Maria Iorizzi | Università del Molise (original) (raw)

Papers by Maria Iorizzi

Research paper thumbnail of Polyoxygenated Marine Steroids from the Deep Water Starfish Styracaster caroli

Journal of Natural Products, Oct 1, 1994

Research paper thumbnail of Starfish Saponins XXX. Isolation of Sixteen Steroidal Glycosides and Three Polyhydroxysteroids from the Mediterranean Starfish Coscinasterias Tenuispina

Bulletin des Sociétés Chimiques Belges, Sep 1, 2010

Research paper thumbnail of Chemical Examination of a Sea Cucumber of Holothuria Genus of the Indian Ocean

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry, Dec 1, 1998

Research paper thumbnail of Starfish saponins : 26

Research paper thumbnail of Two Novel Polyhydroxysteroids with a 24-Ethyl-25-hydroxy-26-sulfoxy Side Chain from the Deep Water Starfish Styracaster caroli

Journal of Natural Products, 1996

ABSTRACT

Research paper thumbnail of Pa25 STEROIDAL GLYCOSIDES FROM SOME JAPANESE STARFISHES

International Symposium on the Chemistry of Natural Products, May 29, 1988

Research paper thumbnail of A novel group of polyhydroxycholanic acid derivatives from the deep water starfish Styracaster caroli

Tetrahedron Letters, Jul 1, 1993

Research paper thumbnail of Starfish Saponins, 45. Novel Sulfated Steroidal Glycosides from the Starfish Astropecten scoparius

Journal of Natural Products, Sep 1, 1990

Research paper thumbnail of Starfish Saponins, Part 46. Steroidal Glycosides and Polyhydroxysteroids from the Starfish Culcita novaeguineae

Journal of Natural Products, Sep 1, 1991

Research paper thumbnail of Starfish Saponins, Part 23. Steroidal Glycosides from the Starfish Halityle regularis

Journal of Natural Products, 1986

Research paper thumbnail of Biological activity of saponins and saponin-like compounds from starfish and brittle-stars

Toxicon, 1989

Twenty-four saponins and saponin-like compounds, isolated from starfish and brittle-stars, have b... more Twenty-four saponins and saponin-like compounds, isolated from starfish and brittle-stars, have been tested in four in vitro tests, based upon bacterial and cell tissue cultures. Saponin-like compounds from brittle-stars have previously not been tested for biological activity. In an antibacterial test based on an agar diffusion test, the Gram positive bacterium S. aureus was affected by the polyhydroxylated steroidal glycosides, polyhydroxylated sterols and disulfated sterols. However, none of the 21 compounds tested were active against the Gram negative bacterium E. coli. In a cytotoxicity test all 21 compounds tested influenced the cells at a concentration of 100 micrograms/ml, while the cells were unaffected at 1 microgram/ml. In an antitumor test, 16 compounds were tested on two lymphoma cell lines. Inhibition of cell growth, at a concentration of 5 ng/ml, was seen for three polyhydroxylated sterols, in one cell line. Weak activity was seen in an antiviral test at a concentration of 10 micrograms/ml.

Research paper thumbnail of Steroid and Triterpenoid Oligoglycosides of Marine Origin

Advances in Experimental Medicine and Biology, 1996

Saponins have been considered for a long time typical metabolites of plant origin. It has been on... more Saponins have been considered for a long time typical metabolites of plant origin. It has been only in the last two decades that the world-wide investigation of marine organisms as sources of new bioactive metabolites disclosed the wide distribution of these molecules also among marine animals. Today saponins are recognized as the most common characteristic metabolites in two classes of the phylum Echinodermata (Holothuroidea and Asteroidea). Furthermore, several steroid and triterpenoid oligoglycosides have been isolated from different species of marine sponges, more rarely Anthozoans, and also from fishes of the genus Pardachirus, where they have been shown to act as shark repellents. This communication offers a general view of the distribution of steroid and triterpenoid oligoglycosides among marine organisms and focuses on a number of recent examples to discuss structural characteristics, biological activities, and methods of investigation.

