Jean AZERAD | Université Paris Diderot (original) (raw)
Papers by Jean AZERAD
The invention concerns a system for virtual reality training, to acquire procedure movements in o... more The invention concerns a system for virtual reality training, to acquire procedure movements in odontology, by sensing data concerning spatial position of a real hand-held element (2), three-dimensional representation of a virtual object (T) on a display screen (7), processing spatial position data for providing spatial display of a virtual instrument (OV) corresponding to the actual spatial position of said real element (2), supplying a virtual instrument (01-04) for operating on said virtual object (T) and modelling an interaction between said virtual instrument and said virtual object (T). The hand-held element (2) belongs to a haptic man-machine interface (IHM) comprising actuators controlled to supply the user holding in his hand said real element (2) with a force-feedback when the virtual instrument (OV) interacts with the virtual object (T). The invention is useful for pedagogical and professional purposes.
PARIS7-Odontologie (751062104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Scientometrics, 2004
The distribution of articles involving artificial neural networks (ANN) in the fields of medicine... more The distribution of articles involving artificial neural networks (ANN) in the fields of medicine and biology and appearing in the ISI (Institute for Scientific Information) databases during the period 2000-2001 was analysed. The following parameters were considered: the number of articles, the total impact factor, the ISI journal category, the source country population, and the gross domestic product. Among the 803 articles and the 49 countries considered, the 5 most prolific (in term of the number of publications) were the USA, The United Kingdom, Germany, Italy, and Canada; other active countries included Sweden, Netherlands, Spain, France, Japan, and China. Comparison between the USA and the European Union, and the distribution of ANN publications among the subdisciplines of the life sciences and clinical medicine are also presented.
Bone, 2014
This study aimed to evaluate the effect of bevacizumab (BVZ) on the severity of osteonecrosis of ... more This study aimed to evaluate the effect of bevacizumab (BVZ) on the severity of osteonecrosis of the jaw (ONJ) in a cohort of cancer patients treated with intravenous zoledronic acid (ZA). We reviewed 42 oncologic patients with ONJ between 2007 and 2010. Only patients with solids tumors and who had received ZA were included. Data analyses included age, sex, underlying disease, ZA and BVZ dosages, dental history and ONJ characteristics. Of the 42 ONJ patients treated with ZA, 10 also received BVZ. In the 10 ZA/BVZ patients, the mean duration of ZA treatment at the time of ONJ diagnosis was 12.4 months (±6.8), compared to 22.9 months (±4.8) in the 32 patients who received ZA only (p<0.05). Cox's model analysis of the delay to ONJ diagnosis confirmed the impact of BVZ on ONJ diagnosis. In the ZA/BVZ-treated group, 7 (70%) patients developed spontaneous osteonecrosis. Multiple logistic regression analysis showed that ZA/BVZ is associated with increased risk of developing spontaneous ONJ (OR 6.07; 95% CI, [1.3-28.2], p<0.05). And finally, the number of ONJ lesions was increased in the ZA/BVZ-treated group compared to the ZA group (p<0.01). Other clinical conditions as type of tumor (prostate, breast…), cancer severity or other chemotherapy drugs also could be involved in ONJ evolution. However, this study demonstrates for the first time the potential negative influence of BVZ on the incidence and severity of ONJ in patients receiving ZA. Within the study limits, our results suggest that combination ZA/BVZ treatment may possibly predispose to the development of spontaneous and earlier ONJ.
Journal of Medical Microbiology, 2009
As antibiotic pressure often triggers bacterial resistance, the use of short-duration therapies i... more As antibiotic pressure often triggers bacterial resistance, the use of short-duration therapies is increasingly recommended. The objective of the present study was to evaluate both the clinical efficiency and the impact on oral streptococci of a 3 day versus a 7 day amoxicillin therapy for odontogenic infection requiring tooth extraction. On day 0, patients were randomly assigned to a 3 day or 7 day amoxicillin treatment. The tooth was extracted on day 2 and the post-operative follow-up was carried out on day 9. Oral flora was collected on days 0, 9 and 30, and the susceptibility of the streptococci to amoxicillin was determined. The results showed that treatment with amoxicillin for 3 or 7 days had a similar clinical efficiency, and also induced similar selection of oral streptococci with reduced susceptibility to amoxicillin, suggesting that the selection of strains with reduced susceptibility to amoxicillin is a rapid phenomenon, appearing even with short-duration therapies.
62ème Congrès de la SFCO, 2014
Neuro - endocrinology letters, 2007
Investigation of pain and nociception refers to different models. Depending upon the intensity of... more Investigation of pain and nociception refers to different models. Depending upon the intensity of stimulation, unmyelinated pulpal fibers or periodontal A-fibers can be stimulated producing a short or a long latency jaw opening reflex of the digastric muscle. This paper investigates the different components of the jaw opening reflex in addition to the correlation between afferent fibers involved in the cortical evoked response. Fifteen awake male rats were implanted with tooth pulp stimulation electrodes, digastric and cortical recording electrodes. Ten rats were submitted to recordings after a single tooth pulp stimulation, while five rats were using conditioning and test stimulation. Tooth pulp evoked potentials and digastric EMG were simultaneously recorded. A multiresolution denoising method was used for signal processing. Following tooth pulp stimulation, a cortical response was produced including the following peaks: P6.5 +/- 1.1, N11 +/- 1.2, P17 +/- 1.2, P27 +/- 2.9, N53 +/-...
