Manohar Kengar | Shivaji University, Kolhapur, India (original) (raw)
Papers by Manohar Kengar
International Journal of Scientific Research in Science and Technology
The purpose of present research work is to expand various suppository bases in order to control d... more The purpose of present research work is to expand various suppository bases in order to control disadvantage of traditional base and to analyses the release of Phenytoin from this bases. Cocoa butter, poloxamer 407, PEG2000 used as base and prepared by fusion method. Improved base is estimated for physicochemical parameters like appearance, hardness, weight variation, hydroxyl vale and this bases used in the preparation of Phenytoin suppositories. Suppositories of Phenytoin were estimated for physical parameter drug content, In vitro drug release reports. Selected suppositories bases were specify by X-ray diffraction, Infra Red spectroscopy studies. Physicochemical parameters of suppositories base show within limit. Hydroxyl value of bases observed in limits 89.76-134.64. From the result it is analyzed Polaxmer 407 and PEG2000 and hydrogenated vegetable oil show fast release. Physicochemical parameters of Phenytoin suppositories show within limit. Product contains poloxamer 407, hyd...
International Journal of Scientific Research in Science and Technology
Medicinal plants have been in use since 5000 years. Oldest known herbal is Pen- t’sao written by ... more Medicinal plants have been in use since 5000 years. Oldest known herbal is Pen- t’sao written by emperor Shen-Nung around 3000 years. It contains 365 drugs, one for each day of the year. Indians worked meticulously to examine and classify the herbs. Charaka made 50 groups of 10 herbs, each of which would suffice an ordinary physician's need. Cryptostegia grandiflora Linn Roxb. (Apocynaceae), commonly known as “Vilayti vakundi” is found all in dry area in India. The study includes preparation of different extracts by successive solvent extraction for detail analysis. Fluorescence analysis of different successive extract and powder were noted under UV light and normal ordinary light, which signifies there characteristics. Preliminary qualitative chemical test for different extracts showed presence of glycosides, flavonoids, fixed oil and fats, phenolic compounds, protein and amino acids, tannins, gum and mucilage and carbohydrates. Qualitative phytochemical analysis of methanol ex...
INDIAN DRUGS, 2019
In acid-base titration or acid-base neutralization reaction the change in color due to change pH ... more In acid-base titration or acid-base neutralization reaction the change in color due to change pH of the solution is caused due to a third substance which is termed as acid-base indicator or pH indicator. Every indicator shows different range of colors at different pH ranges. Synthetic indicators have been widely employed as indicators in acid-base titrations; however, due to environmental pollution, availability and cost, natural compounds are best alternates. Natural pigments in plants are highly colored substances and may show sharp color changes with variation in pH. In the present study an attempt has been made to extract natural indicator from flower of Aristolochia bracteolate. The equivalence points of the titrations namely strong acid-strong base, strong acid-weak base, weak acid-strong base and weak acid weak base titrations, using flower extract of A. bracteolate were coincident with the equivalence points obtained by the synthetic indicator phenolpthalein. From the result...
Today, computers are so ubiquitous in pharmaceutical research and development that it may be hard... more Today, computers are so ubiquitous in pharmaceutical research and development that it may be hard to imagine a time when there were no computers to assist the medicinal chemist or biologist. Quarter century ago, the notion of a computer on the desk of every scientist and company manager was not even contemplated. Now, computers are absolutely essential for generating, managing, and transmitting information. The aim of this paper is to give a brief account of the historical development. It is story of ascendancy and one that continues to unfold. As science advanced scientist began understanding the relation between the chemical structure of a molecule and its molecular properties including biological activity. On the basis of molecular properties so fanny molecule then its structure can be predicted & investigated in laboratory.
