Anca Sirbu | University of Medicine and Pharmacy "Carol Davila" Bucharest (original) (raw)

Papers by Anca Sirbu

Research paper thumbnail of Current Recommendations for Surgical Treatment of Diabetes

Current Recommendations for Surgical Treatment of Diabetes

Treatment of Type 2 Diabetes, 2015

Research paper thumbnail of The Relationship Between Baseline 25HO Vitamin D Serum Levels and the Effect of Antiresorbtive Treatment in 680 Women with Postmenopausal Osteoporosis

The Relationship Between Baseline 25HO Vitamin D Serum Levels and the Effect of Antiresorbtive Treatment in 680 Women with Postmenopausal Osteoporosis

Research paper thumbnail of Impactul diferitelor normative de crestere in evaluarea copiilor de varsta scolara din Bucuresti

Impactul diferitelor normative de crestere in evaluarea copiilor de varsta scolara din Bucuresti

Research paper thumbnail of Prevalenta obezitatii si a tulburarilor de crestere in randul elevilor bucuresteni

Prevalenta obezitatii si a tulburarilor de crestere in randul elevilor bucuresteni

Research paper thumbnail of Asocierea dintre sindromul metabolic si insuficienta vitaminei D la paciente cu osteoporoza

Asocierea dintre sindromul metabolic si insuficienta vitaminei D la paciente cu osteoporoza

Research paper thumbnail of Long-term Benefit of Laparoscopic Sleeve Gasterctomy on Metabolic Parameters

Long-term Benefit of Laparoscopic Sleeve Gasterctomy on Metabolic Parameters

Diabetes Technology &amp Therapeutics

Research paper thumbnail of Can Laparoscopic Sleeve Gastrectomy by Considered for Prevention of Metabolic Syndrome?

Can Laparoscopic Sleeve Gastrectomy by Considered for Prevention of Metabolic Syndrome?

Obesity Surgery

Research paper thumbnail of Relation between plasma levels of adiponectin, cardiometabolic risk factors and adiponectin gene expression in visceral adipose tissue, in a group of severely obese patients

Relation between plasma levels of adiponectin, cardiometabolic risk factors and adiponectin gene expression in visceral adipose tissue, in a group of severely obese patients

Research paper thumbnail of Estrogenic Burden of Parabens Used in Child Care Products

Estrogenic Burden of Parabens Used in Child Care Products

Farmacia

Parabens are extensively used in personal care products as preservatives but the current regulati... more Parabens are extensively used in personal care products as preservatives but the current regulation of cosmetics (Directive 76/768/EEC) did not take into account their potentially endocrine-disrupting effects. Therefore we performed an assessment of the most used parabens (methyl - and n-propylparaben) investigating their estrogenic burden. Systemic exposure dose via cosmetics was estimated using two approaches: ConsExpo modeling and bio-monitoring data. The endocrine-disrupting effects (uterotrophic assay) were selected as the paraben's critical endpoints and using the assumption of the dose addition for combined effects of parabens, due to their toxicological similarity to estradiol, exposure was calculated in terms of estradiol and compared with the physiological ranges.

Research paper thumbnail of Metabolic Surgery for Dabetes Mellitus between Benefits and Risks

Metabolic Surgery for Dabetes Mellitus between Benefits and Risks

Acta Endocrinologica (Bucharest), 2015

Research paper thumbnail of Neutrophil to lymphocyte ratio: relationship with anthropometric and metabolic parameters in morbidly obese patients

Neutrophil to lymphocyte ratio: relationship with anthropometric and metabolic parameters in morbidly obese patients

Endocrine Abstracts, 2015

Research paper thumbnail of IGF1 deficiency in newly diagnosed Graves' disease patients

