Dr. Prakash A . Bansode | Shivaji University, Kolhapur, India (original) (raw)
Papers by Dr. Prakash A . Bansode
Research on Chemical Intermediates
A novel nano-magnetite supported N-heterocyclic carbenegold complex with pendant ferrocenyl group... more A novel nano-magnetite supported N-heterocyclic carbenegold complex with pendant ferrocenyl group has been prepared by using a multi-step procedure. The complex displayed signi cantly higher anticancer activity against the MCF-7 breast cancer cell line with IC50 = 32.38 µg/mL as compared with standard drug 5-uorouracil (IC50 = 25.29 µg/mL) in the MTT assay. The in-ovo antiangiogenic activity of the complex using chicken chorioallantoic membrane assay showed signi cant decrease in secondary blood vessels indicating that it is e cient angiogenesis inhibitor. The hyperthermia studies of the complex revealed a signi cant speci c absorption rate (SAR) value of 246.974 Wg-1 with therapeutic temperature of 46.8 oC.
A novel nano-magnetite supported N-heterocyclic carbene-gold complex with pendant ferrocenyl grou... more A novel nano-magnetite supported N-heterocyclic carbene-gold complex with pendant ferrocenyl group has been prepared by using a multi-step procedure. The complex displayed significantly higher anticancer activity against the MCF-7 breast cancer cell line with IC50 = 32.38 µg/mL as compared with standard drug 5-fluorouracil (IC50 = 25.29 µg/mL) in the MTT assay. The in-ovo antiangiogenic activity of the complex using chicken chorioallantoic membrane assay showed significant decrease in secondary blood vessels indicating that it is efficient angiogenesis inhibitor. The hyperthermia studies of the complex revealed a significant specific absorption rate (SAR) value of 246.974 Wg-1 with therapeutic temperature of 46.8 oC.
Results in Chemistry, 2023
Two new series of structurally diverse ferrocene tethered pyrimidobenzothiazoles and pyrimidobenz... more Two new series of structurally diverse ferrocene tethered pyrimidobenzothiazoles and pyrimidobenzimidazoles were rationally designed, synthesized and evaluated for their in vitro anticancer activity against human breast cancer cell lines. Among the synthesized series, five molecules displayed significantly higher anticancer activity against breast carcinoma MCF-7 and MDA-MB-231 cell lines (GI50 0.018–0.022 µM) as compared to the standard drug doxorubicin (GI50 0.018 µM). Furthermore, most of the synthesized compounds were found to exhibit significant antioxidant activity in DPPH, SOD and FRAP assays as compared to standard ascorbic acid and trolox. Moreover, some of the compounds were found to be potent anti-angiogenic agents with angiogenic score ranging 0.8–1.4 in in-ovo chick allantoic membrane (CAM) assay. The in-silico molecular docking analysis ascertained the mode of action of target compounds via inhibition of heat shock protein90 (Hsp90).
ChemistrySelect, 2021
Caffeine based N-heterocyclic carbene (NHC)-silver complex anchored on magnetic nanoparticles (MN... more Caffeine based N-heterocyclic carbene (NHC)-silver complex anchored on magnetic nanoparticles (MNP-Caff-NHC@Ag complex) has been prepared by covalent grafting of caffeine on the surface of chloro-functionalized Fe 3 O 4 magnetic nanoparticles followed by complexation with silver (I) acetate. The MNP-Caff-NHC@Ag complex has been characterized by Fourier transform infrared (FT-IR) spectroscopy, energy-dispersive X-ray (EDX) spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA) and vibrating sample magnetometer (VSM) analysis. The MNP-Caff-NHC@Ag complex displayed significant in vitro anticancer activity against human hepatocarcinoma HepG2 cell line and antibacterial activity against Escherichia coli (NCIM-2832), Staphylococcus aureus (NCIM-2654) and Bacillus cereus (NCIM-2703). The hyperthermia studies revealed that MNP-Caff-NHC@Ag complex achieved good therapeutic temperature (47°C) under physiological safe range of field and frequency thereby forecasting potential applications as heating mediators in magnetic hyperthermia for selectively killing of cancer cells.
