Hassan Hammouri | Université Claude Bernard Lyon 1 (original) (raw)

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Papers by Hassan Hammouri

Research paper thumbnail of Observers for Infinite Dimensional Bilin ear, Systems

Research paper thumbnail of Regulation of an irrigation canal through the semigroup approach

Research paper thumbnail of On the Admissible Control operators for Linear and Bilinear Systems and the Favard Spaces

Bulletin of the Belgian Mathematical Society, Simon Stevin

The Bulletin of the Belgian Mathematical Society -Simon Stevin is published by The Belgian Mathem... more The Bulletin of the Belgian Mathematical Society -Simon Stevin is published by The Belgian Mathematical Society, with financial support from the Universitaire Stichting van Belgie – Fon-dation Universitaire de Belgique and the Fonds National de la Recherche Scientifique (FNRS). It appears quarterly and is indexed and/or abstracted in Current Contents, Current Mathemat-ical Publications, Mathematical Reviews, Science Citation Index Expanded and Zentralblatt ur Mathematik. The Bulletin of the Belgian Mathematical Society -Simon Stevin is part of Project Euclid (Cornell University Library), an aggregation of electronic journals. It is available online to subscribers to Project Euclid (http://projecteuclid.org). For more informations about the Belgian Mathematical Society -Simon Stevin, see our web site at http://bms.ulb.ac.be

Research paper thumbnail of Monitoring of Recombinant Protein Production Using Bioluminescence in a Semiautomated Fermentation Process

Biotechnology Progress, 2008

On-line optimization of fermentation processes can be greatly aided by the availability of inform... more On-line optimization of fermentation processes can be greatly aided by the availability of information on the physiological state of the cell. The goal of our "BioLux" research project was to design a recombinant cell capable of intracellular monitoring of product synthesis and to use it as part of an automated fermentation system. A recombinant plasmid was constructed containing an inducible promoter that controls the gene coding for a model protein and the genes necessary for bioluminescence. The cells were cultured in microfermenters equipped with an on-line turbidity sensor and a specially designed on-line light sensor capable of continuous measurement of bioluminescence. Initial studies were done under simple culture conditions, and a linear correlation between luminescence and protein production was obtained. Such specially designed recombinant bioluminescent cells can potentially be applied for model-based inference of intracellular product formation, as well as for optimization and control of recombinant fermentation processes.

Research paper thumbnail of Optimal input design for on-line identification: a coupled observer-MPC approach

This paper presents a parametric sensitivity based controller for on line optimal model parameter... more This paper presents a parametric sensitivity based controller for on line optimal model parameter identification using constrained closed loop control tools and an observer. In optimal input design problem, analytical solution exists for few particular cases based on a relatively simple model. The approach proposed here may be used for a process based on a continuous model in the time domain, with two assumptions on the observability and the general structure of the model. The new proposed approach is to solve a model predictive control problem coupled with an on line process parameter estimation at each time using an observer. A dynamic parametric sensitivity model (derived from the process model) is also used on line to get the parametric sensitivity that has to be optimized. Both optimal input and estimated model parameter are therefore obtained on line. The case study presented here is a powder coating curing process where the main thermal parameter to identify influences the powder curing. First simulation results show here the efficiency of the approach in the control software (MPC@CB) developed under Matlab.

Research paper thumbnail of Observers for Infinite Dimensional Bilin ear, Systems

Research paper thumbnail of Regulation of an irrigation canal through the semigroup approach

Research paper thumbnail of On the Admissible Control operators for Linear and Bilinear Systems and the Favard Spaces

Bulletin of the Belgian Mathematical Society, Simon Stevin

The Bulletin of the Belgian Mathematical Society -Simon Stevin is published by The Belgian Mathem... more The Bulletin of the Belgian Mathematical Society -Simon Stevin is published by The Belgian Mathematical Society, with financial support from the Universitaire Stichting van Belgie – Fon-dation Universitaire de Belgique and the Fonds National de la Recherche Scientifique (FNRS). It appears quarterly and is indexed and/or abstracted in Current Contents, Current Mathemat-ical Publications, Mathematical Reviews, Science Citation Index Expanded and Zentralblatt ur Mathematik. The Bulletin of the Belgian Mathematical Society -Simon Stevin is part of Project Euclid (Cornell University Library), an aggregation of electronic journals. It is available online to subscribers to Project Euclid (http://projecteuclid.org). For more informations about the Belgian Mathematical Society -Simon Stevin, see our web site at http://bms.ulb.ac.be

Research paper thumbnail of Monitoring of Recombinant Protein Production Using Bioluminescence in a Semiautomated Fermentation Process

Biotechnology Progress, 2008

On-line optimization of fermentation processes can be greatly aided by the availability of inform... more On-line optimization of fermentation processes can be greatly aided by the availability of information on the physiological state of the cell. The goal of our "BioLux" research project was to design a recombinant cell capable of intracellular monitoring of product synthesis and to use it as part of an automated fermentation system. A recombinant plasmid was constructed containing an inducible promoter that controls the gene coding for a model protein and the genes necessary for bioluminescence. The cells were cultured in microfermenters equipped with an on-line turbidity sensor and a specially designed on-line light sensor capable of continuous measurement of bioluminescence. Initial studies were done under simple culture conditions, and a linear correlation between luminescence and protein production was obtained. Such specially designed recombinant bioluminescent cells can potentially be applied for model-based inference of intracellular product formation, as well as for optimization and control of recombinant fermentation processes.

Research paper thumbnail of Optimal input design for on-line identification: a coupled observer-MPC approach

This paper presents a parametric sensitivity based controller for on line optimal model parameter... more This paper presents a parametric sensitivity based controller for on line optimal model parameter identification using constrained closed loop control tools and an observer. In optimal input design problem, analytical solution exists for few particular cases based on a relatively simple model. The approach proposed here may be used for a process based on a continuous model in the time domain, with two assumptions on the observability and the general structure of the model. The new proposed approach is to solve a model predictive control problem coupled with an on line process parameter estimation at each time using an observer. A dynamic parametric sensitivity model (derived from the process model) is also used on line to get the parametric sensitivity that has to be optimized. Both optimal input and estimated model parameter are therefore obtained on line. The case study presented here is a powder coating curing process where the main thermal parameter to identify influences the powder curing. First simulation results show here the efficiency of the approach in the control software (MPC@CB) developed under Matlab.

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