Joseph Castillo | University of Luzon (original) (raw)
Papers by Joseph Castillo
REVISTA DE GASTROENTEROLOGIA DEL PERU
Lymphocytic colitis and microscopic enteritis are relatively common causes of chronic diarrhea an... more Lymphocytic colitis and microscopic enteritis are relatively common causes of chronic diarrhea and it is characterized by an intraepithelial lymphocytic infiltrate. There have been no previous reports of coexistence between these 2 pathologies. To describe histological and clinical characteristic in patients with coexistence of lymphocytic colitis and microscopic enteritis. All cases with simultaneous diagnosis of lymphocytic duodenosis and lymphocytic colitis were reevaluated during lapse time 2010-2016 in hospital Daniel Carrion. The slides were reviewed by 3 pathologists and clinical information was obtained from clinical records. Expression of CD3 and CD8 was detected in 6 cases by immunohistochemical assays. A total of 35 patients with coexistence of lymphocytic duodenitis and lymphocytic colitis were selected of the pathology archives, 80% were females, Anemia was identified in 28.5% of patients. Blastocysitis hominis infestation was identified in 31.8%. The mean intraepitheli...
i Acknowledgements I would like to express my sincere appreciation to clinical supervisor Dr. Pie... more i Acknowledgements I would like to express my sincere appreciation to clinical supervisor Dr. Pierre Vassallo for his encouragement throughout the course of this research. I would also like to express my gratitude to my academic supervisor Mr Jon Svensson for his guidance throughout the course. Special thanks go to Mrs Helen Gill, superintendent at Oxford MRI Centre for her continuous support and help throughout the preparation of this research. Last but not least, thanks is certainly due to Mr Frankie Zarb for his interest in the subject and Mr Liberato Camilleri for his help in statistics.
The complete study has been published elsewhere (Castillo et al. 2015) dx.
Poster: "ECR 2016 / B-0149 / Validation of a competence profile for MR radiographers using a... more Poster: "ECR 2016 / B-0149 / Validation of a competence profile for MR radiographers using a formal research process " by: " J. Castillo 1, C. J. Caruana1, P. S. Morgan2, C. Westbrook, A. Mizzi; 1Msida/MT, 2Nottingham/UK"
I would like to express my sincere appreciation to clinical supervisor Dr. Pierre Vassallo for hi... more I would like to express my sincere appreciation to clinical supervisor Dr. Pierre Vassallo for his encouragement throughout the course of this research. I would also like to express my gratitude to my academic supervisor Mr Jon Svensson for his guidance throughout the course. Special thanks go to Mrs Helen Gill, superintendent at Oxford MRI Centre for her continuous support and help throughout the preparation of this research. Last but not least, thanks is certainly due to Mr Frankie Zarb for his interest in the subject and Mr Liberato Camilleri for his help in statistics.
In this capstone project, I argue for the importance of incorporating the teaching of morals and ... more In this capstone project, I argue for the importance of incorporating the teaching of morals and ethics within the classroom. I ground this argument in a critical analysis of William Ayers’ Teaching Toward Freedom and a curriculum that links Ayers’ thesis with Dr. Martin Luther King Jr.’s Birmingham Letter. The review of Teaching Toward Freedom is designed to elicit why this is a critical book for the field of teacher education. In particular, the analysis focuses on Ayers’ development of a philosophical argument about the need for public school educators to commit to “moral” and “ethical action” within the curriculum. In developing his argument, Ayers grounds his thesis in the beauty of the arts, especially literature as the tool for “seeing” and “enacting” moral and ethical education. Then, borrowing from Ayers, I present a curriculum based upon Dr. King’s seminal work. I detail how this curriculum should be implemented and argue, in turn, how it will facilitate students’ efforts ...