Launea procumbens commonly known as Pathari belonging to family asteraceae has been investigated ... more Launea procumbens commonly known as Pathari belonging to family asteraceae has been investigated for its anti-urolithiatic activity by constructing an in-vitro model. Various crude extracts of Launea procumbens were evaluated for their potential to dissolve experimentally prepared kidney stones of Calcium oxalate,Calcium phosphate and the results were compared with cystone as a standard polyherbal drug. The detailed phytochemical screening was done to identify active phytoconstituents and photo-micrography was carried out to understand dissolution of stones by extracts.Chloroform ,alcoholic and acetone fractions of plant leaves showed highest dissolution of Calcium oxalate stones as compare to others (63,49,40% resp.) while ethyl acetate, pet ether, acetone fractions of plant leaves were more effective in dissolving Calcium Phosphate (80,30,25% resp.) compared to reference standard-formulation Cystone.
Augmented reality is a technology which can formulate interactive learning environment and foster... more Augmented reality is a technology which can formulate interactive learning environment and foster intellectual curiosity of the students. This study has targeted ‘‘the NMR spectroscopy of hydrocarbons’’ segment of senior college level chemistry classes and, it involved the design and development of a set of Augmented Reality learning tools. Students could control and interact with virtual images using markers and conduct a series of experiments. The AR tool was tested in practice at a senior college in Sangola, Maharashtra, India. Through data analysis and discussion, we conclude that the AR tool has a significant supplemental learning effect as a computer-assisted learning tool and students have positive attitudes toward this software.
Bryophyllum pinnatum commonly known as panphuti belonging to family Crassulaceae has been investi... more Bryophyllum pinnatum commonly known as panphuti belonging to family Crassulaceae has been investigated for its anti-urolithiatic activity by constructing an in-vitro model. Various crude extracts of Bryophyllum pinnatum were evaluated for their potential to dissolve experimentally prepared kidney stones of calcium oxalate, calcium phosphate and the results were compared with cystone as a standard polyherbal drug. The detailed phytochemical screening was done to identify active phytoconstituents and photo-micrography was carried out to understand dissolution of stones by extracts. Chloroform ,alcoholic and acetone fractions of plant leaves showed highest dissolution of Calcium oxalate stones as compare to others (68, 52, 43 % resp.). while Ethyl acetate, pet ether, acetone fractions of plant leaves were more effective in dissolving calcium Phosphate (81, 33, 25% resp.) compared to reference drug Cystone. Copyright©2016, P.A.Bansode et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The flavonoids present in the tea are known to exhibit anticarcinogenic, antimicrobial, antiviral... more The flavonoids present in the tea are known to exhibit anticarcinogenic, antimicrobial, antiviral, antiarteriosclerosis, antihypertensive, antidiabetic, anti-inflammatory and antidiuretic activities and thus they are therapeutically important class of compounds. Therefore it is necessary to find out levels of bioactive compounds in various tea samples. In the present investigation six commercial varieties including black and green tea from Indian market were analyzed for their total flavonoid content using uv-visible spectrophotometer. The total amounts of flavonoid were determined by aluminium chloride method with some modifications and the total flavonoids were expressed as mg/g of quercetin equivalents. The results shown that all tea samples tested found to contain comparable high total flavonoids as rich sources of bioactive compounds and it justifies their use for human health benefits.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Journal of Heterocyclic Chemistry, 2019
Graphene-supported sulfonic acid (Gr@SO 3 H) has been prepared by covalent grafting of (3-mercapt... more Graphene-supported sulfonic acid (Gr@SO 3 H) has been prepared by covalent grafting of (3-mercaptopropyl)trimethoxysilane in the matrix of graphene followed by treatment with sulfuric acid and hydrogen peroxide. Gr@SO 3 H has been successfully characterized by Fourier transform infrared (FT-IR) spectroscopy, Fourier transform Raman (FT-Raman) spectroscopy, CP-MAS 13 C NMR spectroscopy, thermogravimetric analysis (TGA), energy dispersive X-ray analysis (EDX), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) analysis, and X-ray diffractometer (XRD) analysis. Gr@SO 3 H served as a robust heterogeneous catalyst for the synthesis of bioactive 2,3-dihydroquinazolin-4(1H)-ones from anthranilamide and aryl aldehydes in ethanol. Recyclability experiments were executed successfully for six consecutive runs.
