Mohsin Ahmed | University of Dhaka, Bangladesh (original) (raw)
Papers by Mohsin Ahmed
International journal of clinical medicine, 2024
Bangladesh Heart Journal
Objective: Vitamin D deficiency is emerging as a new risk factor for various cardiovascular event... more Objective: Vitamin D deficiency is emerging as a new risk factor for various cardiovascular events. Several studies have been done to find out association of vitamin D level with CAD with varying Results. Very few studies, however, have investigated the association between serum vitamin D levels and clinical outcomes in ACS patients thus far. The Objective of this study was to assess the association between serum vitamin D levels and in-hospital complications of AMI patients in Department of Cardiology, Dhaka Medical College Hospital (DMCH), Dhaka. Methods: This was a cross-sectional observational study. We measured serum vitamin D level in AMI (STEMI and NSTEMI) patients (n=198) admitted in Department of Cardiology, DMCH. Patients with normal vitamin D level (e”30 ng/ml) were considered as Group I and patients with low serum vitamin D level (<30 ng/ml) were considered as Group II; and in-hospital complications were evaluated. Results: The study showed that 51% of study subjects...
Fortune Journals of Cardiology and Cardiovascular Medicine , 2023
Background: Antiplatelet therapy is a cornerstone in the management of the Acute Coronary syndrom... more Background: Antiplatelet therapy is a cornerstone in the management of the Acute Coronary syndrome and the prevention of stent thrombosis after PCI. After aspirin clopidogrel is the widely used antiplatelet drug in our country. Many studies showed that clopidogrel resistance is the emerging problem for managing ACS patients and after coronary intervention. But exact data about clopidogrel resistance of Bangladeshi population is still unknown. Objectives: The purpose of the present study was to determine the prevalence of clopidogrel resistance among the Bangladeshi patients with Acute Coronary Syndrome. Methods: In this observational study a total 200 patients with Acute Coronary Syndrome were enrolled to see the prevalence of Clopidogrel resistance. Results: The mean age of the study population was 52.32±9.86 years and the study showed male predominance (84 % was male and 16 % was female). Female patients and smoker patients had higher incidence of clopidogrel resistance. Dominant CYP2C19 genotype was CYP2C19 (*1/*2) which was 52%. 33% of study population had CYP2C19 (*1/*1) genotype, 9% had CYP2C19 (*1/*17) genotype, 3 % had CYP2C19 (*2/*17) genotype, 2% had CYP2C19 (*17/*17) genotype and only 1% had CYP2C19 (*2/*2) genotype. In this study we found 44 % study population was clopidogrel sensitive (Ultrarapid metabolizer: 11%, Extensive metabolizer: 33%). 56% study population had clopidogrel resistance (Intermediate metabolizer: 55%, Poor metabolizer: 1%). Conclusion: 56% of our study population was clopidogrel resistance among them 55% was intermediate metabolizer and only 1% was poor metabolizer.
Bangladesh Heart Journal
Aim: This study aimed to evaluate the impact of coronavirus disease2019(Covid-19) outbreak on adm... more Aim: This study aimed to evaluate the impact of coronavirus disease2019(Covid-19) outbreak on admissions for acute coronary syndrome (ACS) and related mortality, severity of presentation, major cardiac complications, and outcome in tertiary care hospital (NICVD). Method: This is a cross sectional observational study on ACS admitted patients during the 1st and 2nd phase of COVID-19 from 1st June to 31st August in the year 2020 and 2021 who were COVID negative (RT PCR). Using a control of ACS admitted patients during corresponding period of year 2019 from registry. Results: During the 1st phase of COVID (July to August 2020) 736 ACS patients were enrolled where as during 2nd phase (July to August 2021) 722 ACS patients were enrolled. Mean age were 52±8 vs 53±11 years. Demographic variables such as age, sex and risk factors are almost identical in all groups. Our study showed 46% decline in admission in ACS patients comparing same period of 2019. Though some inclination in 2021 still i...
