Claudia Carrilho | Universidade Estadual de Londrina (original) (raw)
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Papers by Claudia Carrilho
Revista Brasileira de terapia intensiva, 2006
The ventilator-associated pneumonia (VAP) is a severe infection that presents multiple causes whi... more The ventilator-associated pneumonia (VAP) is a severe infection that presents multiple causes which can vary depending on the type of intensive care unit, type of patients, emphasizing the needs for vigilance measures with local data. The aim of this study is to describe the incidence, risk factors and mortality of VAP in patients in a surgical ICU. Prospective cohort conducted from January 2004 to January 2005. It was included all the patients in mechanical ventilation, followed daily to collect data about demographics, diagnostic, APACHE II and TISS 28 scores, duration of mechanical ventilation, length of stay, incidence of VAP and mortality. 462 patients were studied; age 57.2 ± 16.6 years, 55% men. The mean APACHE II score was 18.3 and the incidence of VAP was 18.8%. The TISS score at admission OR = 1.050 (IC 95%: 1.003-1.050) and the enteral nutrition OR = 5.609 (IC 3.351-9.388) were factors associated with VAP and the prophylactic use of antibiotics was a factor of protection ...
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 2007
Pneumonia is the most frequent hospital infection in patients admitted to intensive care units (I... more Pneumonia is the most frequent hospital infection in patients admitted to intensive care units (ICU) and is also responsible for the highest lethality rates, as well as an increase in both the duration and costs of hospitalization. The objective of this study was to identify predisposing factors for pneumonia. A prospective cohort study was carried out between June 1996 and June 1997, and included 540 patients admitted consecutively for periods greater than 24 hours to the adult ICU of the Londrina State University's Teaching Hospital. Of these, 83 (15.4%) developed pneumonia. All patients were analyzed with respect to various risk factors for hospital-acquired pneumonia. Univariate analysis identified the following factors: decreased level of consciousness, craniotomy, prior use of antibiotics, mechanical ventilation, nasogastric tube feeding, enteral feeding, aspiration of gastric contents, central venous catheter and the time spent in the ICU. Multivariate analysis identified...
Revista Brasileira de Terapia Intensiva, 2013
Semina: Ciências Biológicas e da Saúde, 1999
The Brazilian Journal of Infectious Diseases, 2013
648 b r a z j i n f e c t d i s . 2 0 1 3;1 7(6):647-653 Conclusions: Daptomycin had a relevant r... more 648 b r a z j i n f e c t d i s . 2 0 1 3;1 7(6):647-653 Conclusions: Daptomycin had a relevant role in the treatment of Gram-positive infections in the clinical practice setting in Brazil.
Jornal Brasileiro de Pneumologia, 2007
Revista Brasileira de Terapia Intensiva, 2006
... Fotocópia. Texto completo SciELO Brasil (texto : PT). Matsuo, Tiemi. experimental, Documentos... more ... Fotocópia. Texto completo SciELO Brasil (texto : PT). Matsuo, Tiemi. experimental, Documentos relacionados. Id: 485146. Autor: Carrilho, Claudia Maria Dantas de Maio; Grion, Cíntia Magalhães Carvalho; Carvalho, Lais Magalhães; Grion, Adriana dos Santos; Matsuo, Tiemi. ...
American Journal of Infection Control, 2010
but an insignificant correlation between knowledge and compliance (P 5 .152).
Journal of Infection and Chemotherapy, 2015
Background: The aim of this study was to evaluate the in vitro susceptibility of MDR gram-negativ... more Background: The aim of this study was to evaluate the in vitro susceptibility of MDR gram-negatives bacteria to old drugs such as polymyxin B, minocycline and fosfomycin and new drugs such as tigecycline. Methods: One hundred and fifty-three isolates from 4 Brazilian hospitals were evaluated. Forty-seven Acinetobacter baumannii resistant to carbapenens harboring adeB, bla OxA23 , bla OxA51 , bla OxA143 and bla IMP genes, 48 Stenotrophomonas maltophilia including isolates resistant to levofloxacin and/or trimethoprim-sulfamethoxazole harboring sul-1, sul-2 and qnr MR and 8 Serratia marcescens and 50 Klebsiella pneumoniae resistant to carbapenens harboring bla KPC-2 were tested to determine their minimum inhibitory concentrations (MICs) by microdilution to the following drugs: minocycline, ampicillinsulbactam, tigecycline, and polymyxin B and by agar dilution to fosfomycin according with breakpoint criteria of CLSI and EUCAST (fosfomycin). In addition, EUCAST fosfomycin breakpoint for Pseudomonas spp. was applied for Acinetobacter spp and S. maltophilia, the FDA criteria for tigecycline was used for Acinetobacter spp and S. maltophilia and the Pseudomonas spp polymyxin B CLSI criterion was used for S. maltophilia. Results: Tigecycline showed the best in vitro activity against the MDR gram-negative evaluated, followed by polymyxin B and fosfomycin. Polymyxin B resistance among K. pneumoniae was detected in 6 isolates, using the breakpoint of MIC > 8 ug/mL. Two of these isolates were resistant to tigecycline. Minocycline was tested only against S. maltophilia and A. baumannii and showed excellent activity against both. Conclusions: Fosfomycin seems to not be an option to treat infections due to the A. baumannii and S. maltophilia isolates according with EUCAST breakpoint, on the other hand, showed excellent activity against S. marcescens and K. pneumoniae.
