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Research paper thumbnail of Evaluation of anilines models release kinetics from dosage forms using Eudragit-RL as matrix

The galenic forms able to control drug release have been prepared and investigated in this paper.... more The galenic forms able to control drug release have been prepared and investigated in this paper. In o rder to follow and to control the release of anilines model (MA) 1-4, from spherical oral galenic forms in acidic mediu m, several kinetics of (MA) 1-4 release have been carried out at 37°C. Theoretical and experimental analysis of these kinetics were conducted in synthetic gastric fluid medium (pH=1.2), and the process was found to be controlled by transient diffusion, with constant diffusivities , for the liquid into and medical agent (MA) out of the galenic forms. According to Fick’s law, a mathematical trea tment led to evaluate the amount of matter transfer red at time (t). The present study demonstrates that it is possible to derive a direct expression for rate di ffusion’s of medical agent (MA).

Research paper thumbnail of Controlled release of amoxicillin from PMMA and poly ( butylsuccinate ) microspheres

ISSN: 2410-9649 Boukhouya et al / Chemistry International 4(2) (2018) 120-129 iscientic.org.

Research paper thumbnail of Cinnamaldehyde loaded-microparticles obtained by complex coacervation: Influence of the process parameters on the morphology and the release of the core material

Encapsulation by complex coacervation includes several steps that have been developed in order to... more Encapsulation by complex coacervation includes several steps that have been developed in order to attain a better control over the whole process and to achieve an important delayed effect. This has been carried out for the encapsulation of cinnamaldehyde (CN) by the classical gelatin/acacia gum pair of coacervating polymers. This preparation was performed in different conditions (stirring speeds, cooling rate, emulsion and coacervate time, use of surfactant, and polymer concentration) in order to investigate their effect on the encapsulation efficiency and drug release kinetics. Optical microscopy studies showed spherical microcapsules. The yield of the encapsulation attains more than 88% of all prepared microcapsules. The mean Sauter diameter (d 32) of obtained microparticles was in the range from 124 to 200 µm. The microspheres were also characterized by the FTIR method; showing the presence of core and polymers in the microparticles. The release of cinnamaldehyde was performed in...

Research paper thumbnail of Formulation, evaluation and microbiological activity of ampicillin and amoxicillin microspheres

The aim of this study is to improve properties of two antibiotics, ampicillin (AM) and amoxicilli... more The aim of this study is to improve properties of two antibiotics, ampicillin (AM) and amoxicillin (AMO), for controlled delivery. Microspheres loaded with (AM) or (AMO) were prepared by oil-in-water (O/W) emulsion solvent evaporation method. Ethylcellulose (EC) and poly (ε-caprolactone) (PCL) were used to prepare the microspheres with tween80 (T80) and gelatin (GE) as emulsifiers. These systems were characterized by SEM and FTIR spectroscopy and the size distribution was also determined. The results suggest that the entrapment in the microspheres was more than 70%. Data obtained from in-vitro drug release from microspheres were fitted to various kinetic models. Drug release kinetics corresponds to Higuchi model. The antimicrobial activity of the released (AM) and (AMO) was confirmed by Escherichia coli and Klebsiella bioassay.

Research paper thumbnail of Effect of formulation parameters on encapsulation efficiency and release behavior of p-aminobenzoic acid-loaded ethylcellulose microspheres

Journal of the Serbian Chemical Society, 2016

In the current study, p-aminobenzoic acid-loaded ethylcellulose microspheres were prepared under ... more In the current study, p-aminobenzoic acid-loaded ethylcellulose microspheres were prepared under various conditions by the solvent evaporation method (o/w). This preparation was performed with different p-aminobenzoic acid:ethylcellulose (PABA:EC) ratios, stirring speeds, surfactant nature and concentrations in order to investigate their effect on the encapsulation efficiency and drug release kinetics. Scanning electron microscopy (SEM) studies showed spherical microspheres with a porous surface and different structures. The mean Sauter diameter (d 32) of these microparticles was in the range from 47 to 165 µm with PVA and from 793 to 870 µm with Tween 80 by adjusting process parameters. However, the encapsulation efficiency varied from 37.52 to 79.05 % suitable for the adjustment of a p-aminobenzoic acid with prolonged release. The microspheres were characterized by the FTIR, DSC and XRD methods. The release of the cation of p-aminobenzoic acid was performed in simulated gastric medium at pH 1.2 and at 37±0.5 °C using UV-Vis analysis to estimate its content. The release data were best fitted to the Higuchi model with high correlation coefficients (r²) and the values of n obtained from the Korsmeyer-Peppas method showed that the drug release followed the Fickian diffusion mechanism.

