B. Solerte | University of Pavia (original) (raw)

Papers by B. Solerte

Diabetes Research and Clinical Practice, 2016

Journal of endocrinological investigation, 1999

Neuropsychobiology, 2001

Marked hostility toward relatives, therapists and friends is very frequently observed in anorexia... more Marked hostility toward relatives, therapists and friends is very frequently observed in anorexia nervosa (AN) as expression of outward-directed aggressiveness which interferes with the therapeutic programs of the patients. With the purpose to investigate this aspect of the disorder and its biological background, we studied in anorexics some neurotransmitter-hormonal secretions which are known to modulate aggressivity-hostility by measuring plasma concentrations of total (TT) and free testosterone (FT), total estrogens (TE), the TT/E and FT/TE ratios, and the serotonergic function by measuring basal prolactin (PRL) levels and responses to stimulation with the specific serotonin (5-HT)-releasing agent D-fenfluramine (D-Fen). In 13 women with AN, 5 of the restricted (AN-R) and 8 of the bingeing/purging type (AN-BP) in an active phase of the disease, and in 13 healthy controls matched for sex and age, we measured hostility by the SCL-90 scale (subscale items 11, 24, 63, 67, 74, 81). Ba...

The Journal of Clinical Endocrinology & Metabolism, 2000

In this study, we have compared resistance to insulin-mediated glucose disposal and plasma concen... more In this study, we have compared resistance to insulin-mediated glucose disposal and plasma concentrations of nitric oxide (NO) and cyclic-GMP in healthy volunteers with (n ϭ 35) or without (n ϭ 27) at least one sibling and one parent with type 2 diabetes. The 62 volunteers were further divided into groups of those with normal glucose tolerance or impaired glucose tolerance. Insulin-mediated glucose disposal was quantified by determining the insulin sensitivity index (ISI) in response to a low-dose, constant infusion of insulin (25 mU/kg⅐h) and glucose (4 mg/kg⅐min) for 150 min. The mean (ϮSEM) ISI [(mL kg Ϫ1 min Ϫ1 /pmol/L) ϫ 10 3 ] was significantly greater in those without a family history (30.3 Ϯ 2.3) as compared with nondiabetic volunteers with a family history of type 2 diabetes, whether they had normal glucose tolerance (17.0 Ϯ 7.2) or impaired glucose tolerance (9.5 Ϯ 1.4). In addition, basal NO levels, evaluated by the measurement of its stable end products [i.e. nitrite and nitrate levels (NO 2 Ϫ/ NO 3 Ϫ)], were significantly higher, and cyclic-GMP levels, its effector messenger, were significantly lower in those with a family history, irrespective of their degree of glucose tolerance, when compared with healthy volunteers without a family history of type 2 diabetes. Furthermore, when the 62 volunteers were analyzed as one group, there was a negative correlation between ISI and NO 2 Ϫ/NO 3 Ϫ levels (r ϭ Ϫ0.35; P Ͻ 0.005) and a positive correlation between ISI and cyclic-GMP levels (r ϭ 0.30; P Ͻ 0.02). These results have shown that alterations of the NO/cyclic-GMP pathway seem to be an early event in nondiabetic individuals with a family history of type 2 diabetes and these changes are correlated with the degree of insulin resistance.

