D. Dosseh | Université de Lomé (original) (raw)
Papers by D. Dosseh
![Research paper thumbnail of [Anatomical substratum of primary hyperaldosteronism: from the difficulties of the diagnosis to the surgical management]](https://attachments.academia-assets.com/78549990/thumbnails/1.jpg)
](Annales de chirurgie, 2005
L’hyperaldostéronisme primaire résulte de l’hypersécrétion autonome d’aldostérone par la zone glo... more L’hyperaldostéronisme primaire résulte de l’hypersécrétion autonome d’aldostérone par la zone glomérulée du cortex surrénalien. Il est responsable d’hypertension artérielle par rétention hydrosodée. Son incidence parmi la population des hypertendus était estimée entre 1 et 2 %, mais les nouveaux principes de dépistage permettent une réestimation au-delà de 10 %. Il représente une des rares causes d’hypertension artérielle potentiellement curables par la chirurgie, et, de ce fait, l’identification des patients atteints représente un vrai défi diagnostique et thérapeutique.
L’hemangiopericytome retroperitoneal (HPR) est une tumeur vasculaire rare qui se developpe a part... more L’hemangiopericytome retroperitoneal (HPR) est une tumeur vasculaire rare qui se developpe a partir des pericytes de Zimmermann. L’hemangiopericytome retroperitoneal est souvent volumineux, asymptomatique avec un potentiel de malignite variable. Nous rapportons trois cas d’hemangiopericytomes chez des patients de 23 ans, 47 ans et 48 ans, ayant consulte pour une masse abdominale et dont le traitement a ete chirurgical.
Buts : Apprecier la frequence hospitaliere de la FVV, faire un inventaire statistique des besoins... more Buts : Apprecier la frequence hospitaliere de la FVV, faire un inventaire statistique des besoins materiels et en ressouces humaines en vue de son eradication. Materiels et methode : il s’agit d’une etude retrospective et descriptive couvrant une periode de cinq (05) ans. Resultats et commentaires : Trente neuf fistules vesico-vaginales (FVV) ont ete colligees sur un ensemble de 42 fistules obstetricales : plus de 7 FVV par an ; la moyenne d’âge a ete de 17 ans. L’accouchement par dystocie a ete la cause principale ; les patientes ont ete en majorite des referees des services de soins de l’interieur du pays et de ce fait, la fistule obstetricale recule de la capitale vers les villes de l’interieur. Conclusion : La fistule vesico-vaginale est la plus frequente des fistules obstetricales au CHU-Tokoin. La reparation chirurgicale, meme hors de portee des patientes devrait s’accompagner de mesures preventives telles, les consultations prenatales, l’instruction et l’education des populat...
INTRODUCTION : Au bloc operatoire, le materiel utilise ainsi que l’environnement doit etre exemp... more INTRODUCTION : Au bloc operatoire, le materiel utilise ainsi que l’environnement doit etre exempt de toute souillure pouvant etre a l’origine d’une Infection Associee au Soins. Objectif : identifier dans nos conditions de travail, les bacteries retrouvees dans l’environnement du bloc ainsi que sur le materiel. Materiel et Methodes : Il s’est agi d’une etude descriptive prospective realisee au niveau du bloc operatoire du CHU Sylvanus Olympio de Lome d’octobre 2014 a Janvier 2015. Le materiel chirurgical apres leur sterilisation, pendant l’intervention et au cours de la desinfection ; les tables operatoires ; les instruments chirurgicaux ; les scialytiques ; les lavabos ; les mains des chirurgiens et l’air de la salle operatoire ont ete ecouvillonnes. Resultats : Le taux de contamination du bloc central est de 51,11%. 34,78% de positifs ,pendant la desinfection ;39,14% pendant l’intervention et 26,08% apres la sterilisation. Escherichia coli , Pseudomonas et Acinetobacte r, S . aur...