The Journal of Molecular Diagnostics
Neurotrophic tyrosine receptor kinase (NTRK1/2/3) gene fusions are oncogenic drivers in ∼0.3% of ... more Neurotrophic tyrosine receptor kinase (NTRK1/2/3) gene fusions are oncogenic drivers in ∼0.3% of solid tumors. High-quality testing to identify patients with NTRK fusion-positive tumors who could benefit from TRK inhibitors is recommended, but the current NTRK testing landscape, including next-generation sequencing (NGS), is fragmented and availability of assays varies widely. The analytical and clinical performance of four commonly available RNA-based NGS assays, Archer's FusionPlex Lung panel (AFL), Illumina's TruSight Oncology 500 (TSO500), as well as Thermo Fisher's Oncomine Precision Assay (OPA) and Oncomine Focus Assay (OFA) were evaluated. Experiments were conducted using contrived samples (formalin-fixed paraffin-embedded [FFPE] cell lines [n=3] and SeraSeq FFPE reference material [three lots]), NTRK fusion-negative clinical samples (n=30), and NTRK fusion-positive clinical samples (n=14) according to local assays. Estimated limit of detection varied across the four assays: 30-620 fusion copies for AFL (in cell lines), versus ∼30-290 copies for TSO500 and ∼1-28 copies for OFA and OPA. All assays showed 100% specificity for NTRK fusions detection, but QC pass rate was variable (AFL, 43%; TSO500, 77%; OFA, 83%). The NTRK fusion detection rate in QC-validated clinical samples was 100% for all assays. This comparison of the strengths and limitations of four RNA-based NGS assays will inform physicians and pathologists regarding optimal assay selection to support identification of patients with NTRK fusion-positive tumors.
Cancer Research, 2013
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Multiple Myeloma (MM)... more Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Multiple Myeloma (MM) is the second most common hematological malignancy. Despite the advances of therapeutic regimens over the last decade, nearly all patients eventually relapse, highlighting the need for additional therapeutic agents. Pim kinases, a family of serine/threonine kinase, are reported to be oncogenic and required for the maintenance of hematological malignancies. Here, consistent with previous reports, we show that Pim2 kinase expression is most highly elevated in MM. Importantly, shRNA knockdown of Pim2 leads to a significant inhibition of MM cell growth, suggesting that Pim2 is critical in maintaining MM malignancy. We developed a potent and specific small molecule inhibitor for the Pim kinases. Inhibition of Pim2 by this molecule suppresses MM cell growth. We find that Pim inhibitor treatment results in the suppression of cell proliferation, but not induction of apoptosis, in all MM cell lines tested. Further, we identified mTORC1 signaling, which is critical for cell proliferation, as significantly repressed by Pim2 inhibition. The two major mTORC1 downstream effectors: P70S6K and 4EBP1 are rapidly dephosphorylated upon Pim inhibitor treatment of MM cells. We are currently investigating the potential signaling modules that may mediate Pim2’s regulation on mTORC1 pathway. Taken together, our findings strongly support Pim2 as a promising therapeutic target in MM, given its distinct expression in MM and essential role in maintaining proliferation. Citation Format: Jing Lu, Tatiana Zavorotinskaya, Yumin Dai, Xiaohong Niu, Joseph Castillo, Janet Sim, Jianjun Yu, Kevin Shannon, Pablo Garcia. Pim2 is required for maintaining Multiple Myeloma cell proliferation through modulating mTORC1 pathway. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5194. doi:10.1158/1538-7445.AM2013-5194
Introduccion: Colitis linfocitica y enteritis microscopica son causas relativamente comunes de di... more Introduccion: Colitis linfocitica y enteritis microscopica son causas relativamente comunes de diarrea cronica y ambas se caracterizan por un infiltrado linfocitico intraepitelial. No existen reportes previos de la coexistencia de ambas entidades. Objetivo: Describir las caracteristicas clinicas e histologicas de los pacientes que presentan este diagnostico simultaneamente. Material y metodos: Se seleccionaron pacientes adultos con diarrea cronica que tuvieran biopsia simultanea de colon y duodeno tomados el mismo dia, durante los anos 2010-2016, en el Servicio de Gastroenterologia del Hospital Nacional Daniel Alcides Carrion. Se recopilo informacion clinica del archivo de historias. Las laminas fueron reevaluadas histologicamente por 3 patologos. Se realizo estudio inmunohistoquimico de linfocitos intraepiteliales para CD8 y CD3 en 6 casos. Resultados: De 63 pacientes con diarrea cronica y biopsia simultanea de duodeno y colon, se identifico un total de 35 pacientes (55,5%) con dia...