International Journal of Scientific Research in Science and Technology
The present investigation has been undertaken to study the antipsoritic activity properties of et... more The present investigation has been undertaken to study the antipsoritic activity properties of ethyl acetate and aqueous extracts of Simarouba glauca and wound healing activity properties of petroleum ether and acetone extracts of Cinnamomum tmala. The both plants have a long history in herbal medicine in many countries. Experiments were conducted following standard procedures. Both extracts were evaluated for their in vitro antipsoritic activity and wound healing activity properties. The PECT and ACCT suspension of Cinnamomum tmala extract as Myrcene were administered topically, for evaluating the wound healing potential in excision wound model for in infected excision for fifty teen days. Povidone iodine was the standard for excision wound models. Simarouba glauca extract as Quassine evaluating for antipsoritic activity. The result may be attributed to the phytoconstituents such as terpenoids present in it which may be due to their individual or cumulative effect that enhanced wou...
Asian Journal of Pharmaceutical Research
Communicating with variety of patients will primary concern in healthcare today. The way of commu... more Communicating with variety of patients will primary concern in healthcare today. The way of communication in which the doctors, Patients, Physicians or therapist convey the massage regarding the care, relation between patient and pharmacist affected by the different factor which include the patient’s healthcare literacy, the amount of information provided clear vision how much the individuals listen to each other, and tone of voice. In daily routine the contact and communication in between the different types of patients, in this basically the important way that is better communication is achieve better patients compliance, also they identify the problems related to the patient by reviewing prescription, case, notes, records and initial consultation with pharmacist for best effective communication there will various steps in that personal call to the patient, consultation to the pharmacist about the medication and therapy.
Research & Reviews: Journal of Neuroscience, Jan 14, 2021
The COVID-19 pandemic is a major health crisis affecting all nations. The present study discussed... more The COVID-19 pandemic is a major health crisis affecting all nations. The present study discussed the mental health condition during COVID-19 occurrence among healthcare professionals, patients and huge population. The COVID-19 epidemic has been spreading at a fast pace in India, USA, Russia, China, Italy, France and other Asian and European countries. This COVID-19 epidemic has rapidly increased attention all over the world. The patients, healthcare professionals, medical equipment providers and the population are under mental pressure which may cause various types of psychological disorders, such as depression, anxiety, fear and insomnia.
Research Journal of Topical and Cosmetic Sciences, 2018
Asian Journal of Pharmaceutical Analysis, 2018
International Journal of Drug Development and Research, 2020
The aim of the present work was to Design and development of Nifedipine extended release tablet 9... more The aim of the present work was to Design and development of Nifedipine extended release tablet 90 mg by double rotary bi layered compression machine that can provide continuous drug release for period of 24 hours. The granules prepared using polymers such as polyethylene glycol 4000, HPMC and cellulose acetate etc. the osmotic pump mechanism was used, after that mechanical drilling machine was used for drilling with respect in size. Prior to compression, the prepared granules were evaluated for flow and compression characteristics. The principle shows two compartments was present such as the drug layer and push layer, after some time push layer goes contact with aqueous medium then swelling of push layer and suspend drug particle and flow through the delivery orifice. Prepared Nifedipine extended release tablet was evaluated for in vitro drug release study. The prepared Nifedipine extended release tablet 90 mg showed good mechanical properties (hardness and friability) as well as g...
Asian Journal of Research in Pharmaceutical Science, 2020
Asian Journal of Pharmacy and Technology, 2020
Research Journal of Topical and Cosmetic Sciences, 2019
The concept of beauty and cosmetics is as ancient as mankind and civilization. So, they use vario... more The concept of beauty and cosmetics is as ancient as mankind and civilization. So, they use various beauty products that have herbs to look charming and young. Herbal cosmetics are now-a-days widely used by the common people because of concept of fewer side effects and with a better safety and security profile. The present work was aimed to formulate herbal oil for general purpose (application in hairs) using various herbs. The formulated hair oil contain different herbal plants which are traditionally utilized for hair growth plants used are Triphala, Nirgudi, Licorice, Jatamansi, Aloe vera, Shatavari, til oil and coconut oil. The formulated herbal oil was evaluated and various parameters such as viscosity, saponification value, pH etc.