![Research paper thumbnail of [Surgical treatment of the single non traumatic perforation of small bowel: excision-suture or resection-anastomosis]](https://attachments.academia-assets.com/78549989/thumbnails/1.jpg)
](OBJECTIVE To evaluate morbidity and mortality following excision-suture and resection-anastomosis... more OBJECTIVE To evaluate morbidity and mortality following excision-suture and resection-anastomosis for single non traumatic perforations of small bowel (SNTPB). METHODS From July 2002 to June 2003, a simple blind randomized study comparing excision-suture with resection-anastomosis SNTPB. RESULTS Of the 125 patients included, 112 were operated by surgeons on training (89.6%). The perforation sat on the antimesenteric edge of the last ileal portion with an average diameter of 0.8 cm (extreme 0.1 and 4 cm). An excision-suture was performed 66 times (52%) including 5 times by an experienced surgeon. 56 patients had simple continuations (45.2%). Morbidity concerned 68 patients (54,8%). 06 patients died of general complications (4.8%). The technique did not influence the mortality. All dead patients were operated by surgeons on training, P=0.25. The complications were significantly more frequent after resection-anastomosis (79.7%) than after excision-suture (32.3%). The difference was sig...
SUMMARY: The retroperitoneal haemangiopericytoma (RHP) is an uncommon vascular tumor develops fro... more SUMMARY: The retroperitoneal haemangiopericytoma (RHP) is an uncommon vascular tumor develops from the pericytes of Zimmermann. The retroperitoneal hemangiopericytoma is often large, asymptomatic with variable malignant potential. We report three cases of hemangiopericytomas in the patients of 23 years, 47 years and 48 years who consulted for a abdominal mass in and whose treatment was surgical.
Annales de chirurgie, 2006
To evaluate morbidity and mortality following excision-suture and resection-anastomosis for singl... more To evaluate morbidity and mortality following excision-suture and resection-anastomosis for single non traumatic perforations of small bowel (SNTPB). From July 2002 to June 2003, a simple blind randomized study comparing excision-suture with resection-anastomosis SNTPB. Of the 125 patients included, 112 were operated by surgeons on training (89.6%). The perforation sat on the antimesenteric edge of the last ileal portion with an average diameter of 0.8 cm (extreme 0.1 and 4 cm). An excision-suture was performed 66 times (52%) including 5 times by an experienced surgeon. 56 patients had simple continuations (45.2%). Morbidity concerned 68 patients (54,8%). 06 patients died of general complications (4.8%). The technique did not influence the mortality. All dead patients were operated by surgeons on training, P=0.25. The complications were significantly more frequent after resection-anastomosis (79.7%) than after excision-suture (32.3%). The difference was significant for the parietal ...
Surgery, 2006
The optimal surgical approach for tertiary hyperparathyroidism (HPT) after kidney transplantation... more The optimal surgical approach for tertiary hyperparathyroidism (HPT) after kidney transplantation is unknown. Existing studies are limited by small sample size, lack of adjustment for kidney function, and no long-term follow-up. We retrospectively analyzed 74 patients with tertiary HPT who underwent parathyroidectomy at two centers since 1978. Persistent HPT was defined as parathyroid hormone (PTH) concentrations in excess of the K/DOQI target range for the corresponding estimated creatinine clearance (eCrCl). Seventy-four patients had 83 operations (72 subtotal and 11 less-than-subtotal parathyroidectomies). Mean follow-up time was 5.4 +/- 4.7 years. Calcium concentrations decreased significantly after parathyroidectomy (2.83 vs 2.28 mmol/L, P < 0.001), as did eCrCl (54.5 vs 44.9 mL/min, P < 0.001) and PTH (382 vs 132 pg/mL, P < 0.001). In the multivariable regression analysis, only the type of operation and postoperative eCrCl were significantly correlated with PTH at follow-up. A limited parathyroidectomy was associated with a fivefold increase in risk of persistent or recurrent hyperparathyroidism. The use of limited parathyroidectomy for tertiary HPT after kidney transplantation has a higher risk of persistent/recurrent HPT. Subtotal parathyroidectomy is recommended for patients with tertiary HPT.
