D. Decoo | Universiteit Gent (original) (raw)

Papers by D. Decoo

Research paper thumbnail of Multiple Sclerosis Multidisciplinary Care: a national survey and lessons for the global community

Multiple sclerosis and related disorders, Mar 1, 2024

Research paper thumbnail of Comparison of Cerebral Hemodynamic and Oxygen Metabolic Changes Due to Cavernous Angiomas and Arteriovenous-Malformations of the Brain : A Positron Emission Tomography Study

Research paper thumbnail of A positron emission tomographic study of post-carbon monoxide Parkinsonism. Abstr. 10th Int. Symp. Parkinson's Disease, Tokyo, October 27-30, F-3103

Research paper thumbnail of Posthypoxic-ischemic encephalopathy: comparison of clinical outcome and of computed and positron emission tomographic findings.In: J. Neurol., 1992, 239, p. 3

Research paper thumbnail of Hypothalamic blood flow and oxygen metabolism in normal ageing and in pathological conditions : a positron emission tomography study

Research paper thumbnail of PET en Multiple Lacunes: Relatie tussen Lokalisatie, Regionale Cerebrale Doorbloeding en Vasocapacitantie. Nederlandse Vereniging voor Neurologie, Rotterdam, 1991

Research paper thumbnail of The BELTRIMS registry: real-world safety and efficacy of DMTs in Belgium

Research paper thumbnail of Onderzoek van de Hersenfuncties met Positron Emissie Tomografie (PET). Flanders Technology International, 1991

Research paper thumbnail of Endarterectomy for moderate symptomatic carotid stenosis: interim results from the MRC European Carotid Surgery Trial

The Lancet, 1996

The objective of this study was to assess whether carotid endarterectomy is an appropriate treatm... more The objective of this study was to assess whether carotid endarterectomy is an appropriate treatment for patients with recent cerebrovascular events in the territory supplied by a moderately stenosed (30-69%) internal carotid artery. Results have previously been reported for severe (70-99%) and mild (0-29%) stenosis. A multicentre randomised controlled trial recruited 1599 patients with moderate stenosis treated in 97 hospitals from 15 countries. 60% of patients were allocated to receive and 40% to avoid carotid endarterectomy. The analysis was by intention to treat. Nine patients were omitted from the analysis because no follow-up data were received. Stroke-free life expectancy (curtailed at 8 years) was shorter in the surgery patients than in the non-surgery control groups (patients with 30-49% stenosis, life expectancy = 6.16 years [controls: 6.63 years]; patients with 50-69% stenosis, life expectancy = 5.93 [6.14] years). It remains possible that patients might derive some benefit from surgery in the very long term; however, our data show that no benefit would be gained over a period of < 4-5 years in patients with 50-69% stenosis and < 6-7 years in patients with 30-49% stenosis. Previous interim results from this study showed that surgery is beneficial in patients with severe stenosis but harmful in those with mild stenosis. With more randomised patients and longer follow-up, the study now shows that endarterectomy is not indicated for most, possibly all, patients with moderate symptomatic carotid stenosis.

Research paper thumbnail of Fourth metting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Journal of Neurology, 1994

Research paper thumbnail of Redefining the Multiple Sclerosis Severity Score (MSSS): The effect of sex and onset phenotype

Multiple Sclerosis Journal, 2019

Background: The Multiple Sclerosis Severity Score (MSSS) is a widely used measure of the disabili... more Background: The Multiple Sclerosis Severity Score (MSSS) is a widely used measure of the disability progression rate. However, the global MSSS may not be the best basis for comparison between all patient groups. Objective: We evaluated sex-specific and onset phenotype–specific MSSS matrices to determine if they were more effective than the global MSSS as a basis for comparison within these subsets. Methods: Using a large international dataset of multiple sclerosis (MS) patient records and the original MSSS algorithm, we constructed global, sex-specific and onset phenotype–specific MSSS matrices. We compared matrices using permutation analysis. Results: Our final dataset included 30,203 MS cases, with 28.9% males and 6.5% progressive-onset cases. Our global MSSS matrix did not differ from previously published data ( p > 0.05). The progressive-onset-specific matrix differed significantly from the relapsing-onset-specific matrix ( p < 0.001), with lower MSSS attributed to cases w...

