Milena Sorrenti | University of Pavia (original) (raw)

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Research paper thumbnail of Physical chemical characterization of binary systems of triacethyl gamma-cyclodextrins with tosylate salts of vancomycin and teicoplanin

In the scope of improving the energy and power densities of electrochemical double layer capacito... more In the scope of improving the energy and power densities of electrochemical double layer capacitors (EDLCs), the development of high performance electrolytes with enhanced operative voltages is imperative. The formulation of mixtures containing ionic liquids with organic molecular solvents is an important strategy in the pursuit of developing highly electrochemically stable and safe materials while retaining fast transport properties for high power applications. In this work, we report on the physical−chemical investigations into binary mixtures containing the ionic liquid 1-butyl-1-methylpyrrolidinium bis{(trifluoromethyl)sulfonyl}imide with one mononitrile solvent, butyronitrile, and two dinitrile solvents, glutaronitrile and adiponitrile, as potential electrolytes for EDLCs. The thermal, volumetric, and transport properties of the binary mixtures are investigated as functions of the electrolyte composition and temperature. Furthermore, the electrolyte composition which exhibits the highest conductivity for each of the binary mixtures was determined, and its electrochemical stability is reported using a glassy carbon macrodisk electrode.

Research paper thumbnail of An update on solid-state characterization of the polyphenol pterostilbene

Journal of Drug Delivery Science and Technology, May 1, 2022

Research paper thumbnail of Solid forms and solid-state interaction of tacrine with beta-cyclodextrins

Research paper thumbnail of Transizione vetrosa ed entalpia di rilassamento in sistemi binari di vancomicina o teicoplanina con triacetil ciclodestrine

Research paper thumbnail of Biodegradable alginate microspheres for prolonged release of vancomycin loaded on hydrophobic cyclodextrins

Research paper thumbnail of Solubility and interactions of naproxen in ternary systems with hydroxypropyl betacyclodextrin and L-arginine

Research paper thumbnail of Preparation by spray-drying of interaction products of vancomycin with hydrophobic cyclodextrins

Research paper thumbnail of Association of Indocyanine Green with Chitosan Oleate Coated PLGA Nanoparticles for Photodynamic Therapy

Pharmaceutics, Aug 20, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Vancomycin-triacetyl cyclodextrin interaction products: influence of the manufacturing process

ABSTRACT The aim of the present work was to investigate the capability of vancomycin (VCM) to int... more ABSTRACT The aim of the present work was to investigate the capability of vancomycin (VCM) to interact with three hydrophobic cyclodextrins (TACD) (triacetyl alpha-, beta-, or gamma cyclodextrin) and the role played by the preparation technique in the formation of interaction products aimed at prolonging drug delivery for site-specific treatment of bone infections. Physical mixtures of VCM with triacetyl alpha-, beta-, or gamma-cyclodextrin in a 1:1 molar ratio were subjected to kneading, coevaporation, and spray drying from aqueous suspensions or hydroacetonic solution. Thermal behavior (TG, DSC), percent drug content (HPLC), and drug release (Franz cell) of VCM from the physical mixtures, and the relevant binary systems obtained by the various complexation methods were evaluated. All binary systems were characterized by having a particle size compatible with parenteral site-specific administration and with drug-loading efficiencies close to 100%, thus indicating the stability of vancomycin toward each and every complexation process. In vitro drug release measurements showed that the preparation technique plays a different role depending on the type of cyclodextrin used. In the kneading process, the binary system containing TAalphaCD is the most efficient in slowing down the VCM release. With the coevaporation technique, the system based on TAbetaCD was most effective in prolonging drug release. None of the triacetyl-cyclodextrins is suitable in prolonging VCM release upon spray drying from aqueous suspensions, because this preparation technique does not determine drug-cyclodextrin interaction. On the other hand, spray drying from hydroacetonic solutions always results in a reduction in drug release, linked to the formation of VCM-TACD interaction products and is particularly pronounced for the VCM-TAgammaCD interaction product. The unique properties of prolonging drug release and maintaining the antimicrobial activity of the native drug render such an interaction product the most promising candidate in the development of delivery systems intended for parenteral site-specific administration of VCM.

