Liliana Rogozea | Transylvania University of Brasov (original) (raw)

Papers by Liliana Rogozea

Proceedings of the …, 2009

ABSTRACT This paper present the role of ethics using the electronic data, specifically electronic... more ABSTRACT This paper present the role of ethics using the electronic data, specifically electronic card. According with the EU development of a solution for provide information on the patient's medical history, about his or her diseases, treatment made and of course about payment for private medical services. The security is very important and helps us to assure the confidentiality of the data, but, in the same time the accessibility for medical data.

Jurnal Medical Brasovean, 2020

Obiectiv: Pacienții cu epilepsie pot fi ținte ale discriminării și se confruntă cu o calitate a v... more Obiectiv: Pacienții cu epilepsie pot fi ținte ale discriminării și se confruntă cu o calitate a vieții mai scăzută și în ciuda dezvoltării în ultimii douăzeci de ani a medicamentelor antiepileptice o parte dintre aceștia manifestă rezistență la tratament. Obiectivul acestei lucrări este de a corela conceptul de epilepsie farmacorezistentă, cu modalitățile de diagnostic, tratament și impactul asupra calității vieții pe baza datelor disponibile din literatură. Concluzie:Calitatea vieții pacienților cu epilepsie trebuie să îi preocupe pe medicii curanți, iar decizia de prescriere și ajustare a tratamentului trebuie raportată la dobândirea absenței crizelor cu cât mai puține efecte adverse. Sunt necesare studii asupra pacienților cu epilepsie din România cu privire la calitatea vieții și compararea datelor cu cele existente internațional.

The introduction of clozapine for the treatment of non responsive patients with schizophrenia has... more The introduction of clozapine for the treatment of non responsive patients with schizophrenia has determined a real hope among patients, families and psychiatrists. This treatment is available that appears to be more effective than the standard or typical neuroleptics for many such treatment-resistant schizophrenic patients. A growing number of reports suggest that clozapine may also have a role in other psychiatric conditions such as manic episode. Even though this review will focus on treatment- resistant positive symptoms, there is good evidence that psychosocial treatments, such as vocational rehabilitation and social skills training, can contribute to recovery of function once the debilitating psychotic, or positive, symptoms are adequately treated. The data from our study add to the growing evidence for efficacy of clozapine in schizophrenia.

The article is a remembering of the status of Romanian balneology 100 years ago by underlining th... more The article is a remembering of the status of Romanian balneology 100 years ago by underlining the national and international impact of International Congress of Thalasotherapy organised in 1928 in our country, in the context of blooming development of Romania in the time between the First and the Second World War. Information published in journals, articles and books of balneology were used and interpreted ("Curierul B ăilor"-"The Courier of Baths, Climatic Resorts and Tourism", "Revista de Hidrologie Medicala si Climatologie"-"The Magazine of Medical Hydrology and Climatology", numbers published in 1928 and special editions dedicated to the International Congress of Thalasotherapy and National Balneal, Climatic and Touristy Exhibition). Internationally, the Congress represented a unique chance to inform Europe especially about the Romanian scientific concerns and activity in the field of balneology and thalasotherapy and about the potential ...

David (1990) identified three over lapping dimensions in clinicians use of the term insight: a) t... more David (1990) identified three over lapping dimensions in clinicians use of the term insight: a) the recognition that one has a mental illness; b) the ability to relabel unusual mental events as pathological and compliance with treatment. All these aspects can occur independently and need not follow a fixed sequence or simple hierarchy. The four criteria (objectivity, materiality, independence and ethical significance) and their application to lack of insight in schizophrenia increases the chance that persons in like circumstances will be treated equally. Because insight equals or exceeds incompetence on each of the four criteria, intervention based upon lack of insight is more legitimate and ethically justified .