IGF1 deficiency in newly diagnosed Graves' disease patients

Endocrine Abstracts, 2015

Thyroid hormones influence the GH/IGF1 axis, but previous studies have reported discrepant result... more Thyroid hormones influence the GH/IGF1 axis, but previous studies have reported discrepant results regarding serum IGF1 levels in hyperthyroidism. We have therefore investigated, at diagnosis, the relationship between serum IGF1 levels and the main characteristics of Graves' disease (GD): severity of hyperthyroidism, goiter size, presence of active Graves' ophthalmopathy (GO), antythyroid antibodies status and titer. This cross-sectional study included 98 newly diagnosed hyperthyroid patients with GD who presented consecutively at our clinic. The main measured parameters were: TSH, FT4, FT3, TT3, thyroglobulin,anti-thyroid peroxidase antibodies (TPOAb), anti-thyroglobulin antibodies (ATA), thyrotropin receptor antibodies (TRAb), IGF1. Patients were considered IGF deficient if IGF1 z score was ≤-2SD from mean for age. In GD patients, men had higher IGF1 levels (p=0.023) and IGF1 z scores (p=0.013) than women. 18.4% of GD patients were, at diagnosis, IGF1 deficient. Compared to patients without IGF1 deficiency, these patients presented higher thyroglobulin (median=72.55, IQR=116.02 vs median=11.40, IQR=80.74 ng/ml, p=0.002) and FT3 (median=11.30, IQR=7.64 vs median=7.33, IQR=5.72 pg/ml, p=0.027), and lower ATA (median=20, IQR=0 vs median=34.05, IQR=161 iu/ml, p<0.001) levels. Thyroglobulin was independently associated with IGF1 deficiency (AUROC=0.732, 95% CI: 0.620-0.844, p=0.002; cut-off for thyroglobulin=50.40 ng/ml, Se=77.8%, Sp=70%). IGF1 status was not influenced by gender (p=0.084), current smoking (p=0.558), goiter size (p=0.533), active ophthalmopathy (p=0.334), TRAb (p=0.239) or TPOAb status (p=0.367). Nearly one fifth of newly diagnosed GD patients had IGF1 deficiency. IGF1 deficiency was associated with lower ATA titers, higher thyroglobulin levels and more severe FT3 hyperthyroidism at diagnosis.

Research paper thumbnail of Rare form of tuberculosis presented as thyroid mass

Acta Endocrinologica (Bucharest), 2005

Tuberculosis continues to be a universal health problem and recent studies showed an increased in... more Tuberculosis continues to be a universal health problem and recent studies showed an increased incidence of all forms of this disease. We report the case of a 81 year old female patient with a large left cervical tumour and cutaneous lesions that proved to be an unusual form of tuberculosis.

Research paper thumbnail of IGF-1 and Insulin Resistance Are Major Determinants of Common Carotid Artery Thickness in Morbidly Obese Young Patients

IGF-1 and Insulin Resistance Are Major Determinants of Common Carotid Artery Thickness in Morbidly Obese Young Patients

Angiology, Jan 17, 2015

We assessed the relationship between insulin resistance, serum insulin-like growth factor 1 (IGF-... more We assessed the relationship between insulin resistance, serum insulin-like growth factor 1 (IGF-1) levels, and common carotid intima-media thickness (CC-IMT) in morbidly obese young patients. A total of 249 patients (aged 37.9 ± 9.8 years, body mass index [BMI] 45.6 ± 8.3 kg/m(2)) were evaluated (metabolic tests, serum IGF-1 measurements, homeostasis model assessment-insulin resistance [HOMA-IR], and ultrasonographically assessed CC-IMT) in a research program for bariatric surgery candidates. After adjusting for age, gender, BMI, systolic blood pressure, uric acid, antihypertensive and lipid-lowering treatment, metabolic syndrome, and metabolic class, both HOMA-IR and IGF-1 z-score were significantly associated with CC-IMT. These results were confirmed in logistic regression analysis, in which age (β = 1.11, P = .001), gender (β = 3.19, P = .001), HOMA-IR (β = 1.221, P = .005), and IGF-1 z-score (β = 1.734, P = .009) were the only independent determinants of abnormal CC-IMT, presum...