Research paper thumbnail of Evaluating the effect of enhanced physical activity and energy management on fatigue in patients suffering from multiple sclerosis: the MS TeleCoach study

Research paper thumbnail of Longitudinal positron emission tomography study in a patient with presumed extracranial internal carotid dissection

Research paper thumbnail of Contents, Vol 32, 1992

Research paper thumbnail of Fourth metting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Journal of Neurology, 1994

The abstracts have been reviewed and edited by T. Brandt, G. Franck, S. DiDonato, AE Harding, JG ... more The abstracts have been reviewed and edited by T. Brandt, G. Franck, S. DiDonato, AE Harding, JG Hildebrand, WI McDonald, H. Petit, O. Paulson, G. Said, G. Scarlato, A. Steck, PK Thomas, KV Toyka and J. van Gijn ... 2 7 June POSTER SESSION 1 Symposium I: Oral Session 1: Oral Session 2: Oral Session 3: Oral Session 4: Oral Session 5: Oral Session 6: Oral Session 7: Oral Session 8: Oral Session 9: Oral Session 10: Oral Session 11: Oral Session 12: Oral Session 13: Oral Session 14: POSTER SESSION 2 ... 28 June POSTER SESSION 3 Symposium ...

Research paper thumbnail of Management of adverse renal events related to alemtuzumab treatment in multiple sclerosis: a Belgian consensus

Research paper thumbnail of Long-term follow up of glatiramer acetate compassionate use in Belgium

Acta neurologica Belgica, 2005

Between June 1995 and November 1998, 228 patients with relapsing-remitting Multiple Sclerosis sta... more Between June 1995 and November 1998, 228 patients with relapsing-remitting Multiple Sclerosis started treatment with glatiramer acetate (Copaxone) 20 mg once daily in the frame of a "compassionate use" protocol in 15 Belgian centers. Following an average treatment period of 5.8 years, treating neurologists were requested to fill in follow-up forms indicating neurological disability status and side effects during the previous 6 months. These data were available for 134 patients. In this group, the Expanded Disability Status Scale (EDSS) improved in 26.3% of patients. An additional 36.8% of patients remained neurologically stable. The Ambulation Index (AI) showed similar results: 12.5% of patients improved, 50% of patients remained stable, and 37.5% worsened. Only 10% of patients dropped out due to several reasons. The adverse events occurring in the period preceding the follow-up survey were non-serious and consistent with the current product information of glatiramer aceta...

Research paper thumbnail of Longitudinal positron emission tomography study in a patient with presumed extracranial internal carotid dissection

Acta neurologica Belgica, 2001

Research paper thumbnail of 57Co SPECT, 99mTc-ECD SPECT, MRI and neuropsychological testing in senile dementia of the Alzheimer type

Nuclear medicine communications, 2001

Inflammatory mechanisms contribute to the pathophysiology of senile dementia of the Alzheimer typ... more Inflammatory mechanisms contribute to the pathophysiology of senile dementia of the Alzheimer type (sDAT). Previous studies have shown that 57Co single photon emission computed tomography (SPECT) is able to visualize inflammatory lesions, probably by means of the final common pathway of Ca2+ homeostasis disturbance in both neuronal degeneration and inflammation. The aims of this study were: (1) to detect 57Co SPECT changes in sDAT patients; (2) to correlate these findings with those of conventional neuroimaging techniques and neuropsychological testing (NPT); and (3) to compare 57Co SPECT findings in sDAT patients with those in other types of dementia. Six patients suffering from probable sDAT were included and compared with four patients suffering from other types of dementia. All patients had a magnetic resonance imaging (MRI) scan, NPT, 57Co and 99mTc-ethyl cysteinate dimer (ECD) SPECT scan. Perfusion SPECT images were semiquantitatively evaluated by comparison with an age-matche...

Research paper thumbnail of Biodistribution and dosimetry of carbon-11-methoxyprogabidic acid, a possible ligand for GABA-receptors in the brain

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1998

Carbon-11-methoxyprogabidic acid (11C-MPGA) was recently synthetized as a possible ligand for PET... more Carbon-11-methoxyprogabidic acid (11C-MPGA) was recently synthetized as a possible ligand for PET studies of gamma-amino-butyric acid (GABA) receptors in the brain. The data for human absorbed dose estimates are calculated based on the biodistribution of 11C-MPGA in mice and humans. Eighteen mice were killed at preset time intervals after an intravenous bolus injection of 3.7 MBq (100 microCi) 11C-MPGA. Time-activity curves were reconstructed for several organs. Three healthy men each had whole-body PET scans after an intravenous bolus injection of 37 MBq (1 mCi) to determine activity in the critical organs. Animal data were fitted into these human findings to calculate residence times, and the MIRDOSE 3 protocol was used to calculate the radiation absorbed dose. Animal studies demonstrated a rapid distribution of 11C-MPGA in several organs. The highest activity was detected in the intestines, liver and kidneys. Brain activity was low throughout compared to these organs. The human w...