Research paper thumbnail of The first occurrence of polyhydroxylated steroids with phosphate conjugation from the starfish tremaster novaecaledoniae

Tetrahedron Letters, Feb 1, 1992

Research paper thumbnail of Abstracts of short lectures

Pharmaceutisch Weekblad Scientific Edition, 1987

... Some characteristics of this enzyme will be presented. The role of this aad other secondary m... more ... Some characteristics of this enzyme will be presented. The role of this aad other secondary metabolic enzymes, especially phenylalanlne ammonia lyase and a p-hydroxy-benzoic acid glucosyltransferase, in the regulation of shlkonln biosynthesis, in light, will be discussed. ...

Research paper thumbnail of Phosphated and sulphated marine polyhydroxylated steroids from the starfish Tremaster novaecaledoniae

Gazzetta Chimica Italiana, 1993

Research paper thumbnail of Starfish Saponins, Part 53. A Reinvestigation of the Polar Steroids from the Starfish Oreaster reticulatus: Isolation of Sixteen Steroidal Oligoglycosides and Six Polyhydroxysteroids

Journal of Natural Products, 1995

A reinvestigation of the starfish Oreaster reticulatus has led to the isolation of sixteen steroi... more A reinvestigation of the starfish Oreaster reticulatus has led to the isolation of sixteen steroidal oligoglycosides and six polyhydroxysteroids. One steroidal monoglycoside has been identified as asterosaponin-1 [5], previously isolated from the same organism, and one pentaglycoside steroidal sulfate has been identified with the known ophidianoside F [1], previously isolated from starfish species of the family Ophidiasteridae. The novel pentaglycoside steroidal sulfates reticulatosides A [3] and B [4] represent the second examples of asterosaponins containing the 5 alpha-cholesta-9(11)-en-3 beta,6 alpha,20,22-tetraol aglycone. Of the remaining new steroidal oligoglycosides, the majority are characterized by the common (24S)-5 alpha-cholesta-3 beta,6 alpha,8,15 alpha,24-pentaol aglycone, with some having a sulfate group at C-6, and differing in the sugar moiety. Compounds 11, 12, 15, and 16 represent major departures from the more common structural features encountered in steroidal glycosides from starfish with the presence in 11 and 12 of a rare 5-O-methylgalactofuranosyl unit and in 15 and 16 of a 3-O-methyl-2-O-sulfate-xylopyranosyl unit. The latter was shown by nmr data combined with molecular dynamics calculations to exist in an 8:2 equilibrium mixture of the 1C4 and 4C1 conformations.

Research paper thumbnail of Starfish Saponins, 48. Isolation of Fifteen Sterol Constituents (Six Glycosides and Nine Polyhydroxysteroids) from the Starfish Solaster borealis

Journal of Natural Products, Jul 1, 1992

This paper reports a complete steroid glycoside and polyhydroxysteroid analysis of the starfish S... more This paper reports a complete steroid glycoside and polyhydroxysteroid analysis of the starfish Solaster borealis, collected at Mutsu Bay, Japan. The glycosides include a new pentaglycoside steroid sulfate ("asterosaponin"), designated solasteroside A [1], two new sulfated 24-O-diglycosides, both with the common 5 alpha-cholesta-3 beta,6 alpha,8,15 alpha, 24-pentaol aglycone, borealosides A [2] and B [3], two new 24-O-(3-O-methyl)xylosides, borealosides C [4] and D [5], having the same aglycone with an additional hydroxy group at 4 beta-position in 5, and the known amurensoside B, previously isolated from Asterias amurensis. Among the polyhydroxysteroid constituents, four (7-10) are new, and five (11-15) have previously been isolated from starfishes.

Research paper thumbnail of Starfish Saponins, 52. Chemical Constituents from the Starfish Echinaster brasiliensis

Journal of Natural Products, Dec 1, 1993

Research paper thumbnail of Ethnobotanical study on the medicinal plants in the Mainarde Mountains (central-southern Apennine, Italy)

Journal of Ethnopharmacology, May 1, 2016

Research paper thumbnail of Distribution of tetrodotoxin, 6-epitetrodotoxin, and 11-deoxytetrodotoxin in newts

Toxicon, 1990

Tetrodotoxin was detected in all nine species of newts tested, 6-epitetrodotoxin in six species, ... more Tetrodotoxin was detected in all nine species of newts tested, 6-epitetrodotoxin in six species, and 11-deoxytetrodotoxin in five species. Only one species lacked the analogues, thus suggesting that the analogues were common metabolites among newts. Toxin levels were high in Taricha granulosa and Notophthalmus viridescens followed by Cynops spp. Distinct differences in toxin contents and profiles existed among species and tissues.