Research paper thumbnail of Conjugation, Prodrug, and Co-Administration Strategies in Support of Nanotechnologies to Improve the Therapeutic Efficacy of Phytochemicals in the Central Nervous System

Pharmaceutics

Phytochemicals, produced as secondary plant metabolites, have shown interesting potential therape... more Phytochemicals, produced as secondary plant metabolites, have shown interesting potential therapeutic activities against neurodegenerative diseases and cancer. Unfortunately, poor bioavailability and rapid metabolic processes compromise their therapeutic use, and several strategies are currently proposed for overcoming these issues. The present review summarises strategies for enhancing the central nervous system’s phytochemical efficacy. Particular attention has been paid to the use of phytochemicals in combination with other drugs (co-administrations) or administration of phytochemicals as prodrugs or conjugates, particularly when these approaches are supported by nanotechnologies exploiting conjugation strategies with appropriate targeting molecules. These aspects are described for polyphenols and essential oil components, which can improve their loading as prodrugs in nanocarriers, or be part of nanocarriers designed for targeted co-delivery to achieve synergistic anti-glioma or...

Research paper thumbnail of Nanoemulsions of Clove Oil Stabilized with Chitosan Oleate—Antioxidant and Wound-Healing Activity

Antioxidants

Clove oil (CO) is a powerful antioxidant essential oil (EO) with anti-inflammatory, anesthetic, a... more Clove oil (CO) is a powerful antioxidant essential oil (EO) with anti-inflammatory, anesthetic, and anti-infective properties. It can be therefore considered a good candidate for wound-healing applications, especially for chronic or diabetic wounds or burns, where the balance of reactive oxygen species (ROS) production and detoxification is altered. However, EOs require suitable formulations to be efficiently administered in moist wound environments. Chitosan hydrophobically modified by an ionic interaction with oleic acid (chitosan oleate, CSO) was used in the present work to stabilize CO nanoemulsions (NEs). The dimensions of the NE were maintained at around 300 nm as the volume distribution for up to six months, and the CO content did not decrease to under 80% over 4 months, confirming the good stabilizing properties of CSO. The antioxidant properties of the CO NE were evaluated in vitro by a 2,2-diphenil-2-picrylhydrazyl hydrate (DPPH) assay, and in fibroblast cell lines by elec...

Research paper thumbnail of Complexation between the Antioxidant Pterostilbene and Derivatized Cyclodextrins in the Solid State and in Aqueous Solution

Pharmaceuticals

Inadequate aqueous solubilities of bioactive compounds hinder their ability to be developed for m... more Inadequate aqueous solubilities of bioactive compounds hinder their ability to be developed for medicinal applications. The potent antioxidant pterostilbene (PTB) is a case in point. The aim of this study was to use a series of modified water-soluble cyclodextrins (CDs), namely, hydroxypropyl β-CD (HPβCD), dimethylated β-CD (DIMEB), randomly methylated β-CD (RAMEB), and sulfobutyl ether β-CD sodium salt (SBECD) to prepare inclusion complexes of PTB via various solid, semi-solid, and solution-based treatments. Putative CD–PTB products generated by solid-state co-grinding, kneading, irradiation with microwaves, and the evaporative treatment of CD–PTB solutions were considered to have potential for future applications. Primary analytical methods for examining CD–PTB products included differential scanning calorimetry and Fourier transform infrared spectroscopy to detect the occurrence of binary complex formation. Phase solubility analysis was used to probe CD–PTB complexation in an aqu...

