Adriana Lena | Università degli Studi di Palermo (original) (raw)

Papers by Adriana Lena

Research paper thumbnail of Imaging Findings of Hepatic Focal Nodular Hyperplasia in GD-Eob-Dtpa vs. GD-Bopta-Enhanced Mri

Euromediterranean Biomedical Journal, 2012

Focal nodular hyperplasia (FNH) is a benign focal lesion of the liver. Magnetic resonance imaging... more Focal nodular hyperplasia (FNH) is a benign focal lesion of the liver. Magnetic resonance imaging (MRI) plays a key role in the detection and characterization of focal hepatic lesions, thanks to the widespread availability of conventional contrast media, especially liver-specific media such as Gd-BOPTA (Multihance, or Gadobenate Dimeglumine) and GdEOB-DTPA (Primovist, or Gadoxetic Acid) that are selectively accumulated in hepatocytes and partially excreted by the biliary system. There are no significant differences in FNH enhancement, neither during the dynamic phase nor during the liver-specific phase of MRI, following the infusion with GD-BOPTA or GD-EOB-DTPA.

Research paper thumbnail of Colorectal Cancer with Liver Metastasis and Treatment with Anti-Angiogenic Drugs

giovedì, 26 aprile 2012 Colorectal cancer is the third most common malignancy and the third leadi... more giovedì, 26 aprile 2012 Colorectal cancer is the third most common malignancy and the third leading cause of cancer-related death worldwide. Recently, the introduction of novel drugs (anti-angiogenic drugs) has led to a significant improvement in the survival rates of patients with metastatic colorectal cancer. The RECIST (Response Evaluation Criteria for Solid Tumors) parameters cannot adequately detect important effects of treatment and response to the application of these new drugs. New radiologic methods, such as diffusion-weighted MRI, could help to assess the quality and quantity of the response more accurately. Diffusion-weighted MRI imaging is based on a technique sensitive to the Brownian motion of water molecules over short distances. This article describes our experience with this method in patients with liver metastasis from colorectal cancer after treatment with bevacizumab.

Research paper thumbnail of The Role of Human Heat Shock Proteins in Carcinogenesis

Research paper thumbnail of Intraoperative air leak test reduces the rate of postoperative anastomotic leak: analysis of 777 laparoscopic left-sided colon resections

Surgical endoscopy, Jan 10, 2018

The evidence supporting the use of the air leak test (ALT) after laparoscopic left-sided colon re... more The evidence supporting the use of the air leak test (ALT) after laparoscopic left-sided colon resection (LLCR) to test the colorectal anastomosis (CA) integrity aiming at reducing the rate of postoperative CA leakage (CAL) is not conclusive. The aim of this study was to challenge the use of ALT after elective LLCR. It is a retrospective analysis of a prospectively collected database including all patients undergoing elective LLCR with primary CA and no proximal bowel diversion between January 1996 and June 2017. The decision to perform the ALT was based on the individual surgeon routine practice. A multivariate analysis was performed to identify independent risk factors for CAL. A total of 777 LLCR without proximal diversion were included in the analysis: the CA was tested in 398 patients (ALT group), while intraoperative ALT was not performed in 379 patients (No-ALT group). The two groups were similar in demographic characteristics, indication, and type of procedure. Intraoperativ...

Research paper thumbnail of Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel

Anticancer research, 2014

Heat shock proteins (Hsps) assist other proteins in their folding and drive the degradation of de... more Heat shock proteins (Hsps) assist other proteins in their folding and drive the degradation of defective proteins. During evolution, these proteins have also acquired other roles. Hsp10 is involved in immunomodulation and tumor progression. Hsp90 stabilizes a range of "client" proteins involved in cell signaling. The present study evaluated the expression levels of Hsp10 and Hsp90 in normal mucosa and adenocarcinoma samples of human large bowel. Samples of normal mucosa and adenocarcinoma were collected and Reverse transcriptase-polymerase chain reaction RT-PCR, western blotting (WB) analyses, as well as immunohistochemistry were performed to evaluate the expression levels of Hsp10 and Hsp90. RT-PCR showed a higher gene expression of Hsp10 and Hsp90 in adenocarcinoma samples compared to healthy mucosa. WB results confirmed these findings. Immunohistochemistry revealed higher levels of Hsp10 in adenocarcinoma in both the epithelium and the lamina propria, while Hsp90 expres...