Clinical Nutrition Supplements, 2008

Methods: 21 patients in need of enteral long term feeding were evaluated for 10 weeks. The study ... more Methods: 21 patients in need of enteral long term feeding were evaluated for 10 weeks. The study was interventional, uncontrolled and hypothesis-generating. Patients were receiving a standard diet (SD) for 14 days followed by 8 weeks of NFTF. Energy intake and GIT were recorded daily. MT [triglycerides (TG), post-absorptive glucose (p-a BG), post-prandial glucose (p-p BG), insulin requirements (IR)], weight, body composition (bioimpedance), laboratory assessment were assessed on day 14 and 56. Statistical evaluation: comparison of the follow up data with baseline values on day 14 (mean average value). Results: Energy intake was equal during supply of both feeds (28 kcal/kg). Number of patients presenting with GIT (NFTF vs. SD): flatulence (9 vs. 0), reflux (15 vs. 9), constipation (2 vs. 0), diarrhoea (8 vs. 10). Mean changes in MT during NFTF: p-a BG 5.8 mg/dl, TG +42.61 mg/dl (mean values within normal ranges). Differences between feeds were regarded as clinically irrelevant. However, in insulin-dependent patients (n = 5) glycaemic control appeared to be superior during NFTF: p-a BG 17.8 mg/dl; p-p BG 12.3 mg/dl; IR 15 IU/die. Assessment of NS after NFTF revealed a decrease in weight ( 2.13 kg) along with a loss in fat mass ( 3.2 kg) whereas lean body mass (+3.4 kg) and blood levels of functional proteins (total protein +0.36 mg/dl; albumin +0.27 mg/dl) increased. This was associated with a rise in plasma creatinine (0.158 mg/dl) while blood urea ( 3.13 mg/dl) decreased. Conclusions: The newly developed NFTF was well tolerated. Whether NFTF compared to SD is more effective in improving glycaemic control and increasing lean body mass will be evaluated in a hypothesis confirming trial that is under preparation.

Thrombosis and haemostasis, 1981

Some haemostatic parameters have been evaluated in a group of rigorously selected patients with m... more Some haemostatic parameters have been evaluated in a group of rigorously selected patients with maturity-onset diabetes mellitus without thromboembolic complications and in apparently normal subjects of the same age before and after the venous occlusion test (VOT). In basal conditions diabetics had higher levels of AT III as biological activity and higher fibrinolytic and antifibrinolytic activities than controls. After VOT, F VIII R:Ag increased significantly in both groups, more markedly in controls than in diabetics, while F VIII: C showed no modification. Also AT III R:Ag increased after the test, but such variation was significant only in diabetics; on the contrary, the biological activity of AT III was always significantly decreased after the test. After VOT there were also in both groups highly significant increases in the fibrinolytic and antifibrinolytic activities. Finally, HbA1c levels directly correlated with AT III as biological activity before VOT, but with no other pa...

Methods: 21 patients in need of enteral long term feeding were evaluated for 10 weeks. The study ... more Methods: 21 patients in need of enteral long term feeding were evaluated for 10 weeks. The study was interventional, uncontrolled and hypothesis-generating. Patients were receiving a standard diet (SD) for 14 days followed by 8 weeks of NFTF. Energy intake and GIT were recorded daily. MT [triglycerides (TG), post-absorptive glucose (p-a BG), post-prandial glucose (p-p BG), insulin requirements (IR)], weight, body composition (bioimpedance), laboratory assessment were assessed on day 14 and 56. Statistical evaluation: comparison of the follow up data with baseline values on day 14 (mean average value). Results: Energy intake was equal during supply of both feeds (28 kcal/kg). Number of patients presenting with GIT (NFTF vs. SD): flatulence (9 vs. 0), reflux (15 vs. 9), constipation (2 vs. 0), diarrhoea (8 vs. 10). Mean changes in MT during NFTF: p-a BG 5.8 mg/dl, TG +42.61 mg/dl (mean values within normal ranges). Differences between feeds were regarded as clinically irrelevant. However, in insulin-dependent patients (n = 5) glycaemic control appeared to be superior during NFTF: p-a BG 17.8 mg/dl; p-p BG 12.3 mg/dl; IR 15 IU/die. Assessment of NS after NFTF revealed a decrease in weight ( 2.13 kg) along with a loss in fat mass ( 3.2 kg) whereas lean body mass (+3.4 kg) and blood levels of functional proteins (total protein +0.36 mg/dl; albumin +0.27 mg/dl) increased. This was associated with a rise in plasma creatinine (0.158 mg/dl) while blood urea ( 3.13 mg/dl) decreased. Conclusions: The newly developed NFTF was well tolerated. Whether NFTF compared to SD is more effective in improving glycaemic control and increasing lean body mass will be evaluated in a hypothesis confirming trial that is under preparation.

Atherosclerosis Supplements - ATHEROSCLER SUPPL, 2006

Objective: To evaluate the association of inflammatory markers with restenosis after implantation... more Objective: To evaluate the association of inflammatory markers with restenosis after implantation drug-eluting coronary stents.

