Giovanni Palumbo | Università degli Studi di Napoli "Federico II" (original) (raw)
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Papers by Giovanni Palumbo
Tetrahedron, 1996
A new strategy is designed to synthesize polyhydroxyl compounds (and/or carbohydrates) by couplin... more A new strategy is designed to synthesize polyhydroxyl compounds (and/or carbohydrates) by coupling of 5, 6-dihydro-1, 4-dithiins-carrying a vinylic hydrogen atom-with chiral aldehydes and, in sequence, stereoselective removal of the dithiodimethylene dithiin ...
Chemistry – A European Journal, 2020
(D.D.). Supporting information for this article is given via a link at the end of the document.
NASA and The Getty Conservation Institute are conducting an experiment in the application of remo... more NASA and The Getty Conservation Institute are conducting an experiment in the application of remotely sensed multispectral and radar data for monitoring change at World Heritage Sites. The project is concerned both with the principles of this approach and with current limitations. The latter have clearly demonstrated that automatic monitoring cannot be easily achieved, due to problems of low resolution, lack of repeatability, and cost, but the integration of this remotely sensed data with other data types into a geographic data management system may provide a monitoring management tool that can be used to test the potential of a fully integrated approach to site definition, monitoring, and management. The test case being adopted covers the area of Chaco Culture National Historic Park, in New Mexico, USA, a major Anasazi complex which is registered in the UNESCOs World Heritage List. Data assembled included a variety of remotely-sensed information, GPS surveys, and the preparation o...
Journal of medicinal chemistry, Jan 7, 2017
The highly stereocontrolled de novo synthesis of L-NBDNJ (the unnatural enantiomer of the iminosu... more The highly stereocontrolled de novo synthesis of L-NBDNJ (the unnatural enantiomer of the iminosugar drug Miglustat) and a preliminary evaluation of its chaperoning potential are herein reported. L-NBDNJ is able to enhance lysosomal α-glucosidase levels in Pompe disease fibroblasts, either when administered singularly or when co-incubated with the recombinant human α-glucosidase. In addition, differently from its D-enantiomer, L-NBDNJ does not act as a glycosidase inhibitor.
Synthesis Stuttgart, 2006
The Journal of Organic Chemistry, Aug 1, 2008
An expeditious and efficient synthesis of 1,6-anhydro-beta-L-hexopyranosyl derivatives 3 as valua... more An expeditious and efficient synthesis of 1,6-anhydro-beta-L-hexopyranosyl derivatives 3 as valuable building blocks for the preparation of L-sugars is herein reported. This route relies upon the use of a domino reaction involving five synthetic steps from the 5,6-dihydro-1,4-dithiin 4. As 1,6-anhydro derivatives 3 are obtained, dithioethylene bridge removal and double-bond dihydroxylation give access to protected L-allose and L-glucose in stereoselective fashion and high yields.
Synthesis Stuttgart, 1991
Http Dx Doi Org 10 1080 00397919508011763, Sep 23, 2006
Cheminform, 2010
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Phosphor Sulfur Silicon, 1999
A new reagent, based on a 5,6-dihydro-1,4-dithiin heterocyclic system, has been devised and conve... more A new reagent, based on a 5,6-dihydro-1,4-dithiin heterocyclic system, has been devised and conveniently used for 3 carbon elongations of various electrophiles. In fact, it acts as either a propenyl alcohol or an acrolein anion equivalent, introducing into the new molecule a moiety consisting of fully protected double bond and allylic oxygen.
Tetrahedron Asymmetry, Nov 1, 2006
A short and efficient enantioselective synthesis of (R)-3-hydroxydodecanoic acid is described, in... more A short and efficient enantioselective synthesis of (R)-3-hydroxydodecanoic acid is described, involving a Sharpless asymmetric dihydroxylation to produce the required (R)-stereochemistry.
Reaction of a lithiated dithiinyl reagent with a O-perbenzylated D-glycono-delta-lactone readily ... more Reaction of a lithiated dithiinyl reagent with a O-perbenzylated D-glycono-delta-lactone readily generates the corresponding masked C-vinyl galactosides in high yields and full beta-selectivity. Removal of the sulfur mask renders the free vinyl aglycone with the vinyl group in either the Z or E configuration, depending on the desulfurization conditions chosen.