SAGE Open Medicine, 2020

Objective: We aimed to evaluate the association of risk factors such as smoking and professional ... more Objective: We aimed to evaluate the association of risk factors such as smoking and professional status (students vs employed) as determinants of disparities in perceived wellness among Romanian individuals. Methods: We conducted a cross-sectional study in which 145 participants were enrolled from December 2017 to February 2018, in Brasov, Brasov County, Transylvania, Romania. We used a simplified Perceived Wellness Survey model to measure the holistic individual perceived wellness status by professional and smoking status. Basic descriptive and multivariate analyses of variance were used to assess and contrast participants’ characteristics and wellness score distributions. A factor analysis was used to estimate Kaiser–Meyer–Olkin values and calculate standardized Cronbach’s coefficients. Results: The average age of our participants was 27.7 years. Compared with students, more employed participants tended to smoke electronic cigarettes ( p

Jurnal Medical Brasovean, 2019

To appreciate the real progress achieved in the epidemiology and in the clinical part of hospital... more To appreciate the real progress achieved in the epidemiology and in the clinical part of hospital acquired infections it is important to understand the history of nosocomial infections. The historical sources available were difficult to access, and they were revised for different historical periods, ranging from simple to complex, from direct observation to objectification, to the barriers that are now in place to effectively control of nosocomial infections. Rezumat Pentru a aprecia progresele actuale obținute în epidemiologia și clinica infecțiilor asociate actului medical este important să înțelegem istoricul infecțiilor nosocomiale. Sursele istorice disponibile, dificil de accesat au fost revizuite pentru perioade istorice diferite, care parcurg drumul de la simplu la complex, de la observație directă la obiectivizare, la barierele care se ridică acum în controlul eficient al nosocomialității.

Jurnal Medical Brasovean, 2020

Resveratrol is a powerful antioxidant found in grape beans, blueberries, rosehip and wine. Due to... more Resveratrol is a powerful antioxidant found in grape beans, blueberries, rosehip and wine. Due to its antioxidant and anti-inflammatory properties, it can also be consumed as a supplement. Purpose of the work was to determine the optimal chromatographic conditions for the chromatographic dosing of resveratrol using HPLC-UV / VIS detection. As an apparatus, an HPLC liquid chromatograph with Shimadzu LC-20ADsp equipped with C18 column-Macherey Nagel, Nucleosil 5 µm it was used. For a real sample tested, resveratrol Helcor 25 mg supplemental tablet was used, and the chosen solvents were absolute ethyl alcohol and phosphate buffer system at pH 8.0. The performed calibration curves indicate a near-linearity coefficient which indicates a good linearization of the working methods. A higher sensitivity was observed in the case of experiments with absolute ethyl alcohol. In the case of tests performed on real samples, the degree of recovery of the bioactive compound was calculated by the interpolation method. For the experiments with ethyl alcohol solvent, a 84% resveratrol recovery rate was calculated, and in the case of phosphate buffer experiments it had a value of 116.21±0.19% (using the calibration curve specific to the peak areas) and an overestimation of 161.76 ± 0.19% (using the calibration curve specific to the height of the peaks). The methods can be successfully used as references for other assays for determinations of resveratrol Rezumat Resveratrolul este un antioxidant puternic regăsit în boabele de struguri, afine, măceșe și vin. Având în vedere proprietățile lui antioxidante și antiinflamatoare, acesta este consumat și sub forma suplimentelor alimentare. Scopul acestei lucrări a fost determinarea condițiilor cromatografice optime pentru dozarea resveratrolului folosind sistemul HPLC-cu detecție UV/VIS. Ca aparatură s-a utilizat un cromatograf de lichide HPLC cu echipamentul Shimadzu LC-20ADsp echipat cu o coloană C18-Macherey Nagel, Nucleosil 5 µm. Pentru proba reală testată s-au folosit comprimate de supliment alimentar de resveratrol Helcor 25 mg, iar ca solvenți s-au ales alcool etilic absolut și sistem tampon fosfat la pH 8.0. Curbele de calibrare realizate indică un coeficient de liniaritate aproape unitar ceea ce indică o liniarizare bună a metodelor de lucru. O sensibilitate mai crescută s-a evidențiat în cazul experimentelor cu alcool etilic absolut. În cazul testelor efectuate pe probe reale de supliment alimentar s-a calculat prin metoda interpolării gradul de regăsire a compusului bioactiv. Pentru experimentele cu solvent alcool etilic s-a calculat un grad de regăsire a resveratrolului de 84%, iar în cazul experimentelor cu sistem tampon fosfat a avut o valoare de 116,21±0,19% (folosind dreapta de calibrare specifică ariilor picurilor) și respectiv o supraestimare de 161,76±0,19% (folosind dreapta de calibrare specifică înălțimii picurilor). Metodele se pot utiliza cu succes ca referințe și pentru alte analize pentru determinări ale resveratrolului.