Introduction: SARS-CoV2 infection can impact all organs structurally and functionally. Persisting... more Introduction: SARS-CoV2 infection can impact all organs structurally and functionally. Persisting symptoms in patients recovering from coronavirus disease 2019 (COVID-19) are common and with close follow-up can be detected in nearly 90% of patients 60 days from the original diagnosis1. The most common symptoms are fatigue, dyspnea, joint pain, chest pain, cough, insomnia and headache. Given the well-documented involvement of the circulatory system in COVID-19, including small, moderate and large-sized veins and arteries, coupled with robust immune and resulting local and systemic inflammatory responses, one would anticipate a prolonged recovery period and potentially long-term cardiovascular effects. The following review summarizes the pathogenesis of structural, functional and metabolic abnormalities associated with COVID-19 and postulates long-term cardiovascular effects and management strategies under a broad clinical umbrella referred to as post-COVID-19 syndrome.
Bangladesh Heart Journal, 2018
Background:Young women undergoing percutaneous coronary intervention (PCI) for acute coronary syn... more Background:Young women undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) experience greater short-term adverse events than young men. There is a scarcity of data on the short-term adverse outcomes between young Bangladeshi males and females with ACS undergoing PCI.Objectives: This study was conducted to compare the short-term outcomes of PCI between young males and females presenting with ACS.Methods: This prospective observational study was done in the Department of Cardiology, National Institute of Cardiovascular Diseases (NICVD) fromApril 2016 to March 2017. 190 young patients with ACS and undergoing PCI were enrolled. They were equally divided into two groups, group I (young females <55 years) and group II (young males <45 years).Results: The mean age of young females and males was 43.8±6.9 years and 40.1±4.3 years respectively. Young women had significantly higher risk factors of hypertension (62.1% vs 33.7%, p<0.0010) and diabetes (...
Cardiovascular Journal, 2010
Infective mitral valve endocarditis developed in a 35-year-old male patient after a percutaneous ... more Infective mitral valve endocarditis developed in a 35-year-old male patient after a percutaneous transvenous mitral commissurotomy (PTMC). The echocardiogram demonstrated vegetation in the anterior leaflet of the mitral valve and blood culture showed growth of Pseudomonas species which was sensitive to Ceftazidime, Ciprofloxacin, Cotrimoxazole and Imipenem and resistant to Amikacin, Ceftriaxone, Gentamycin and Nitilmycin. The patient underwent treatment with intravenous ceftazidime and ciprofloxacin for six weeks and patient improved significantly and got cure of the disease. Infective mitral valve endocarditis should be recognized as a potentially lethal complication after PTMC. The important measures to prevent bacteremia during PTMC and the appropriate role of antibiotics and operation are discussed. Keywords: PTMC; Infective endocarditis. DOI: 10.3329/cardio.v2i2.6649Cardiovasc. j. 2010; 2(2) : 252-255
Bangladesh Heart Journal, 2018
Background: Recent evidence suggests that inflammatory markers and poor glycemic control are sign... more Background: Recent evidence suggests that inflammatory markers and poor glycemic control are significantly associated with the development of cardiovascular complications. The purpose of this study was to determine the association between inflammatory marker (CRP) and glycemic status (HbA1c) in ischemic heart disease patients. Method: This cross sectional study was performed on 668 patients of ischemic heart disease in the Department of Cardiology, Dhaka Medical College Hospital, Dhaka, who underwent Coronary angiogram from January 2017 to December 2017. CRP value were divided into normal (<6 mg/L), borderline (6-10 mg/L) and high (>10 mg/L) and HbA1c was divided <6.5% and ≥6.5%. After performed Coronary angiography the extent of disease was divided into insignificant CAD of (<50% stenosis), significant CAD considered as >50% stenosis and single vessel, double vessel, triple vessel CAD and normal coronaries. The relationship between CRP with HbA1c was analyzed by Chi ...
Bangladesh Heart Journal, 2019
The prevalence of peripheral artery disease (PAD) continues to increase worldwide. It is importan... more The prevalence of peripheral artery disease (PAD) continues to increase worldwide. It is important to identify patients with PAD because of the increased risk of myocardial infarction, stroke, and cardiovascular death and impaired quality of life because of a profound limitation in exercise performance.Lower extremity PAD affects approximately 10% of population, with 30% to 40% of these patients presenting with claudication symptoms. Peripheral arterial disease is common, but the diagnosis frequently is overlooked because of subtle physical findings and lack of classic symptoms. Screening based on the ankle brachial index using doppler ultrasonography may be more useful than physical examination alone. Noninvasive modalities to locate lesions include duplex scanning, computed tomography angiogram, magnetic resonance angiography and invasive modalities peripheral angiogram is the gold standard. Major risk factors for peripheral arterial disease are cigarette smoking, diabetes mellitu...