Asian Journal of Pharmaceutical Research, 2019
Research Journal of Pharmaceutical Dosage Forms and Technology, 2019
Asian Journal of Pharmacy and Technology, 2019
Asian Journal of Research in Pharmaceutical Science, 2019
Alzheimer disease (AD) is the most common form of the dementia which occurs among older people ab... more Alzheimer disease (AD) is the most common form of the dementia which occurs among older people above the age of 60 years. The Alzheimer's disease once considered a rare disorder and it is now seen as a major public health problem that is seriously affecting millions of older people and their families world over. The incidence of AD ranges from 1 to 4 percent of the population per year rising from its lowest level at ages 65 to 70 years to rates that may approach 6 percent for those over the age of 85 years. Strategies for neurorescue, neurorepair, neuroprotection or treatment are being actively pursued by the basic, translational, and clinical research communities. As our population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. In all cultures, the origins of herbal medicine are lost in the mists of time. There is little doubt that humans used herbs for healing well before anything could be written about them. At some point in an advancing culture, written documents become the repository for knowledge that had been passed on from one generation to the next. Among the earliest such documents are those describing the religious beliefs of the people and those describing the medical practices.
Asian Journal of Pharmaceutical Research, 2019
Pharmacovigilance has its own unique terminology that is important to understand. Pharmacovigilan... more Pharmacovigilance has its own unique terminology that is important to understand. Pharmacovigilance also known as drug safety, is the pharmacological science relating to the collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. As such, pharmacovigilance heavily focuses on adverse drug reactions, or ADRs, which are defined as any response to a drug which is noxious and unintended, including lack of efficacy (the condition that this definition only applies with the doses normally used for the prophylaxis, diagnosis or therapy of disease, or for the modification of physiological disorder function was excluded with the latest amendment of the applicable legislation). Hence, need of pharmacovigilance arises which include, securing the early detection of new adverse reactions or patients subgroups of exceptional sensitivity; and introducing certain measures in order to manage such risks. Moreover, it is essential that new and medically still evolving treatments are monitored for their effectiveness and safety under real-life conditions after being marketed. The role of pharmacovigilance is to check the safety monitoring in clinical trials involves collecting adverse events, laboratory investigations and details of the clinical examination of patients. Pharmacovigilance staff may be involved to varying degrees in all phases of clinical trials, including the planning, execution, data analysis and reporting of safety.
International Journal of Scientific Research in Science and Technology
The purpose of present research work is to expand various suppository bases in order to control d... more The purpose of present research work is to expand various suppository bases in order to control disadvantage of traditional base and to analyses the release of Phenytoin from this bases. Cocoa butter, poloxamer 407, PEG2000 used as base and prepared by fusion method. Improved base is estimated for physicochemical parameters like appearance, hardness, weight variation, hydroxyl vale and this bases used in the preparation of Phenytoin suppositories. Suppositories of Phenytoin were estimated for physical parameter drug content, In vitro drug release reports. Selected suppositories bases were specify by X-ray diffraction, Infra Red spectroscopy studies. Physicochemical parameters of suppositories base show within limit. Hydroxyl value of bases observed in limits 89.76-134.64. From the result it is analyzed Polaxmer 407 and PEG2000 and hydrogenated vegetable oil show fast release. Physicochemical parameters of Phenytoin suppositories show within limit. Product contains poloxamer 407, hyd...
International Journal of Scientific Research in Science and Technology
Medicinal plants have been in use since 5000 years. Oldest known herbal is Pen- t’sao written by ... more Medicinal plants have been in use since 5000 years. Oldest known herbal is Pen- t’sao written by emperor Shen-Nung around 3000 years. It contains 365 drugs, one for each day of the year. Indians worked meticulously to examine and classify the herbs. Charaka made 50 groups of 10 herbs, each of which would suffice an ordinary physician's need. Cryptostegia grandiflora Linn Roxb. (Apocynaceae), commonly known as “Vilayti vakundi” is found all in dry area in India. The study includes preparation of different extracts by successive solvent extraction for detail analysis. Fluorescence analysis of different successive extract and powder were noted under UV light and normal ordinary light, which signifies there characteristics. Preliminary qualitative chemical test for different extracts showed presence of glycosides, flavonoids, fixed oil and fats, phenolic compounds, protein and amino acids, tannins, gum and mucilage and carbohydrates. Qualitative phytochemical analysis of methanol ex...