Research paper thumbnail of Synthesis of some poly (N-2-vinyl pyrrolidone-co-metha crylamide)s as model carriers of anilines. Study of the release of anilines in aqueous heterogeneous medium of pH=1.2 at 37°C

Mediterranean Journal of Chemistry, 2011

Four secondary amides have been prepared by the Schotten-Baumann reaction between model anilines ... more Four secondary amides have been prepared by the Schotten-Baumann reaction between model anilines (Pa 1-4 : p-XC 6 H 4 NH 2: X 1 : H; X 2 :CH 3 ; X 3 :COCH 3 ; X 4 : CN) and methacryloyl chloride using aqueous THF/NaOH mixture at 0°C. MS 1 , MS 2 and MS 4 liquid monomers are obtained whereas MS 3 is a solid monomer. Mass radical copolymerization of the different monomers (MS 1-4) with N-vinyl-2-pyrrolidone yields to the corresponding four copolymers. All the monomers have been characterized by IR, 1 H and 13 C NMR. The (CP 1-4) have been characterized by IR spectra, microanalysis, Tg ° and M v. The kinetics of aniline delivery to give anilinium cations (PaH +) 1-4 from solid MS 3 and CP 1-4 dispersed in water (pH= 1.2, 37°C) showed that aniline delivery from the different supports is controlled by a diffusion process and not the rate of amide hydrolysis. The amount (%) of free anilinium cations is inversely proportional to the molecular weight of polymeric supports. Accordingly, the monomer MS 3 gave the largest amount of free anilinium cations (PaH +) 1-4 .

Research paper thumbnail of Evaluation of anilines models release kinetics from dosage forms using Eudragit-RL as matrix

The galenic forms able to control drug release have been prepared and investigated in this paper.... more The galenic forms able to control drug release have been prepared and investigated in this paper. In o rder to follow and to control the release of anilines model (MA) 1-4, from spherical oral galenic forms in acidic mediu m, several kinetics of (MA) 1-4 release have been carried out at 37°C. Theoretical and experimental analysis of these kinetics were conducted in synthetic gastric fluid medium (pH=1.2), and the process was found to be controlled by transient diffusion, with constant diffusivities , for the liquid into and medical agent (MA) out of the galenic forms. According to Fick’s law, a mathematical trea tment led to evaluate the amount of matter transfer red at time (t). The present study demonstrates that it is possible to derive a direct expression for rate di ffusion’s of medical agent (MA).

Research paper thumbnail of Controlled release of amoxicillin from PMMA and poly ( butylsuccinate ) microspheres

ISSN: 2410-9649 Boukhouya et al / Chemistry International 4(2) (2018) 120-129 iscientic.org.

Research paper thumbnail of Cinnamaldehyde loaded-microparticles obtained by complex coacervation: Influence of the process parameters on the morphology and the release of the core material

Encapsulation by complex coacervation includes several steps that have been developed in order to... more Encapsulation by complex coacervation includes several steps that have been developed in order to attain a better control over the whole process and to achieve an important delayed effect. This has been carried out for the encapsulation of cinnamaldehyde (CN) by the classical gelatin/acacia gum pair of coacervating polymers. This preparation was performed in different conditions (stirring speeds, cooling rate, emulsion and coacervate time, use of surfactant, and polymer concentration) in order to investigate their effect on the encapsulation efficiency and drug release kinetics. Optical microscopy studies showed spherical microcapsules. The yield of the encapsulation attains more than 88% of all prepared microcapsules. The mean Sauter diameter (d 32) of obtained microparticles was in the range from 124 to 200 µm. The microspheres were also characterized by the FTIR method; showing the presence of core and polymers in the microparticles. The release of cinnamaldehyde was performed in...

