Francesca Papacci - Profile on Academia.edu (original) (raw)

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Papers by Francesca Papacci

Research paper thumbnail of Cationic liposomes formulated with DMPC and a gemini surfactant traverse the cell membrane without causing a significant bio-damage

Biochimica et biophysica acta, 2014

Cationic liposomes have been intensively studied both in basic and applied research because of th... more Cationic liposomes have been intensively studied both in basic and applied research because of their promising potential as non-viral molecular vehicles. This work was aimed to gain more information on the interactions between the plasmamembrane and liposomes formed by a natural phospholipid and a cationic surfactant of the gemini family. The present work was conducted with the synergistic use of diverse experimental approaches: electro-rotation measurements, atomic force microscopy, ζ-potential measurements, laser scanning confocal microscopy and biomolecular/cellular techniques. Electro-rotation measurements pointed out that the interaction of cationic liposomes with the cell membrane alters significantly its dielectric and geometric parameters. This alteration, being accompanied by significant changes of the membrane surface roughness as measured by atomic force microscopy, suggests that the interaction with the liposomes causes locally substantial modifications to the structure ...

Research paper thumbnail of Use of Cat-Anionic Vesicles as Molecular Vectors for Gene Transfer into Target Cells

Use of Cat-Anionic Vesicles as Molecular Vectors for Gene Transfer into Target Cells

Journal of Modern Medicinal Chemistry, 2014

Research paper thumbnail of Cationic liposomes formulated with DMPC and a gemini surfactant traverse the cell membrane without causing a significant bio-damage

Biochimica et biophysica acta, 2014

Cationic liposomes have been intensively studied both in basic and applied research because of th... more Cationic liposomes have been intensively studied both in basic and applied research because of their promising potential as non-viral molecular vehicles. This work was aimed to gain more information on the interactions between the plasmamembrane and liposomes formed by a natural phospholipid and a cationic surfactant of the gemini family. The present work was conducted with the synergistic use of diverse experimental approaches: electro-rotation measurements, atomic force microscopy, ζ-potential measurements, laser scanning confocal microscopy and biomolecular/cellular techniques. Electro-rotation measurements pointed out that the interaction of cationic liposomes with the cell membrane alters significantly its dielectric and geometric parameters. This alteration, being accompanied by significant changes of the membrane surface roughness as measured by atomic force microscopy, suggests that the interaction with the liposomes causes locally substantial modifications to the structure ...

Research paper thumbnail of Use of Cat-Anionic Vesicles as Molecular Vectors for Gene Transfer into Target Cells

Use of Cat-Anionic Vesicles as Molecular Vectors for Gene Transfer into Target Cells

Journal of Modern Medicinal Chemistry, 2014

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