Langenbeck's Archives of Surgery, 2006
Background and aims Intra-operative parathyroid hormone (IOPTH) results are not known in the sett... more Background and aims Intra-operative parathyroid hormone (IOPTH) results are not known in the setting of tertiary hyperparathyroidism (HPT) after renal transplantation. Materials and methods A retrospective analysis of 35 tertiary HPT patients who all underwent subtotal parathyroidectomy and IOPTH monitoring was conducted. Results The mean follow-up time was 2.2±1.4 years. Thirty-four patients were cured; one patient (2.8%) had a persistent disease and was cured after reoperation. Median parathyroid hormone (PTH) (median percent decrease from highest) at baseline and at 5, 10, 20, and 30 min were 244, 78 (69%), 63 (75%), 53 (79%), and 49 pg/ml (83%), respectively. Four patients who were cured had a decrease of <50% at 5 min and two of them had a decrease of <50% at 10 min. The patient with persistent disease had a decrease of >50% at 10 min. The sensitivity of the test was 94% at 10 min using the Miami criteria. Conclusion This study shows that IOPTH in tertiary hyperparathyroidism has a high sensitivity. However, because of the low risk of persistent hyperparathyroidism when a subtotal parathyroidectomy is performed, its potential impact on the overall success rate is very small. We therefore do not recommend the routine use of IOPTH in tertiary hyperparathyroidism.
Annales de Chirurgie, 2006
To evaluate morbidity and mortality following excision-suture and resection-anastomosis for singl... more To evaluate morbidity and mortality following excision-suture and resection-anastomosis for single non traumatic perforations of small bowel (SNTPB). From July 2002 to June 2003, a simple blind randomized study comparing excision-suture with resection-anastomosis SNTPB. Of the 125 patients included, 112 were operated by surgeons on training (89.6%). The perforation sat on the antimesenteric edge of the last ileal portion with an average diameter of 0.8 cm (extreme 0.1 and 4 cm). An excision-suture was performed 66 times (52%) including 5 times by an experienced surgeon. 56 patients had simple continuations (45.2%). Morbidity concerned 68 patients (54,8%). 06 patients died of general complications (4.8%). The technique did not influence the mortality. All dead patients were operated by surgeons on training, P=0.25. The complications were significantly more frequent after resection-anastomosis (79.7%) than after excision-suture (32.3%). The difference was significant for the parietal abscesses (P=0,01), the exteriorized fistulas (P=0.04), the septic shocks (P=0.05). Whereas mortality was not influenced by the technique, the postoperative course was more complicated after resection-anastomosis (performed in majority by less experienced surgeons). We recommend excision-suture to repair SNTPB.
Annales de Chirurgie, 2006
Background. – Due to the relatively small number of patients involved, there is currently no cons... more Background. – Due to the relatively small number of patients involved, there is currently no consensus on what operation should be performed in patients with tertiary hyperparathyroidism after renal transplantation.Method. – Retrospective analysis of the 70 patients with tertiary hyperparathyroidism who all underwent subtotal parathyroidectomy with transcervical thymectomy in the same institution between 1978 and 2003.Results. – The delay between
European Journal of Anaesthesiology, 2004
British Journal of Surgery, 2005
Background: There is currently no consensus on the operation that should be performed in patients... more Background: There is currently no consensus on the operation that should be performed in patients with tertiary hyperparathyroidism (HPT) after renal transplantation.
Annals of Surgery, 2006
To analyze the penetrance and clinical course of isolated nonfunctioning tumors of the pancreas (... more To analyze the penetrance and clinical course of isolated nonfunctioning tumors of the pancreas (NFTP) in MEN 1 patients, and to propose a strategy for managing them. Pancreaticoduodenal tumors develop in a majority of MEN 1 patients and are a major cause of death. The natural history of NFTP is poorly defined, and no clear-cut guidelines have been widely accepted regarding treatment. Data on 108 patients with isolated NFTP among 579 MEN 1 patients from the French Endocrine Tumor Study Group (GTE) were analyzed. Survival rates were calculated using the Kaplan-Meier method. The penetrance of NFTP was 34% at age 50, making it the most frequent pancreaticoduodenal tumor in MEN 1 patients. Forty-three patients (40%) underwent surgery, 32 of them curatively. No patient died because of surgery. Average life expectancy for patients with NFTP was shorter than that for MEN 1 patients who did not have pancreaticoduodenal tumors. Thirteen patients died during follow-up, 10 due to NFTP. Tumor size was correlated with the risks of metastasis and death. These risks were low for patients with tumors&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;or=20 mm. NFTP are currently the most common tumors of the pancreaticoduodenal region in patients with MEN 1. Prevention of tumor spread by surgery should be balanced with potential operative mortality and morbidity. We do not recommend routine surgery for NFTP&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;or=20 mm.