INDIAN DRUGS, 2019
In acid-base titration or acid-base neutralization reaction the change in color due to change pH ... more In acid-base titration or acid-base neutralization reaction the change in color due to change pH of the solution is caused due to a third substance which is termed as acid-base indicator or pH indicator. Every indicator shows different range of colors at different pH ranges. Synthetic indicators have been widely employed as indicators in acid-base titrations; however, due to environmental pollution, availability and cost, natural compounds are best alternates. Natural pigments in plants are highly colored substances and may show sharp color changes with variation in pH. In the present study an attempt has been made to extract natural indicator from flower of Aristolochia bracteolate. The equivalence points of the titrations namely strong acid-strong base, strong acid-weak base, weak acid-strong base and weak acid weak base titrations, using flower extract of A. bracteolate were coincident with the equivalence points obtained by the synthetic indicator phenolpthalein. From the result...
Today, computers are so ubiquitous in pharmaceutical research and development that it may be hard... more Today, computers are so ubiquitous in pharmaceutical research and development that it may be hard to imagine a time when there were no computers to assist the medicinal chemist or biologist. Quarter century ago, the notion of a computer on the desk of every scientist and company manager was not even contemplated. Now, computers are absolutely essential for generating, managing, and transmitting information. The aim of this paper is to give a brief account of the historical development. It is story of ascendancy and one that continues to unfold. As science advanced scientist began understanding the relation between the chemical structure of a molecule and its molecular properties including biological activity. On the basis of molecular properties so fanny molecule then its structure can be predicted & investigated in laboratory.
International Journal of Scientific Research in Science and Technology
The present investigation has been undertaken to study the antipsoritic activity properties of et... more The present investigation has been undertaken to study the antipsoritic activity properties of ethyl acetate and aqueous extracts of Simarouba glauca and wound healing activity properties of petroleum ether and acetone extracts of Cinnamomum tmala. The both plants have a long history in herbal medicine in many countries. Experiments were conducted following standard procedures. Both extracts were evaluated for their in vitro antipsoritic activity and wound healing activity properties. The PECT and ACCT suspension of Cinnamomum tmala extract as Myrcene were administered topically, for evaluating the wound healing potential in excision wound model for in infected excision for fifty teen days. Povidone iodine was the standard for excision wound models. Simarouba glauca extract as Quassine evaluating for antipsoritic activity. The result may be attributed to the phytoconstituents such as terpenoids present in it which may be due to their individual or cumulative effect that enhanced wou...
Asian Journal of Pharmaceutical Research
Communicating with variety of patients will primary concern in healthcare today. The way of commu... more Communicating with variety of patients will primary concern in healthcare today. The way of communication in which the doctors, Patients, Physicians or therapist convey the massage regarding the care, relation between patient and pharmacist affected by the different factor which include the patient’s healthcare literacy, the amount of information provided clear vision how much the individuals listen to each other, and tone of voice. In daily routine the contact and communication in between the different types of patients, in this basically the important way that is better communication is achieve better patients compliance, also they identify the problems related to the patient by reviewing prescription, case, notes, records and initial consultation with pharmacist for best effective communication there will various steps in that personal call to the patient, consultation to the pharmacist about the medication and therapy.
Research & Reviews: Journal of Neuroscience, Jan 14, 2021
The COVID-19 pandemic is a major health crisis affecting all nations. The present study discussed... more The COVID-19 pandemic is a major health crisis affecting all nations. The present study discussed the mental health condition during COVID-19 occurrence among healthcare professionals, patients and huge population. The COVID-19 epidemic has been spreading at a fast pace in India, USA, Russia, China, Italy, France and other Asian and European countries. This COVID-19 epidemic has rapidly increased attention all over the world. The patients, healthcare professionals, medical equipment providers and the population are under mental pressure which may cause various types of psychological disorders, such as depression, anxiety, fear and insomnia.