Http Dx Doi Org 10 1080 03086648308073277, Dec 13, 2006
Tetrahedron, 1996
A new strategy is designed to synthesize polyhydroxyl compounds (and/or carbohydrates) by couplin... more A new strategy is designed to synthesize polyhydroxyl compounds (and/or carbohydrates) by coupling of 5, 6-dihydro-1, 4-dithiins-carrying a vinylic hydrogen atom-with chiral aldehydes and, in sequence, stereoselective removal of the dithiodimethylene dithiin ...
Chemistry – A European Journal, 2020
(D.D.). Supporting information for this article is given via a link at the end of the document.
NASA and The Getty Conservation Institute are conducting an experiment in the application of remo... more NASA and The Getty Conservation Institute are conducting an experiment in the application of remotely sensed multispectral and radar data for monitoring change at World Heritage Sites. The project is concerned both with the principles of this approach and with current limitations. The latter have clearly demonstrated that automatic monitoring cannot be easily achieved, due to problems of low resolution, lack of repeatability, and cost, but the integration of this remotely sensed data with other data types into a geographic data management system may provide a monitoring management tool that can be used to test the potential of a fully integrated approach to site definition, monitoring, and management. The test case being adopted covers the area of Chaco Culture National Historic Park, in New Mexico, USA, a major Anasazi complex which is registered in the UNESCOs World Heritage List. Data assembled included a variety of remotely-sensed information, GPS surveys, and the preparation o...
Journal of medicinal chemistry, Jan 7, 2017
The highly stereocontrolled de novo synthesis of L-NBDNJ (the unnatural enantiomer of the iminosu... more The highly stereocontrolled de novo synthesis of L-NBDNJ (the unnatural enantiomer of the iminosugar drug Miglustat) and a preliminary evaluation of its chaperoning potential are herein reported. L-NBDNJ is able to enhance lysosomal α-glucosidase levels in Pompe disease fibroblasts, either when administered singularly or when co-incubated with the recombinant human α-glucosidase. In addition, differently from its D-enantiomer, L-NBDNJ does not act as a glycosidase inhibitor.
Synthesis Stuttgart, 2006
The Journal of Organic Chemistry, Aug 1, 2008
An expeditious and efficient synthesis of 1,6-anhydro-beta-L-hexopyranosyl derivatives 3 as valua... more An expeditious and efficient synthesis of 1,6-anhydro-beta-L-hexopyranosyl derivatives 3 as valuable building blocks for the preparation of L-sugars is herein reported. This route relies upon the use of a domino reaction involving five synthetic steps from the 5,6-dihydro-1,4-dithiin 4. As 1,6-anhydro derivatives 3 are obtained, dithioethylene bridge removal and double-bond dihydroxylation give access to protected L-allose and L-glucose in stereoselective fashion and high yields.
Synthesis Stuttgart, 1991
Http Dx Doi Org 10 1080 00397919508011763, Sep 23, 2006
Cheminform, 2010
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Phosphor Sulfur Silicon, 1999
A new reagent, based on a 5,6-dihydro-1,4-dithiin heterocyclic system, has been devised and conve... more A new reagent, based on a 5,6-dihydro-1,4-dithiin heterocyclic system, has been devised and conveniently used for 3 carbon elongations of various electrophiles. In fact, it acts as either a propenyl alcohol or an acrolein anion equivalent, introducing into the new molecule a moiety consisting of fully protected double bond and allylic oxygen.
Tetrahedron Asymmetry, Nov 1, 2006
A short and efficient enantioselective synthesis of (R)-3-hydroxydodecanoic acid is described, in... more A short and efficient enantioselective synthesis of (R)-3-hydroxydodecanoic acid is described, involving a Sharpless asymmetric dihydroxylation to produce the required (R)-stereochemistry.
Reaction of a lithiated dithiinyl reagent with a O-perbenzylated D-glycono-delta-lactone readily ... more Reaction of a lithiated dithiinyl reagent with a O-perbenzylated D-glycono-delta-lactone readily generates the corresponding masked C-vinyl galactosides in high yields and full beta-selectivity. Removal of the sulfur mask renders the free vinyl aglycone with the vinyl group in either the Z or E configuration, depending on the desulfurization conditions chosen.
Http Dx Doi Org 10 1080 03086648308073277, Dec 13, 2006