Antimicrobial Resistance and Infection Control, 2013
Annales de chirurgie, 2005
L’hyperaldostéronisme primaire résulte de l’hypersécrétion autonome d’aldostérone par la zone glo... more L’hyperaldostéronisme primaire résulte de l’hypersécrétion autonome d’aldostérone par la zone glomérulée du cortex surrénalien. Il est responsable d’hypertension artérielle par rétention hydrosodée. Son incidence parmi la population des hypertendus était estimée entre 1 et 2 %, mais les nouveaux principes de dépistage permettent une réestimation au-delà de 10 %. Il représente une des rares causes d’hypertension artérielle potentiellement curables par la chirurgie, et, de ce fait, l’identification des patients atteints représente un vrai défi diagnostique et thérapeutique.
L’hemangiopericytome retroperitoneal (HPR) est une tumeur vasculaire rare qui se developpe a part... more L’hemangiopericytome retroperitoneal (HPR) est une tumeur vasculaire rare qui se developpe a partir des pericytes de Zimmermann. L’hemangiopericytome retroperitoneal est souvent volumineux, asymptomatique avec un potentiel de malignite variable. Nous rapportons trois cas d’hemangiopericytomes chez des patients de 23 ans, 47 ans et 48 ans, ayant consulte pour une masse abdominale et dont le traitement a ete chirurgical.
Buts : Apprecier la frequence hospitaliere de la FVV, faire un inventaire statistique des besoins... more Buts : Apprecier la frequence hospitaliere de la FVV, faire un inventaire statistique des besoins materiels et en ressouces humaines en vue de son eradication. Materiels et methode : il s’agit d’une etude retrospective et descriptive couvrant une periode de cinq (05) ans. Resultats et commentaires : Trente neuf fistules vesico-vaginales (FVV) ont ete colligees sur un ensemble de 42 fistules obstetricales : plus de 7 FVV par an ; la moyenne d’âge a ete de 17 ans. L’accouchement par dystocie a ete la cause principale ; les patientes ont ete en majorite des referees des services de soins de l’interieur du pays et de ce fait, la fistule obstetricale recule de la capitale vers les villes de l’interieur. Conclusion : La fistule vesico-vaginale est la plus frequente des fistules obstetricales au CHU-Tokoin. La reparation chirurgicale, meme hors de portee des patientes devrait s’accompagner de mesures preventives telles, les consultations prenatales, l’instruction et l’education des populat...
INTRODUCTION : Au bloc operatoire, le materiel utilise ainsi que l’environnement doit etre exemp... more INTRODUCTION : Au bloc operatoire, le materiel utilise ainsi que l’environnement doit etre exempt de toute souillure pouvant etre a l’origine d’une Infection Associee au Soins. Objectif : identifier dans nos conditions de travail, les bacteries retrouvees dans l’environnement du bloc ainsi que sur le materiel. Materiel et Methodes : Il s’est agi d’une etude descriptive prospective realisee au niveau du bloc operatoire du CHU Sylvanus Olympio de Lome d’octobre 2014 a Janvier 2015. Le materiel chirurgical apres leur sterilisation, pendant l’intervention et au cours de la desinfection ; les tables operatoires ; les instruments chirurgicaux ; les scialytiques ; les lavabos ; les mains des chirurgiens et l’air de la salle operatoire ont ete ecouvillonnes. Resultats : Le taux de contamination du bloc central est de 51,11%. 34,78% de positifs ,pendant la desinfection ;39,14% pendant l’intervention et 26,08% apres la sterilisation. Escherichia coli , Pseudomonas et Acinetobacte r, S . aur...