Journal of the American College of Cardiology, 2015
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: Bangladesh is a densely populated country of South East Asia with low resource settin... more Background: Bangladesh is a densely populated country of South East Asia with low resource setting where cervical cancer is the 2nd leading cause of female cancer. In more than 80% cases are diagnosed at advanced and inoperable stage. Regarding socio demographic context of this country VIA has been introduced as a screening method for cervical cancer which is most simple, cost effective, and acceptable test for all women. In Bangladesh among 3 million garment workers more than 80% are women. The objective of this study was to identify prevalence of VIA positive cases among garment workers. So that it can reduce the incidence of cervical cancer in Bangladesh. Methods: It was a cross–sectional observational study conducted in some selected garment factories in Chattogram city of Bangladesh from January 2021 to July 2021, where we enrolled 534 female workers for VIA test. Results: Among all the respondents 56% were 30 years or younger, 38% were aged between 31 to 40 years. Among 534 pa...
Journal of Invasive and Clinical Cardiology, 2022
Background: A country's intellectual and academic status can be determined by the quality and qua... more Background: A country's intellectual and academic status can be determined by the quality and quantity of its published scientific articles. Impact Factor (IF) is a widely accepted tool to discern this status. The aim of this review paper is to get an idea about the status of medical publications in Bangladesh. Methods: Advanced searches were performed to carry out this study. Various National and International databases were used. Literature searches were performed using ISI, Scopus and PubMed (Medline) computer databases. Results: Though there are 155 medical and dental journals in Bangladesh, only 4 journals from Bangladesh are indexed in the Scopus database (Scientific Bangladesh, 2019). The output of indexed medical journals from Bangladesh is much less than other South Asian countries like India and Pakistan. Conclusions: Comparing to our two very neighboring countries India and Pakistan, we still lag behind in terms of medical publications let alone other European countries. Government as well as other concerned authorities should come forward to mitigating this disparity.
Bangladesh Heart Journal, 2016
Introduction: Brain abscess is a complication of congenital cyanotic heart disease with or withou... more Introduction: Brain abscess is a complication of congenital cyanotic heart disease with or without shunt anomaly. It is more common in children. Here, we delineated a case of 19-year-old young Bangladeshi-Bengali male who presenting with brain abscess, an unusual presentation of cyanotic complex congenital heart disease. This case report focuses not only on the unusual presentation of congenital heart disease but also emphasizes the importance of early recognition of neurological complication for referal management.
Journal of the American College of Cardiology, 2002
This study was designed to determine the relationship between baseline white blood cell (WBC) cou... more This study was designed to determine the relationship between baseline white blood cell (WBC) count and angiographic and clinical outcomes in patients with unstable angina (UA)/non-ST-segment elevation myocardial infarction (NSTEMI) and to see if WBC count was a significant predictor of outcomes independent of other biomarkers. BACKGROUND Inflammation has been shown to play a role in atherosclerosis and acute coronary syndromes. METHODS We evaluated the relationship between baseline WBC count, other baseline variables and biomarkers, angiographic findings, and clinical outcomes in 2,208 patients in the Treat angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombolysis In Myocardial Infarction 18 (TACTICS-TIMI 18) trial. RESULTS Higher baseline WBC counts were associated with lower Thrombolysis In Myocardial Infarction (TIMI) flow grades (p ϭ 0.0045) and TIMI myocardial perfusion grades (p ϭ 0.03) as well as a greater extent of coronary artery disease (CAD) (p Ͻ 0.0001). A higher baseline WBC count was predictive of higher six-month mortality, ranging from 1.5% to 3.6% to 5.1% for patients with low, intermediate, and high WBC counts, respectively (p ϭ 0.0017). In a multivariable proportional hazards model, patients with a low C-reactive protein (CRP) but an elevated WBC remained at significantly higher risk of death at six months (hazard ratio [HR] 4.3, p ϭ 0.049), and patients with a high CRP were at even higher risk (HR 8.6, p ϭ 0.004). CONCLUSIONS In patients with UA/NSTEMI, elevations in a simple, widely available blood test, the WBC count, were associated with impaired epicardial and myocardial perfusion, more extensive CAD, and higher six-month mortality. After adjustment for traditional risk factors and other biomarkers, assessment of two inflammatory markers, WBC count and CRP, can be used to stratify patients across an eightfold gradation of six-month mortality risk.