Research Journal of Topical and Cosmetic Sciences, 2018
Asian Journal of Pharmaceutical Analysis, 2018
International Journal of Drug Development and Research, 2020
The aim of the present work was to Design and development of Nifedipine extended release tablet 9... more The aim of the present work was to Design and development of Nifedipine extended release tablet 90 mg by double rotary bi layered compression machine that can provide continuous drug release for period of 24 hours. The granules prepared using polymers such as polyethylene glycol 4000, HPMC and cellulose acetate etc. the osmotic pump mechanism was used, after that mechanical drilling machine was used for drilling with respect in size. Prior to compression, the prepared granules were evaluated for flow and compression characteristics. The principle shows two compartments was present such as the drug layer and push layer, after some time push layer goes contact with aqueous medium then swelling of push layer and suspend drug particle and flow through the delivery orifice. Prepared Nifedipine extended release tablet was evaluated for in vitro drug release study. The prepared Nifedipine extended release tablet 90 mg showed good mechanical properties (hardness and friability) as well as g...
Asian Journal of Research in Pharmaceutical Science, 2020
Asian Journal of Pharmacy and Technology, 2020
Research Journal of Topical and Cosmetic Sciences, 2019
The concept of beauty and cosmetics is as ancient as mankind and civilization. So, they use vario... more The concept of beauty and cosmetics is as ancient as mankind and civilization. So, they use various beauty products that have herbs to look charming and young. Herbal cosmetics are now-a-days widely used by the common people because of concept of fewer side effects and with a better safety and security profile. The present work was aimed to formulate herbal oil for general purpose (application in hairs) using various herbs. The formulated hair oil contain different herbal plants which are traditionally utilized for hair growth plants used are Triphala, Nirgudi, Licorice, Jatamansi, Aloe vera, Shatavari, til oil and coconut oil. The formulated herbal oil was evaluated and various parameters such as viscosity, saponification value, pH etc.
Asian Journal of Pharmaceutical Research, 2019
Research Journal of Pharmaceutical Dosage Forms and Technology, 2019
Asian Journal of Pharmacy and Technology, 2019
Asian Journal of Research in Pharmaceutical Science, 2019
Alzheimer disease (AD) is the most common form of the dementia which occurs among older people ab... more Alzheimer disease (AD) is the most common form of the dementia which occurs among older people above the age of 60 years. The Alzheimer's disease once considered a rare disorder and it is now seen as a major public health problem that is seriously affecting millions of older people and their families world over. The incidence of AD ranges from 1 to 4 percent of the population per year rising from its lowest level at ages 65 to 70 years to rates that may approach 6 percent for those over the age of 85 years. Strategies for neurorescue, neurorepair, neuroprotection or treatment are being actively pursued by the basic, translational, and clinical research communities. As our population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. In all cultures, the origins of herbal medicine are lost in the mists of time. There is little doubt that humans used herbs for healing well before anything could be written about them. At some point in an advancing culture, written documents become the repository for knowledge that had been passed on from one generation to the next. Among the earliest such documents are those describing the religious beliefs of the people and those describing the medical practices.
Asian Journal of Pharmaceutical Research, 2019
Pharmacovigilance has its own unique terminology that is important to understand. Pharmacovigilan... more Pharmacovigilance has its own unique terminology that is important to understand. Pharmacovigilance also known as drug safety, is the pharmacological science relating to the collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. As such, pharmacovigilance heavily focuses on adverse drug reactions, or ADRs, which are defined as any response to a drug which is noxious and unintended, including lack of efficacy (the condition that this definition only applies with the doses normally used for the prophylaxis, diagnosis or therapy of disease, or for the modification of physiological disorder function was excluded with the latest amendment of the applicable legislation). Hence, need of pharmacovigilance arises which include, securing the early detection of new adverse reactions or patients subgroups of exceptional sensitivity; and introducing certain measures in order to manage such risks. Moreover, it is essential that new and medically still evolving treatments are monitored for their effectiveness and safety under real-life conditions after being marketed. The role of pharmacovigilance is to check the safety monitoring in clinical trials involves collecting adverse events, laboratory investigations and details of the clinical examination of patients. Pharmacovigilance staff may be involved to varying degrees in all phases of clinical trials, including the planning, execution, data analysis and reporting of safety.