Research paper thumbnail of Native Cyclodextrins as Complexation Agents for Pterostilbene: Complex Preparation and Characterization in Solution and in the Solid State

Pharmaceutics

Pterostilbene (3,5-dimethoxy-4′-hydroxystilbene, PTB) is a natural dietary stilbene, occurring pr... more Pterostilbene (3,5-dimethoxy-4′-hydroxystilbene, PTB) is a natural dietary stilbene, occurring primarily in blueberries and Pterocarpus marsupium heartwood. The interest in this compound is related to its different biological and pharmacological properties, such as its antioxidant, anti-inflammatory, and anticarcinogenic activities and its capacity to reduce and regulate cholesterol and blood sugar levels. Nevertheless, its use in therapy is hindered by its low aqueous solubility; to overcome this limitation we studied the feasibility of the use of cyclodextrins (CDs) as solubility-enhancing agents. CDs are natural macrocyclic oligomers composed of α-d-glucose units linked by α-1,4 glycosidic bonds to form torus-shaped molecules, responsible for inclusion complex formation with organic molecules. In particular, the aim of this study was to evaluate the feasibility of complexation between PTB and native CDs using various preparative methods. The isolated solid products were character...

Research paper thumbnail of Alginate-chitosan microspheres for prolonged release of vancomycin loaded on a hydrophobic cyclodextrin

5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2006

Research paper thumbnail of Binary mixtures of vancomycin with amorphous and crystalline cyclodextrins for site-specific controlled release

43° Simposio AFI 2003, 2003

Research paper thumbnail of 2-hydroxypropyl-beta-cyclodextrin as stabilizing agent of G6PD for a possible therapy of favism, an enzyme-deficiency disorder

XVII Simposio ADRITELF, 2000

Research paper thumbnail of Mucoadhesive nanoparticles carrying permeation enhancers for nasal delivery of tacrine hydrochloride

XXI simposio A.D.R.I.T.E.L.F., Cagliari, 10-13 Settembre 2009, 2009

Research paper thumbnail of The influence of pH and water-soluble polymers on naproxen cyclodextrin complexation

Research paper thumbnail of Thermal behaviour and phase diagrams of Tetroxoprim-Sulfonamide Binary Systems

Research paper thumbnail of Vancomycin-triacetyl cyclodextrin combinations for prolonged release of vancomycin

Research paper thumbnail of Physical chemical characterization of binary systems of triacethyl gamma-cyclodextrins with tosylate salts of vancomycin and teicoplanin

In the scope of improving the energy and power densities of electrochemical double layer capacito... more In the scope of improving the energy and power densities of electrochemical double layer capacitors (EDLCs), the development of high performance electrolytes with enhanced operative voltages is imperative. The formulation of mixtures containing ionic liquids with organic molecular solvents is an important strategy in the pursuit of developing highly electrochemically stable and safe materials while retaining fast transport properties for high power applications. In this work, we report on the physical−chemical investigations into binary mixtures containing the ionic liquid 1-butyl-1-methylpyrrolidinium bis{(trifluoromethyl)sulfonyl}imide with one mononitrile solvent, butyronitrile, and two dinitrile solvents, glutaronitrile and adiponitrile, as potential electrolytes for EDLCs. The thermal, volumetric, and transport properties of the binary mixtures are investigated as functions of the electrolyte composition and temperature. Furthermore, the electrolyte composition which exhibits the highest conductivity for each of the binary mixtures was determined, and its electrochemical stability is reported using a glassy carbon macrodisk electrode.

Research paper thumbnail of An update on solid-state characterization of the polyphenol pterostilbene

Journal of Drug Delivery Science and Technology, May 1, 2022

Research paper thumbnail of Solid forms and solid-state interaction of tacrine with beta-cyclodextrins

Research paper thumbnail of Transizione vetrosa ed entalpia di rilassamento in sistemi binari di vancomicina o teicoplanina con triacetil ciclodestrine

Research paper thumbnail of Biodegradable alginate microspheres for prolonged release of vancomycin loaded on hydrophobic cyclodextrins

Research paper thumbnail of Solubility and interactions of naproxen in ternary systems with hydroxypropyl betacyclodextrin and L-arginine

Research paper thumbnail of Preparation by spray-drying of interaction products of vancomycin with hydrophobic cyclodextrins

