PROFESSOR FAOZIYAT ADENIKE Sulaiman | University of Ilorin,Ilorin Nigeria (original) (raw)

Papers by PROFESSOR FAOZIYAT ADENIKE Sulaiman

Eureka, Physics and Engineering./Eureka, Physics and Engineering, May 27, 2024

Lithium-ion batteries are commonly employed as energy providers for portable electronic gadgets d... more Lithium-ion batteries are commonly employed as energy providers for portable electronic gadgets due to their notable characteristics, which encompass a substantial energy storage capacity, exceptional efficiency, and lightweight design. Nonetheless, it's worth noting that current commercially available LIBs continue to confront challenges, such as comparatively lower power density and a shorter overall cycle life when compared to other significant electrochemical energy storage alternatives. This research describes the method of making graphene derived from graphite and making anodes used in lithium-ion battery applications. The process of making graphene is that graphite is weighed as much as 7 grams, then mixed into a solution of H 2 SO 4 and H 3 PO 4 in a ratio (9:1) of 840 mL H 2 SO 4 and 93.8 mL H 3 PO 4. The next process is stirring using magnetic stirrer for 6 hours at 1000 rpm and added slowly KMnO 4 42 grams to solution. The resulting solution was then mixed using ice cubes added with H 2 O 2 (2800 mL and 21 mL), then the solution was filtrated using filter paper. The next process is washing, the solution that has been filtered is then washed using deionized water (1400 mL), ethanol (1400 mL). The sample was then dried by allowing it to stand at room temperature for 12 hours. After that, the process of making battery anodes by mixing 5 grams of graphene with boron acid solutions (0.5 M and 1 M) as much as 100 ml and then given hydrothermal treatment to the sample. Anodes of GO, BrGO 0.5 M, BrGO 1 M has the potential to enhance the perform of lithium-ion batteries. In the FTIR test results, it is known that B-C bond is found at a peak of 1222 cm-1 and the B-O bond at a peak of 1454 cm-1. XRD testing shows the crystal size of GO is 4.55 nm, BrGO 0.5 is 3.89 nm, and BrGO 1 shows a sample size of 3.19 nm.

Pharmacological Research - Natural Products

Journal of Pharmacy & Pharmacognosy Research, 2020

Context: Nicotiana tabacum is an herbaceous plant mostly known as tobacco. Locally, people do ext... more Context: Nicotiana tabacum is an herbaceous plant mostly known as tobacco. Locally, people do extract this plant with cow urine, they call it "Adimenu" and they claimed it is effective in managing various ailments, even with taking just a spoonful of the extract. Thus, profiling the toxicity and or otherwise of the cow-urine extracted tobacco plant cannot be overemphasized. Aims: To characterize the cow urine extracts of N. tabacum and evaluated the sub-acute toxicity of smokeless exposure in male Wistar rats. Methods: Forty male Wistar rats were randomly assigned into groups and exposed to different doses (50, 100 and 200 mg/kg body weight) of N. tabacum extract for 7 and 28 days, after which the animals were sacrificed for the biochemical assays. Results: The GC-MS analysis revealed 21 compounds in the N. tabacum extract. As expected, nicotine was predominant among the identified compounds. The sub-acute exposure of rats to cow-urine extract of N. tabacum extract might h...

Exportin-1, the ubiquitous nuclear protein transporter, is widely confirmed as an active chemothe... more Exportin-1, the ubiquitous nuclear protein transporter, is widely confirmed as an active chemotherapeutic target in non-small cell lung cancer condition while Juglans mandshurica is a well-studied anticancer plant in some lung cancer cell lines. We intend to find novel exportin-1 inhibitor from Juglans mandshurica with better potential tolerability and pharmaco-dynamo-kinetic properties than the current selective inhibitors of nuclear export in non-small cell lung cancer treatment. Osiris property explorer DataWarrior, Glide standard precision docking, quantum mechanics polarized ligand docking, MMGBSA binding free energy calculations, Jaguar density functional theory analysis, and the online web-based SwissADME were employed respectively in this study to filter the retrieved compounds based on tolerability, toxicity, and Lipinsky’s rule of five violation potential, determine their druggability, establish relative stability of the lead compound in water solvation model, and evaluate...

Annals of Science and Technology, 2018

This study evaluated the chemical composition, physicochemical properties, toxicological and envi... more This study evaluated the chemical composition, physicochemical properties, toxicological and environmental potentials of the Datura metel (D. metel) leaves extracts. Fresh leaves of D. metel were harvested at three different times of the day (morning, afternoon and evening), extraction done in succession using n-hexane and ethanol solvents respectively. Preliminary phytochemical screening, physicochemical analysis for specific gravity, pH, colour, total ash and moisture contents of the dried extracts were determined. The characterisation of the bioactive compounds using Gas Chromatography-Mass Spectrometry, showed the presence of different compounds at the three different times of the day, out of which phytol and 9,12,15-octadecatrienoic acid were present at all times. These results confirmed that some bioactive compounds present in this plant are dependent on environmental factor , time of harvest and the choice of solvent used while the presence of others are independent on these ...