Medicine and Pharmacy Reports, 2019

Background and aim. Physiotherapy has a distinct feature in terms of patient relationship, regard... more Background and aim. Physiotherapy has a distinct feature in terms of patient relationship, regarding the level of communication, especially how physical therapy sessions take place throughout the rehabilitation process. One of the particularities encountered in Romanian physiotherapy practice is related to obtaining informed consent (IC), considering that the initial contact of the patient is with a rehabilitation doctor when general consent is obtained. The aim of this study was to investigate Romanian physiotherapists aspects related to the frequency and use of IC at the beginning of physiotherapy. Method. A cross-sectional study was conducted among Romanian physiotherapists using a survey with 2 open and 37 closed items, including nine demographics items, developed after a systematic literature review. The closed items were Likert type scales, measuring frequency or agreement on scale from 1 to 5. The questionnaire was distributed online from November 2017 until May 2018 and data...

Science of The Total Environment, 2018

Persistent organochlorine pollutants (POPs) are highly lipophilic and resistant to degradation, h... more Persistent organochlorine pollutants (POPs) are highly lipophilic and resistant to degradation, hence these substances are commonly found in the environment even decades after their prohibition. The aim of the present study was to determine human serum concentrations of POPs and polycyclic aromatic hydrocarbons (PAHs) in the Romanian population, investigating the role of demographic variables on the body burden of such chemicals. A cross-sectional study including a total of 121 subjects from Brasov (Transylvania region) was designed. The concentration of 62 chemicals, including organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (BDEs) and PAHs, was measured by gas chromatography-mass spectrometry (GC-MS) in the serum of the participants. p,p′-DDE and β-HCH were detected in 100% and 62% of the series (median values = 2.1 and 0.5 μg/L); PCB-153 was detected in 77.7% of the subjects and PCB-28 showed the highest median concentration (0.5 μg/L); BDE-47 was detected at a low concentration in 11.6% of the individuals; phenanthrene and naphthalene were present in 98.3% and 38.8% of the serum samples (median values = 0.9 and 6.5 μg/L, respectively). Age was the main determinant of the total body burden of OCPs and PCBs. A positive correlation was observed between p,p′-DDE and age (Spearman Rho = 0.312, P b 0.0001), suggesting the prevalence of higher levels of pollutants at older ages. The present results showed a significant decrease in serum levels of p,p′

Environmental research, 2018

Smoking is considered an important source for inorganic elements, most of them toxic for human he... more Smoking is considered an important source for inorganic elements, most of them toxic for human health. During the last years, there has been a significant increase in the use of e-cigarettes, although the role of them as source of inorganic elements has not been well established. A cross-sectional study including a total of 150 subjects from Brasov (Romania), divided into three groups (non-smokers, cigarette smokers and electronic cigarettes smokers) were recruited to disclose the role of smoking on the human exposure to inorganic elements. Concentration of 42 elements, including trace elements, elements in the ATSDR's priority pollutant list and rare earth elements (REE) were measured by ICP-MS in the blood serum of participants. Cigarette smokers showed the highest levels of copper, molybdenum, zinc, antimony, and strontium. Electronic cigarette (e-cigarette) users presented the highest concentrations of selenium, silver, and vanadium. Beryllium, europium and lanthanides were ...

