Abhijeet Aher | University of Pune (original) (raw)

Papers by Abhijeet Aher

International Journal of Molecular Sciences

Psoriasis is linked with unusual differentiation and hyperproliferation of epidermal keratinocyte... more Psoriasis is linked with unusual differentiation and hyperproliferation of epidermal keratinocytes that significantly impair the quality of life (QoL) of patients. The present treatment options only provide symptomatic relief and are surrounded by various adverse effects. Recently, nanostructured lipid carriers (NLCs) have emerged as next-generation nanocarriers with better physicochemical characteristics. The current manuscript provides background information on psoriasis, its pathophysiology, existing treatment options, and its limitations. It highlights the advantages, rationale, and mechanism of the permeation of NLCs for the treatment of psoriasis. It further gives a detailed account of various NLC nanoformulations for the treatment of psoriasis. In addition, tabular information is provided on the most relevant patents on NLCs for treating psoriasis. Lastly, light is shed on regulatory considerations related to NLC-like nanoformulations. In the treatment of psoriasis, NLCs disp...

International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN)

Background: In today's world, type 2 diabetes mellitus, and hypertension have become universa... more Background: In today's world, type 2 diabetes mellitus, and hypertension have become universal, and a large number of patients are living with diabetes mellitus and hypertension, which often coexist. The core idea of this study was the development of bilayer tablets collected from two unlike categories of drugs through a straightforward and easy-to-scale-up approach. Objective: In the present investigation, a bilayer tablet of Gliclazide and Nimodipine was developed to enhance long-suffering patient compliance. The objective of the current investigation was to develop a bilayer dosage form of Gliclazide and Nimodipine for oral route of administration that will liberate Nimodipine immediately and Gliclazide for 12 hrs. to increase the oral bioavailability of the drug. Methodology: The immediate-release (IR) sheet was developed by a variety of super-disintegrants like Crospovidone, Croscarmellose sodium, and sodium starch glycolate, and the sustained-release (SR) sheet was develop...

Aqueous and Chloroform extract of bark of Bauhinia Variegata were investigated for their anthelmi... more Aqueous and Chloroform extract of bark of Bauhinia Variegata were investigated for their anthelmintic activity against Pheretima posthuma and Ascardia galli. All extracts exhibited a dose dependent (25, 50 and 100 mg/ml) inhibition of spontaneous motility (paralysis) and time of death of the worms. Extract obtained from bark not only killed the Pheretima posthuma but also killed the Ascardia galli. The observations were comparable with standard drug Piperazine citrate at a concentration of 20 mg/ml and distilled water as control. Maximum vermicide activity was shown by both extract at the concentration of 100mg/ml. From the experiment performed, it can be said that the aqueous and chloroform extract of bark of Bauhinia variegata bearing a potential anthelmintic activity.

Out of many, one of the most promising strategies to improve the oral bioavailability of poorly w... more Out of many, one of the most promising strategies to improve the oral bioavailability of poorly water-soluble drugs is to develop amorphous solid dispersions. Reduction in drug particle size improves drug wettability and oral bioavailability significantly. Poorly soluble drugs are benefited by formulation approaches that overcome the issue of poor solubility and dissolution rate limited bioavailability. As Gibbs free energy is higher, the solubility of amorphous compounds is much greater than the more stable crystalline form. Moreover, amorphous forms are kinetically trapped high energy disordered materials that lack the periodicity of crystals but behave mechanically as solids. Lipophilic drugs, especially those belonging to the biopharmaceutics classification system (BCS) class II and IV, dissolve at a slower rate, leading to incomplete release of drug from the dosage form, poor oral bioavailability, increased food effect, and high inter-patient variability. Hence, to improve the ...

Research Journal of Pharmacy and Technology, 2017

ABSTRACT

Medicinal Chemistry, 2015

Materials and Methods Synthesis of co-crystals Method like solvent evaporation co-crystallization... more Materials and Methods Synthesis of co-crystals Method like solvent evaporation co-crystallization was employed for the synthesis of co crystals of Lactic acid and Adipic acid with Efavirenz. Solvent evaporation method was found to be the suitable for the synthesis of co-crystals in the present study.

Journal of Pharmaceutical Sciences, 1968

... Analgesic and Anti-Inflammatory Evaluation of Thymotic Acid and Certain Homologs By FRED J. M... more ... Analgesic and Anti-Inflammatory Evaluation of Thymotic Acid and Certain Homologs By FRED J. MAROZZI and MARVIN H. MALONE Ortho-thymotic acid and nine homologs were submitted for general, analgesic, and antistress evaluations in the rat. ...