Ife Journal of Science, 2019

Large quantities of agricultural wastes generated annually from the processing of agricultural pr... more Large quantities of agricultural wastes generated annually from the processing of agricultural produce are disposed of indiscriminately in the environment, thus contributing to environmental pollution. Value addition to cassava (Manihot esculenta Crantz) peels, and a mixture of yam (Dioscorea spp.) and plantain (Musa paradisiaca) peels, which accumulate during manual peeling will help reduce this environmental impact in addition to being a source of income. The effects of fungal fermentation on their proximate composition and suitability for use as enriched animal feed were thus investigated in this study. Cassava peel and yam-plantain peel mixture were each o fermented with Aspergillus niger and Trichoderma spp. at 32 C at moisture content of 52% and 60% respectively for a week and the potential of the biomass was investigated in feeding trials of Wistar rats over a four-week period. After sacrifice, their sera and vital organs were analysed for key enzymes and metabolic products. It was observed that Aspergillus niger-fermented cassava peel (FCP) was the best treatment with increased protein content (from 6.73% to 19.3%) due to microbial biomass. While the carbohydrate content decreased following fermentation, the calorific value remained similar to that of the raw peel. No mortality was recorded in the experimental rats fed the FCP and standard commercial feed (CF) while 100% mortality was th observed by the 4 week in the control group fed unfermented cassava peel (UCP). Organ-body weight ratio and some biochemical parameters e.g. cholesterol, high density lipoprotein (HDL), urea of FCP-fed rats were similar to those of the CF group. Lower amounts of some markers e.g. aspartate transaminase (ALP) and alanine transaminase (AST) were observed relative to UCP group. This research demonstrates the potential of microbially-detoxified food waste to replace commercial feed as a cheap alternative with minimal undesirable physiological effects in the animal models.

Advances in Traditional Medicine, 2020

The Trypanosoma brucei is the causative agent of African trypanosomiasis, a disease that affects ... more The Trypanosoma brucei is the causative agent of African trypanosomiasis, a disease that affects both humans and animals. Chemotherapy which forms the major means of control for the disease has several shortcomings such as limited efficacy and adverse side effects amongst others. Thus, motivating the search for better therapies. In this study, extracts of some tropical plants including the Acacia nilotica, Bombax buonopozense and Khaya senegalensis were evaluated for therapeutic and prophylactic potential in mouse model of experimental trypanosomiasis. Both diminazene aceturate and isometamidium chloride were included as reference drugs. Results showed that T. brucei caused an elevation in rat plasma indirect bilirubin and a reduction in rat plasma albumin and total protein which suggest mild hepatic dysfunction due to experimental infection. Data also revealed that the plant extracts significantly reduced the rat parasite burden both in the prophylaxis and therapeutic treatment groups when compared with the negative drug control. The infection and treatments had no adverse effect on the rat organ and body weights. The infection did not alter the activity of rat plasma ALT, AST and ALP compared with the administered extracts of A. nilotica and B. buonopozense. Further, the plant extracts ameliorated some trypanosomiasisinduced pathologies in treated rats compared with negative drug control. Taken together, findings do not only lend credence to the folkloric use of these plants for medicinal purposes but also suggest these plant extracts have potential to serve as alternative source of anti-parasitic agents particularly for the control of trypanosomiasis.

African Journal of Biotechnology, 2006

African Journal of Urology, 2021

Background Cancer of the prostate (CaP) is a public health problem that affects the male genitour... more Background Cancer of the prostate (CaP) is a public health problem that affects the male genitourinary system causing a significant threat to men’s quality of life (QoL). Experiencing financial constraints and poor illness perception may further compromise the QoL of men with CaP. Methods Aim: To examine the relationship between financial toxicity and illness perception with quality of life in men with CaP. The descriptive cross-sectional study used simple random sampling technique to recruit 173 men with CaP from four tertiary health facilities in Nigeria. Data were collected with the comprehensive score for financial toxicity (COST-FACIT), the brief illness perception questionnaire (Brief IPQ) and the functional assessment of cancer therapy-prostate (FACT-P). Analysis of data was carried out using analysis of variance, correlation and hierarchical regression analyses. Results The 173 participants had an average age of 71.57 ± 11.18, and 53.18% had one comorbid disease. Significant...