Computational Biology and Chemistry, 2019
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
![Research paper thumbnail of Graphene Oxide-Supported Ionic Liquid Phase Catalyzed Synthesis of 3,4-Dihydro-2H-naphtho[2,3-e][1,3]oxazine-5,10-diones](https://attachments.academia-assets.com/89689738/thumbnails/1.jpg)
](Catalysis Letters, 2019
Graphene oxide-supported ionic liquid phase catalyst ([GrFemBenzImi]OH) has been prepared by cova... more Graphene oxide-supported ionic liquid phase catalyst ([GrFemBenzImi]OH) has been prepared by covalent grafting of 1-N-ferrocenylmethyl benzimidazole in the matrix of functionalized graphene oxide followed by anion metathesis reaction. [GrFemBenzImi]OH has been characterized by fourier transform infrared (FT-IR) spectroscopy, fourier transform Raman (FT-Raman spectroscopy), CP-MAS 13 C NMR spectroscopy, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), energy dispersive X-ray (EDX) analysis, X-ray diffraction (XRD) and Brunauer-Emmett-Teller (BET) surface area. [GrFemBenzImi]OH served as a robust heterogeneous catalyst for the synthesis of bioactive 3,4-dihydro-2H-naphtho[2,3-e][1,3]oxazine-5,10-diones by reaction of formaldehyde, 2-hydroxy-1,4-naphthoquinone with structurally diverse aromatic anilines. Recyclability experiments were executed successfully for six consecutive runs.
Applied Organometallic Chemistry, 2019
Journal of Organometallic Chemistry, 2018
A new magnetically retrievable N-heterocyclic carbene-silver complex with wingtip ferrocenyl grou... more A new magnetically retrievable N-heterocyclic carbene-silver complex with wingtip ferrocenyl group has been prepared by multi-step procedure. The formation of complex was confirmed on the basis of analytical techniques such as FT-IR, Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), X-Ray diffraction (XRD), transmission electron microscopy (TEM), VSM (vibrating sample magnetometer) analysis. The complex was successfully employed as an efficient heterogeneous catalyst for Sonogashira coupling reaction of aryl halides with terminal alkynes. The catalyst could be separated easily by applying external magnet. The reusability studies of catalyst revealed that complex can be reused up to eight times without significant decrease in catalytic activity.
Journal of Molecular Liquids, 2019
A novel series of ferrocene tethered ionic liquids (ILs) has been synthesized by quaternization o... more A novel series of ferrocene tethered ionic liquids (ILs) has been synthesized by quaternization of 1-N-(ferrocenylmethyl)benzimidazole, 1-N-(ferrocenylmethyl)imidazole and 1-N-(ferrocenylmethyl)-1,2,4-triazole with long chain alkyl bromides. The synthesized ILs were screened for their anticancer activity against human breast cancer cell line MCF-7. ILs 2a-d and 4b displayed significant anticancer activity (GI 50 0.016-0.064 µM). IL 2d was found to be the most active IL with GI 50 value of 0.016 µM which was even less than the standard drug doxorubicin (GI 50 = 0.018 µM). All ILs exhibit moderate to good selectivity against breast cancer cells MCF-7 over normal Vero cells. The ADME prediction studies revealed that ferrocene tethered ILs exhibit good pharmacological parameters. The molecular docking studies ascertained mode of action of these ILs via inhibition of lysosomal peptidase cathepsin B.
Applied Organometallic Chemistry, 2019
Ferrocene tethered N-heterocyclic carbene-copper complex anchored on graphene ([GrFemImi]NHC@Cu c... more Ferrocene tethered N-heterocyclic carbene-copper complex anchored on graphene ([GrFemImi]NHC@Cu complex) has been synthesized by covalent grafting of ferrocenyl ionic liquid in the matrix of graphene followed by metallation with copper (I) iodide. The [GrFemImi]NHC@Cu complex has been characterized by fourier transform infrared (FT-IR), fourier transform Raman (FT-Raman), CP-MAS 13 C NMR spectroscopy, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), energy dispersive Xray (EDX) analysis, X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) surface area analysis and X-ray diffractometer (XRD) analysis. This novel complex served as a robust heterogeneous catalyst for the synthesis of bioactive N-aryl sulfonamides from variety of aryl boronic acids and sulfonyl azides in ethanol by Chan-Lam coupling. Recyclability experiments were executed successfully for six consecutive runs.