Research paper thumbnail of Polyoxygenated Marine Steroids from the Deep Water Starfish Styracaster caroli

Journal of Natural Products, Oct 1, 1994

Research paper thumbnail of Starfish Saponins XXX. Isolation of Sixteen Steroidal Glycosides and Three Polyhydroxysteroids from the Mediterranean Starfish Coscinasterias Tenuispina

Bulletin des Sociétés Chimiques Belges, Sep 1, 2010

Research paper thumbnail of Chemical Examination of a Sea Cucumber of Holothuria Genus of the Indian Ocean

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry, Dec 1, 1998

Research paper thumbnail of Starfish saponins : 26

Research paper thumbnail of Two Novel Polyhydroxysteroids with a 24-Ethyl-25-hydroxy-26-sulfoxy Side Chain from the Deep Water Starfish Styracaster caroli

Journal of Natural Products, 1996

ABSTRACT

Research paper thumbnail of Pa25 STEROIDAL GLYCOSIDES FROM SOME JAPANESE STARFISHES

International Symposium on the Chemistry of Natural Products, May 29, 1988

Research paper thumbnail of A novel group of polyhydroxycholanic acid derivatives from the deep water starfish Styracaster caroli

Tetrahedron Letters, Jul 1, 1993

Research paper thumbnail of Starfish Saponins, 45. Novel Sulfated Steroidal Glycosides from the Starfish Astropecten scoparius

Journal of Natural Products, Sep 1, 1990

Research paper thumbnail of Starfish Saponins, Part 46. Steroidal Glycosides and Polyhydroxysteroids from the Starfish Culcita novaeguineae

Journal of Natural Products, Sep 1, 1991

Research paper thumbnail of Starfish Saponins, Part 23. Steroidal Glycosides from the Starfish Halityle regularis

Journal of Natural Products, 1986

Research paper thumbnail of Biological activity of saponins and saponin-like compounds from starfish and brittle-stars

Toxicon, 1989

Twenty-four saponins and saponin-like compounds, isolated from starfish and brittle-stars, have b... more Twenty-four saponins and saponin-like compounds, isolated from starfish and brittle-stars, have been tested in four in vitro tests, based upon bacterial and cell tissue cultures. Saponin-like compounds from brittle-stars have previously not been tested for biological activity. In an antibacterial test based on an agar diffusion test, the Gram positive bacterium S. aureus was affected by the polyhydroxylated steroidal glycosides, polyhydroxylated sterols and disulfated sterols. However, none of the 21 compounds tested were active against the Gram negative bacterium E. coli. In a cytotoxicity test all 21 compounds tested influenced the cells at a concentration of 100 micrograms/ml, while the cells were unaffected at 1 microgram/ml. In an antitumor test, 16 compounds were tested on two lymphoma cell lines. Inhibition of cell growth, at a concentration of 5 ng/ml, was seen for three polyhydroxylated sterols, in one cell line. Weak activity was seen in an antiviral test at a concentration of 10 micrograms/ml.

Research paper thumbnail of Steroid and Triterpenoid Oligoglycosides of Marine Origin

Advances in Experimental Medicine and Biology, 1996

Saponins have been considered for a long time typical metabolites of plant origin. It has been on... more Saponins have been considered for a long time typical metabolites of plant origin. It has been only in the last two decades that the world-wide investigation of marine organisms as sources of new bioactive metabolites disclosed the wide distribution of these molecules also among marine animals. Today saponins are recognized as the most common characteristic metabolites in two classes of the phylum Echinodermata (Holothuroidea and Asteroidea). Furthermore, several steroid and triterpenoid oligoglycosides have been isolated from different species of marine sponges, more rarely Anthozoans, and also from fishes of the genus Pardachirus, where they have been shown to act as shark repellents. This communication offers a general view of the distribution of steroid and triterpenoid oligoglycosides among marine organisms and focuses on a number of recent examples to discuss structural characteristics, biological activities, and methods of investigation.

Research paper thumbnail of The first occurrence of polyhydroxylated steroids with phosphate conjugation from the starfish tremaster novaecaledoniae

Tetrahedron Letters, Feb 1, 1992

Research paper thumbnail of Abstracts of short lectures

Pharmaceutisch Weekblad Scientific Edition, 1987

... Some characteristics of this enzyme will be presented. The role of this aad other secondary m... more ... Some characteristics of this enzyme will be presented. The role of this aad other secondary metabolic enzymes, especially phenylalanlne ammonia lyase and a p-hydroxy-benzoic acid glucosyltransferase, in the regulation of shlkonln biosynthesis, in light, will be discussed. ...