Research paper thumbnail of ANATOMICAL VARIATIONS OF THE INTERNAL JUGULAR VEIN: THE ROLE OF ULTRASONOGRAPHY

EuroMediterranean Biomedical Journal

Central venous catheterization (CVC) is a common procedure used for long term central intravenous... more Central venous catheterization (CVC) is a common procedure used for long term central intravenous therapy, central venous pressure monitoring, dialysis and apheresys (1-3). The most commonly used technique is percutaneous catheterisation of the internal jugular vein (IJV) which can be found by the identification of an anatomical landmark (Sedillot triangle, formed by medial and lateral heads of the sternocleido-mastoid muscle and base by medial end of the clavicle) ), or by Ultrasonography scanning. The aim of the present paper is to determine the rate of anatomical variations of IJV, in relation with the other structures of the neck, particularly the CCA (4-7), in a cohort of patients who underwent US-guided CVC, in order to underline the importance of anatomical knowledge to reduce the complications related to this procedure, such as difficult or Original Article © EUROMEDITERRANEAN BIOMEDICAL JOURNAL 2014, 9(12):112-117. Available on-line at: http://www.embj.org SUMMARY Purpose: In many places, especially in emergency department, central venous catheter is still inserted using anatomical landmark guidance with a success rate up to 97.6% and complications up to 15%. This study was aimed to determine by the support of ultrasonography (US) the anatomical variations of the internal jugular vein (IJV) in relation with other structures of the neck, such as the common carotid artery (CCA). Material and Methods: 830 patients requiring central vein catheterization (CVC) were included in the analysis. The position of the IJV in relation to the other structures of the neck was demonstrated by portable ultrasonography.

Research paper thumbnail of Imaging Findings of Hepatic Focal Nodular Hyperplasia in GD-Eob-Dtpa vs. GD-Bopta-Enhanced Mri

Euromediterranean Biomedical Journal, 2012

Focal nodular hyperplasia (FNH) is a benign focal lesion of the liver. Magnetic resonance imaging... more Focal nodular hyperplasia (FNH) is a benign focal lesion of the liver. Magnetic resonance imaging (MRI) plays a key role in the detection and characterization of focal hepatic lesions, thanks to the widespread availability of conventional contrast media, especially liver-specific media such as Gd-BOPTA (Multihance, or Gadobenate Dimeglumine) and GdEOB-DTPA (Primovist, or Gadoxetic Acid) that are selectively accumulated in hepatocytes and partially excreted by the biliary system. There are no significant differences in FNH enhancement, neither during the dynamic phase nor during the liver-specific phase of MRI, following the infusion with GD-BOPTA or GD-EOB-DTPA.

Research paper thumbnail of Colorectal Cancer with Liver Metastasis and Treatment with Anti-Angiogenic Drugs

giovedì, 26 aprile 2012 Colorectal cancer is the third most common malignancy and the third leadi... more giovedì, 26 aprile 2012 Colorectal cancer is the third most common malignancy and the third leading cause of cancer-related death worldwide. Recently, the introduction of novel drugs (anti-angiogenic drugs) has led to a significant improvement in the survival rates of patients with metastatic colorectal cancer. The RECIST (Response Evaluation Criteria for Solid Tumors) parameters cannot adequately detect important effects of treatment and response to the application of these new drugs. New radiologic methods, such as diffusion-weighted MRI, could help to assess the quality and quantity of the response more accurately. Diffusion-weighted MRI imaging is based on a technique sensitive to the Brownian motion of water molecules over short distances. This article describes our experience with this method in patients with liver metastasis from colorectal cancer after treatment with bevacizumab.

