Manuel Menéndez-gonzález | University of Oviedo / Universidad de Oviedo (original) (raw)
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Papers by Manuel Menéndez-gonzález
Neurología (Barcelona, Spain), 2009
Revista de neurologia
Prion encephalopathies are a group of diseases with a hereditary or acquired origin which, after ... more Prion encephalopathies are a group of diseases with a hereditary or acquired origin which, after a long asymptomatic period, give rise to rapidly progressing neurological disorders. This progression can only be explained by an exponential growth of the pathogenic protein load, which allows to keep the load in low levels for many years and then to grow swiftly in a few months. Bearing in mind the knowledge currently available about the pathogenesis of prion diseases and patients' clinical progression, it becomes possible to distinguish several different periods of progression, the length of which can be estimated for each disease by reviewing the series of cases published to date. In general, the infectious prion diseases have a shorter period of latency than the hereditary ones and those caused by insertion of genetic material are associated to shorter latencies and to longer periods of illness than those caused by sporadic mutations. The rate of growth of the prion load depends...
Neurología (Barcelona, Spain), 2005
Memory loss is an increasingly frequent reason for consultation in neurology. The aim of this wor... more Memory loss is an increasingly frequent reason for consultation in neurology. The aim of this work is to know the current frequency as well as the characteristics and disorders of the patients who come for this reason. We studied 200 patients who came to general neurology consultation due to loss of memory. 18.47% of the patients who came for the first time to a general neurology consultation did so due to memory loss, this being subjective loss of memory (SLM) in 39% of the cases and referred loss of memory (RLM) in 61% of the cases. The diagnostic groups to which the patients belonged are, in diminishing order, the following: degenerative primary dementia type Alzheimer's disease, mild cognitive impairment, mixed dementia, pure vascular dementia, depressive pseudodementia, attributable to drugs, secondary to systemic disease, non-Alzheimer's type disease primary degenerative dementia, structural reasons, transitory global amnesia and epilepsy. No disease was found in 13% o...
Abstract Growing evidence support the hypothesis that cathepsin D (catD) is related to AD but the... more Abstract Growing evidence support the hypothesis that cathepsin D (catD) is related to AD but the activity of serum catD had never been assessed inpatients with dementia. We studied the activity of serum catD in different stages of AD as well as in patients with Mild ...
The functional outcome in patients after decompressive craniectomy in malignant middle cerebral a... more The functional outcome in patients after decompressive craniectomy in malignant middle cerebral artery infarction has been widely reported. But there are no many studies about the neuropsychological deficits in these patients. Our main aim is to analyse this neuropsychological sequelae.
Patients with Down syndrome (DS) who exhibit Alzheimer disease (AD) are associated with age. Both... more Patients with Down syndrome (DS) who exhibit Alzheimer disease (AD) are associated with age. Both diseases with a common neuropathological basis have been associated with late-onset myoclonic epilepsy (LOMEDS). This entity presents electroencephalogram features as generalized polyspike-wave discharges. We present a series of 11 patients with the diagnosis of DS or AD who developed myoclonic seizures or generalized tonic-clonic seizures. In all cases, clinical and neuroimaging studies and polygraph EEG monitoring was performed. In all cases, cognitive impairment progressed quickly after the onset of epilepsy causing an increase in the degree of dependence. The most common finding in the EEG was a slowing of brain activity with theta and delta rhythms, plus intercritical generalized polyspike-waves were objectified in eight patients. In neuroimaging studies was found cerebral cortical atrophy. The most effective drug in this series was the levetiracetam. The association of generalized epilepsy with elderly DS represents an epiphenomenon in evolution which is associated with a progressive deterioration of cognitive and motor functions. This epilepsy has some electroclinical characteristics and behaves as progressive myoclonic epilepsy, which is probably related to the structural changes that characterize the evolutionary similarity of DS with AD. Recognition of this syndrome is important, since it has prognostic implications and requires proper treatment.
Neurología (Barcelona, Spain), 2009
Revista de neurologia
Prion encephalopathies are a group of diseases with a hereditary or acquired origin which, after ... more Prion encephalopathies are a group of diseases with a hereditary or acquired origin which, after a long asymptomatic period, give rise to rapidly progressing neurological disorders. This progression can only be explained by an exponential growth of the pathogenic protein load, which allows to keep the load in low levels for many years and then to grow swiftly in a few months. Bearing in mind the knowledge currently available about the pathogenesis of prion diseases and patients' clinical progression, it becomes possible to distinguish several different periods of progression, the length of which can be estimated for each disease by reviewing the series of cases published to date. In general, the infectious prion diseases have a shorter period of latency than the hereditary ones and those caused by insertion of genetic material are associated to shorter latencies and to longer periods of illness than those caused by sporadic mutations. The rate of growth of the prion load depends...
Neurología (Barcelona, Spain), 2005
Memory loss is an increasingly frequent reason for consultation in neurology. The aim of this wor... more Memory loss is an increasingly frequent reason for consultation in neurology. The aim of this work is to know the current frequency as well as the characteristics and disorders of the patients who come for this reason. We studied 200 patients who came to general neurology consultation due to loss of memory. 18.47% of the patients who came for the first time to a general neurology consultation did so due to memory loss, this being subjective loss of memory (SLM) in 39% of the cases and referred loss of memory (RLM) in 61% of the cases. The diagnostic groups to which the patients belonged are, in diminishing order, the following: degenerative primary dementia type Alzheimer's disease, mild cognitive impairment, mixed dementia, pure vascular dementia, depressive pseudodementia, attributable to drugs, secondary to systemic disease, non-Alzheimer's type disease primary degenerative dementia, structural reasons, transitory global amnesia and epilepsy. No disease was found in 13% o...
Abstract Growing evidence support the hypothesis that cathepsin D (catD) is related to AD but the... more Abstract Growing evidence support the hypothesis that cathepsin D (catD) is related to AD but the activity of serum catD had never been assessed inpatients with dementia. We studied the activity of serum catD in different stages of AD as well as in patients with Mild ...
The functional outcome in patients after decompressive craniectomy in malignant middle cerebral a... more The functional outcome in patients after decompressive craniectomy in malignant middle cerebral artery infarction has been widely reported. But there are no many studies about the neuropsychological deficits in these patients. Our main aim is to analyse this neuropsychological sequelae.
Patients with Down syndrome (DS) who exhibit Alzheimer disease (AD) are associated with age. Both... more Patients with Down syndrome (DS) who exhibit Alzheimer disease (AD) are associated with age. Both diseases with a common neuropathological basis have been associated with late-onset myoclonic epilepsy (LOMEDS). This entity presents electroencephalogram features as generalized polyspike-wave discharges. We present a series of 11 patients with the diagnosis of DS or AD who developed myoclonic seizures or generalized tonic-clonic seizures. In all cases, clinical and neuroimaging studies and polygraph EEG monitoring was performed. In all cases, cognitive impairment progressed quickly after the onset of epilepsy causing an increase in the degree of dependence. The most common finding in the EEG was a slowing of brain activity with theta and delta rhythms, plus intercritical generalized polyspike-waves were objectified in eight patients. In neuroimaging studies was found cerebral cortical atrophy. The most effective drug in this series was the levetiracetam. The association of generalized epilepsy with elderly DS represents an epiphenomenon in evolution which is associated with a progressive deterioration of cognitive and motor functions. This epilepsy has some electroclinical characteristics and behaves as progressive myoclonic epilepsy, which is probably related to the structural changes that characterize the evolutionary similarity of DS with AD. Recognition of this syndrome is important, since it has prognostic implications and requires proper treatment.