Research paper thumbnail of Association of Indocyanine Green with Chitosan Oleate Coated PLGA Nanoparticles for Photodynamic Therapy

Pharmaceutics, Aug 20, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Vancomycin-triacetyl cyclodextrin interaction products: influence of the manufacturing process

ABSTRACT The aim of the present work was to investigate the capability of vancomycin (VCM) to int... more ABSTRACT The aim of the present work was to investigate the capability of vancomycin (VCM) to interact with three hydrophobic cyclodextrins (TACD) (triacetyl alpha-, beta-, or gamma cyclodextrin) and the role played by the preparation technique in the formation of interaction products aimed at prolonging drug delivery for site-specific treatment of bone infections. Physical mixtures of VCM with triacetyl alpha-, beta-, or gamma-cyclodextrin in a 1:1 molar ratio were subjected to kneading, coevaporation, and spray drying from aqueous suspensions or hydroacetonic solution. Thermal behavior (TG, DSC), percent drug content (HPLC), and drug release (Franz cell) of VCM from the physical mixtures, and the relevant binary systems obtained by the various complexation methods were evaluated. All binary systems were characterized by having a particle size compatible with parenteral site-specific administration and with drug-loading efficiencies close to 100%, thus indicating the stability of vancomycin toward each and every complexation process. In vitro drug release measurements showed that the preparation technique plays a different role depending on the type of cyclodextrin used. In the kneading process, the binary system containing TAalphaCD is the most efficient in slowing down the VCM release. With the coevaporation technique, the system based on TAbetaCD was most effective in prolonging drug release. None of the triacetyl-cyclodextrins is suitable in prolonging VCM release upon spray drying from aqueous suspensions, because this preparation technique does not determine drug-cyclodextrin interaction. On the other hand, spray drying from hydroacetonic solutions always results in a reduction in drug release, linked to the formation of VCM-TACD interaction products and is particularly pronounced for the VCM-TAgammaCD interaction product. The unique properties of prolonging drug release and maintaining the antimicrobial activity of the native drug render such an interaction product the most promising candidate in the development of delivery systems intended for parenteral site-specific administration of VCM.

Research paper thumbnail of Conjugation, Prodrug, and Co-Administration Strategies in Support of Nanotechnologies to Improve the Therapeutic Efficacy of Phytochemicals in the Central Nervous System

Pharmaceutics

Phytochemicals, produced as secondary plant metabolites, have shown interesting potential therape... more Phytochemicals, produced as secondary plant metabolites, have shown interesting potential therapeutic activities against neurodegenerative diseases and cancer. Unfortunately, poor bioavailability and rapid metabolic processes compromise their therapeutic use, and several strategies are currently proposed for overcoming these issues. The present review summarises strategies for enhancing the central nervous system’s phytochemical efficacy. Particular attention has been paid to the use of phytochemicals in combination with other drugs (co-administrations) or administration of phytochemicals as prodrugs or conjugates, particularly when these approaches are supported by nanotechnologies exploiting conjugation strategies with appropriate targeting molecules. These aspects are described for polyphenols and essential oil components, which can improve their loading as prodrugs in nanocarriers, or be part of nanocarriers designed for targeted co-delivery to achieve synergistic anti-glioma or...

Research paper thumbnail of Nanoemulsions of Clove Oil Stabilized with Chitosan Oleate—Antioxidant and Wound-Healing Activity

Antioxidants

Clove oil (CO) is a powerful antioxidant essential oil (EO) with anti-inflammatory, anesthetic, a... more Clove oil (CO) is a powerful antioxidant essential oil (EO) with anti-inflammatory, anesthetic, and anti-infective properties. It can be therefore considered a good candidate for wound-healing applications, especially for chronic or diabetic wounds or burns, where the balance of reactive oxygen species (ROS) production and detoxification is altered. However, EOs require suitable formulations to be efficiently administered in moist wound environments. Chitosan hydrophobically modified by an ionic interaction with oleic acid (chitosan oleate, CSO) was used in the present work to stabilize CO nanoemulsions (NEs). The dimensions of the NE were maintained at around 300 nm as the volume distribution for up to six months, and the CO content did not decrease to under 80% over 4 months, confirming the good stabilizing properties of CSO. The antioxidant properties of the CO NE were evaluated in vitro by a 2,2-diphenil-2-picrylhydrazyl hydrate (DPPH) assay, and in fibroblast cell lines by elec...