premature death in most part of the world. Acute myocardial infarction (AMl) is one of the leadin... more premature death in most part of the world. Acute myocardial infarction (AMl) is one of the leading causes of death and disability. lt generally occurs due to sudden occlusion of a coronary artery by formation of thrombus at the site of fissured or ruptured atherosclerotic plaque.lThe major aspect of treatment of ST elevated Myocardial lnfarction (STEMI) is reperfusion of the infarct related artery. DO I : http ://dx.doi.org/1 0. 3329/bhj.v 33i2.39 3 07 Copyright A 2U7 Bangladesh Cardiac Society. Published by Bangladesh Cardiac Society. This is an Open.Access articles pubtished under the Creative Commons Attribution-Noncommercial 4.0 lnternational License (CC BY-NC). This license permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
This is an Open Access articles published under the Creative CommonsAttribution-Noncommercial 4.A... more This is an Open Access articles published under the Creative CommonsAttribution-Noncommercial 4.Alnbrnatianal License(CCBY-NC). Thislicensepermitsuse,distributionancl reprocluctioninanymedium,providecl the original work is propely cited and is not used for commercial purposes.
High-Density Lipoprotein as a Therapeutic Target: Treatment Strategies MA(.I Chowd,hurv, ;i;;; nM... more High-Density Lipoprotein as a Therapeutic Target: Treatment Strategies MA(.I Chowd,hurv, ;i;;; nM Rahnt'Ln' AEMM Islam' AKMM Islam New Hope for Resistant Hypertention
International journal of clinical medicine, 2024
Bangladesh Heart Journal
Objective: Vitamin D deficiency is emerging as a new risk factor for various cardiovascular event... more Objective: Vitamin D deficiency is emerging as a new risk factor for various cardiovascular events. Several studies have been done to find out association of vitamin D level with CAD with varying Results. Very few studies, however, have investigated the association between serum vitamin D levels and clinical outcomes in ACS patients thus far. The Objective of this study was to assess the association between serum vitamin D levels and in-hospital complications of AMI patients in Department of Cardiology, Dhaka Medical College Hospital (DMCH), Dhaka. Methods: This was a cross-sectional observational study. We measured serum vitamin D level in AMI (STEMI and NSTEMI) patients (n=198) admitted in Department of Cardiology, DMCH. Patients with normal vitamin D level (e”30 ng/ml) were considered as Group I and patients with low serum vitamin D level (<30 ng/ml) were considered as Group II; and in-hospital complications were evaluated. Results: The study showed that 51% of study subjects...
Fortune Journals of Cardiology and Cardiovascular Medicine , 2023
Background: Antiplatelet therapy is a cornerstone in the management of the Acute Coronary syndrom... more Background: Antiplatelet therapy is a cornerstone in the management of the Acute Coronary syndrome and the prevention of stent thrombosis after PCI. After aspirin clopidogrel is the widely used antiplatelet drug in our country. Many studies showed that clopidogrel resistance is the emerging problem for managing ACS patients and after coronary intervention. But exact data about clopidogrel resistance of Bangladeshi population is still unknown. Objectives: The purpose of the present study was to determine the prevalence of clopidogrel resistance among the Bangladeshi patients with Acute Coronary Syndrome. Methods: In this observational study a total 200 patients with Acute Coronary Syndrome were enrolled to see the prevalence of Clopidogrel resistance. Results: The mean age of the study population was 52.32±9.86 years and the study showed male predominance (84 % was male and 16 % was female). Female patients and smoker patients had higher incidence of clopidogrel resistance. Dominant CYP2C19 genotype was CYP2C19 (*1/*2) which was 52%. 33% of study population had CYP2C19 (*1/*1) genotype, 9% had CYP2C19 (*1/*17) genotype, 3 % had CYP2C19 (*2/*17) genotype, 2% had CYP2C19 (*17/*17) genotype and only 1% had CYP2C19 (*2/*2) genotype. In this study we found 44 % study population was clopidogrel sensitive (Ultrarapid metabolizer: 11%, Extensive metabolizer: 33%). 56% study population had clopidogrel resistance (Intermediate metabolizer: 55%, Poor metabolizer: 1%). Conclusion: 56% of our study population was clopidogrel resistance among them 55% was intermediate metabolizer and only 1% was poor metabolizer.