BMC health services research, Jul 6, 2017

The main objective of this cross sectional study was to assess the psychometric properties of a n... more The main objective of this cross sectional study was to assess the psychometric properties of a new research instrument. The secondary aim was to analyze patients' levels of dissatisfaction with the professionalism of medical staff. A social survey questionnaire was created and administered online. The instrument consisted of two scales: the 30-item patient dissatisfaction scale and the 10 items institutional scale. In this article, we assessed only the patient dissatisfaction scale. The research population includes 1838 subjects. The statistical procedures used were descriptive statistics, Pearson's correlation, and factorial analyses with the SPSS.19 software. The internal consistency of the instrument was determined using the Cronbach's alpha coefficient. We used a principal component analysis to investigate the factorial validity of the scale. The patients' scale of dissatisfaction obtained an alpha Cronbach score of 0.81. Three latent factors corresponding to th...

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2015

The study aims to present the main ethical dilemmas that research on animals raised for anyone in... more The study aims to present the main ethical dilemmas that research on animals raised for anyone involved in this process, starting from the idea that there are rights of animals to be known and respected. The evolution of medicine is inextricably linked to the production of new drugs, the occurrence of surgical techniques; none of these can be possible without the study of experimental animals, in vivo experimentation being part of the process of medical research. The article analyzes the main ethical dilemmas related to the use of animals in medical research, in the current legislative context and historical perspective of achieving such studies. The use of animals in medical research must be conducted in accordance with clearly established moral rules, which facilitate reducing to the maximum the negative effects on the animals, avoiding unnecessary suffering to them and especially to facilitate progress achievement with the minimum possible animals sacrificed.

Proceedings of the 12th …, 2010

The aim of this paper is the assessment of the ultrasound and mammography examination in detectio... more The aim of this paper is the assessment of the ultrasound and mammography examination in detection of mammary opacities. This study will analyse the value and the limits of these methods in diagnosis. Mammary ultrasound is complementary to mammography. Combining the two methods will increase the accuracy in finding and defining the mammary nodule, suspect of malignancy.

Revista Romana De Bioetica, Jul 30, 2014

Informed consent is the act by which the patient makes decisions regarding therapeutic conduct or... more Informed consent is the act by which the patient makes decisions regarding therapeutic conduct or participation in a medical research, based on information provided by a doctor or scientist. Providing adequate information is therefore an essential prerequisite for allowing exertion of patient right to voluntarism. Adding to many aspects of current debate or research related to informed consent in developed Western civilisations it has been shown that particular ethical challenges derive from particularities in locations without a vast experience in the protection of human subjects' rights, as well as from cultural or socio-economical particularities. Meanwhile, there is a lack of information concerning the level of conceptualization of the informed consent in Eastern European countries. The aim of this study is to evaluate the people's levels of understanding and information regarding various general aspects of informed consent and to identify gaps and needs which could be solved by subsequent actions of education on the subject. Our study results showed a great willingness of people to be informed about the medical act, as well as the deficiencies existing in real practice and significant lack of information regarding general aspects of informed consent. The design of a web site aimed to improve Romanian people's understanding of the concept of informed consent will enable people to get actively involved in the process when needed, and to shift from viewing it as a formality or as a measure of physician's legal protection, to an expression of patient oriented medicine, meant ultimately to improve patient outcome and satisfaction.

Organizing health campaigns in Romania at the beginning of the twentieth century was a proof of t... more Organizing health campaigns in Romania at the beginning of the twentieth century was a proof of the concern that our country had begun to pay to population's health. In the 1938 health campaign, Braşov County was an example of organization, implementation and provision of human and material resources and the preparation of monographs for the localities in the county.

Proceedings of the …, 2008

This paper is the result of a research that examined, analyzed and interpreted the differences in... more This paper is the result of a research that examined, analyzed and interpreted the differences in the perceptions of violence in communication in six different university settings in Romania, by investigating the relative and the combined influence of the place and ...

Bulletin of the Transilvania University of Braşov• Vol, 2010

Abstract: Developing sanitary campaigns in the county of Braşov emerged as absolute necessity und... more Abstract: Developing sanitary campaigns in the county of Braşov emerged as absolute necessity under the conditions of the first half of the 20th century and especially during the period in-between World Wars. The case study comprised within the article herein – led to achieving the ...