Journal of Molecular Structure, 2018
Anticancer activity of ruthenocenyl chalcones and their molecular docking studies
RSC Advances, 2016
Potentially antibreast cancer enamidines were synthesized and evaluated against human breast canc... more Potentially antibreast cancer enamidines were synthesized and evaluated against human breast cancer cell line MCF7 displaying GI50values lower than doxorubicin.
Research on Chemical Intermediates
A novel nano-magnetite supported N-heterocyclic carbenegold complex with pendant ferrocenyl group... more A novel nano-magnetite supported N-heterocyclic carbenegold complex with pendant ferrocenyl group has been prepared by using a multi-step procedure. The complex displayed signi cantly higher anticancer activity against the MCF-7 breast cancer cell line with IC50 = 32.38 µg/mL as compared with standard drug 5-uorouracil (IC50 = 25.29 µg/mL) in the MTT assay. The in-ovo antiangiogenic activity of the complex using chicken chorioallantoic membrane assay showed signi cant decrease in secondary blood vessels indicating that it is e cient angiogenesis inhibitor. The hyperthermia studies of the complex revealed a signi cant speci c absorption rate (SAR) value of 246.974 Wg-1 with therapeutic temperature of 46.8 oC.
A novel nano-magnetite supported N-heterocyclic carbene-gold complex with pendant ferrocenyl grou... more A novel nano-magnetite supported N-heterocyclic carbene-gold complex with pendant ferrocenyl group has been prepared by using a multi-step procedure. The complex displayed significantly higher anticancer activity against the MCF-7 breast cancer cell line with IC50 = 32.38 µg/mL as compared with standard drug 5-fluorouracil (IC50 = 25.29 µg/mL) in the MTT assay. The in-ovo antiangiogenic activity of the complex using chicken chorioallantoic membrane assay showed significant decrease in secondary blood vessels indicating that it is efficient angiogenesis inhibitor. The hyperthermia studies of the complex revealed a significant specific absorption rate (SAR) value of 246.974 Wg-1 with therapeutic temperature of 46.8 oC.
Results in Chemistry, 2023
Two new series of structurally diverse ferrocene tethered pyrimidobenzothiazoles and pyrimidobenz... more Two new series of structurally diverse ferrocene tethered pyrimidobenzothiazoles and pyrimidobenzimidazoles were rationally designed, synthesized and evaluated for their in vitro anticancer activity against human breast cancer cell lines. Among the synthesized series, five molecules displayed significantly higher anticancer activity against breast carcinoma MCF-7 and MDA-MB-231 cell lines (GI50 0.018–0.022 µM) as compared to the standard drug doxorubicin (GI50 0.018 µM). Furthermore, most of the synthesized compounds were found to exhibit significant antioxidant activity in DPPH, SOD and FRAP assays as compared to standard ascorbic acid and trolox. Moreover, some of the compounds were found to be potent anti-angiogenic agents with angiogenic score ranging 0.8–1.4 in in-ovo chick allantoic membrane (CAM) assay. The in-silico molecular docking analysis ascertained the mode of action of target compounds via inhibition of heat shock protein90 (Hsp90).
ChemistrySelect, 2021
Caffeine based N-heterocyclic carbene (NHC)-silver complex anchored on magnetic nanoparticles (MN... more Caffeine based N-heterocyclic carbene (NHC)-silver complex anchored on magnetic nanoparticles (MNP-Caff-NHC@Ag complex) has been prepared by covalent grafting of caffeine on the surface of chloro-functionalized Fe 3 O 4 magnetic nanoparticles followed by complexation with silver (I) acetate. The MNP-Caff-NHC@Ag complex has been characterized by Fourier transform infrared (FT-IR) spectroscopy, energy-dispersive X-ray (EDX) spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA) and vibrating sample magnetometer (VSM) analysis. The MNP-Caff-NHC@Ag complex displayed significant in vitro anticancer activity against human hepatocarcinoma HepG2 cell line and antibacterial activity against Escherichia coli (NCIM-2832), Staphylococcus aureus (NCIM-2654) and Bacillus cereus (NCIM-2703). The hyperthermia studies revealed that MNP-Caff-NHC@Ag complex achieved good therapeutic temperature (47°C) under physiological safe range of field and frequency thereby forecasting potential applications as heating mediators in magnetic hyperthermia for selectively killing of cancer cells.