Revista Brasileira de terapia intensiva, 2006
The ventilator-associated pneumonia (VAP) is a severe infection that presents multiple causes whi... more The ventilator-associated pneumonia (VAP) is a severe infection that presents multiple causes which can vary depending on the type of intensive care unit, type of patients, emphasizing the needs for vigilance measures with local data. The aim of this study is to describe the incidence, risk factors and mortality of VAP in patients in a surgical ICU. Prospective cohort conducted from January 2004 to January 2005. It was included all the patients in mechanical ventilation, followed daily to collect data about demographics, diagnostic, APACHE II and TISS 28 scores, duration of mechanical ventilation, length of stay, incidence of VAP and mortality. 462 patients were studied; age 57.2 ± 16.6 years, 55% men. The mean APACHE II score was 18.3 and the incidence of VAP was 18.8%. The TISS score at admission OR = 1.050 (IC 95%: 1.003-1.050) and the enteral nutrition OR = 5.609 (IC 3.351-9.388) were factors associated with VAP and the prophylactic use of antibiotics was a factor of protection ...
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 2007
Pneumonia is the most frequent hospital infection in patients admitted to intensive care units (I... more Pneumonia is the most frequent hospital infection in patients admitted to intensive care units (ICU) and is also responsible for the highest lethality rates, as well as an increase in both the duration and costs of hospitalization. The objective of this study was to identify predisposing factors for pneumonia. A prospective cohort study was carried out between June 1996 and June 1997, and included 540 patients admitted consecutively for periods greater than 24 hours to the adult ICU of the Londrina State University's Teaching Hospital. Of these, 83 (15.4%) developed pneumonia. All patients were analyzed with respect to various risk factors for hospital-acquired pneumonia. Univariate analysis identified the following factors: decreased level of consciousness, craniotomy, prior use of antibiotics, mechanical ventilation, nasogastric tube feeding, enteral feeding, aspiration of gastric contents, central venous catheter and the time spent in the ICU. Multivariate analysis identified...
Revista Brasileira de Terapia Intensiva, 2013
Semina: Ciências Biológicas e da Saúde, 1999
The Brazilian Journal of Infectious Diseases, 2013
648 b r a z j i n f e c t d i s . 2 0 1 3;1 7(6):647-653 Conclusions: Daptomycin had a relevant r... more 648 b r a z j i n f e c t d i s . 2 0 1 3;1 7(6):647-653 Conclusions: Daptomycin had a relevant role in the treatment of Gram-positive infections in the clinical practice setting in Brazil.
Jornal Brasileiro de Pneumologia, 2007
Revista Brasileira de Terapia Intensiva, 2006
... Fotocópia. Texto completo SciELO Brasil (texto : PT). Matsuo, Tiemi. experimental, Documentos... more ... Fotocópia. Texto completo SciELO Brasil (texto : PT). Matsuo, Tiemi. experimental, Documentos relacionados. Id: 485146. Autor: Carrilho, Claudia Maria Dantas de Maio; Grion, Cíntia Magalhães Carvalho; Carvalho, Lais Magalhães; Grion, Adriana dos Santos; Matsuo, Tiemi. ...
American Journal of Infection Control, 2010
but an insignificant correlation between knowledge and compliance (P 5 .152).
Journal of Infection and Chemotherapy, 2015
Background: The aim of this study was to evaluate the in vitro susceptibility of MDR gram-negativ... more Background: The aim of this study was to evaluate the in vitro susceptibility of MDR gram-negatives bacteria to old drugs such as polymyxin B, minocycline and fosfomycin and new drugs such as tigecycline. Methods: One hundred and fifty-three isolates from 4 Brazilian hospitals were evaluated. Forty-seven Acinetobacter baumannii resistant to carbapenens harboring adeB, bla OxA23 , bla OxA51 , bla OxA143 and bla IMP genes, 48 Stenotrophomonas maltophilia including isolates resistant to levofloxacin and/or trimethoprim-sulfamethoxazole harboring sul-1, sul-2 and qnr MR and 8 Serratia marcescens and 50 Klebsiella pneumoniae resistant to carbapenens harboring bla KPC-2 were tested to determine their minimum inhibitory concentrations (MICs) by microdilution to the following drugs: minocycline, ampicillinsulbactam, tigecycline, and polymyxin B and by agar dilution to fosfomycin according with breakpoint criteria of CLSI and EUCAST (fosfomycin). In addition, EUCAST fosfomycin breakpoint for Pseudomonas spp. was applied for Acinetobacter spp and S. maltophilia, the FDA criteria for tigecycline was used for Acinetobacter spp and S. maltophilia and the Pseudomonas spp polymyxin B CLSI criterion was used for S. maltophilia. Results: Tigecycline showed the best in vitro activity against the MDR gram-negative evaluated, followed by polymyxin B and fosfomycin. Polymyxin B resistance among K. pneumoniae was detected in 6 isolates, using the breakpoint of MIC > 8 ug/mL. Two of these isolates were resistant to tigecycline. Minocycline was tested only against S. maltophilia and A. baumannii and showed excellent activity against both. Conclusions: Fosfomycin seems to not be an option to treat infections due to the A. baumannii and S. maltophilia isolates according with EUCAST breakpoint, on the other hand, showed excellent activity against S. marcescens and K. pneumoniae.