Research paper thumbnail of Phosphated and sulphated marine polyhydroxylated steroids from the starfish Tremaster novaecaledoniae

Gazzetta Chimica Italiana, 1993

Research paper thumbnail of Starfish Saponins, Part 53. A Reinvestigation of the Polar Steroids from the Starfish Oreaster reticulatus: Isolation of Sixteen Steroidal Oligoglycosides and Six Polyhydroxysteroids

Journal of Natural Products, 1995

A reinvestigation of the starfish Oreaster reticulatus has led to the isolation of sixteen steroi... more A reinvestigation of the starfish Oreaster reticulatus has led to the isolation of sixteen steroidal oligoglycosides and six polyhydroxysteroids. One steroidal monoglycoside has been identified as asterosaponin-1 [5], previously isolated from the same organism, and one pentaglycoside steroidal sulfate has been identified with the known ophidianoside F [1], previously isolated from starfish species of the family Ophidiasteridae. The novel pentaglycoside steroidal sulfates reticulatosides A [3] and B [4] represent the second examples of asterosaponins containing the 5 alpha-cholesta-9(11)-en-3 beta,6 alpha,20,22-tetraol aglycone. Of the remaining new steroidal oligoglycosides, the majority are characterized by the common (24S)-5 alpha-cholesta-3 beta,6 alpha,8,15 alpha,24-pentaol aglycone, with some having a sulfate group at C-6, and differing in the sugar moiety. Compounds 11, 12, 15, and 16 represent major departures from the more common structural features encountered in steroidal glycosides from starfish with the presence in 11 and 12 of a rare 5-O-methylgalactofuranosyl unit and in 15 and 16 of a 3-O-methyl-2-O-sulfate-xylopyranosyl unit. The latter was shown by nmr data combined with molecular dynamics calculations to exist in an 8:2 equilibrium mixture of the 1C4 and 4C1 conformations.

Research paper thumbnail of Starfish Saponins, 48. Isolation of Fifteen Sterol Constituents (Six Glycosides and Nine Polyhydroxysteroids) from the Starfish Solaster borealis

Journal of Natural Products, Jul 1, 1992

This paper reports a complete steroid glycoside and polyhydroxysteroid analysis of the starfish S... more This paper reports a complete steroid glycoside and polyhydroxysteroid analysis of the starfish Solaster borealis, collected at Mutsu Bay, Japan. The glycosides include a new pentaglycoside steroid sulfate ("asterosaponin"), designated solasteroside A [1], two new sulfated 24-O-diglycosides, both with the common 5 alpha-cholesta-3 beta,6 alpha,8,15 alpha, 24-pentaol aglycone, borealosides A [2] and B [3], two new 24-O-(3-O-methyl)xylosides, borealosides C [4] and D [5], having the same aglycone with an additional hydroxy group at 4 beta-position in 5, and the known amurensoside B, previously isolated from Asterias amurensis. Among the polyhydroxysteroid constituents, four (7-10) are new, and five (11-15) have previously been isolated from starfishes.

Research paper thumbnail of Starfish Saponins, 52. Chemical Constituents from the Starfish Echinaster brasiliensis

Journal of Natural Products, Dec 1, 1993

Research paper thumbnail of Ethnobotanical study on the medicinal plants in the Mainarde Mountains (central-southern Apennine, Italy)

Journal of Ethnopharmacology, May 1, 2016

Research paper thumbnail of Distribution of tetrodotoxin, 6-epitetrodotoxin, and 11-deoxytetrodotoxin in newts

Toxicon, 1990

Tetrodotoxin was detected in all nine species of newts tested, 6-epitetrodotoxin in six species, ... more Tetrodotoxin was detected in all nine species of newts tested, 6-epitetrodotoxin in six species, and 11-deoxytetrodotoxin in five species. Only one species lacked the analogues, thus suggesting that the analogues were common metabolites among newts. Toxin levels were high in Taricha granulosa and Notophthalmus viridescens followed by Cynops spp. Distinct differences in toxin contents and profiles existed among species and tissues.