Giovanni Ricevuti | University of Pavia (original) (raw)
Papers by Giovanni Ricevuti
Zhongguo Shenjing Zaisheng Yanjiu(Yingwenban), 2016
European Heart Journal Supplements, 2021
European Heart Journal Supplements, 2021
Rivista di anatomia patologica e di oncologia, Feb 13, 1970
Bollettino della Società Medico Chirurgica di Pavia, 2014
The object of this research is to analyse the correlation between the high levels of the inflamma... more The object of this research is to analyse the correlation between the high levels of the inflammatory indices and the fall of the cognitive functions in the patients admitted to rehabilitative and long hospitalization institution. It has considered a group of 200 patients, both males and females, aged between 60 and 98, admitted to the geriatric unit of the S. Margherita Institution in Pavia. The retrospective research took place in a period of about 12 month in 2007-2008 and it based itself on the medical records of the patients admitted in the institution for a rehabilitative period of about three months each. The data gathered have been: the age, the sex, the provenance and the destination, the admission diagnosis and the discharged diagnosis, the admission to hospital and the operation in the course of the thirty days before the admission day, the attendant pathologies, the medicines taken, the vescical catheter, the venous catheter, PEG, the decubitus ulcers, centre of infectio...
Cordylobia Anthropophaga known as Tumbu Fly is during larval stage large mammals parasite, (inclu... more Cordylobia Anthropophaga known as Tumbu Fly is during larval stage large mammals parasite, (including humans). It is endemic in the Africa and Asia central regions. The larvae penetrate the skin upon contact with a human or mammal, they migrate to the subcutaneous tissue and progressively increase their size. We decided to emphasize a disease not typical of our latitudes for several factors: first to the rarity of the condition that if out of context could be misunderstood and progress towards more severe forms, secondarily for the multi-ethnicity of patients presenting in emergency rooms now and then open horizons about different pathological conditions.
Ozone Therapy, 2016
After several years of scientific research and accurate clinical practice, the oxygen-ozone thera... more After several years of scientific research and accurate clinical practice, the oxygen-ozone therapy continues to represent a method full of prospects and new opportunities. On this basis we present an updated review on basic mechanisms through which the ozone acts. Ozone, a molecule notable for its heterodoxy and atypicalness, has been regarded with suspicious for a long time since it was a possible generator of free radicals and correlated pathologies, but it is important distinguishing between the oxidative damage from free radicals, characterized by irreversible chemical modifications of the molecular target, and the physiological effects from free radicals (redox signaling), characterized on the other hand, by reversible chemical and selective alterations, which are potentially suitable to become an active part in the various metabolic regulation mechanisms, with positive effects on several pathologies.
Ozone Therapy, 2019
The prevention of surgical site infections is a priority within the objectives of the National He... more The prevention of surgical site infections is a priority within the objectives of the National Health System. The negative consequences of postoperative infections (morbidity, duration of hospitalization, mortality) are particularly serious events for the individual patient and for the community, given both the welfare resources needed to treat them, and the continued growth of the phenomenon of antibiotic resistance. In a global health context in which evidence-based medicine has established itself, all medical interventions must be reconsidered in the light of what can be inferred from the literature evaluated according to strict methodological criteria, all the more so when the evidence is available and unanimously shared. The future objective will be to introduce in the national guidelines a protocol involving the use of ozone therapy alongside antibiotic therapy, both in the prevention and treatment of infections, to avoid the emergence of antibiotic resistance and thus reduce ...
