Marta Bosia | Università Vita-Salute San Raffaele (original) (raw)

Papers by Marta Bosia

Schizophrenia Research: Cognition, Dec 1, 2014

European Neuropsychopharmacology, Mar 1, 2009

drug existed, the other antidepressant was given non-randomly [2]. TISI was defined as previously... more drug existed, the other antidepressant was given non-randomly [2]. TISI was defined as previously described [1] and comprised both treatment-emergent and treatment-worsening suicidal ideation. To relax the assumption of conditional independence in the responses of the same person and for the same centre of recruitment, we used a generalised linear latent and mixed model with a subject-specific random intercept nested in a centre-specific random intercept. All analyses were adjusted on age, gender, randomisation status, dropouts, history of suicide attempts and drug. Results: 213 (35.9%) of the subjects had TISI during the 12 weeks of follow-up. High baseline NS (NS for subjects with TISI: 103.2 (16) vs. NS for subjects without TISI: 101.6 (15.5), p = 0.0001) and low HA (105.7 (26.6) vs. 107.7 (24.2), p < 0.0001) predicted TISI. The association with HA was accounted mainly by the individuals taking nortriptyline. Moreover among the subjects taking nortriptyline, low baseline RD (p = 0.001), self-directedness (SD) (0.018), cooperativeness (CO) (p = 0.0002) and self-transcendence (ST) (p = 0.017) predicted TISI. No gender effect was observed. Conclusions: In agreement with previous studies of suicidal behaviour, we found that high NS and low RD, SD, and CO predicted TISI. Only HA and ST showed an opposite direction to previous association studies. Nevertheless our results suggest a continuum between suicidal behaviour and TISI. In the line of our hypothesis, NS was associated with TISI in the whole sample; whereas, RD was associated with TISI only in subjects taking nortriptyline. However, in contrary of our hypothesis, HA predicted TISI mainly in individuals taking nortriptyline. This result suggests an involvement of noradrenergic system also in this more serotoninergic dimension. Our data also suggest that the three character dimensions (SD, CO and ST) are linked to TISI through perturbation of noradrenergic function. The limitations of the study have been addressed previously [1]. In conclusion, our data suggest that the evaluation of personality, using Cloninger's model, could be used as a predictor of increased risk of TISI during antidepressant treatment.

Schizophrenia Research: Cognition, 2022

Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and functi... more Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and functional recovery. This expert group paper brings together experts in schizophrenia treatment to discuss scientific progress in the domain of cognitive impairment to address cognitive impairments and their consequences in the most effective way. We report on the onset and course of cognitive deficits, linking them to the alterations in brain function and structure in schizophrenia and discussing their role in predicting the transition to psychosis in people at risk. We then address the assessment tools with reference to functioning and social cognition, examining the role of subjective measures and addressing new methods for measuring functional outcomes including technology based approaches. Finally, we briefly review treatment options for cognitive deficits, focusing on cognitive remediation programs, highlighting their effects on brain activity and conclude with the potential benefit of individualized integrated interventions combing cognitive remediation with other approaches.

Healthcare services require rapid assessment tools, as well as the possibility of using them flex... more Healthcare services require rapid assessment tools, as well as the possibility of using them flexibly in different contexts, such as those experienced during the COVID-19 pandemic, that favor remote interaction over traditional care. These needs become especially challenging when assessing language and communication skills, for which few tools exist. This work aimed to develop and evaluate the psychometric properties of a novel test for the rapid and tele-assessment of pragmatic skills in Italian-speaking individuals, including an alternate form to allow for monitoring and follow-up. Inspired by Gricean pragmatics and modelled after the already validated Assessment of Pragmatic Abilities and Cognitive Substrates (APACS) in-person test, the new APACS Brief Remote test includes 18 original items assessing discourse and non-literal language understanding in expressive and receptive modalities. The test lasts approximately 10 minutes and is suited for video-conference administration. Re...

European Neuropsychopharmacology, Dec 1, 2021

European Psychiatry, Apr 1, 2021

Conclusions: The differential impact of trauma severity on ER in males and females with FEP may b... more Conclusions: The differential impact of trauma severity on ER in males and females with FEP may be theoretically interpreted as the distinct way that hypervigilance affects the sexes. Early intervention services should refine social cognitive interventions in male and female trauma survivors to facilitate social functioning improvements.