OBJECTIVE To evaluate morbidity and mortality following excision-suture and resection-anastomosis... more OBJECTIVE To evaluate morbidity and mortality following excision-suture and resection-anastomosis for single non traumatic perforations of small bowel (SNTPB). METHODS From July 2002 to June 2003, a simple blind randomized study comparing excision-suture with resection-anastomosis SNTPB. RESULTS Of the 125 patients included, 112 were operated by surgeons on training (89.6%). The perforation sat on the antimesenteric edge of the last ileal portion with an average diameter of 0.8 cm (extreme 0.1 and 4 cm). An excision-suture was performed 66 times (52%) including 5 times by an experienced surgeon. 56 patients had simple continuations (45.2%). Morbidity concerned 68 patients (54,8%). 06 patients died of general complications (4.8%). The technique did not influence the mortality. All dead patients were operated by surgeons on training, P=0.25. The complications were significantly more frequent after resection-anastomosis (79.7%) than after excision-suture (32.3%). The difference was sig...
SUMMARY: The retroperitoneal haemangiopericytoma (RHP) is an uncommon vascular tumor develops fro... more SUMMARY: The retroperitoneal haemangiopericytoma (RHP) is an uncommon vascular tumor develops from the pericytes of Zimmermann. The retroperitoneal hemangiopericytoma is often large, asymptomatic with variable malignant potential. We report three cases of hemangiopericytomas in the patients of 23 years, 47 years and 48 years who consulted for a abdominal mass in and whose treatment was surgical.
Annales de chirurgie, 2006
To evaluate morbidity and mortality following excision-suture and resection-anastomosis for singl... more To evaluate morbidity and mortality following excision-suture and resection-anastomosis for single non traumatic perforations of small bowel (SNTPB). From July 2002 to June 2003, a simple blind randomized study comparing excision-suture with resection-anastomosis SNTPB. Of the 125 patients included, 112 were operated by surgeons on training (89.6%). The perforation sat on the antimesenteric edge of the last ileal portion with an average diameter of 0.8 cm (extreme 0.1 and 4 cm). An excision-suture was performed 66 times (52%) including 5 times by an experienced surgeon. 56 patients had simple continuations (45.2%). Morbidity concerned 68 patients (54,8%). 06 patients died of general complications (4.8%). The technique did not influence the mortality. All dead patients were operated by surgeons on training, P=0.25. The complications were significantly more frequent after resection-anastomosis (79.7%) than after excision-suture (32.3%). The difference was significant for the parietal ...
Surgery, 2006
The optimal surgical approach for tertiary hyperparathyroidism (HPT) after kidney transplantation... more The optimal surgical approach for tertiary hyperparathyroidism (HPT) after kidney transplantation is unknown. Existing studies are limited by small sample size, lack of adjustment for kidney function, and no long-term follow-up. We retrospectively analyzed 74 patients with tertiary HPT who underwent parathyroidectomy at two centers since 1978. Persistent HPT was defined as parathyroid hormone (PTH) concentrations in excess of the K/DOQI target range for the corresponding estimated creatinine clearance (eCrCl). Seventy-four patients had 83 operations (72 subtotal and 11 less-than-subtotal parathyroidectomies). Mean follow-up time was 5.4 +/- 4.7 years. Calcium concentrations decreased significantly after parathyroidectomy (2.83 vs 2.28 mmol/L, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), as did eCrCl (54.5 vs 44.9 mL/min, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001) and PTH (382 vs 132 pg/mL, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001). In the multivariable regression analysis, only the type of operation and postoperative eCrCl were significantly correlated with PTH at follow-up. A limited parathyroidectomy was associated with a fivefold increase in risk of persistent or recurrent hyperparathyroidism. The use of limited parathyroidectomy for tertiary HPT after kidney transplantation has a higher risk of persistent/recurrent HPT. Subtotal parathyroidectomy is recommended for patients with tertiary HPT.