Proceedings of the …, 2009

ABSTRACT This paper present the role of ethics using the electronic data, specifically electronic... more ABSTRACT This paper present the role of ethics using the electronic data, specifically electronic card. According with the EU development of a solution for provide information on the patient's medical history, about his or her diseases, treatment made and of course about payment for private medical services. The security is very important and helps us to assure the confidentiality of the data, but, in the same time the accessibility for medical data.

Jurnal Medical Brasovean, 2020

Obiectiv: Pacienții cu epilepsie pot fi ținte ale discriminării și se confruntă cu o calitate a v... more Obiectiv: Pacienții cu epilepsie pot fi ținte ale discriminării și se confruntă cu o calitate a vieții mai scăzută și în ciuda dezvoltării în ultimii douăzeci de ani a medicamentelor antiepileptice o parte dintre aceștia manifestă rezistență la tratament. Obiectivul acestei lucrări este de a corela conceptul de epilepsie farmacorezistentă, cu modalitățile de diagnostic, tratament și impactul asupra calității vieții pe baza datelor disponibile din literatură. Concluzie:Calitatea vieții pacienților cu epilepsie trebuie să îi preocupe pe medicii curanți, iar decizia de prescriere și ajustare a tratamentului trebuie raportată la dobândirea absenței crizelor cu cât mai puține efecte adverse. Sunt necesare studii asupra pacienților cu epilepsie din România cu privire la calitatea vieții și compararea datelor cu cele existente internațional.

The introduction of clozapine for the treatment of non responsive patients with schizophrenia has... more The introduction of clozapine for the treatment of non responsive patients with schizophrenia has determined a real hope among patients, families and psychiatrists. This treatment is available that appears to be more effective than the standard or typical neuroleptics for many such treatment-resistant schizophrenic patients. A growing number of reports suggest that clozapine may also have a role in other psychiatric conditions such as manic episode. Even though this review will focus on treatment- resistant positive symptoms, there is good evidence that psychosocial treatments, such as vocational rehabilitation and social skills training, can contribute to recovery of function once the debilitating psychotic, or positive, symptoms are adequately treated. The data from our study add to the growing evidence for efficacy of clozapine in schizophrenia.

The article is a remembering of the status of Romanian balneology 100 years ago by underlining th... more The article is a remembering of the status of Romanian balneology 100 years ago by underlining the national and international impact of International Congress of Thalasotherapy organised in 1928 in our country, in the context of blooming development of Romania in the time between the First and the Second World War. Information published in journals, articles and books of balneology were used and interpreted ("Curierul B ăilor"-"The Courier of Baths, Climatic Resorts and Tourism", "Revista de Hidrologie Medicala si Climatologie"-"The Magazine of Medical Hydrology and Climatology", numbers published in 1928 and special editions dedicated to the International Congress of Thalasotherapy and National Balneal, Climatic and Touristy Exhibition). Internationally, the Congress represented a unique chance to inform Europe especially about the Romanian scientific concerns and activity in the field of balneology and thalasotherapy and about the potential ...

David (1990) identified three over lapping dimensions in clinicians use of the term insight: a) t... more David (1990) identified three over lapping dimensions in clinicians use of the term insight: a) the recognition that one has a mental illness; b) the ability to relabel unusual mental events as pathological and compliance with treatment. All these aspects can occur independently and need not follow a fixed sequence or simple hierarchy. The four criteria (objectivity, materiality, independence and ethical significance) and their application to lack of insight in schizophrenia increases the chance that persons in like circumstances will be treated equally. Because insight equals or exceeds incompetence on each of the four criteria, intervention based upon lack of insight is more legitimate and ethically justified .