The Journal of Immunology, 2002

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2004

Background. Leptin has been shown to be linked to adiposity and insulin resistance in middle-aged... more Background. Leptin has been shown to be linked to adiposity and insulin resistance in middle-aged participants. However, the association between leptin and metabolic syndrome independently of body fat and body fat distribution has not been evaluated in healthy elderly people.

The Journal of Clinical Endocrinology & Metabolism, 2000

In this study, we have compared resistance to insulin-mediated glucose disposal and plasma concen... more In this study, we have compared resistance to insulin-mediated glucose disposal and plasma concentrations of nitric oxide (NO) and cyclic-GMP in healthy volunteers with (n = 35) or without (n = 27) at least one sibling and one parent with type 2 diabetes. The 62 volunteers were further divided into groups of those with normal glucose tolerance or impaired glucose tolerance. Insulin-mediated glucose disposal was quantified by determining the insulin sensitivity index (ISI) in response to a low-dose, constant infusion of insulin (25 mU/kg x h) and glucose (4 mg/kg x min) for 150 min. The mean (+/-SEM) ISI [(mL kg(-1) min(-1)/pmol/L) x 10(3)] was significantly greater in those without a family history (30.3 +/- 2.3) as compared with nondiabetic volunteers with a family history of type 2 diabetes, whether they had normal glucose tolerance (17.0 +/- 7.2) or impaired glucose tolerance (9.5 +/- 1.4). In addition, basal NO levels, evaluated by the measurement of its stable end products [i.e. nitrite and nitrate levels (NO2-/ NO3-)], were significantly higher, and cyclic-GMP levels, its effector messenger, were significantly lower in those with a family history, irrespective of their degree of glucose tolerance, when compared with healthy volunteers without a family history of type 2 diabetes. Furthermore, when the 62 volunteers were analyzed as one group, there was a negative correlation between ISI and NO2-/NO3- levels (r = -0.35; P < 0.005) and a positive correlation between ISI and cyclic-GMP levels (r = 0.30; P < 0.02). These results have shown that alterations of the NO/cyclic-GMP pathway seem to be an early event in nondiabetic individuals with a family history of type 2 diabetes and these changes are correlated with the degree of insulin resistance.

Diabetes Research and Clinical Practice, 2016

Journal of endocrinological investigation, 1999

Neuropsychobiology, 2001

Marked hostility toward relatives, therapists and friends is very frequently observed in anorexia... more Marked hostility toward relatives, therapists and friends is very frequently observed in anorexia nervosa (AN) as expression of outward-directed aggressiveness which interferes with the therapeutic programs of the patients. With the purpose to investigate this aspect of the disorder and its biological background, we studied in anorexics some neurotransmitter-hormonal secretions which are known to modulate aggressivity-hostility by measuring plasma concentrations of total (TT) and free testosterone (FT), total estrogens (TE), the TT/E and FT/TE ratios, and the serotonergic function by measuring basal prolactin (PRL) levels and responses to stimulation with the specific serotonin (5-HT)-releasing agent D-fenfluramine (D-Fen). In 13 women with AN, 5 of the restricted (AN-R) and 8 of the bingeing/purging type (AN-BP) in an active phase of the disease, and in 13 healthy controls matched for sex and age, we measured hostility by the SCL-90 scale (subscale items 11, 24, 63, 67, 74, 81). Ba...