Research paper thumbnail of Carotid IMT values are related to insulin resistance and visceral disposition of adiposity in obese patients

Carotid IMT values are related to insulin resistance and visceral disposition of adiposity in obese patients

Research paper thumbnail of The clinical value of human leukocyte antigen HLA-DRB1 subtypes associated to Graves' disease in Romanian population

The clinical value of human leukocyte antigen HLA-DRB1 subtypes associated to Graves' disease in Romanian population

Immunological Investigations

The aim of this study was to identify the primary susceptibility HLA-DRB1 alleles associated with... more The aim of this study was to identify the primary susceptibility HLA-DRB1 alleles associated with GD in Romanian population and to seek whether specific HLA-DRB1 haplotypes are associated with differences in the clinical presentation of GD at diagnosis. Molecular typing of HLA-DRB1 alleles was performed in 77 Romanian Caucasian GD patients and 445 racially matched controls. In GD patients, age, presence of eye disease, goiter grade, autoantibody status and titer, TSH, FT4, FT3, TT3 levels were recorded at diagnosis. The allelic frequencies of HLA-DRB1*03 (41.55% vs. 17.75%, p < 0.0001, χ(2) = 20.81) and DRB1*11 (42.85% vs. 30.56%, p = 0.045, χ(2)= 3.98)were higher, whereas those of HLA-DRB1*01(3.89% vs. 16.40%, p = 0.007, χ(2) = 7.281) and DRB1*15 (10.38% vs. 21.34%, p = 0.038, χ(2) = 4.309)were lower in GD patients than in controls. FT4/TT3 ratio (p = 0.015) and anti-thyroglobulin antibodies (p = 0.024) were higher in *03/11 patients compared to *X/X, *11/Z, *03/Y patients (wher...

Research paper thumbnail of Preoperative metabolic status is associated with adiponectin levels attained 6 months after laparoscopic sleeve gastrectomy, independently of the degree of weight loss

Preoperative metabolic status is associated with adiponectin levels attained 6 months after laparoscopic sleeve gastrectomy, independently of the degree of weight loss

Research paper thumbnail of Rare form of tuberculosis presented as" thyroid" mass

Tuberculosis continues to be a universal health problem and recent studies showed an increased in... more Tuberculosis continues to be a universal health problem and recent studies showed an increased incidence of all forms of this disease. We report the case of a 81 year old female patient with a large left cervical tumour and cutaneous lesions that proved to be an unusual form of tuberculosis. The patient had a 2 years history of slowly increasing left cervical mass with no significant clinical manifestation. Medical assistance was requested mostly by the family, concerned about the large mass visible on the left side of the patient's neck. Clinical and laboratory investigation revealed: a large left laterocervical tumour and the presence of erythematous, non pruriginous skin lesions. No significant changes were shown by routine blood tests. Thyroid function was in the normal range. Neck ultrasound revealed the presence of a 5/6 cm, well defined hypoechoic mass and the thyroid scan showed no accumulation of the radiotracer in the cervical tumour. Routine tuberculosis test was nega...

Research paper thumbnail of Thyroid hormones and proinflammatory cytokines' profile in amiodarone-induced thyrotoxicosis