SAGE Open Medicine, 2020

Objective: We aimed to evaluate the association of risk factors such as smoking and professional ... more Objective: We aimed to evaluate the association of risk factors such as smoking and professional status (students vs employed) as determinants of disparities in perceived wellness among Romanian individuals. Methods: We conducted a cross-sectional study in which 145 participants were enrolled from December 2017 to February 2018, in Brasov, Brasov County, Transylvania, Romania. We used a simplified Perceived Wellness Survey model to measure the holistic individual perceived wellness status by professional and smoking status. Basic descriptive and multivariate analyses of variance were used to assess and contrast participants’ characteristics and wellness score distributions. A factor analysis was used to estimate Kaiser–Meyer–Olkin values and calculate standardized Cronbach’s coefficients. Results: The average age of our participants was 27.7 years. Compared with students, more employed participants tended to smoke electronic cigarettes ( p

Jurnal Medical Brasovean, 2019

To appreciate the real progress achieved in the epidemiology and in the clinical part of hospital... more To appreciate the real progress achieved in the epidemiology and in the clinical part of hospital acquired infections it is important to understand the history of nosocomial infections. The historical sources available were difficult to access, and they were revised for different historical periods, ranging from simple to complex, from direct observation to objectification, to the barriers that are now in place to effectively control of nosocomial infections. Rezumat Pentru a aprecia progresele actuale obținute în epidemiologia și clinica infecțiilor asociate actului medical este important să înțelegem istoricul infecțiilor nosocomiale. Sursele istorice disponibile, dificil de accesat au fost revizuite pentru perioade istorice diferite, care parcurg drumul de la simplu la complex, de la observație directă la obiectivizare, la barierele care se ridică acum în controlul eficient al nosocomialității.

Jurnal Medical Brasovean, 2020

Resveratrol is a powerful antioxidant found in grape beans, blueberries, rosehip and wine. Due to... more Resveratrol is a powerful antioxidant found in grape beans, blueberries, rosehip and wine. Due to its antioxidant and anti-inflammatory properties, it can also be consumed as a supplement. Purpose of the work was to determine the optimal chromatographic conditions for the chromatographic dosing of resveratrol using HPLC-UV / VIS detection. As an apparatus, an HPLC liquid chromatograph with Shimadzu LC-20ADsp equipped with C18 column-Macherey Nagel, Nucleosil 5 µm it was used. For a real sample tested, resveratrol Helcor 25 mg supplemental tablet was used, and the chosen solvents were absolute ethyl alcohol and phosphate buffer system at pH 8.0. The performed calibration curves indicate a near-linearity coefficient which indicates a good linearization of the working methods. A higher sensitivity was observed in the case of experiments with absolute ethyl alcohol. In the case of tests performed on real samples, the degree of recovery of the bioactive compound was calculated by the interpolation method. For the experiments with ethyl alcohol solvent, a 84% resveratrol recovery rate was calculated, and in the case of phosphate buffer experiments it had a value of 116.21±0.19% (using the calibration curve specific to the peak areas) and an overestimation of 161.76 ± 0.19% (using the calibration curve specific to the height of the peaks). The methods can be successfully used as references for other assays for determinations of resveratrol Rezumat Resveratrolul este un antioxidant puternic regăsit în boabele de struguri, afine, măceșe și vin. Având în vedere proprietățile lui antioxidante și antiinflamatoare, acesta este consumat și sub forma suplimentelor alimentare. Scopul acestei lucrări a fost determinarea condițiilor cromatografice optime pentru dozarea resveratrolului folosind sistemul HPLC-cu detecție UV/VIS. Ca aparatură s-a utilizat un cromatograf de lichide HPLC cu echipamentul Shimadzu LC-20ADsp echipat cu o coloană C18-Macherey Nagel, Nucleosil 5 µm. Pentru proba reală testată s-au folosit comprimate de supliment alimentar de resveratrol Helcor 25 mg, iar ca solvenți s-au ales alcool etilic absolut și sistem tampon fosfat la pH 8.0. Curbele de calibrare realizate indică un coeficient de liniaritate aproape unitar ceea ce indică o liniarizare bună a metodelor de lucru. O sensibilitate mai crescută s-a evidențiat în cazul experimentelor cu alcool etilic absolut. În cazul testelor efectuate pe probe reale de supliment alimentar s-a calculat prin metoda interpolării gradul de regăsire a compusului bioactiv. Pentru experimentele cu solvent alcool etilic s-a calculat un grad de regăsire a resveratrolului de 84%, iar în cazul experimentelor cu sistem tampon fosfat a avut o valoare de 116,21±0,19% (folosind dreapta de calibrare specifică ariilor picurilor) și respectiv o supraestimare de 161,76±0,19% (folosind dreapta de calibrare specifică înălțimii picurilor). Metodele se pot utiliza cu succes ca referințe și pentru alte analize pentru determinări ale resveratrolului.