Bangladesh Heart Journal
Aim: This study aimed to evaluate the impact of coronavirus disease2019(Covid-19) outbreak on adm... more Aim: This study aimed to evaluate the impact of coronavirus disease2019(Covid-19) outbreak on admissions for acute coronary syndrome (ACS) and related mortality, severity of presentation, major cardiac complications, and outcome in tertiary care hospital (NICVD). Method: This is a cross sectional observational study on ACS admitted patients during the 1st and 2nd phase of COVID-19 from 1st June to 31st August in the year 2020 and 2021 who were COVID negative (RT PCR). Using a control of ACS admitted patients during corresponding period of year 2019 from registry. Results: During the 1st phase of COVID (July to August 2020) 736 ACS patients were enrolled where as during 2nd phase (July to August 2021) 722 ACS patients were enrolled. Mean age were 52±8 vs 53±11 years. Demographic variables such as age, sex and risk factors are almost identical in all groups. Our study showed 46% decline in admission in ACS patients comparing same period of 2019. Though some inclination in 2021 still i...
Introduction: SARS-CoV2 infection can impact all organs structurally and functionally. Persisting... more Introduction: SARS-CoV2 infection can impact all organs structurally and functionally. Persisting symptoms in patients recovering from coronavirus disease 2019 (COVID-19) are common and with close follow-up can be detected in nearly 90% of patients 60 days from the original diagnosis1. The most common symptoms are fatigue, dyspnea, joint pain, chest pain, cough, insomnia and headache. Given the well-documented involvement of the circulatory system in COVID-19, including small, moderate and large-sized veins and arteries, coupled with robust immune and resulting local and systemic inflammatory responses, one would anticipate a prolonged recovery period and potentially long-term cardiovascular effects. The following review summarizes the pathogenesis of structural, functional and metabolic abnormalities associated with COVID-19 and postulates long-term cardiovascular effects and management strategies under a broad clinical umbrella referred to as post-COVID-19 syndrome.
Bangladesh Heart Journal, 2018
Background:Young women undergoing percutaneous coronary intervention (PCI) for acute coronary syn... more Background:Young women undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) experience greater short-term adverse events than young men. There is a scarcity of data on the short-term adverse outcomes between young Bangladeshi males and females with ACS undergoing PCI.Objectives: This study was conducted to compare the short-term outcomes of PCI between young males and females presenting with ACS.Methods: This prospective observational study was done in the Department of Cardiology, National Institute of Cardiovascular Diseases (NICVD) fromApril 2016 to March 2017. 190 young patients with ACS and undergoing PCI were enrolled. They were equally divided into two groups, group I (young females <55 years) and group II (young males <45 years).Results: The mean age of young females and males was 43.8±6.9 years and 40.1±4.3 years respectively. Young women had significantly higher risk factors of hypertension (62.1% vs 33.7%, p<0.0010) and diabetes (...
