the baroreflex is normal about 10 days after myocardiai infarction. This condition markedly impairs the cardtopulmonary reflex, but the impairment is also transient.
American Heart Journal, 1989
Journal of Hypertension, 2011
Hypertension, Dec 1, 2011
See Editorial Commentary, pp 991-993 Abstract-Obesity is associated with a higher risk of develop... more See Editorial Commentary, pp 991-993 Abstract-Obesity is associated with a higher risk of developing diabetes mellitus (DM), hypertension (HT), and left ventricular hypertrophy (LVH). The present study assessed in the general population the impact of body weight and visceral obesity on the development of alterations in glucose metabolism and cardiac structure, as well as of elevation in blood pressure. In 1412 subjects randomly selected and representative of the general population of Monza, we assessed twice (in 1990/1991 and 2000/2001) body mass index (BMI); waist circumference; office, home, and 24-hour ambulatory (24-hour) blood pressure, fasting glycemia, and left ventricular mass (echocardiography). New-onset high-risk conditions were DM; impaired fasting glucose; office, home, and 24-hour HT; and LVH. The incidence of new-onset DM; impaired fasting glucose; office, home, and 24-hour HT; and LVH increased progressively from the quintile with the lowest to the quintile with the highest BMI values. Adjusting for confounders, the risk of developing new-onset DM; impaired fasting glucose; office, home, and 24-hour HT; and LVH increased significantly for an increase of 1 kg/m 2 of BMI and 1 cm of waist circumference (
European Heart Journal Supplements
Background MessengerRNA (mRNA) COVID–19 vaccination has been associated with a higher–than–expect... more Background MessengerRNA (mRNA) COVID–19 vaccination has been associated with a higher–than–expected occurrence of acute myocarditis. Scarce information is available on mid–term prognosis and changes in cardiac function, volumes, and tissue characterization on cardiac magnetic resonance (CMR). Methods Retrospective, multicenter study including patients with a definite diagnosis of acute myocarditis within 30 days from mRNA COVID–19 vaccination. The diagnosis is based on endomyocardial biopsy (EMB) or autopsy or by the coexistence of positive biomarkers (troponin >99th upper reference limit or elevated creatine kinase myocardial band [CK–MB]) and cardiac MRI findings consistent with AM according to the 2018 updated Lake Louise Criteria. Results 77 patients (median age 25 years [IQR 20–35], 15% female) were included and followed–up for 147 days [IQR 74–215]. Follow–up CMR was available in n=49 patients and showed no changes in biventricular ejection fraction (EF) as compared to CMR ...
European society of hypertension, 2010