The Open emergency medicine journal, Sep 6, 2013
Background: antibiotic therapy and prophylaxis of epidermal wounds in emergency room are often ma... more Background: antibiotic therapy and prophylaxis of epidermal wounds in emergency room are often made empirically in case of clinics due to infective complications, although there are no scientific evidences supporting their validity yet. Furthermore, resistance to many antibiotics is a constantly growing problem, especially in Lombardy, Italy. When needed, better prefer beta-lactams or macrolides for their large-spectrum activity. Methods: We identified all patients (pts) treated to our emergency room for epidermal wounds in a period between 1st and 31st july 2012. Then, we performed a retrospective, observational analysis of epidemiological, clinical and therapeutic features of those pts. <12 years old individuals were exluded. We considered at high risk of infections pts with at least one of the following comorbidities: diabetes, neoplastic disease, therapy with corticosteroids, immunodepression. Results: A total of 201 pts were evaluated, 143 males (71.1%) and 58 females (28.9%). The median age was 46,3 yrs. Among the pts 101 (50.2%) needed treatment with suture. 13 (6.5%) pts came after at least 12 hrs after the accident. 107 (53,2%) pts did not need therapy, while in 82 (40.8%) cases antibiotic prophylaxis (89% beta-lactams, 9.8% macrolides, 1.2% others) has been prescribed; 4 (2%) were adviced to start antibiotic therapy only in case of acute epidermal infection development at home; we don't have this information about 8 pts (4%). In 185 (93.5%) pts clinical signs of acute epidermal infection were missing. 15 (7.5%) pts had an high risk of developing infections in history taking; 3 of them received antibiotic prophylaxis, 8 didn't, 4 not known. In 143 individuals (71,1%) the history taking has been insufficient. Conclusions: Even if acute local infection is possible in wounded pts, only subjects at high risk should be closely screened and monitored to detect early infection, in order to evaluate the necessity of specific antibiotic therapy. Clinical evaluation should also include comorbilities as valvulopathy or immunosuppression.
International Journal of Immunopathology and Pharmacology, May 1, 1989
The clinical syndrome of acute myocardial ischemia includes the processes of acute coronary occlu... more The clinical syndrome of acute myocardial ischemia includes the processes of acute coronary occlusion, possible reperfusion and inflammation (6,8). Each of these processes has been shown to involve granulocytes which disrupt tissues and the contractile machinery of the myocardium (3). The neutrophils are not normally sequestered in the heart; instead they are activated by processes occurring during ischemia and re-oxygenation that lead to their active accumulation. The accumulation of neutrophils is temporally, regionally, and quantitatively associated with the development of myocardial injury (2,14). Drugs, antibodies, or filters that either prevent neutrophil activation (and consequently accumulation) or deplete the blood of neutrophils diminish the area of damage and improve function after ischemia and reperfusion (13). The purpose of this brief report is to discuss the mechanism by which neutrophils may contribute to ischemia-induced myocardial injury and disfunction. Attention will be placed on the potential role of neutrophil-derived mediators in the injurious process, in particular, the metabolites of arachodonic acid (AA) and the oxygen derived free radicals. Recently, these mediators have assumed primary importance because inhibitors of AA lipoxygenation or free-radical scavengers, independently can reduce infarct size.
PubMed, 1989
Eccrine spiradenoma is a rare, usually benign tumor, originating from cutaneous sweat glands. Its... more Eccrine spiradenoma is a rare, usually benign tumor, originating from cutaneous sweat glands. Its clinical and histologic diagnosis can be difficult at times, especially when malignant features are present. Proper management requires radical surgical excision. Two cases of spiradenoma are reported, one of which highly malignant with diffuse pulmonary metastases leading to the patient's death in spite of repeated radical surgery.
PubMed, Nov 1, 1990
The authors report the clinical and biological findings of a case of a rare haematological malign... more The authors report the clinical and biological findings of a case of a rare haematological malignant entity, morphologically characterised by a bizarre nuclear abnormality in granulocytes, consisting of exaggerated chromatin clumping and apparent fragmentation of the nucleus, with a loss of segmentation. They emphasize the coexistence of proliferative and dysplastic characteristics as a distinctive marker of this disorder and suggest it may represent a distinct rare morphological entity among the atypical chronic myeloid leukaemias, Ph1 and ber negative.
International Journal of Immunopathology and Pharmacology, Jul 1, 2010
Journal of Medical Virology, Jun 30, 2021
On October 2020, Sestili and Fimognari reported that acetaminophen (N-aetyl-para-aminophenol), co... more On October 2020, Sestili and Fimognari reported that acetaminophen (N-aetyl-para-aminophenol), commonly known as paracetamol, induces or worsens glutathione (GSH) consumption in elderly patients affected by early or mild COVID-19 This article is protected by copyright. All rights reserved.