In this study we aimed to assess amiodarone's effects on thyroid hormones, C reactive protein... more In this study we aimed to assess amiodarone's effects on thyroid hormones, C reactive protein (CRP), interleukin 6 (IL-6) and tumor necrosis factor (TNF-α) profile in amiodarone-induced thyrotoxicosis (AIT) and their relationship with arrhythmias. In 60 patients with AIT (29M/31F), aged 59.7 ± 1.5 years and 105 hyperthyroid patients (25M/80F), aged 59.4 ± 1 years, TSH, total T 3 , total T 4 , free T 4 were measured by IRMA or microenzymatic immunoassay. In 11 AIT patients and 26 patients with common hyperthyroidism, without significant Graves' ophthalmopathy, CRP, IL-6 and TNF-α were measured by chemiluminescent immunoassays. AIT patients showed significantly lower T 3 levels (273.82 ± 18.76 ng/dL) as compared to common thyrotoxicosis (361.89 ± 13.47 ng/dL), p<0.001, while T 4 and FT 4 were similar. AIT patients showed similar CRP, IL-6 and TNF-α levels to common hyperthyroidism (10.22 ± 3.03 mg/L vs. 6.31 ± 2.33 mg/L, p=0.11, for CRP, 17.46 ± 13.09 pg/mL vs. 6.46 ± 1.14 ...

Research paper thumbnail of Six months results of laparoscopic sleeve gastrectomy in treatment of obesity and its metabolic complications

Six months results of laparoscopic sleeve gastrectomy in treatment of obesity and its metabolic complications

Chirurgia (Bucharest, Romania: 1990)

Laparoscopic sleeve gastrectomy (LSG) has become a popular bariatric surgical procedure, with pro... more Laparoscopic sleeve gastrectomy (LSG) has become a popular bariatric surgical procedure, with proven results in achieving weight loss, however data regarding its effectiveness on metabolic syndrome (MetS) components are scarce. The aims of the present study were to assess the outcomes of LSG on weight loss and obesity associated metabolic complications at six months following intervention. This was a retrospective study on 124 consecutive obese patients (29.8% men), who had undergone LSG between 01/01/2008 and 12/31/2010, in a highly specialized clinic. The dynamic of anthropometric and biochemical data between baseline and six months following LSG were evaluated. We also determined the change in MetS prevalence and used logistic regression to estimate predictors of MetS remission 6 months after LSG, the body mass index (BMI) decreased from 46.84 +/- 8.62 to 33.81 +/- 7.04 kg/m2 (p < 0.001). Mean excess BMI loss (EBL) was 65.24 +/- 25.16%. The best results on weight loss were obs...

Research paper thumbnail of Current Recommendations for Surgical Treatment of Diabetes

Current Recommendations for Surgical Treatment of Diabetes

Treatment of Type 2 Diabetes, 2015

Research paper thumbnail of The Relationship Between Baseline 25HO Vitamin D Serum Levels and the Effect of Antiresorbtive Treatment in 680 Women with Postmenopausal Osteoporosis

The Relationship Between Baseline 25HO Vitamin D Serum Levels and the Effect of Antiresorbtive Treatment in 680 Women with Postmenopausal Osteoporosis

Research paper thumbnail of Impactul diferitelor normative de crestere in evaluarea copiilor de varsta scolara din Bucuresti

Impactul diferitelor normative de crestere in evaluarea copiilor de varsta scolara din Bucuresti

Research paper thumbnail of Prevalenta obezitatii si a tulburarilor de crestere in randul elevilor bucuresteni

Prevalenta obezitatii si a tulburarilor de crestere in randul elevilor bucuresteni

Research paper thumbnail of Asocierea dintre sindromul metabolic si insuficienta vitaminei D la paciente cu osteoporoza

Asocierea dintre sindromul metabolic si insuficienta vitaminei D la paciente cu osteoporoza

Research paper thumbnail of Long-term Benefit of Laparoscopic Sleeve Gasterctomy on Metabolic Parameters

Long-term Benefit of Laparoscopic Sleeve Gasterctomy on Metabolic Parameters

Diabetes Technology &amp Therapeutics

Research paper thumbnail of Can Laparoscopic Sleeve Gastrectomy by Considered for Prevention of Metabolic Syndrome?

Can Laparoscopic Sleeve Gastrectomy by Considered for Prevention of Metabolic Syndrome?