Cancer Epidemiology, Biomarkers & Prevention, 2020

This study was conducted to determine if prostate cancer status, demographic and health factors a... more This study was conducted to determine if prostate cancer status, demographic and health factors as well as social support, illness perception, financial toxicity and resilience predict the quality of life (QoL) in men and to ascertain the differences between men with and without cancer of the prostate (CaP) in the QoL subscales and significant predictors of QoL. Quality of life, social support, illness perception, financial toxicity and resilience were assessed using the Functional Assessment of Cancer Therapy-Prostate (FACT-P), the Multidimensional Scale of Perceived Social Support (MSPSS), Brief Illness Perception Questionnaire (BriefIPQ), The COmprehensive Score for financial Toxicity (Cost Facit) and the Brief Resilience Scale (BRS) respectively. Each scale was assessed and found to possess acceptable levels of reliability (Alpha =.551 to .899). Demographic and clinical information were also collected include age, marital status, religion, education, income, ethnic group, health...

Comparative Clinical Pathology, 2016

This study evaluated the toxicity potential of platinum (Pt) nanoparticles in Wistar rats. Wistar... more This study evaluated the toxicity potential of platinum (Pt) nanoparticles in Wistar rats. Wistar rats weighing between 180 and 193 g were randomly assigned into four groups. Animals in group 1 served as the control and received distilled water. Those in groups 2, 3, and 4 were administered with 10, 50, and 100 mg/kg body weight of Pt nanoparticles, respectively. At the end of treatments, the rats were fasted for 24 h and sacrificed under mild anesthesia. The blood and vital organs were collected and used for the biochemical and histopathological examinations. Pt nanoparticles caused significant alterations to the rat organ weights relative to the control. Also, the Pt nanoparticles altered the rat level of lipid profile and significantly elevated the atherogenic index relative to the control. The total protein level was increased in the tissues while the albumin decreased following nanoparticle treatment. Also, the nanoparticles inconsistently altered the level of serum urea and creatinine while the serum bilirubin level was raised. The activities of aspartate transaminase and alkaline phosphatase were reduced by nanoparticle treatments. However, the level of alanine aminotransferase (ALT) was inconsistently altered in serum and tissues by nanoparticle treatment with a significant elevation in the liver. Furthermore, nanoparticle exposure in rats caused several morphological lesions including inflammation and cellular degeneration, all of which were conspicuously absent in the control group. We show evidence that Pt nanoparticles potentiated alteration of rat biochemical and morphological indices in manners reminiscent of early cellular injury.

Heliyon, 2021

Malaria, a parasitic disease, is one of the major causes of morbidity and mortality, particularly... more Malaria, a parasitic disease, is one of the major causes of morbidity and mortality, particularly in the tropics. Following the increased resistance of the primary causative parasite, Plasmodium sp, to the mainstream drug, artemisinin combination therapies (ACTs), combating malaria incidences, morbidity and mortality have remained elusive. Novel pyrano-benzodioxepin derivatives (DHA-PABA and DHA-LEVO) were synthesized and characterized using Fourier transform infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopies. The compounds were subjected to standard in vivo antimalarial screening (using chloroquine-sensitive strain) in mice, and the toxicity was also determined using a standard assay. The observed elevation in serum alkaline phosphatase and acid phosphatase activity in the untreated and the group administered lower doses of DHA-LEVO is an indication of the hepatic stage of the parasite in the experimental animal, which is accompanied by significant perturbation in the membrane of the hepatocyte leading to leakage of this enzyme out of the liver cells. The semisynthetic pyrano-benzodioxepin derivatives act rapidly by clearing the parasite load from the blood. The novel pyrano-benzodioxepin candidates containing endoperoxide functionality hold promise in the pursuit of new monotherapy drug candidates against the virulent strain of the plasmodium.

This study investigated the nutritional value of pre-treated rice and wheat bran wastes as feed f... more This study investigated the nutritional value of pre-treated rice and wheat bran wastes as feed formulation in experimental rats. Aspergillus niger KM isolated from decomposing organic matter was tested for cellulase assay. The lignocellulosic agricultural residues (wheat bran and rice bran) were pretreated with ammonia and diluted sulfuric acid after which solid substrate fermentation with Aspergillus niger KM was carried out. Determination of reducing sugar was carried out and the fermented residues were included as components in feed formulation and were fed to different groups of rats for four weeks. The proximate analysis of the feed formulation showed that the NH 3 pretreated feeds gave higher protein content of 21.94%, relative to the control or other groups. Growth performances of animals fed with NH 3 pretreated wheat bran significantly increased from 158.25 to 201.66 g throughout the feeding periods. Evaluation of the various feeds’ effect on tissue marker enzymes reveal...