Medicine and Pharmacy Reports, 2019

Background and aim. Physiotherapy has a distinct feature in terms of patient relationship, regard... more Background and aim. Physiotherapy has a distinct feature in terms of patient relationship, regarding the level of communication, especially how physical therapy sessions take place throughout the rehabilitation process. One of the particularities encountered in Romanian physiotherapy practice is related to obtaining informed consent (IC), considering that the initial contact of the patient is with a rehabilitation doctor when general consent is obtained. The aim of this study was to investigate Romanian physiotherapists aspects related to the frequency and use of IC at the beginning of physiotherapy. Method. A cross-sectional study was conducted among Romanian physiotherapists using a survey with 2 open and 37 closed items, including nine demographics items, developed after a systematic literature review. The closed items were Likert type scales, measuring frequency or agreement on scale from 1 to 5. The questionnaire was distributed online from November 2017 until May 2018 and data...

Science of The Total Environment, 2018

Persistent organochlorine pollutants (POPs) are highly lipophilic and resistant to degradation, h... more Persistent organochlorine pollutants (POPs) are highly lipophilic and resistant to degradation, hence these substances are commonly found in the environment even decades after their prohibition. The aim of the present study was to determine human serum concentrations of POPs and polycyclic aromatic hydrocarbons (PAHs) in the Romanian population, investigating the role of demographic variables on the body burden of such chemicals. A cross-sectional study including a total of 121 subjects from Brasov (Transylvania region) was designed. The concentration of 62 chemicals, including organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (BDEs) and PAHs, was measured by gas chromatography-mass spectrometry (GC-MS) in the serum of the participants. p,p′-DDE and β-HCH were detected in 100% and 62% of the series (median values = 2.1 and 0.5 μg/L); PCB-153 was detected in 77.7% of the subjects and PCB-28 showed the highest median concentration (0.5 μg/L); BDE-47 was detected at a low concentration in 11.6% of the individuals; phenanthrene and naphthalene were present in 98.3% and 38.8% of the serum samples (median values = 0.9 and 6.5 μg/L, respectively). Age was the main determinant of the total body burden of OCPs and PCBs. A positive correlation was observed between p,p′-DDE and age (Spearman Rho = 0.312, P b 0.0001), suggesting the prevalence of higher levels of pollutants at older ages. The present results showed a significant decrease in serum levels of p,p′

Environmental research, 2018

Smoking is considered an important source for inorganic elements, most of them toxic for human he... more Smoking is considered an important source for inorganic elements, most of them toxic for human health. During the last years, there has been a significant increase in the use of e-cigarettes, although the role of them as source of inorganic elements has not been well established. A cross-sectional study including a total of 150 subjects from Brasov (Romania), divided into three groups (non-smokers, cigarette smokers and electronic cigarettes smokers) were recruited to disclose the role of smoking on the human exposure to inorganic elements. Concentration of 42 elements, including trace elements, elements in the ATSDR's priority pollutant list and rare earth elements (REE) were measured by ICP-MS in the blood serum of participants. Cigarette smokers showed the highest levels of copper, molybdenum, zinc, antimony, and strontium. Electronic cigarette (e-cigarette) users presented the highest concentrations of selenium, silver, and vanadium. Beryllium, europium and lanthanides were ...