Research paper thumbnail of Complexation between the Antioxidant Pterostilbene and Derivatized Cyclodextrins in the Solid State and in Aqueous Solution

Pharmaceuticals

Inadequate aqueous solubilities of bioactive compounds hinder their ability to be developed for m... more Inadequate aqueous solubilities of bioactive compounds hinder their ability to be developed for medicinal applications. The potent antioxidant pterostilbene (PTB) is a case in point. The aim of this study was to use a series of modified water-soluble cyclodextrins (CDs), namely, hydroxypropyl β-CD (HPβCD), dimethylated β-CD (DIMEB), randomly methylated β-CD (RAMEB), and sulfobutyl ether β-CD sodium salt (SBECD) to prepare inclusion complexes of PTB via various solid, semi-solid, and solution-based treatments. Putative CD–PTB products generated by solid-state co-grinding, kneading, irradiation with microwaves, and the evaporative treatment of CD–PTB solutions were considered to have potential for future applications. Primary analytical methods for examining CD–PTB products included differential scanning calorimetry and Fourier transform infrared spectroscopy to detect the occurrence of binary complex formation. Phase solubility analysis was used to probe CD–PTB complexation in an aqu...

Research paper thumbnail of Native Cyclodextrins as Complexation Agents for Pterostilbene: Complex Preparation and Characterization in Solution and in the Solid State

Pharmaceutics

Pterostilbene (3,5-dimethoxy-4′-hydroxystilbene, PTB) is a natural dietary stilbene, occurring pr... more Pterostilbene (3,5-dimethoxy-4′-hydroxystilbene, PTB) is a natural dietary stilbene, occurring primarily in blueberries and Pterocarpus marsupium heartwood. The interest in this compound is related to its different biological and pharmacological properties, such as its antioxidant, anti-inflammatory, and anticarcinogenic activities and its capacity to reduce and regulate cholesterol and blood sugar levels. Nevertheless, its use in therapy is hindered by its low aqueous solubility; to overcome this limitation we studied the feasibility of the use of cyclodextrins (CDs) as solubility-enhancing agents. CDs are natural macrocyclic oligomers composed of α-d-glucose units linked by α-1,4 glycosidic bonds to form torus-shaped molecules, responsible for inclusion complex formation with organic molecules. In particular, the aim of this study was to evaluate the feasibility of complexation between PTB and native CDs using various preparative methods. The isolated solid products were character...

Research paper thumbnail of Alginate-chitosan microspheres for prolonged release of vancomycin loaded on a hydrophobic cyclodextrin

5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2006

Research paper thumbnail of Binary mixtures of vancomycin with amorphous and crystalline cyclodextrins for site-specific controlled release

43° Simposio AFI 2003, 2003

Research paper thumbnail of 2-hydroxypropyl-beta-cyclodextrin as stabilizing agent of G6PD for a possible therapy of favism, an enzyme-deficiency disorder

XVII Simposio ADRITELF, 2000

Research paper thumbnail of Mucoadhesive nanoparticles carrying permeation enhancers for nasal delivery of tacrine hydrochloride

XXI simposio A.D.R.I.T.E.L.F., Cagliari, 10-13 Settembre 2009, 2009

Research paper thumbnail of The influence of pH and water-soluble polymers on naproxen cyclodextrin complexation

Research paper thumbnail of Thermal behaviour and phase diagrams of Tetroxoprim-Sulfonamide Binary Systems

Research paper thumbnail of Vancomycin-triacetyl cyclodextrin combinations for prolonged release of vancomycin