Drug Development and Industrial Pharmacy, 2012

Dry powder inhaler (DPI) has become a well accepted drug delivery for pulmonary system to treat m... more Dry powder inhaler (DPI) has become a well accepted drug delivery for pulmonary system to treat many related diseases including symptomatic and life threatening diseases. Successful delivery of dry powder to the lung requires careful consideration of powder production process, formulation and inhaler device. The formulation of DPI mostly comprises of lactose as a carrier for drug delivery. In DPI formulation, particulate interactions within the formulation govern both the drug dissociation from carrier particles and the disaggregation of drug into primary particles with a capacity to penetrate deep into lung. Two contradictory requirements must be fulfilled for this type of dry powder formulation. On one hand, adhesion between carrier and drug must be sufficient for the blend drug/carrier to be stable. On the other hand, adhesion drug/carrier has to be weak enough to enable the release of drug from carrier during patient inhalation. Thus the carrier use restricted due to detachment problem. Different methods are proposed to reduce the cohesive forces between drug and carrier to desired level. Various studies conducted for understanding the mechanism of deposition into lungs and making formulation with optimum carrier drug cohesive force. This review provides information on various processes involved in reducing the cohesive forces between drug and carrier, to a required level.

Journal of Structural Chemistry

Marmara Pharmaceutical Journal, 2014

The aim of present study was to investigate the anti-diarrheal activity of Ficus microcarpa again... more The aim of present study was to investigate the anti-diarrheal activity of Ficus microcarpa against experimentally induced diarrhea in rats. Albino rats were used for the experiment. Anti-diarrheal activity was determined by castor oil induced diarrhea. The extract of the bark administered orally at a dose 300 mg/kg and 600 mg/kg. The extract of Ficus microcarpa produced a marked anti-diarrheal effect in rats. Both doses of extract significantly decreased (P<0.05) the total number of wet feces produced by administration of castor oil (4.31 at the dose of 300 mg/kg and 7.16 at the dose of 600 mg/kg) as compared to the castor oil treated control group (20.75). The Ficus microcarpa extract was found to possess an anti-enteropooling activity. Oral administration of castor oil produced a significant increase (P<0.05) in the intestinal fluid (3.14 ml) as compared to the normal rat (1.29 ml). The extract when given orally one hour before castor oil, significantly inhibited (P<0.05) the enteropooling; 1.48 ml (300mg/kg) and 1.68 ml (600mg/kg). The results revealed that the extract inhibited the small intestinal motility of the charcoal marker in the rats by 23.92-31.12% whereas the inhibition was noted to be 61.2% in the case of treatment by loperamide. The results of this investigation conclude that the extract contains pharmacologically active substances with anti-diarrheal properties. Further research is to be carried out to fractionate and purify the extract, in order to find the molecules responsible for the anti-diarrheal activity.

Coloring skin particularly skin of face and lips is an ancient practice going back to prehistoric... more Coloring skin particularly skin of face and lips is an ancient practice going back to prehistoric period. In present days the use of such product has increased and choice of shades of color, texture and luster have been changed and become wider. This can be observed from the fact that lipsticks are marked in hundreds of shades of colors to satisfy the demand of women. The present investigation was done to formulate herbal lipstick from Bixa Orellana seeds, since lipsticks are one of the key cosmetics to be used by the women. Due to various adverse effects of available synthetic preparation the present work was conceived by us to formulate a herbal lipstick having minimal or no side effects which will extensively used by the women of our communities with great surety and satisfaction. Attempt was also made to evaluate the formulated herbal lipstick and the F-IV was found better and accepted by female volunteers.

Ficus Microcarpa L. is a medicinal plant used for the treatment of various body pains in India tr... more Ficus Microcarpa L. is a medicinal plant used for the treatment of various body pains in India traditionally. It is also used in various conditions like diabetes, ulcers, burning sensations, haemorrhages, leprosy, itching, liver disease. The methanol extract of its leaves was investigated for its analgesic and anti-inflammatory activities in animal models. The extract at 50, 100 and 200mg/kg body weight reduced significantly the formation of oedema induced by carrageenan and histamine. Statistical analysis of the data was done using one-way analysis of variance (ANOVA) followed by Dunnett's test and significance determined using P-values <0.05.In the acetic acid-induced writhing model, the extract had a good analgesic effect characterized by a reduction in the number of writhes when compared to the control. Similarly, the extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin. These results were also comparable to those of diclofenac sodium, the reference drug used in this study. Acute toxicity test showed that the plant may be safe for the pharmacological uses. This study has provided some justification for the folkloric use of the plant in several communities for conditions such as pain, skin allergies and inflammations.