OBJECTIVE Investigation of pain and nociception refers to different models. Depending upon the in... more OBJECTIVE Investigation of pain and nociception refers to different models. Depending upon the intensity of stimulation, unmyelinated pulpal fibers or periodontal A-fibers can be stimulated producing a short or a long latency jaw opening reflex of the digastric muscle. This paper investigates the different components of the jaw opening reflex in addition to the correlation between afferent fibers involved in the cortical evoked response. DESIGN AND SETTING Fifteen awake male rats were implanted with tooth pulp stimulation electrodes, digastric and cortical recording electrodes. Ten rats were submitted to recordings after a single tooth pulp stimulation, while five rats were using conditioning and test stimulation. Tooth pulp evoked potentials and digastric EMG were simultaneously recorded. A multiresolution denoising method was used for signal processing. RESULTS Following tooth pulp stimulation, a cortical response was produced including the following peaks: P6.5 +/- 1.1, N11 +/- 1...
Revue d'Épidémiologie et de Santé Publique, 2006
Revue d'Épidémiologie et de Santé Publique, 2004
Revue d'Épidémiologie et de Santé Publique, 2006
Revue d'épidémiologie et de santé publique, 2006
The oral status of people living in precarious conditions is problematic. Although the public uni... more The oral status of people living in precarious conditions is problematic. Although the public universal health insurance should allow better access to care, access to dental care remains a critical issue. The analysis of the patient population of a hospital dental consultation (Groupe Pitié-Salpêtrière, Paris) seemed relevant to evaluate the needs of care and the means to provide it. The principal objectives are: to estimate dental health and needs of this population, to describe their sociodemographic characteristics and to compare them with patients living in common social conditions. A cross sectional study was conducted from February to June 2003. A medical questionnaire and a dental file record were used. All outpatients coming to the dental consultation, in need of conservative or prosthetic treatment, were included. We analysed the risk factors associated with poor dental health. Three hundred and thirty three questionnaires were analysed: two third were men, 45% were foreign...
Revue d'odonto-stomatologie
Oral Oncology Supplement, 2009
European Journal of Oral Sciences, 2012
Revue d'Épidémiologie et de Santé Publique, 2006
The invention concerns a system for virtual reality training, to acquire procedure movements in o... more The invention concerns a system for virtual reality training, to acquire procedure movements in odontology, by sensing data concerning spatial position of a real hand-held element (2), three-dimensional representation of a virtual object (T) on a display screen (7), processing spatial position data for providing spatial display of a virtual instrument (OV) corresponding to the actual spatial position of said real element (2), supplying a virtual instrument (01-04) for operating on said virtual object (T) and modelling an interaction between said virtual instrument and said virtual object (T). The hand-held element (2) belongs to a haptic man-machine interface (IHM) comprising actuators controlled to supply the user holding in his hand said real element (2) with a force-feedback when the virtual instrument (OV) interacts with the virtual object (T). The invention is useful for pedagogical and professional purposes.
PARIS7-Odontologie (751062104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Scientometrics, 2004
The distribution of articles involving artificial neural networks (ANN) in the fields of medicine... more The distribution of articles involving artificial neural networks (ANN) in the fields of medicine and biology and appearing in the ISI (Institute for Scientific Information) databases during the period 2000-2001 was analysed. The following parameters were considered: the number of articles, the total impact factor, the ISI journal category, the source country population, and the gross domestic product. Among the 803 articles and the 49 countries considered, the 5 most prolific (in term of the number of publications) were the USA, The United Kingdom, Germany, Italy, and Canada; other active countries included Sweden, Netherlands, Spain, France, Japan, and China. Comparison between the USA and the European Union, and the distribution of ANN publications among the subdisciplines of the life sciences and clinical medicine are also presented.
Bone, 2014
This study aimed to evaluate the effect of bevacizumab (BVZ) on the severity of osteonecrosis of ... more This study aimed to evaluate the effect of bevacizumab (BVZ) on the severity of osteonecrosis of the jaw (ONJ) in a cohort of cancer patients treated with intravenous zoledronic acid (ZA). We reviewed 42 oncologic patients with ONJ between 2007 and 2010. Only patients with solids tumors and who had received ZA were included. Data analyses included age, sex, underlying disease, ZA and BVZ dosages, dental history and ONJ characteristics. Of the 42 ONJ patients treated with ZA, 10 also received BVZ. In the 10 ZA/BVZ patients, the mean duration of ZA treatment at the time of ONJ diagnosis was 12.4 months (±6.8), compared to 22.9 months (±4.8) in the 32 patients who received ZA only (p<0.05). Cox's model analysis of the delay to ONJ diagnosis confirmed the impact of BVZ on ONJ diagnosis. In the ZA/BVZ-treated group, 7 (70%) patients developed spontaneous osteonecrosis. Multiple logistic regression analysis showed that ZA/BVZ is associated with increased risk of developing spontaneous ONJ (OR 6.07; 95% CI, [1.3-28.2], p<0.05). And finally, the number of ONJ lesions was increased in the ZA/BVZ-treated group compared to the ZA group (p<0.01). Other clinical conditions as type of tumor (prostate, breast…), cancer severity or other chemotherapy drugs also could be involved in ONJ evolution. However, this study demonstrates for the first time the potential negative influence of BVZ on the incidence and severity of ONJ in patients receiving ZA. Within the study limits, our results suggest that combination ZA/BVZ treatment may possibly predispose to the development of spontaneous and earlier ONJ.