Research paper thumbnail of Multiple Sclerosis Multidisciplinary Care: a national survey and lessons for the global community

Multiple sclerosis and related disorders, Mar 1, 2024

Research paper thumbnail of Comparison of Cerebral Hemodynamic and Oxygen Metabolic Changes Due to Cavernous Angiomas and Arteriovenous-Malformations of the Brain : A Positron Emission Tomography Study

Research paper thumbnail of A positron emission tomographic study of post-carbon monoxide Parkinsonism. Abstr. 10th Int. Symp. Parkinson's Disease, Tokyo, October 27-30, F-3103

Research paper thumbnail of Posthypoxic-ischemic encephalopathy: comparison of clinical outcome and of computed and positron emission tomographic findings.In: J. Neurol., 1992, 239, p. 3

Research paper thumbnail of Hypothalamic blood flow and oxygen metabolism in normal ageing and in pathological conditions : a positron emission tomography study

Research paper thumbnail of PET en Multiple Lacunes: Relatie tussen Lokalisatie, Regionale Cerebrale Doorbloeding en Vasocapacitantie. Nederlandse Vereniging voor Neurologie, Rotterdam, 1991

Research paper thumbnail of The BELTRIMS registry: real-world safety and efficacy of DMTs in Belgium

Research paper thumbnail of Onderzoek van de Hersenfuncties met Positron Emissie Tomografie (PET). Flanders Technology International, 1991

Research paper thumbnail of Endarterectomy for moderate symptomatic carotid stenosis: interim results from the MRC European Carotid Surgery Trial

The Lancet, 1996

The objective of this study was to assess whether carotid endarterectomy is an appropriate treatm... more The objective of this study was to assess whether carotid endarterectomy is an appropriate treatment for patients with recent cerebrovascular events in the territory supplied by a moderately stenosed (30-69%) internal carotid artery. Results have previously been reported for severe (70-99%) and mild (0-29%) stenosis. A multicentre randomised controlled trial recruited 1599 patients with moderate stenosis treated in 97 hospitals from 15 countries. 60% of patients were allocated to receive and 40% to avoid carotid endarterectomy. The analysis was by intention to treat. Nine patients were omitted from the analysis because no follow-up data were received. Stroke-free life expectancy (curtailed at 8 years) was shorter in the surgery patients than in the non-surgery control groups (patients with 30-49% stenosis, life expectancy = 6.16 years [controls: 6.63 years]; patients with 50-69% stenosis, life expectancy = 5.93 [6.14] years). It remains possible that patients might derive some benefit from surgery in the very long term; however, our data show that no benefit would be gained over a period of &lt; 4-5 years in patients with 50-69% stenosis and &lt; 6-7 years in patients with 30-49% stenosis. Previous interim results from this study showed that surgery is beneficial in patients with severe stenosis but harmful in those with mild stenosis. With more randomised patients and longer follow-up, the study now shows that endarterectomy is not indicated for most, possibly all, patients with moderate symptomatic carotid stenosis.

Research paper thumbnail of Fourth metting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Journal of Neurology, 1994

Research paper thumbnail of Redefining the Multiple Sclerosis Severity Score (MSSS): The effect of sex and onset phenotype

Multiple Sclerosis Journal, 2019

Background: The Multiple Sclerosis Severity Score (MSSS) is a widely used measure of the disabili... more Background: The Multiple Sclerosis Severity Score (MSSS) is a widely used measure of the disability progression rate. However, the global MSSS may not be the best basis for comparison between all patient groups. Objective: We evaluated sex-specific and onset phenotype–specific MSSS matrices to determine if they were more effective than the global MSSS as a basis for comparison within these subsets. Methods: Using a large international dataset of multiple sclerosis (MS) patient records and the original MSSS algorithm, we constructed global, sex-specific and onset phenotype–specific MSSS matrices. We compared matrices using permutation analysis. Results: Our final dataset included 30,203 MS cases, with 28.9% males and 6.5% progressive-onset cases. Our global MSSS matrix did not differ from previously published data ( p > 0.05). The progressive-onset-specific matrix differed significantly from the relapsing-onset-specific matrix ( p < 0.001), with lower MSSS attributed to cases w...