Launea procumbens commonly known as Pathari belonging to family asteraceae has been investigated ... more Launea procumbens commonly known as Pathari belonging to family asteraceae has been investigated for its anti-urolithiatic activity by constructing an in-vitro model. Various crude extracts of Launea procumbens were evaluated for their potential to dissolve experimentally prepared kidney stones of Calcium oxalate,Calcium phosphate and the results were compared with cystone as a standard polyherbal drug. The detailed phytochemical screening was done to identify active phytoconstituents and photo-micrography was carried out to understand dissolution of stones by extracts.Chloroform ,alcoholic and acetone fractions of plant leaves showed highest dissolution of Calcium oxalate stones as compare to others (63,49,40% resp.) while ethyl acetate, pet ether, acetone fractions of plant leaves were more effective in dissolving Calcium Phosphate (80,30,25% resp.) compared to reference standard-formulation Cystone.
Augmented reality is a technology which can formulate interactive learning environment and foster... more Augmented reality is a technology which can formulate interactive learning environment and foster intellectual curiosity of the students. This study has targeted ‘‘the NMR spectroscopy of hydrocarbons’’ segment of senior college level chemistry classes and, it involved the design and development of a set of Augmented Reality learning tools. Students could control and interact with virtual images using markers and conduct a series of experiments. The AR tool was tested in practice at a senior college in Sangola, Maharashtra, India. Through data analysis and discussion, we conclude that the AR tool has a significant supplemental learning effect as a computer-assisted learning tool and students have positive attitudes toward this software.
Bryophyllum pinnatum commonly known as panphuti belonging to family Crassulaceae has been investi... more Bryophyllum pinnatum commonly known as panphuti belonging to family Crassulaceae has been investigated for its anti-urolithiatic activity by constructing an in-vitro model. Various crude extracts of Bryophyllum pinnatum were evaluated for their potential to dissolve experimentally prepared kidney stones of calcium oxalate, calcium phosphate and the results were compared with cystone as a standard polyherbal drug. The detailed phytochemical screening was done to identify active phytoconstituents and photo-micrography was carried out to understand dissolution of stones by extracts. Chloroform ,alcoholic and acetone fractions of plant leaves showed highest dissolution of Calcium oxalate stones as compare to others (68, 52, 43 % resp.). while Ethyl acetate, pet ether, acetone fractions of plant leaves were more effective in dissolving calcium Phosphate (81, 33, 25% resp.) compared to reference drug Cystone. Copyright©2016, P.A.Bansode et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The flavonoids present in the tea are known to exhibit anticarcinogenic, antimicrobial, antiviral... more The flavonoids present in the tea are known to exhibit anticarcinogenic, antimicrobial, antiviral, antiarteriosclerosis, antihypertensive, antidiabetic, anti-inflammatory and antidiuretic activities and thus they are therapeutically important class of compounds. Therefore it is necessary to find out levels of bioactive compounds in various tea samples. In the present investigation six commercial varieties including black and green tea from Indian market were analyzed for their total flavonoid content using uv-visible spectrophotometer. The total amounts of flavonoid were determined by aluminium chloride method with some modifications and the total flavonoids were expressed as mg/g of quercetin equivalents. The results shown that all tea samples tested found to contain comparable high total flavonoids as rich sources of bioactive compounds and it justifies their use for human health benefits.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Journal of Heterocyclic Chemistry, 2019
Graphene-supported sulfonic acid (Gr@SO 3 H) has been prepared by covalent grafting of (3-mercapt... more Graphene-supported sulfonic acid (Gr@SO 3 H) has been prepared by covalent grafting of (3-mercaptopropyl)trimethoxysilane in the matrix of graphene followed by treatment with sulfuric acid and hydrogen peroxide. Gr@SO 3 H has been successfully characterized by Fourier transform infrared (FT-IR) spectroscopy, Fourier transform Raman (FT-Raman) spectroscopy, CP-MAS 13 C NMR spectroscopy, thermogravimetric analysis (TGA), energy dispersive X-ray analysis (EDX), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) analysis, and X-ray diffractometer (XRD) analysis. Gr@SO 3 H served as a robust heterogeneous catalyst for the synthesis of bioactive 2,3-dihydroquinazolin-4(1H)-ones from anthranilamide and aryl aldehydes in ethanol. Recyclability experiments were executed successfully for six consecutive runs.