European Neuropsychopharmacology, Dec 1, 2021

Psychiatry Research-neuroimaging, 2019

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service... more This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  Integrating multiple data to disentangle functioning in schizophrenia is necessary.  A non-linear approach might better capture clinical heterogeneity in schizophrenia.  Four Profiles of functioning emerged, with quantitative and qualitative differences.  Implications of functional profiles encompass both clinical and research fields.

Journal of The International Neuropsychological Society, Sep 11, 2019

Objectives:Premorbid dysfunction during childhood and adolescence is well documented in patients ... more Objectives:Premorbid dysfunction during childhood and adolescence is well documented in patients with schizophrenia. Literature pointed out multiple premorbid trajectories leading to different patients’ cognitive status, symptomatology, and global functioning after disease onset. This study aimed at identifying groups of premorbid trajectories and disentangling between group differences in clinical and cognitive measures, focusing on theory of mind (ToM) and autistic traits (ATs).Methods:Ninety-seven patients with schizophrenia were recruited and assessed for cognitive and ToM abilities, psychopathology, and ATs. A two-step cluster analysis identified three different groups of patients based on premorbid adjustment during childhood, adolescence, and late adolescence (i.e., stable-good, stable-poor, and “deteriorating”).Results:Compared to 66 healthy controls, results showed a widespread impairment in cognitive and ToM abilities among all groups of patients, except for affective ToM and executive functions in the stable-good group. Moreover, the stable-poor group exhibited more pronounced ATs and a more severe ToM impairment, compared to the other two groups of patients.Conclusions:Our findings highlight the existence of a group of patients with poor premorbid adjustment since childhood, more pronounced ATs and a severe ToM impairment affecting those basic mentalizing skills that are usually preserved in schizophrenia. Results might have intriguing implications in identifying underpinning endophenotypes and implementing cutting-edge rehabilitation programs.

European Neuropsychopharmacology, Dec 1, 2021

European Neuropsychopharmacology, Sep 1, 2009

European Neuropsychopharmacology, Dec 1, 2021

Journal of Psychiatric Research, May 1, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Neuroscience applied, 2022

Psychiatry Research Communications, Apr 1, 2022

Schizophrenia Research: Cognition, Dec 1, 2014

European Neuropsychopharmacology, Mar 1, 2009

drug existed, the other antidepressant was given non-randomly [2]. TISI was defined as previously... more drug existed, the other antidepressant was given non-randomly [2]. TISI was defined as previously described [1] and comprised both treatment-emergent and treatment-worsening suicidal ideation. To relax the assumption of conditional independence in the responses of the same person and for the same centre of recruitment, we used a generalised linear latent and mixed model with a subject-specific random intercept nested in a centre-specific random intercept. All analyses were adjusted on age, gender, randomisation status, dropouts, history of suicide attempts and drug. Results: 213 (35.9%) of the subjects had TISI during the 12 weeks of follow-up. High baseline NS (NS for subjects with TISI: 103.2 (16) vs. NS for subjects without TISI: 101.6 (15.5), p = 0.0001) and low HA (105.7 (26.6) vs. 107.7 (24.2), p < 0.0001) predicted TISI. The association with HA was accounted mainly by the individuals taking nortriptyline. Moreover among the subjects taking nortriptyline, low baseline RD (p = 0.001), self-directedness (SD) (0.018), cooperativeness (CO) (p = 0.0002) and self-transcendence (ST) (p = 0.017) predicted TISI. No gender effect was observed. Conclusions: In agreement with previous studies of suicidal behaviour, we found that high NS and low RD, SD, and CO predicted TISI. Only HA and ST showed an opposite direction to previous association studies. Nevertheless our results suggest a continuum between suicidal behaviour and TISI. In the line of our hypothesis, NS was associated with TISI in the whole sample; whereas, RD was associated with TISI only in subjects taking nortriptyline. However, in contrary of our hypothesis, HA predicted TISI mainly in individuals taking nortriptyline. This result suggests an involvement of noradrenergic system also in this more serotoninergic dimension. Our data also suggest that the three character dimensions (SD, CO and ST) are linked to TISI through perturbation of noradrenergic function. The limitations of the study have been addressed previously [1]. In conclusion, our data suggest that the evaluation of personality, using Cloninger's model, could be used as a predictor of increased risk of TISI during antidepressant treatment.