Research paper thumbnail of Formulation, evaluation and microbiological activity of ampicillin and amoxicillin microspheres

The aim of this study is to improve properties of two antibiotics, ampicillin (AM) and amoxicilli... more The aim of this study is to improve properties of two antibiotics, ampicillin (AM) and amoxicillin (AMO), for controlled delivery. Microspheres loaded with (AM) or (AMO) were prepared by oil-in-water (O/W) emulsion solvent evaporation method. Ethylcellulose (EC) and poly (ε-caprolactone) (PCL) were used to prepare the microspheres with tween80 (T80) and gelatin (GE) as emulsifiers. These systems were characterized by SEM and FTIR spectroscopy and the size distribution was also determined. The results suggest that the entrapment in the microspheres was more than 70%. Data obtained from in-vitro drug release from microspheres were fitted to various kinetic models. Drug release kinetics corresponds to Higuchi model. The antimicrobial activity of the released (AM) and (AMO) was confirmed by Escherichia coli and Klebsiella bioassay.

Research paper thumbnail of Effect of formulation parameters on encapsulation efficiency and release behavior of p-aminobenzoic acid-loaded ethylcellulose microspheres

Journal of the Serbian Chemical Society, 2016

In the current study, p-aminobenzoic acid-loaded ethylcellulose microspheres were prepared under ... more In the current study, p-aminobenzoic acid-loaded ethylcellulose microspheres were prepared under various conditions by the solvent evaporation method (o/w). This preparation was performed with different p-aminobenzoic acid:ethylcellulose (PABA:EC) ratios, stirring speeds, surfactant nature and concentrations in order to investigate their effect on the encapsulation efficiency and drug release kinetics. Scanning electron microscopy (SEM) studies showed spherical microspheres with a porous surface and different structures. The mean Sauter diameter (d 32) of these microparticles was in the range from 47 to 165 µm with PVA and from 793 to 870 µm with Tween 80 by adjusting process parameters. However, the encapsulation efficiency varied from 37.52 to 79.05 % suitable for the adjustment of a p-aminobenzoic acid with prolonged release. The microspheres were characterized by the FTIR, DSC and XRD methods. The release of the cation of p-aminobenzoic acid was performed in simulated gastric medium at pH 1.2 and at 37±0.5 °C using UV-Vis analysis to estimate its content. The release data were best fitted to the Higuchi model with high correlation coefficients (r²) and the values of n obtained from the Korsmeyer-Peppas method showed that the drug release followed the Fickian diffusion mechanism.

Research paper thumbnail of Synthesis of some poly (N-2-vinyl pyrrolidone-co-metha crylamide)s as model carriers of anilines. Study of the release of anilines in aqueous heterogeneous medium of pH=1.2 at 37°C

Mediterranean Journal of Chemistry, 2011

Four secondary amides have been prepared by the Schotten-Baumann reaction between model anilines ... more Four secondary amides have been prepared by the Schotten-Baumann reaction between model anilines (Pa 1-4 : p-XC 6 H 4 NH 2: X 1 : H; X 2 :CH 3 ; X 3 :COCH 3 ; X 4 : CN) and methacryloyl chloride using aqueous THF/NaOH mixture at 0°C. MS 1 , MS 2 and MS 4 liquid monomers are obtained whereas MS 3 is a solid monomer. Mass radical copolymerization of the different monomers (MS 1-4) with N-vinyl-2-pyrrolidone yields to the corresponding four copolymers. All the monomers have been characterized by IR, 1 H and 13 C NMR. The (CP 1-4) have been characterized by IR spectra, microanalysis, Tg ° and M v. The kinetics of aniline delivery to give anilinium cations (PaH +) 1-4 from solid MS 3 and CP 1-4 dispersed in water (pH= 1.2, 37°C) showed that aniline delivery from the different supports is controlled by a diffusion process and not the rate of amide hydrolysis. The amount (%) of free anilinium cations is inversely proportional to the molecular weight of polymeric supports. Accordingly, the monomer MS 3 gave the largest amount of free anilinium cations (PaH +) 1-4 .