Journal of Medical Microbiology, 2009
As antibiotic pressure often triggers bacterial resistance, the use of short-duration therapies i... more As antibiotic pressure often triggers bacterial resistance, the use of short-duration therapies is increasingly recommended. The objective of the present study was to evaluate both the clinical efficiency and the impact on oral streptococci of a 3 day versus a 7 day amoxicillin therapy for odontogenic infection requiring tooth extraction. On day 0, patients were randomly assigned to a 3 day or 7 day amoxicillin treatment. The tooth was extracted on day 2 and the post-operative follow-up was carried out on day 9. Oral flora was collected on days 0, 9 and 30, and the susceptibility of the streptococci to amoxicillin was determined. The results showed that treatment with amoxicillin for 3 or 7 days had a similar clinical efficiency, and also induced similar selection of oral streptococci with reduced susceptibility to amoxicillin, suggesting that the selection of strains with reduced susceptibility to amoxicillin is a rapid phenomenon, appearing even with short-duration therapies.
62ème Congrès de la SFCO, 2014
Neuro - endocrinology letters, 2007
Investigation of pain and nociception refers to different models. Depending upon the intensity of... more Investigation of pain and nociception refers to different models. Depending upon the intensity of stimulation, unmyelinated pulpal fibers or periodontal A-fibers can be stimulated producing a short or a long latency jaw opening reflex of the digastric muscle. This paper investigates the different components of the jaw opening reflex in addition to the correlation between afferent fibers involved in the cortical evoked response. Fifteen awake male rats were implanted with tooth pulp stimulation electrodes, digastric and cortical recording electrodes. Ten rats were submitted to recordings after a single tooth pulp stimulation, while five rats were using conditioning and test stimulation. Tooth pulp evoked potentials and digastric EMG were simultaneously recorded. A multiresolution denoising method was used for signal processing. Following tooth pulp stimulation, a cortical response was produced including the following peaks: P6.5 +/- 1.1, N11 +/- 1.2, P17 +/- 1.2, P27 +/- 2.9, N53 +/-...
OBJECTIVE Investigation of pain and nociception refers to different models. Depending upon the in... more OBJECTIVE Investigation of pain and nociception refers to different models. Depending upon the intensity of stimulation, unmyelinated pulpal fibers or periodontal A-fibers can be stimulated producing a short or a long latency jaw opening reflex of the digastric muscle. This paper investigates the different components of the jaw opening reflex in addition to the correlation between afferent fibers involved in the cortical evoked response. DESIGN AND SETTING Fifteen awake male rats were implanted with tooth pulp stimulation electrodes, digastric and cortical recording electrodes. Ten rats were submitted to recordings after a single tooth pulp stimulation, while five rats were using conditioning and test stimulation. Tooth pulp evoked potentials and digastric EMG were simultaneously recorded. A multiresolution denoising method was used for signal processing. RESULTS Following tooth pulp stimulation, a cortical response was produced including the following peaks: P6.5 +/- 1.1, N11 +/- 1...
Revue d'Épidémiologie et de Santé Publique, 2006
Revue d'Épidémiologie et de Santé Publique, 2004
Revue d'Épidémiologie et de Santé Publique, 2006
Revue d'épidémiologie et de santé publique, 2006
The oral status of people living in precarious conditions is problematic. Although the public uni... more The oral status of people living in precarious conditions is problematic. Although the public universal health insurance should allow better access to care, access to dental care remains a critical issue. The analysis of the patient population of a hospital dental consultation (Groupe Pitié-Salpêtrière, Paris) seemed relevant to evaluate the needs of care and the means to provide it. The principal objectives are: to estimate dental health and needs of this population, to describe their sociodemographic characteristics and to compare them with patients living in common social conditions. A cross sectional study was conducted from February to June 2003. A medical questionnaire and a dental file record were used. All outpatients coming to the dental consultation, in need of conservative or prosthetic treatment, were included. We analysed the risk factors associated with poor dental health. Three hundred and thirty three questionnaires were analysed: two third were men, 45% were foreign...
Revue d'odonto-stomatologie
Oral Oncology Supplement, 2009
European Journal of Oral Sciences, 2012
Revue d'Épidémiologie et de Santé Publique, 2006