BMC health services research, Jul 6, 2017

The main objective of this cross sectional study was to assess the psychometric properties of a n... more The main objective of this cross sectional study was to assess the psychometric properties of a new research instrument. The secondary aim was to analyze patients' levels of dissatisfaction with the professionalism of medical staff. A social survey questionnaire was created and administered online. The instrument consisted of two scales: the 30-item patient dissatisfaction scale and the 10 items institutional scale. In this article, we assessed only the patient dissatisfaction scale. The research population includes 1838 subjects. The statistical procedures used were descriptive statistics, Pearson's correlation, and factorial analyses with the SPSS.19 software. The internal consistency of the instrument was determined using the Cronbach's alpha coefficient. We used a principal component analysis to investigate the factorial validity of the scale. The patients' scale of dissatisfaction obtained an alpha Cronbach score of 0.81. Three latent factors corresponding to th...

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2015

The study aims to present the main ethical dilemmas that research on animals raised for anyone in... more The study aims to present the main ethical dilemmas that research on animals raised for anyone involved in this process, starting from the idea that there are rights of animals to be known and respected. The evolution of medicine is inextricably linked to the production of new drugs, the occurrence of surgical techniques; none of these can be possible without the study of experimental animals, in vivo experimentation being part of the process of medical research. The article analyzes the main ethical dilemmas related to the use of animals in medical research, in the current legislative context and historical perspective of achieving such studies. The use of animals in medical research must be conducted in accordance with clearly established moral rules, which facilitate reducing to the maximum the negative effects on the animals, avoiding unnecessary suffering to them and especially to facilitate progress achievement with the minimum possible animals sacrificed.

Proceedings of the 12th …, 2010

The aim of this paper is the assessment of the ultrasound and mammography examination in detectio... more The aim of this paper is the assessment of the ultrasound and mammography examination in detection of mammary opacities. This study will analyse the value and the limits of these methods in diagnosis. Mammary ultrasound is complementary to mammography. Combining the two methods will increase the accuracy in finding and defining the mammary nodule, suspect of malignancy.

Revista Romana De Bioetica, Jul 30, 2014

Informed consent is the act by which the patient makes decisions regarding therapeutic conduct or... more Informed consent is the act by which the patient makes decisions regarding therapeutic conduct or participation in a medical research, based on information provided by a doctor or scientist. Providing adequate information is therefore an essential prerequisite for allowing exertion of patient right to voluntarism. Adding to many aspects of current debate or research related to informed consent in developed Western civilisations it has been shown that particular ethical challenges derive from particularities in locations without a vast experience in the protection of human subjects' rights, as well as from cultural or socio-economical particularities. Meanwhile, there is a lack of information concerning the level of conceptualization of the informed consent in Eastern European countries. The aim of this study is to evaluate the people's levels of understanding and information regarding various general aspects of informed consent and to identify gaps and needs which could be solved by subsequent actions of education on the subject. Our study results showed a great willingness of people to be informed about the medical act, as well as the deficiencies existing in real practice and significant lack of information regarding general aspects of informed consent. The design of a web site aimed to improve Romanian people's understanding of the concept of informed consent will enable people to get actively involved in the process when needed, and to shift from viewing it as a formality or as a measure of physician's legal protection, to an expression of patient oriented medicine, meant ultimately to improve patient outcome and satisfaction.

Organizing health campaigns in Romania at the beginning of the twentieth century was a proof of t... more Organizing health campaigns in Romania at the beginning of the twentieth century was a proof of the concern that our country had begun to pay to population's health. In the 1938 health campaign, Braşov County was an example of organization, implementation and provision of human and material resources and the preparation of monographs for the localities in the county.

Proceedings of the …, 2008

This paper is the result of a research that examined, analyzed and interpreted the differences in... more This paper is the result of a research that examined, analyzed and interpreted the differences in the perceptions of violence in communication in six different university settings in Romania, by investigating the relative and the combined influence of the place and ...

Bulletin of the Transilvania University of Braşov• Vol, 2010

Abstract: Developing sanitary campaigns in the county of Braşov emerged as absolute necessity und... more Abstract: Developing sanitary campaigns in the county of Braşov emerged as absolute necessity under the conditions of the first half of the 20th century and especially during the period in-between World Wars. The case study comprised within the article herein – led to achieving the ...