Cardiovascular Journal, 2010
Infective mitral valve endocarditis developed in a 35-year-old male patient after a percutaneous ... more Infective mitral valve endocarditis developed in a 35-year-old male patient after a percutaneous transvenous mitral commissurotomy (PTMC). The echocardiogram demonstrated vegetation in the anterior leaflet of the mitral valve and blood culture showed growth of Pseudomonas species which was sensitive to Ceftazidime, Ciprofloxacin, Cotrimoxazole and Imipenem and resistant to Amikacin, Ceftriaxone, Gentamycin and Nitilmycin. The patient underwent treatment with intravenous ceftazidime and ciprofloxacin for six weeks and patient improved significantly and got cure of the disease. Infective mitral valve endocarditis should be recognized as a potentially lethal complication after PTMC. The important measures to prevent bacteremia during PTMC and the appropriate role of antibiotics and operation are discussed. Keywords: PTMC; Infective endocarditis. DOI: 10.3329/cardio.v2i2.6649Cardiovasc. j. 2010; 2(2) : 252-255
Bangladesh Heart Journal, 2018
Background: Recent evidence suggests that inflammatory markers and poor glycemic control are sign... more Background: Recent evidence suggests that inflammatory markers and poor glycemic control are significantly associated with the development of cardiovascular complications. The purpose of this study was to determine the association between inflammatory marker (CRP) and glycemic status (HbA1c) in ischemic heart disease patients. Method: This cross sectional study was performed on 668 patients of ischemic heart disease in the Department of Cardiology, Dhaka Medical College Hospital, Dhaka, who underwent Coronary angiogram from January 2017 to December 2017. CRP value were divided into normal (<6 mg/L), borderline (6-10 mg/L) and high (>10 mg/L) and HbA1c was divided <6.5% and ≥6.5%. After performed Coronary angiography the extent of disease was divided into insignificant CAD of (<50% stenosis), significant CAD considered as >50% stenosis and single vessel, double vessel, triple vessel CAD and normal coronaries. The relationship between CRP with HbA1c was analyzed by Chi ...
Bangladesh Heart Journal, 2019
The prevalence of peripheral artery disease (PAD) continues to increase worldwide. It is importan... more The prevalence of peripheral artery disease (PAD) continues to increase worldwide. It is important to identify patients with PAD because of the increased risk of myocardial infarction, stroke, and cardiovascular death and impaired quality of life because of a profound limitation in exercise performance.Lower extremity PAD affects approximately 10% of population, with 30% to 40% of these patients presenting with claudication symptoms. Peripheral arterial disease is common, but the diagnosis frequently is overlooked because of subtle physical findings and lack of classic symptoms. Screening based on the ankle brachial index using doppler ultrasonography may be more useful than physical examination alone. Noninvasive modalities to locate lesions include duplex scanning, computed tomography angiogram, magnetic resonance angiography and invasive modalities peripheral angiogram is the gold standard. Major risk factors for peripheral arterial disease are cigarette smoking, diabetes mellitu...
Journal of the American College of Cardiology, 2015
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: Bangladesh is a densely populated country of South East Asia with low resource settin... more Background: Bangladesh is a densely populated country of South East Asia with low resource setting where cervical cancer is the 2nd leading cause of female cancer. In more than 80% cases are diagnosed at advanced and inoperable stage. Regarding socio demographic context of this country VIA has been introduced as a screening method for cervical cancer which is most simple, cost effective, and acceptable test for all women. In Bangladesh among 3 million garment workers more than 80% are women. The objective of this study was to identify prevalence of VIA positive cases among garment workers. So that it can reduce the incidence of cervical cancer in Bangladesh. Methods: It was a cross–sectional observational study conducted in some selected garment factories in Chattogram city of Bangladesh from January 2021 to July 2021, where we enrolled 534 female workers for VIA test. Results: Among all the respondents 56% were 30 years or younger, 38% were aged between 31 to 40 years. Among 534 pa...
Journal of Invasive and Clinical Cardiology, 2022
Background: A country's intellectual and academic status can be determined by the quality and qua... more Background: A country's intellectual and academic status can be determined by the quality and quantity of its published scientific articles. Impact Factor (IF) is a widely accepted tool to discern this status. The aim of this review paper is to get an idea about the status of medical publications in Bangladesh. Methods: Advanced searches were performed to carry out this study. Various National and International databases were used. Literature searches were performed using ISI, Scopus and PubMed (Medline) computer databases. Results: Though there are 155 medical and dental journals in Bangladesh, only 4 journals from Bangladesh are indexed in the Scopus database (Scientific Bangladesh, 2019). The output of indexed medical journals from Bangladesh is much less than other South Asian countries like India and Pakistan. Conclusions: Comparing to our two very neighboring countries India and Pakistan, we still lag behind in terms of medical publications let alone other European countries. Government as well as other concerned authorities should come forward to mitigating this disparity.