International Journal of Immunopathology and Pharmacology, Jul 1, 2005
We analyzed soluble vascular adhesion molecules (sVCAM-l), reactive oxygen metabolites (ROMs) lev... more We analyzed soluble vascular adhesion molecules (sVCAM-l), reactive oxygen metabolites (ROMs) level, total antioxidant status (TAS) and telediastolic left ventricular volume (TLVV) in patients with myocardial infarction undergoing reperfusion therapy and treated with antioxidant vitamins (AT) or placebo (P) before and for 1 month after reperfusion. After reperfusion, sVCAM-l serum concentration, reactive oxygen metabolites level, and TLVV were significantly higher in patients treated with placebo than in those treated with antioxidant vitamins, while TAS was significantly higher in patients treated with antioxidant supplementation. We observed that 48 hours after reperfusion sVCAM-l (P) vs sVCAM-l(AT) was 2.03±O.5 vs 1.63±O.7 ug/ml with p<O.Ol; ROMs (P) vs ROMs (AT) were 335.60±35.80 vs 307.50±47.10 V.CARR with p<O.05; TAS (P) vs TAS (AT) was 526.47±44.24 vs 737.65±51.15 umol/l with p<O.Ol; 1 week after reperfusion TLVV (P) vs TLVV (AT) was 125.12±29.80vs 119.40±29.40 ml with p<O.05; 1 month after reperfusion TLVV (P) vs TLVV (AV) was 132.00±33.50 vs 123.40±21.60 ml with p<O.05. In the first period after infarction, vitamin treatment improves the antioxidant system and reduces oxidative stress, inflammatory process and left ventricular remodeling. In acute myocardial infarction (AMI), the ischemic events are triggered by disruption of atheromatous plaque, with thrombus formation (1). The plaque derives from cholesterol deposition and intima infiltration from monocytes and neutrophils (PMN). The PMN generate free radicals that damage the endothelial cells and increase proinflammatory cytokines and tumour necrosis factor-alpha level (2-5). These molecules activate PMN, that play an important role in this process, by release of proteolytic enzyme and generation of oxygen free radicals, that can cause injury to membranes and mitochondria (6-10). ROS derived by PMN activation (11) may have an important role in the pathophysiology of AMI because it can induce functional and structural damage of cardiac myocytes (12-14) due to the damage of cellular membranes, proteins, mitochondria, DNA, lipoproteins, and lipid peroxydation (15-18). Moreover, reperfusion therapy after AMI can induce a response similar to the acute inflammation, with endothelial cell injury and inflammatory cell infiltration that produce further ROS (6, 19-22). AMI frequently produces left ventricular (LV) dilatation and hypertrophy of the noninfarcted
Zhongguo Shenjing Zaisheng Yanjiu(Yingwenban), 2016
European Heart Journal Supplements, 2021
European Heart Journal Supplements, 2021
Rivista di anatomia patologica e di oncologia, Feb 13, 1970
Bollettino della Società Medico Chirurgica di Pavia, 2014
The object of this research is to analyse the correlation between the high levels of the inflamma... more The object of this research is to analyse the correlation between the high levels of the inflammatory indices and the fall of the cognitive functions in the patients admitted to rehabilitative and long hospitalization institution. It has considered a group of 200 patients, both males and females, aged between 60 and 98, admitted to the geriatric unit of the S. Margherita Institution in Pavia. The retrospective research took place in a period of about 12 month in 2007-2008 and it based itself on the medical records of the patients admitted in the institution for a rehabilitative period of about three months each. The data gathered have been: the age, the sex, the provenance and the destination, the admission diagnosis and the discharged diagnosis, the admission to hospital and the operation in the course of the thirty days before the admission day, the attendant pathologies, the medicines taken, the vescical catheter, the venous catheter, PEG, the decubitus ulcers, centre of infectio...
Cordylobia Anthropophaga known as Tumbu Fly is during larval stage large mammals parasite, (inclu... more Cordylobia Anthropophaga known as Tumbu Fly is during larval stage large mammals parasite, (including humans). It is endemic in the Africa and Asia central regions. The larvae penetrate the skin upon contact with a human or mammal, they migrate to the subcutaneous tissue and progressively increase their size. We decided to emphasize a disease not typical of our latitudes for several factors: first to the rarity of the condition that if out of context could be misunderstood and progress towards more severe forms, secondarily for the multi-ethnicity of patients presenting in emergency rooms now and then open horizons about different pathological conditions.