Research paper thumbnail of The Role of Human Heat Shock Proteins in Carcinogenesis

Research paper thumbnail of Intraoperative air leak test reduces the rate of postoperative anastomotic leak: analysis of 777 laparoscopic left-sided colon resections

Surgical endoscopy, Jan 10, 2018

The evidence supporting the use of the air leak test (ALT) after laparoscopic left-sided colon re... more The evidence supporting the use of the air leak test (ALT) after laparoscopic left-sided colon resection (LLCR) to test the colorectal anastomosis (CA) integrity aiming at reducing the rate of postoperative CA leakage (CAL) is not conclusive. The aim of this study was to challenge the use of ALT after elective LLCR. It is a retrospective analysis of a prospectively collected database including all patients undergoing elective LLCR with primary CA and no proximal bowel diversion between January 1996 and June 2017. The decision to perform the ALT was based on the individual surgeon routine practice. A multivariate analysis was performed to identify independent risk factors for CAL. A total of 777 LLCR without proximal diversion were included in the analysis: the CA was tested in 398 patients (ALT group), while intraoperative ALT was not performed in 379 patients (No-ALT group). The two groups were similar in demographic characteristics, indication, and type of procedure. Intraoperativ...

Research paper thumbnail of Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel

Anticancer research, 2014

Heat shock proteins (Hsps) assist other proteins in their folding and drive the degradation of de... more Heat shock proteins (Hsps) assist other proteins in their folding and drive the degradation of defective proteins. During evolution, these proteins have also acquired other roles. Hsp10 is involved in immunomodulation and tumor progression. Hsp90 stabilizes a range of "client" proteins involved in cell signaling. The present study evaluated the expression levels of Hsp10 and Hsp90 in normal mucosa and adenocarcinoma samples of human large bowel. Samples of normal mucosa and adenocarcinoma were collected and Reverse transcriptase-polymerase chain reaction RT-PCR, western blotting (WB) analyses, as well as immunohistochemistry were performed to evaluate the expression levels of Hsp10 and Hsp90. RT-PCR showed a higher gene expression of Hsp10 and Hsp90 in adenocarcinoma samples compared to healthy mucosa. WB results confirmed these findings. Immunohistochemistry revealed higher levels of Hsp10 in adenocarcinoma in both the epithelium and the lamina propria, while Hsp90 expres...

Research paper thumbnail of ANATOMICAL VARIATIONS OF THE INTERNAL JUGULAR VEIN: THE ROLE OF ULTRASONOGRAPHY

EuroMediterranean Biomedical Journal

Central venous catheterization (CVC) is a common procedure used for long term central intravenous... more Central venous catheterization (CVC) is a common procedure used for long term central intravenous therapy, central venous pressure monitoring, dialysis and apheresys (1-3). The most commonly used technique is percutaneous catheterisation of the internal jugular vein (IJV) which can be found by the identification of an anatomical landmark (Sedillot triangle, formed by medial and lateral heads of the sternocleido-mastoid muscle and base by medial end of the clavicle) ), or by Ultrasonography scanning. The aim of the present paper is to determine the rate of anatomical variations of IJV, in relation with the other structures of the neck, particularly the CCA (4-7), in a cohort of patients who underwent US-guided CVC, in order to underline the importance of anatomical knowledge to reduce the complications related to this procedure, such as difficult or Original Article © EUROMEDITERRANEAN BIOMEDICAL JOURNAL 2014, 9(12):112-117. Available on-line at: http://www.embj.org SUMMARY Purpose: In many places, especially in emergency department, central venous catheter is still inserted using anatomical landmark guidance with a success rate up to 97.6% and complications up to 15%. This study was aimed to determine by the support of ultrasonography (US) the anatomical variations of the internal jugular vein (IJV) in relation with other structures of the neck, such as the common carotid artery (CCA). Material and Methods: 830 patients requiring central vein catheterization (CVC) were included in the analysis. The position of the IJV in relation to the other structures of the neck was demonstrated by portable ultrasonography.