Breast cancer is the most diagnosed and prevalent cancer in women both in developed and developin... more Breast cancer is the most diagnosed and prevalent cancer in women both in developed and developing countries, this constitutes a threat to the society and world economic stability. In situ carcinoma and invasive carcinoma are the broad rubric of breast cancer. In established breast carcinoma, about 80% depends on the gird of estrogen hormone for growth. Hence, the down-regulation of aromatase activities has been one of the strategies used in the treatment of breast-related carcinomas. This study explores Syzygium aqueum for the best drug-gable compound via computation tools. Seventy-one compounds were obtained from Syzygium aqueum plant which was retrieved from works of literature and were docked into the active site of aromatase p450 for their antagonistic effects. Α-selinene, the lead compound with the binding energy of -8.5 kcal/mol was obtained using PyRx, autodock vina tools used in the molecular docking to obtain the docking scores. To ensure and validate that the right target...

In this study, the antidiarrheal, cytotoxic and genotoxic properties of sorghum, millet and corn ... more In this study, the antidiarrheal, cytotoxic and genotoxic properties of sorghum, millet and corn steep liquors as well as mistletoe extract in wistar rats were investigated. Comparative analysis of antidiarrheal potentials of sorghum, millet and steep liqours with standard drug (loperamide) and oral rehydration solution (ORS) in a castor oil-induced diarrheal model was carried out. Blood was examined for serum biochemical parameters and genotoxic effects were investigated using micronucleus test. In the antidiarrheal test, the test agents showed action which was significant (P<0.05). Mistletoe extract exerted maximum inhibition (55.56 %) against defecation, whereas 44.44 % and 59.26 % inhibitions were obtained for ORS and loperamide respectively. The genotoxicity studies of these steep liquors and mistletoe extract revealed damage to the genetic material and alteration of the activities of some marker enzymes, which is indicative of tissue damage. Although sorghum, millet and cor...

UNED Research Journal, 2018

The rapid growth of motor vehicles use, together with poor waste disposal, produce environmental ... more The rapid growth of motor vehicles use, together with poor waste disposal, produce environmental and biological threats. We evaluated the genotoxicity and enzyme activity of simulated automobile waste leachate in Swiss albino male mice (Mus musculus). Four mice per group were intraperitoneally treated with four leachate concentrations (10%, 15%, 20% and 25% v/v: simulant (IOASL)/distilled water), as well as a negative control (0.5mL UILSL); and a positive control (cyclophosphamide 20mg/Kg body weight) for five consecutive days. There was a concentration-dependent increase in sperm abnormality compared to the negative control (except at 10% and 15%;…

Journal of Acute Medicine, 2015

Objective: This study evaluated the biochemical effect of the oral administration of silver nanop... more Objective: This study evaluated the biochemical effect of the oral administration of silver nanoparticles on some biochemical parameters and tissue morphology. Methods: Wistar rats of both sexes with an average weight of 160 ± 5 g were randomly assigned into four groups. Animals in Group 1 served as the control and received 0.5 mL of distilled water (drug vehicle). Those in Groups 2, 3, and 4 were administered with 10, 50, and 100 mg/kg body weight silver nanoparticles, respectively. The animals were sacrificed under slight anesthesia 24 hours after the last treatment. Results: Silver nanoparticle exposure in rats elevated the level of rat serum total cholesterol, triacylglyceride, free glycerol, low density lipoproteincholesterol, and bilirubin (p < 0.05) when compared with the control. The level of high density lipoprotein-cholesterol was depleted by nanoparticle exposure, whereas the atherogenic index rose. The levels of albumin, urea, creatinine, as well as activities of aspartate transaminase and alkaline phosphatase were decreased by the nanoparticles, whereas the total protein and alanine transaminase were inconsistently altered relative to the control. Furthermore, the nanoparticle treatment caused morphological lesions in rat cardiac, renal, and hepatic tissues relative to the control. Conclusion: We show evidence that silver nanoparticle potentiated biochemical changes predisposing to liver injury and cardiovascular disorder in rat.

Nigerian Journal of Biochemistry …, 2010

A lower semicontinuity result is obtained for the BV extension of an integral functional of the t... more A lower semicontinuity result is obtained for the BV extension of an integral functional of the type Ω f (x, u(x), ∇u(x)) dx , where the energy density f is not coercive and satisfies mild regularity assumptions.

Background: The increasing application of plants for medicinal purposes necessitates safety/toxic... more Background: The increasing application of plants for medicinal purposes necessitates safety/toxicity profiling. Objective: In the present study, we evaluated the toxicological effects of the ethanolic extracts of the leaves (CAL), root (CAR) and stem (CAS) of Capsicum annuum in rats. Methods: Male Wistar rats were randomly assigned groups and given oral administration of the extracts or distilled water for 28 days. Results: Data showed that administration of ethanolic extracts of CAL, CAR and CAS did alter the liver function indices but not in a clear-cut manner to suggest hepatotoxicity. The CAR and CAS extracts decreased (p Conclusion: Taken together, findings do not only support the cardio-protective potential of C. annuum extracts, but implicate the nephrotoxic tendency of the plant extracts.