Bangladesh Heart Journal, 2016
Introduction: Brain abscess is a complication of congenital cyanotic heart disease with or withou... more Introduction: Brain abscess is a complication of congenital cyanotic heart disease with or without shunt anomaly. It is more common in children. Here, we delineated a case of 19-year-old young Bangladeshi-Bengali male who presenting with brain abscess, an unusual presentation of cyanotic complex congenital heart disease. This case report focuses not only on the unusual presentation of congenital heart disease but also emphasizes the importance of early recognition of neurological complication for referal management.
Journal of the American College of Cardiology, 2002
This study was designed to determine the relationship between baseline white blood cell (WBC) cou... more This study was designed to determine the relationship between baseline white blood cell (WBC) count and angiographic and clinical outcomes in patients with unstable angina (UA)/non-ST-segment elevation myocardial infarction (NSTEMI) and to see if WBC count was a significant predictor of outcomes independent of other biomarkers. BACKGROUND Inflammation has been shown to play a role in atherosclerosis and acute coronary syndromes. METHODS We evaluated the relationship between baseline WBC count, other baseline variables and biomarkers, angiographic findings, and clinical outcomes in 2,208 patients in the Treat angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombolysis In Myocardial Infarction 18 (TACTICS-TIMI 18) trial. RESULTS Higher baseline WBC counts were associated with lower Thrombolysis In Myocardial Infarction (TIMI) flow grades (p ϭ 0.0045) and TIMI myocardial perfusion grades (p ϭ 0.03) as well as a greater extent of coronary artery disease (CAD) (p Ͻ 0.0001). A higher baseline WBC count was predictive of higher six-month mortality, ranging from 1.5% to 3.6% to 5.1% for patients with low, intermediate, and high WBC counts, respectively (p ϭ 0.0017). In a multivariable proportional hazards model, patients with a low C-reactive protein (CRP) but an elevated WBC remained at significantly higher risk of death at six months (hazard ratio [HR] 4.3, p ϭ 0.049), and patients with a high CRP were at even higher risk (HR 8.6, p ϭ 0.004). CONCLUSIONS In patients with UA/NSTEMI, elevations in a simple, widely available blood test, the WBC count, were associated with impaired epicardial and myocardial perfusion, more extensive CAD, and higher six-month mortality. After adjustment for traditional risk factors and other biomarkers, assessment of two inflammatory markers, WBC count and CRP, can be used to stratify patients across an eightfold gradation of six-month mortality risk.
premature death in most part of the world. Acute myocardial infarction (AMl) is one of the leadin... more premature death in most part of the world. Acute myocardial infarction (AMl) is one of the leading causes of death and disability. lt generally occurs due to sudden occlusion of a coronary artery by formation of thrombus at the site of fissured or ruptured atherosclerotic plaque.lThe major aspect of treatment of ST elevated Myocardial lnfarction (STEMI) is reperfusion of the infarct related artery. DO I : http ://dx.doi.org/1 0. 3329/bhj.v 33i2.39 3 07 Copyright A 2U7 Bangladesh Cardiac Society. Published by Bangladesh Cardiac Society. This is an Open.Access articles pubtished under the Creative Commons Attribution-Noncommercial 4.0 lnternational License (CC BY-NC). This license permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
This is an Open Access articles published under the Creative CommonsAttribution-Noncommercial 4.A... more This is an Open Access articles published under the Creative CommonsAttribution-Noncommercial 4.Alnbrnatianal License(CCBY-NC). Thislicensepermitsuse,distributionancl reprocluctioninanymedium,providecl the original work is propely cited and is not used for commercial purposes.
High-Density Lipoprotein as a Therapeutic Target: Treatment Strategies MA(.I Chowd,hurv, ;i;;; nM... more High-Density Lipoprotein as a Therapeutic Target: Treatment Strategies MA(.I Chowd,hurv, ;i;;; nM Rahnt'Ln' AEMM Islam' AKMM Islam New Hope for Resistant Hypertention