Computational Biology and Chemistry, 2019
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Catalysis Letters, 2019
Graphene oxide-supported ionic liquid phase catalyst ([GrFemBenzImi]OH) has been prepared by cova... more Graphene oxide-supported ionic liquid phase catalyst ([GrFemBenzImi]OH) has been prepared by covalent grafting of 1-N-ferrocenylmethyl benzimidazole in the matrix of functionalized graphene oxide followed by anion metathesis reaction. [GrFemBenzImi]OH has been characterized by fourier transform infrared (FT-IR) spectroscopy, fourier transform Raman (FT-Raman spectroscopy), CP-MAS 13 C NMR spectroscopy, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), energy dispersive X-ray (EDX) analysis, X-ray diffraction (XRD) and Brunauer-Emmett-Teller (BET) surface area. [GrFemBenzImi]OH served as a robust heterogeneous catalyst for the synthesis of bioactive 3,4-dihydro-2H-naphtho[2,3-e][1,3]oxazine-5,10-diones by reaction of formaldehyde, 2-hydroxy-1,4-naphthoquinone with structurally diverse aromatic anilines. Recyclability experiments were executed successfully for six consecutive runs.
Applied Organometallic Chemistry, 2019
Journal of Organometallic Chemistry, 2018
A new magnetically retrievable N-heterocyclic carbene-silver complex with wingtip ferrocenyl grou... more A new magnetically retrievable N-heterocyclic carbene-silver complex with wingtip ferrocenyl group has been prepared by multi-step procedure. The formation of complex was confirmed on the basis of analytical techniques such as FT-IR, Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), X-Ray diffraction (XRD), transmission electron microscopy (TEM), VSM (vibrating sample magnetometer) analysis. The complex was successfully employed as an efficient heterogeneous catalyst for Sonogashira coupling reaction of aryl halides with terminal alkynes. The catalyst could be separated easily by applying external magnet. The reusability studies of catalyst revealed that complex can be reused up to eight times without significant decrease in catalytic activity.
Journal of Molecular Liquids, 2019
A novel series of ferrocene tethered ionic liquids (ILs) has been synthesized by quaternization o... more A novel series of ferrocene tethered ionic liquids (ILs) has been synthesized by quaternization of 1-N-(ferrocenylmethyl)benzimidazole, 1-N-(ferrocenylmethyl)imidazole and 1-N-(ferrocenylmethyl)-1,2,4-triazole with long chain alkyl bromides. The synthesized ILs were screened for their anticancer activity against human breast cancer cell line MCF-7. ILs 2a-d and 4b displayed significant anticancer activity (GI 50 0.016-0.064 µM). IL 2d was found to be the most active IL with GI 50 value of 0.016 µM which was even less than the standard drug doxorubicin (GI 50 = 0.018 µM). All ILs exhibit moderate to good selectivity against breast cancer cells MCF-7 over normal Vero cells. The ADME prediction studies revealed that ferrocene tethered ILs exhibit good pharmacological parameters. The molecular docking studies ascertained mode of action of these ILs via inhibition of lysosomal peptidase cathepsin B.
Applied Organometallic Chemistry, 2019
Ferrocene tethered N-heterocyclic carbene-copper complex anchored on graphene ([GrFemImi]NHC@Cu c... more Ferrocene tethered N-heterocyclic carbene-copper complex anchored on graphene ([GrFemImi]NHC@Cu complex) has been synthesized by covalent grafting of ferrocenyl ionic liquid in the matrix of graphene followed by metallation with copper (I) iodide. The [GrFemImi]NHC@Cu complex has been characterized by fourier transform infrared (FT-IR), fourier transform Raman (FT-Raman), CP-MAS 13 C NMR spectroscopy, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), energy dispersive Xray (EDX) analysis, X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) surface area analysis and X-ray diffractometer (XRD) analysis. This novel complex served as a robust heterogeneous catalyst for the synthesis of bioactive N-aryl sulfonamides from variety of aryl boronic acids and sulfonyl azides in ethanol by Chan-Lam coupling. Recyclability experiments were executed successfully for six consecutive runs.
Journal of Molecular Structure, 2018
Anticancer activity of ruthenocenyl chalcones and their molecular docking studies
RSC Advances, 2016
Potentially antibreast cancer enamidines were synthesized and evaluated against human breast canc... more Potentially antibreast cancer enamidines were synthesized and evaluated against human breast cancer cell line MCF7 displaying GI50values lower than doxorubicin.