Research paper thumbnail of Evaluating the effect of enhanced physical activity and energy management on fatigue in patients suffering from multiple sclerosis: the MS TeleCoach study

Research paper thumbnail of Longitudinal positron emission tomography study in a patient with presumed extracranial internal carotid dissection

Research paper thumbnail of Contents, Vol 32, 1992

Research paper thumbnail of Fourth metting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Journal of Neurology, 1994

The abstracts have been reviewed and edited by T. Brandt, G. Franck, S. DiDonato, AE Harding, JG ... more The abstracts have been reviewed and edited by T. Brandt, G. Franck, S. DiDonato, AE Harding, JG Hildebrand, WI McDonald, H. Petit, O. Paulson, G. Said, G. Scarlato, A. Steck, PK Thomas, KV Toyka and J. van Gijn ... 2 7 June POSTER SESSION 1 Symposium I: Oral Session 1: Oral Session 2: Oral Session 3: Oral Session 4: Oral Session 5: Oral Session 6: Oral Session 7: Oral Session 8: Oral Session 9: Oral Session 10: Oral Session 11: Oral Session 12: Oral Session 13: Oral Session 14: POSTER SESSION 2 ... 28 June POSTER SESSION 3 Symposium ...

Research paper thumbnail of Management of adverse renal events related to alemtuzumab treatment in multiple sclerosis: a Belgian consensus

Research paper thumbnail of Long-term follow up of glatiramer acetate compassionate use in Belgium

Acta neurologica Belgica, 2005

Between June 1995 and November 1998, 228 patients with relapsing-remitting Multiple Sclerosis sta... more Between June 1995 and November 1998, 228 patients with relapsing-remitting Multiple Sclerosis started treatment with glatiramer acetate (Copaxone) 20 mg once daily in the frame of a "compassionate use" protocol in 15 Belgian centers. Following an average treatment period of 5.8 years, treating neurologists were requested to fill in follow-up forms indicating neurological disability status and side effects during the previous 6 months. These data were available for 134 patients. In this group, the Expanded Disability Status Scale (EDSS) improved in 26.3% of patients. An additional 36.8% of patients remained neurologically stable. The Ambulation Index (AI) showed similar results: 12.5% of patients improved, 50% of patients remained stable, and 37.5% worsened. Only 10% of patients dropped out due to several reasons. The adverse events occurring in the period preceding the follow-up survey were non-serious and consistent with the current product information of glatiramer aceta...

Research paper thumbnail of Longitudinal positron emission tomography study in a patient with presumed extracranial internal carotid dissection

Acta neurologica Belgica, 2001

Research paper thumbnail of 57Co SPECT, 99mTc-ECD SPECT, MRI and neuropsychological testing in senile dementia of the Alzheimer type

Nuclear medicine communications, 2001

Inflammatory mechanisms contribute to the pathophysiology of senile dementia of the Alzheimer typ... more Inflammatory mechanisms contribute to the pathophysiology of senile dementia of the Alzheimer type (sDAT). Previous studies have shown that 57Co single photon emission computed tomography (SPECT) is able to visualize inflammatory lesions, probably by means of the final common pathway of Ca2+ homeostasis disturbance in both neuronal degeneration and inflammation. The aims of this study were: (1) to detect 57Co SPECT changes in sDAT patients; (2) to correlate these findings with those of conventional neuroimaging techniques and neuropsychological testing (NPT); and (3) to compare 57Co SPECT findings in sDAT patients with those in other types of dementia. Six patients suffering from probable sDAT were included and compared with four patients suffering from other types of dementia. All patients had a magnetic resonance imaging (MRI) scan, NPT, 57Co and 99mTc-ethyl cysteinate dimer (ECD) SPECT scan. Perfusion SPECT images were semiquantitatively evaluated by comparison with an age-matche...

Research paper thumbnail of Biodistribution and dosimetry of carbon-11-methoxyprogabidic acid, a possible ligand for GABA-receptors in the brain

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1998

Carbon-11-methoxyprogabidic acid (11C-MPGA) was recently synthetized as a possible ligand for PET... more Carbon-11-methoxyprogabidic acid (11C-MPGA) was recently synthetized as a possible ligand for PET studies of gamma-amino-butyric acid (GABA) receptors in the brain. The data for human absorbed dose estimates are calculated based on the biodistribution of 11C-MPGA in mice and humans. Eighteen mice were killed at preset time intervals after an intravenous bolus injection of 3.7 MBq (100 microCi) 11C-MPGA. Time-activity curves were reconstructed for several organs. Three healthy men each had whole-body PET scans after an intravenous bolus injection of 37 MBq (1 mCi) to determine activity in the critical organs. Animal data were fitted into these human findings to calculate residence times, and the MIRDOSE 3 protocol was used to calculate the radiation absorbed dose. Animal studies demonstrated a rapid distribution of 11C-MPGA in several organs. The highest activity was detected in the intestines, liver and kidneys. Brain activity was low throughout compared to these organs. The human w...