Obesity Surgery

Research paper thumbnail of Relation between plasma levels of adiponectin, cardiometabolic risk factors and adiponectin gene expression in visceral adipose tissue, in a group of severely obese patients

Relation between plasma levels of adiponectin, cardiometabolic risk factors and adiponectin gene expression in visceral adipose tissue, in a group of severely obese patients

Research paper thumbnail of Estrogenic Burden of Parabens Used in Child Care Products

Estrogenic Burden of Parabens Used in Child Care Products

Farmacia

Parabens are extensively used in personal care products as preservatives but the current regulati... more Parabens are extensively used in personal care products as preservatives but the current regulation of cosmetics (Directive 76/768/EEC) did not take into account their potentially endocrine-disrupting effects. Therefore we performed an assessment of the most used parabens (methyl - and n-propylparaben) investigating their estrogenic burden. Systemic exposure dose via cosmetics was estimated using two approaches: ConsExpo modeling and bio-monitoring data. The endocrine-disrupting effects (uterotrophic assay) were selected as the paraben's critical endpoints and using the assumption of the dose addition for combined effects of parabens, due to their toxicological similarity to estradiol, exposure was calculated in terms of estradiol and compared with the physiological ranges.

Research paper thumbnail of Metabolic Surgery for Dabetes Mellitus between Benefits and Risks

Metabolic Surgery for Dabetes Mellitus between Benefits and Risks

Acta Endocrinologica (Bucharest), 2015

Research paper thumbnail of Neutrophil to lymphocyte ratio: relationship with anthropometric and metabolic parameters in morbidly obese patients

Neutrophil to lymphocyte ratio: relationship with anthropometric and metabolic parameters in morbidly obese patients

Endocrine Abstracts, 2015

Research paper thumbnail of IGF1 deficiency in newly diagnosed Graves' disease patients

IGF1 deficiency in newly diagnosed Graves' disease patients

Endocrine Abstracts, 2015

Thyroid hormones influence the GH/IGF1 axis, but previous studies have reported discrepant result... more Thyroid hormones influence the GH/IGF1 axis, but previous studies have reported discrepant results regarding serum IGF1 levels in hyperthyroidism. We have therefore investigated, at diagnosis, the relationship between serum IGF1 levels and the main characteristics of Graves&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; disease (GD): severity of hyperthyroidism, goiter size, presence of active Graves&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; ophthalmopathy (GO), antythyroid antibodies status and titer. This cross-sectional study included 98 newly diagnosed hyperthyroid patients with GD who presented consecutively at our clinic. The main measured parameters were: TSH, FT4, FT3, TT3, thyroglobulin,anti-thyroid peroxidase antibodies (TPOAb), anti-thyroglobulin antibodies (ATA), thyrotropin receptor antibodies (TRAb), IGF1. Patients were considered IGF deficient if IGF1 z score was ≤-2SD from mean for age. In GD patients, men had higher IGF1 levels (p=0.023) and IGF1 z scores (p=0.013) than women. 18.4% of GD patients were, at diagnosis, IGF1 deficient. Compared to patients without IGF1 deficiency, these patients presented higher thyroglobulin (median=72.55, IQR=116.02 vs median=11.40, IQR=80.74 ng/ml, p=0.002) and FT3 (median=11.30, IQR=7.64 vs median=7.33, IQR=5.72 pg/ml, p=0.027), and lower ATA (median=20, IQR=0 vs median=34.05, IQR=161 iu/ml, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) levels. Thyroglobulin was independently associated with IGF1 deficiency (AUROC=0.732, 95% CI: 0.620-0.844, p=0.002; cut-off for thyroglobulin=50.40 ng/ml, Se=77.8%, Sp=70%). IGF1 status was not influenced by gender (p=0.084), current smoking (p=0.558), goiter size (p=0.533), active ophthalmopathy (p=0.334), TRAb (p=0.239) or TPOAb status (p=0.367). Nearly one fifth of newly diagnosed GD patients had IGF1 deficiency. IGF1 deficiency was associated with lower ATA titers, higher thyroglobulin levels and more severe FT3 hyperthyroidism at diagnosis.