Langenbeck's Archives of Surgery, 2006
Background and aims Intra-operative parathyroid hormone (IOPTH) results are not known in the sett... more Background and aims Intra-operative parathyroid hormone (IOPTH) results are not known in the setting of tertiary hyperparathyroidism (HPT) after renal transplantation. Materials and methods A retrospective analysis of 35 tertiary HPT patients who all underwent subtotal parathyroidectomy and IOPTH monitoring was conducted. Results The mean follow-up time was 2.2±1.4 years. Thirty-four patients were cured; one patient (2.8%) had a persistent disease and was cured after reoperation. Median parathyroid hormone (PTH) (median percent decrease from highest) at baseline and at 5, 10, 20, and 30 min were 244, 78 (69%), 63 (75%), 53 (79%), and 49 pg/ml (83%), respectively. Four patients who were cured had a decrease of <50% at 5 min and two of them had a decrease of <50% at 10 min. The patient with persistent disease had a decrease of >50% at 10 min. The sensitivity of the test was 94% at 10 min using the Miami criteria. Conclusion This study shows that IOPTH in tertiary hyperparathyroidism has a high sensitivity. However, because of the low risk of persistent hyperparathyroidism when a subtotal parathyroidectomy is performed, its potential impact on the overall success rate is very small. We therefore do not recommend the routine use of IOPTH in tertiary hyperparathyroidism.
Annales de Chirurgie, 2006
To evaluate morbidity and mortality following excision-suture and resection-anastomosis for singl... more To evaluate morbidity and mortality following excision-suture and resection-anastomosis for single non traumatic perforations of small bowel (SNTPB). From July 2002 to June 2003, a simple blind randomized study comparing excision-suture with resection-anastomosis SNTPB. Of the 125 patients included, 112 were operated by surgeons on training (89.6%). The perforation sat on the antimesenteric edge of the last ileal portion with an average diameter of 0.8 cm (extreme 0.1 and 4 cm). An excision-suture was performed 66 times (52%) including 5 times by an experienced surgeon. 56 patients had simple continuations (45.2%). Morbidity concerned 68 patients (54,8%). 06 patients died of general complications (4.8%). The technique did not influence the mortality. All dead patients were operated by surgeons on training, P=0.25. The complications were significantly more frequent after resection-anastomosis (79.7%) than after excision-suture (32.3%). The difference was significant for the parietal abscesses (P=0,01), the exteriorized fistulas (P=0.04), the septic shocks (P=0.05). Whereas mortality was not influenced by the technique, the postoperative course was more complicated after resection-anastomosis (performed in majority by less experienced surgeons). We recommend excision-suture to repair SNTPB.
Annales de Chirurgie, 2006
Background. – Due to the relatively small number of patients involved, there is currently no cons... more Background. – Due to the relatively small number of patients involved, there is currently no consensus on what operation should be performed in patients with tertiary hyperparathyroidism after renal transplantation.Method. – Retrospective analysis of the 70 patients with tertiary hyperparathyroidism who all underwent subtotal parathyroidectomy with transcervical thymectomy in the same institution between 1978 and 2003.Results. – The delay between
European Journal of Anaesthesiology, 2004
British Journal of Surgery, 2005
Background: There is currently no consensus on the operation that should be performed in patients... more Background: There is currently no consensus on the operation that should be performed in patients with tertiary hyperparathyroidism (HPT) after renal transplantation.
Annals of Surgery, 2006
To analyze the penetrance and clinical course of isolated nonfunctioning tumors of the pancreas (... more To analyze the penetrance and clinical course of isolated nonfunctioning tumors of the pancreas (NFTP) in MEN 1 patients, and to propose a strategy for managing them. Pancreaticoduodenal tumors develop in a majority of MEN 1 patients and are a major cause of death. The natural history of NFTP is poorly defined, and no clear-cut guidelines have been widely accepted regarding treatment. Data on 108 patients with isolated NFTP among 579 MEN 1 patients from the French Endocrine Tumor Study Group (GTE) were analyzed. Survival rates were calculated using the Kaplan-Meier method. The penetrance of NFTP was 34% at age 50, making it the most frequent pancreaticoduodenal tumor in MEN 1 patients. Forty-three patients (40%) underwent surgery, 32 of them curatively. No patient died because of surgery. Average life expectancy for patients with NFTP was shorter than that for MEN 1 patients who did not have pancreaticoduodenal tumors. Thirteen patients died during follow-up, 10 due to NFTP. Tumor size was correlated with the risks of metastasis and death. These risks were low for patients with tumors&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;or=20 mm. NFTP are currently the most common tumors of the pancreaticoduodenal region in patients with MEN 1. Prevention of tumor spread by surgery should be balanced with potential operative mortality and morbidity. We do not recommend routine surgery for NFTP&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;or=20 mm.
Antimicrobial Resistance and Infection Control, 2013