Schizophrenia Research: Cognition, 2022

Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and functi... more Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and functional recovery. This expert group paper brings together experts in schizophrenia treatment to discuss scientific progress in the domain of cognitive impairment to address cognitive impairments and their consequences in the most effective way. We report on the onset and course of cognitive deficits, linking them to the alterations in brain function and structure in schizophrenia and discussing their role in predicting the transition to psychosis in people at risk. We then address the assessment tools with reference to functioning and social cognition, examining the role of subjective measures and addressing new methods for measuring functional outcomes including technology based approaches. Finally, we briefly review treatment options for cognitive deficits, focusing on cognitive remediation programs, highlighting their effects on brain activity and conclude with the potential benefit of individualized integrated interventions combing cognitive remediation with other approaches.

Healthcare services require rapid assessment tools, as well as the possibility of using them flex... more Healthcare services require rapid assessment tools, as well as the possibility of using them flexibly in different contexts, such as those experienced during the COVID-19 pandemic, that favor remote interaction over traditional care. These needs become especially challenging when assessing language and communication skills, for which few tools exist. This work aimed to develop and evaluate the psychometric properties of a novel test for the rapid and tele-assessment of pragmatic skills in Italian-speaking individuals, including an alternate form to allow for monitoring and follow-up. Inspired by Gricean pragmatics and modelled after the already validated Assessment of Pragmatic Abilities and Cognitive Substrates (APACS) in-person test, the new APACS Brief Remote test includes 18 original items assessing discourse and non-literal language understanding in expressive and receptive modalities. The test lasts approximately 10 minutes and is suited for video-conference administration. Re...

European Neuropsychopharmacology, Dec 1, 2021

European Psychiatry, Apr 1, 2021

Conclusions: The differential impact of trauma severity on ER in males and females with FEP may b... more Conclusions: The differential impact of trauma severity on ER in males and females with FEP may be theoretically interpreted as the distinct way that hypervigilance affects the sexes. Early intervention services should refine social cognitive interventions in male and female trauma survivors to facilitate social functioning improvements.

European Neuropsychopharmacology, Dec 1, 2021

Psychiatry Research-neuroimaging, 2019

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service... more This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  Integrating multiple data to disentangle functioning in schizophrenia is necessary.  A non-linear approach might better capture clinical heterogeneity in schizophrenia.  Four Profiles of functioning emerged, with quantitative and qualitative differences.  Implications of functional profiles encompass both clinical and research fields.

Journal of The International Neuropsychological Society, Sep 11, 2019

Objectives:Premorbid dysfunction during childhood and adolescence is well documented in patients ... more Objectives:Premorbid dysfunction during childhood and adolescence is well documented in patients with schizophrenia. Literature pointed out multiple premorbid trajectories leading to different patients’ cognitive status, symptomatology, and global functioning after disease onset. This study aimed at identifying groups of premorbid trajectories and disentangling between group differences in clinical and cognitive measures, focusing on theory of mind (ToM) and autistic traits (ATs).Methods:Ninety-seven patients with schizophrenia were recruited and assessed for cognitive and ToM abilities, psychopathology, and ATs. A two-step cluster analysis identified three different groups of patients based on premorbid adjustment during childhood, adolescence, and late adolescence (i.e., stable-good, stable-poor, and “deteriorating”).Results:Compared to 66 healthy controls, results showed a widespread impairment in cognitive and ToM abilities among all groups of patients, except for affective ToM and executive functions in the stable-good group. Moreover, the stable-poor group exhibited more pronounced ATs and a more severe ToM impairment, compared to the other two groups of patients.Conclusions:Our findings highlight the existence of a group of patients with poor premorbid adjustment since childhood, more pronounced ATs and a severe ToM impairment affecting those basic mentalizing skills that are usually preserved in schizophrenia. Results might have intriguing implications in identifying underpinning endophenotypes and implementing cutting-edge rehabilitation programs.

European Neuropsychopharmacology, Dec 1, 2021

European Neuropsychopharmacology, Sep 1, 2009

European Neuropsychopharmacology, Dec 1, 2021

Journal of Psychiatric Research, May 1, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Neuroscience applied, 2022

Psychiatry Research Communications, Apr 1, 2022