Research paper thumbnail of Rare form of tuberculosis presented as thyroid mass

Acta Endocrinologica (Bucharest), 2005

Tuberculosis continues to be a universal health problem and recent studies showed an increased in... more Tuberculosis continues to be a universal health problem and recent studies showed an increased incidence of all forms of this disease. We report the case of a 81 year old female patient with a large left cervical tumour and cutaneous lesions that proved to be an unusual form of tuberculosis.

Research paper thumbnail of IGF-1 and Insulin Resistance Are Major Determinants of Common Carotid Artery Thickness in Morbidly Obese Young Patients

IGF-1 and Insulin Resistance Are Major Determinants of Common Carotid Artery Thickness in Morbidly Obese Young Patients

Angiology, Jan 17, 2015

We assessed the relationship between insulin resistance, serum insulin-like growth factor 1 (IGF-... more We assessed the relationship between insulin resistance, serum insulin-like growth factor 1 (IGF-1) levels, and common carotid intima-media thickness (CC-IMT) in morbidly obese young patients. A total of 249 patients (aged 37.9 ± 9.8 years, body mass index [BMI] 45.6 ± 8.3 kg/m(2)) were evaluated (metabolic tests, serum IGF-1 measurements, homeostasis model assessment-insulin resistance [HOMA-IR], and ultrasonographically assessed CC-IMT) in a research program for bariatric surgery candidates. After adjusting for age, gender, BMI, systolic blood pressure, uric acid, antihypertensive and lipid-lowering treatment, metabolic syndrome, and metabolic class, both HOMA-IR and IGF-1 z-score were significantly associated with CC-IMT. These results were confirmed in logistic regression analysis, in which age (β = 1.11, P = .001), gender (β = 3.19, P = .001), HOMA-IR (β = 1.221, P = .005), and IGF-1 z-score (β = 1.734, P = .009) were the only independent determinants of abnormal CC-IMT, presum...

Research paper thumbnail of Carotid IMT values are related to insulin resistance and visceral disposition of adiposity in obese patients

Carotid IMT values are related to insulin resistance and visceral disposition of adiposity in obese patients

Research paper thumbnail of The clinical value of human leukocyte antigen HLA-DRB1 subtypes associated to Graves' disease in Romanian population

The clinical value of human leukocyte antigen HLA-DRB1 subtypes associated to Graves' disease in Romanian population

Immunological Investigations

The aim of this study was to identify the primary susceptibility HLA-DRB1 alleles associated with... more The aim of this study was to identify the primary susceptibility HLA-DRB1 alleles associated with GD in Romanian population and to seek whether specific HLA-DRB1 haplotypes are associated with differences in the clinical presentation of GD at diagnosis. Molecular typing of HLA-DRB1 alleles was performed in 77 Romanian Caucasian GD patients and 445 racially matched controls. In GD patients, age, presence of eye disease, goiter grade, autoantibody status and titer, TSH, FT4, FT3, TT3 levels were recorded at diagnosis. The allelic frequencies of HLA-DRB1*03 (41.55% vs. 17.75%, p < 0.0001, χ(2) = 20.81) and DRB1*11 (42.85% vs. 30.56%, p = 0.045, χ(2)= 3.98)were higher, whereas those of HLA-DRB1*01(3.89% vs. 16.40%, p = 0.007, χ(2) = 7.281) and DRB1*15 (10.38% vs. 21.34%, p = 0.038, χ(2) = 4.309)were lower in GD patients than in controls. FT4/TT3 ratio (p = 0.015) and anti-thyroglobulin antibodies (p = 0.024) were higher in *03/11 patients compared to *X/X, *11/Z, *03/Y patients (wher...