Ozone Therapy, 2016
After several years of scientific research and accurate clinical practice, the oxygen-ozone thera... more After several years of scientific research and accurate clinical practice, the oxygen-ozone therapy continues to represent a method full of prospects and new opportunities. On this basis we present an updated review on basic mechanisms through which the ozone acts. Ozone, a molecule notable for its heterodoxy and atypicalness, has been regarded with suspicious for a long time since it was a possible generator of free radicals and correlated pathologies, but it is important distinguishing between the oxidative damage from free radicals, characterized by irreversible chemical modifications of the molecular target, and the physiological effects from free radicals (redox signaling), characterized on the other hand, by reversible chemical and selective alterations, which are potentially suitable to become an active part in the various metabolic regulation mechanisms, with positive effects on several pathologies.
Ozone Therapy, 2019
The prevention of surgical site infections is a priority within the objectives of the National He... more The prevention of surgical site infections is a priority within the objectives of the National Health System. The negative consequences of postoperative infections (morbidity, duration of hospitalization, mortality) are particularly serious events for the individual patient and for the community, given both the welfare resources needed to treat them, and the continued growth of the phenomenon of antibiotic resistance. In a global health context in which evidence-based medicine has established itself, all medical interventions must be reconsidered in the light of what can be inferred from the literature evaluated according to strict methodological criteria, all the more so when the evidence is available and unanimously shared. The future objective will be to introduce in the national guidelines a protocol involving the use of ozone therapy alongside antibiotic therapy, both in the prevention and treatment of infections, to avoid the emergence of antibiotic resistance and thus reduce ...
The Open emergency medicine journal, Sep 6, 2013
Background: antibiotic therapy and prophylaxis of epidermal wounds in emergency room are often ma... more Background: antibiotic therapy and prophylaxis of epidermal wounds in emergency room are often made empirically in case of clinics due to infective complications, although there are no scientific evidences supporting their validity yet. Furthermore, resistance to many antibiotics is a constantly growing problem, especially in Lombardy, Italy. When needed, better prefer beta-lactams or macrolides for their large-spectrum activity. Methods: We identified all patients (pts) treated to our emergency room for epidermal wounds in a period between 1st and 31st july 2012. Then, we performed a retrospective, observational analysis of epidemiological, clinical and therapeutic features of those pts. <12 years old individuals were exluded. We considered at high risk of infections pts with at least one of the following comorbidities: diabetes, neoplastic disease, therapy with corticosteroids, immunodepression. Results: A total of 201 pts were evaluated, 143 males (71.1%) and 58 females (28.9%). The median age was 46,3 yrs. Among the pts 101 (50.2%) needed treatment with suture. 13 (6.5%) pts came after at least 12 hrs after the accident. 107 (53,2%) pts did not need therapy, while in 82 (40.8%) cases antibiotic prophylaxis (89% beta-lactams, 9.8% macrolides, 1.2% others) has been prescribed; 4 (2%) were adviced to start antibiotic therapy only in case of acute epidermal infection development at home; we don't have this information about 8 pts (4%). In 185 (93.5%) pts clinical signs of acute epidermal infection were missing. 15 (7.5%) pts had an high risk of developing infections in history taking; 3 of them received antibiotic prophylaxis, 8 didn't, 4 not known. In 143 individuals (71,1%) the history taking has been insufficient. Conclusions: Even if acute local infection is possible in wounded pts, only subjects at high risk should be closely screened and monitored to detect early infection, in order to evaluate the necessity of specific antibiotic therapy. Clinical evaluation should also include comorbilities as valvulopathy or immunosuppression.
International Journal of Immunopathology and Pharmacology, May 1, 1989
The clinical syndrome of acute myocardial ischemia includes the processes of acute coronary occlu... more The clinical syndrome of acute myocardial ischemia includes the processes of acute coronary occlusion, possible reperfusion and inflammation (6,8). Each of these processes has been shown to involve granulocytes which disrupt tissues and the contractile machinery of the myocardium (3). The neutrophils are not normally sequestered in the heart; instead they are activated by processes occurring during ischemia and re-oxygenation that lead to their active accumulation. The accumulation of neutrophils is temporally, regionally, and quantitatively associated with the development of myocardial injury (2,14). Drugs, antibodies, or filters that either prevent neutrophil activation (and consequently accumulation) or deplete the blood of neutrophils diminish the area of damage and improve function after ischemia and reperfusion (13). The purpose of this brief report is to discuss the mechanism by which neutrophils may contribute to ischemia-induced myocardial injury and disfunction. Attention will be placed on the potential role of neutrophil-derived mediators in the injurious process, in particular, the metabolites of arachodonic acid (AA) and the oxygen derived free radicals. Recently, these mediators have assumed primary importance because inhibitors of AA lipoxygenation or free-radical scavengers, independently can reduce infarct size.