The Journal of Clinical Endocrinology & Metabolism, 2000

In this study, we have compared resistance to insulin-mediated glucose disposal and plasma concen... more In this study, we have compared resistance to insulin-mediated glucose disposal and plasma concentrations of nitric oxide (NO) and cyclic-GMP in healthy volunteers with (n ϭ 35) or without (n ϭ 27) at least one sibling and one parent with type 2 diabetes. The 62 volunteers were further divided into groups of those with normal glucose tolerance or impaired glucose tolerance. Insulin-mediated glucose disposal was quantified by determining the insulin sensitivity index (ISI) in response to a low-dose, constant infusion of insulin (25 mU/kg⅐h) and glucose (4 mg/kg⅐min) for 150 min. The mean (ϮSEM) ISI [(mL kg Ϫ1 min Ϫ1 /pmol/L) ϫ 10 3 ] was significantly greater in those without a family history (30.3 Ϯ 2.3) as compared with nondiabetic volunteers with a family history of type 2 diabetes, whether they had normal glucose tolerance (17.0 Ϯ 7.2) or impaired glucose tolerance (9.5 Ϯ 1.4). In addition, basal NO levels, evaluated by the measurement of its stable end products [i.e. nitrite and nitrate levels (NO 2 Ϫ/ NO 3 Ϫ)], were significantly higher, and cyclic-GMP levels, its effector messenger, were significantly lower in those with a family history, irrespective of their degree of glucose tolerance, when compared with healthy volunteers without a family history of type 2 diabetes. Furthermore, when the 62 volunteers were analyzed as one group, there was a negative correlation between ISI and NO 2 Ϫ/NO 3 Ϫ levels (r ϭ Ϫ0.35; P Ͻ 0.005) and a positive correlation between ISI and cyclic-GMP levels (r ϭ 0.30; P Ͻ 0.02). These results have shown that alterations of the NO/cyclic-GMP pathway seem to be an early event in nondiabetic individuals with a family history of type 2 diabetes and these changes are correlated with the degree of insulin resistance.

Clinical Nutrition Supplements, 2008

Methods: 21 patients in need of enteral long term feeding were evaluated for 10 weeks. The study ... more Methods: 21 patients in need of enteral long term feeding were evaluated for 10 weeks. The study was interventional, uncontrolled and hypothesis-generating. Patients were receiving a standard diet (SD) for 14 days followed by 8 weeks of NFTF. Energy intake and GIT were recorded daily. MT [triglycerides (TG), post-absorptive glucose (p-a BG), post-prandial glucose (p-p BG), insulin requirements (IR)], weight, body composition (bioimpedance), laboratory assessment were assessed on day 14 and 56. Statistical evaluation: comparison of the follow up data with baseline values on day 14 (mean average value). Results: Energy intake was equal during supply of both feeds (28 kcal/kg). Number of patients presenting with GIT (NFTF vs. SD): flatulence (9 vs. 0), reflux (15 vs. 9), constipation (2 vs. 0), diarrhoea (8 vs. 10). Mean changes in MT during NFTF: p-a BG 5.8 mg/dl, TG +42.61 mg/dl (mean values within normal ranges). Differences between feeds were regarded as clinically irrelevant. However, in insulin-dependent patients (n = 5) glycaemic control appeared to be superior during NFTF: p-a BG 17.8 mg/dl; p-p BG 12.3 mg/dl; IR 15 IU/die. Assessment of NS after NFTF revealed a decrease in weight ( 2.13 kg) along with a loss in fat mass ( 3.2 kg) whereas lean body mass (+3.4 kg) and blood levels of functional proteins (total protein +0.36 mg/dl; albumin +0.27 mg/dl) increased. This was associated with a rise in plasma creatinine (0.158 mg/dl) while blood urea ( 3.13 mg/dl) decreased. Conclusions: The newly developed NFTF was well tolerated. Whether NFTF compared to SD is more effective in improving glycaemic control and increasing lean body mass will be evaluated in a hypothesis confirming trial that is under preparation.

Thrombosis and haemostasis, 1981

Some haemostatic parameters have been evaluated in a group of rigorously selected patients with m... more Some haemostatic parameters have been evaluated in a group of rigorously selected patients with maturity-onset diabetes mellitus without thromboembolic complications and in apparently normal subjects of the same age before and after the venous occlusion test (VOT). In basal conditions diabetics had higher levels of AT III as biological activity and higher fibrinolytic and antifibrinolytic activities than controls. After VOT, F VIII R:Ag increased significantly in both groups, more markedly in controls than in diabetics, while F VIII: C showed no modification. Also AT III R:Ag increased after the test, but such variation was significant only in diabetics; on the contrary, the biological activity of AT III was always significantly decreased after the test. After VOT there were also in both groups highly significant increases in the fibrinolytic and antifibrinolytic activities. Finally, HbA1c levels directly correlated with AT III as biological activity before VOT, but with no other pa...