Research paper thumbnail of Preoperative metabolic status is associated with adiponectin levels attained 6 months after laparoscopic sleeve gastrectomy, independently of the degree of weight loss

Preoperative metabolic status is associated with adiponectin levels attained 6 months after laparoscopic sleeve gastrectomy, independently of the degree of weight loss

Research paper thumbnail of Rare form of tuberculosis presented as" thyroid" mass

Tuberculosis continues to be a universal health problem and recent studies showed an increased in... more Tuberculosis continues to be a universal health problem and recent studies showed an increased incidence of all forms of this disease. We report the case of a 81 year old female patient with a large left cervical tumour and cutaneous lesions that proved to be an unusual form of tuberculosis. The patient had a 2 years history of slowly increasing left cervical mass with no significant clinical manifestation. Medical assistance was requested mostly by the family, concerned about the large mass visible on the left side of the patient's neck. Clinical and laboratory investigation revealed: a large left laterocervical tumour and the presence of erythematous, non pruriginous skin lesions. No significant changes were shown by routine blood tests. Thyroid function was in the normal range. Neck ultrasound revealed the presence of a 5/6 cm, well defined hypoechoic mass and the thyroid scan showed no accumulation of the radiotracer in the cervical tumour. Routine tuberculosis test was nega...

Research paper thumbnail of Thyroid hormones and proinflammatory cytokines' profile in amiodarone-induced thyrotoxicosis

In this study we aimed to assess amiodarone's effects on thyroid hormones, C reactive protein... more In this study we aimed to assess amiodarone's effects on thyroid hormones, C reactive protein (CRP), interleukin 6 (IL-6) and tumor necrosis factor (TNF-α) profile in amiodarone-induced thyrotoxicosis (AIT) and their relationship with arrhythmias. In 60 patients with AIT (29M/31F), aged 59.7 ± 1.5 years and 105 hyperthyroid patients (25M/80F), aged 59.4 ± 1 years, TSH, total T 3 , total T 4 , free T 4 were measured by IRMA or microenzymatic immunoassay. In 11 AIT patients and 26 patients with common hyperthyroidism, without significant Graves' ophthalmopathy, CRP, IL-6 and TNF-α were measured by chemiluminescent immunoassays. AIT patients showed significantly lower T 3 levels (273.82 ± 18.76 ng/dL) as compared to common thyrotoxicosis (361.89 ± 13.47 ng/dL), p<0.001, while T 4 and FT 4 were similar. AIT patients showed similar CRP, IL-6 and TNF-α levels to common hyperthyroidism (10.22 ± 3.03 mg/L vs. 6.31 ± 2.33 mg/L, p=0.11, for CRP, 17.46 ± 13.09 pg/mL vs. 6.46 ± 1.14 ...

Research paper thumbnail of Six months results of laparoscopic sleeve gastrectomy in treatment of obesity and its metabolic complications

Six months results of laparoscopic sleeve gastrectomy in treatment of obesity and its metabolic complications

Chirurgia (Bucharest, Romania: 1990)

Laparoscopic sleeve gastrectomy (LSG) has become a popular bariatric surgical procedure, with pro... more Laparoscopic sleeve gastrectomy (LSG) has become a popular bariatric surgical procedure, with proven results in achieving weight loss, however data regarding its effectiveness on metabolic syndrome (MetS) components are scarce. The aims of the present study were to assess the outcomes of LSG on weight loss and obesity associated metabolic complications at six months following intervention. This was a retrospective study on 124 consecutive obese patients (29.8% men), who had undergone LSG between 01/01/2008 and 12/31/2010, in a highly specialized clinic. The dynamic of anthropometric and biochemical data between baseline and six months following LSG were evaluated. We also determined the change in MetS prevalence and used logistic regression to estimate predictors of MetS remission 6 months after LSG, the body mass index (BMI) decreased from 46.84 +/- 8.62 to 33.81 +/- 7.04 kg/m2 (p < 0.001). Mean excess BMI loss (EBL) was 65.24 +/- 25.16%. The best results on weight loss were obs...