PubMed, 1989
Eccrine spiradenoma is a rare, usually benign tumor, originating from cutaneous sweat glands. Its... more Eccrine spiradenoma is a rare, usually benign tumor, originating from cutaneous sweat glands. Its clinical and histologic diagnosis can be difficult at times, especially when malignant features are present. Proper management requires radical surgical excision. Two cases of spiradenoma are reported, one of which highly malignant with diffuse pulmonary metastases leading to the patient's death in spite of repeated radical surgery.
PubMed, Nov 1, 1990
The authors report the clinical and biological findings of a case of a rare haematological malign... more The authors report the clinical and biological findings of a case of a rare haematological malignant entity, morphologically characterised by a bizarre nuclear abnormality in granulocytes, consisting of exaggerated chromatin clumping and apparent fragmentation of the nucleus, with a loss of segmentation. They emphasize the coexistence of proliferative and dysplastic characteristics as a distinctive marker of this disorder and suggest it may represent a distinct rare morphological entity among the atypical chronic myeloid leukaemias, Ph1 and ber negative.
International Journal of Immunopathology and Pharmacology, Jul 1, 2010
Journal of Medical Virology, Jun 30, 2021
On October 2020, Sestili and Fimognari reported that acetaminophen (N-aetyl-para-aminophenol), co... more On October 2020, Sestili and Fimognari reported that acetaminophen (N-aetyl-para-aminophenol), commonly known as paracetamol, induces or worsens glutathione (GSH) consumption in elderly patients affected by early or mild COVID-19 This article is protected by copyright. All rights reserved.
International Journal of Immunopathology and Pharmacology, Jul 1, 2005
We analyzed soluble vascular adhesion molecules (sVCAM-l), reactive oxygen metabolites (ROMs) lev... more We analyzed soluble vascular adhesion molecules (sVCAM-l), reactive oxygen metabolites (ROMs) level, total antioxidant status (TAS) and telediastolic left ventricular volume (TLVV) in patients with myocardial infarction undergoing reperfusion therapy and treated with antioxidant vitamins (AT) or placebo (P) before and for 1 month after reperfusion. After reperfusion, sVCAM-l serum concentration, reactive oxygen metabolites level, and TLVV were significantly higher in patients treated with placebo than in those treated with antioxidant vitamins, while TAS was significantly higher in patients treated with antioxidant supplementation. We observed that 48 hours after reperfusion sVCAM-l (P) vs sVCAM-l(AT) was 2.03±O.5 vs 1.63±O.7 ug/ml with p<O.Ol; ROMs (P) vs ROMs (AT) were 335.60±35.80 vs 307.50±47.10 V.CARR with p<O.05; TAS (P) vs TAS (AT) was 526.47±44.24 vs 737.65±51.15 umol/l with p<O.Ol; 1 week after reperfusion TLVV (P) vs TLVV (AT) was 125.12±29.80vs 119.40±29.40 ml with p<O.05; 1 month after reperfusion TLVV (P) vs TLVV (AV) was 132.00±33.50 vs 123.40±21.60 ml with p<O.05. In the first period after infarction, vitamin treatment improves the antioxidant system and reduces oxidative stress, inflammatory process and left ventricular remodeling. In acute myocardial infarction (AMI), the ischemic events are triggered by disruption of atheromatous plaque, with thrombus formation (1). The plaque derives from cholesterol deposition and intima infiltration from monocytes and neutrophils (PMN). The PMN generate free radicals that damage the endothelial cells and increase proinflammatory cytokines and tumour necrosis factor-alpha level (2-5). These molecules activate PMN, that play an important role in this process, by release of proteolytic enzyme and generation of oxygen free radicals, that can cause injury to membranes and mitochondria (6-10). ROS derived by PMN activation (11) may have an important role in the pathophysiology of AMI because it can induce functional and structural damage of cardiac myocytes (12-14) due to the damage of cellular membranes, proteins, mitochondria, DNA, lipoproteins, and lipid peroxydation (15-18). Moreover, reperfusion therapy after AMI can induce a response similar to the acute inflammation, with endothelial cell injury and inflammatory cell infiltration that produce further ROS (6, 19-22). AMI frequently produces left ventricular (LV) dilatation and hypertrophy of the noninfarcted