Methods: 21 patients in need of enteral long term feeding were evaluated for 10 weeks. The study ... more Methods: 21 patients in need of enteral long term feeding were evaluated for 10 weeks. The study was interventional, uncontrolled and hypothesis-generating. Patients were receiving a standard diet (SD) for 14 days followed by 8 weeks of NFTF. Energy intake and GIT were recorded daily. MT [triglycerides (TG), post-absorptive glucose (p-a BG), post-prandial glucose (p-p BG), insulin requirements (IR)], weight, body composition (bioimpedance), laboratory assessment were assessed on day 14 and 56. Statistical evaluation: comparison of the follow up data with baseline values on day 14 (mean average value). Results: Energy intake was equal during supply of both feeds (28 kcal/kg). Number of patients presenting with GIT (NFTF vs. SD): flatulence (9 vs. 0), reflux (15 vs. 9), constipation (2 vs. 0), diarrhoea (8 vs. 10). Mean changes in MT during NFTF: p-a BG 5.8 mg/dl, TG +42.61 mg/dl (mean values within normal ranges). Differences between feeds were regarded as clinically irrelevant. However, in insulin-dependent patients (n = 5) glycaemic control appeared to be superior during NFTF: p-a BG 17.8 mg/dl; p-p BG 12.3 mg/dl; IR 15 IU/die. Assessment of NS after NFTF revealed a decrease in weight ( 2.13 kg) along with a loss in fat mass ( 3.2 kg) whereas lean body mass (+3.4 kg) and blood levels of functional proteins (total protein +0.36 mg/dl; albumin +0.27 mg/dl) increased. This was associated with a rise in plasma creatinine (0.158 mg/dl) while blood urea ( 3.13 mg/dl) decreased. Conclusions: The newly developed NFTF was well tolerated. Whether NFTF compared to SD is more effective in improving glycaemic control and increasing lean body mass will be evaluated in a hypothesis confirming trial that is under preparation.

Atherosclerosis Supplements - ATHEROSCLER SUPPL, 2006

Objective: To evaluate the association of inflammatory markers with restenosis after implantation... more Objective: To evaluate the association of inflammatory markers with restenosis after implantation drug-eluting coronary stents.

The Journal of Immunology, 2002

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2004

Background. Leptin has been shown to be linked to adiposity and insulin resistance in middle-aged... more Background. Leptin has been shown to be linked to adiposity and insulin resistance in middle-aged participants. However, the association between leptin and metabolic syndrome independently of body fat and body fat distribution has not been evaluated in healthy elderly people.

The Journal of Clinical Endocrinology & Metabolism, 2000

In this study, we have compared resistance to insulin-mediated glucose disposal and plasma concen... more In this study, we have compared resistance to insulin-mediated glucose disposal and plasma concentrations of nitric oxide (NO) and cyclic-GMP in healthy volunteers with (n = 35) or without (n = 27) at least one sibling and one parent with type 2 diabetes. The 62 volunteers were further divided into groups of those with normal glucose tolerance or impaired glucose tolerance. Insulin-mediated glucose disposal was quantified by determining the insulin sensitivity index (ISI) in response to a low-dose, constant infusion of insulin (25 mU/kg x h) and glucose (4 mg/kg x min) for 150 min. The mean (+/-SEM) ISI [(mL kg(-1) min(-1)/pmol/L) x 10(3)] was significantly greater in those without a family history (30.3 +/- 2.3) as compared with nondiabetic volunteers with a family history of type 2 diabetes, whether they had normal glucose tolerance (17.0 +/- 7.2) or impaired glucose tolerance (9.5 +/- 1.4). In addition, basal NO levels, evaluated by the measurement of its stable end products [i.e. nitrite and nitrate levels (NO2-/ NO3-)], were significantly higher, and cyclic-GMP levels, its effector messenger, were significantly lower in those with a family history, irrespective of their degree of glucose tolerance, when compared with healthy volunteers without a family history of type 2 diabetes. Furthermore, when the 62 volunteers were analyzed as one group, there was a negative correlation between ISI and NO2-/NO3- levels (r = -0.35; P < 0.005) and a positive correlation between ISI and cyclic-GMP levels (r = 0.30; P < 0.02). These results have shown that alterations of the NO/cyclic-GMP pathway seem to be an early event in nondiabetic individuals with a family history of type 2 diabetes and these changes are correlated with the degree of insulin resistance.