Cancer Immunology Research
Indonesian Journal of Electrical Engineering and Computer Science
Whenever a broadcast transmitter is on-air, it is required to be tended by licensed broadcast tec... more Whenever a broadcast transmitter is on-air, it is required to be tended by licensed broadcast technicians. Technicians periodically monitor the transmitter performance, record the supply voltage and current at the last stage of the power amplifier and keeps a copy for at least two years. Also recorded are the times the transmitter is turned ON and OFF as well as the times the transmitter shuts down and returns back to air. This paper proposes a system to remotely tend analog transmitters in one central monitoring station. The remote tending of several transmitters in one location is made possible through internet connection. However, the challenge in the proposed system is in the gathering of transmitter data. A prototype of the system was constructed and tested in an FM broadcast transmitter. Test results on the prototype performance show that the proposed system can effectively be used to remotely monitor, record data and control the status of analog broadcast transmitters. The pr...
Indonesian Journal of Electrical Engineering and Computer Science
Once broadcast transmitters are put into operation, regulatory bodies in different countries requ... more Once broadcast transmitters are put into operation, regulatory bodies in different countries require the equipment to be monitored, data logged and controlled. Normally, transmitter personnel turn ON the transmitter at the start of the broadcasting activities, and turn it OFF at the end of the activities. They also regularly record the transmitter meter readings on output power, voltage and current as long as the transmitter is on-air. These data must be logged and saved for future references. These procedures are done by transmitter personnel manually. With the advent of internet technology, this paper presents a system to remotely monitor, gather and record meter readings, and a provision to control the turning ON/OFF as well as to adjust the output power of a number of digital transmitters. All these procedures are done in one central location. The system was implemented and then tested using a digital television transmitter. Results of the tests show that the developed system ca...
Experimental and Molecular Therapeutics
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru
Lymphocytic colitis and microscopic enteritis are relatively common causes of chronic diarrhea an... more Lymphocytic colitis and microscopic enteritis are relatively common causes of chronic diarrhea and it is characterized by an intraepithelial lymphocytic infiltrate. There have been no previous reports of coexistence between these 2 pathologies. To describe histological and clinical characteristic in patients with coexistence of lymphocytic colitis and microscopic enteritis. All cases with simultaneous diagnosis of lymphocytic duodenosis and lymphocytic colitis were reevaluated during lapse time 2010-2016 in hospital Daniel Carrion. The slides were reviewed by 3 pathologists and clinical information was obtained from clinical records. Expression of CD3 and CD8 was detected in 6 cases by immunohistochemical assays. A total of 35 patients with coexistence of lymphocytic duodenitis and lymphocytic colitis were selected of the pathology archives, 80% were females, Anemia was identified in 28.5% of patients. Blastocysitis hominis infestation was identified in 31.8%. The mean intraepitheli...
Genes & nutrition, 2017
A large number of genome-wide association studies, transferability studies, and candidate gene st... more A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with common human obesity. The mounting evidence suggests that these obesity gene variants interact with multiple environmental factors and increase susceptibility to this complex metabolic disease. The objective of this review article is to provide concise and updated information on energy balance, heritability of body weight, origins of gene variants, and gene-nutrient interactions in relation to human obesity. It is proposed that knowledge of these related topics will provide valuable insight for future preventative lifestyle intervention using targeted nutritional and medicinal therapies.
Gene, Jan 5, 2017
It is generally accepted that the selection of gene variants during human evolution optimized ene... more It is generally accepted that the selection of gene variants during human evolution optimized energy metabolism that now interacts with our obesogenic environment to increase the prevalence of obesity. The purpose of this study was to perform a global evolutionary and metabolic analysis of human obesity gene risk variants (110 human obesity genes with 127 nearest gene risk variants) identified using genome-wide association studies (GWAS) to enhance our knowledge of early and late genotypes. As a result of determining the mean frequency of these obesity gene risk variants in 13 available populations from around the world our results provide evidence for the early selection of ancestral risk variants (defined as selection before migration from Africa) and late selection of derived risk variants (defined as selection after migration from Africa). Our results also provide novel information for association of these obesity genes or encoded proteins with diverse metabolic pathways and oth...
Metal Finishing
Recycling rinsewaters with Ion Exchange has long been known to reduce waste discharge. Convention... more Recycling rinsewaters with Ion Exchange has long been known to reduce waste discharge. Conventional Ion Exchange systems, however, produce large volumes of regenerant waste, making evaporation expensive. The 786 series Rinsewater Recycling Systems from Hydromatix reduce regenerant waste by 98%, making ZERO Discharge feasible. For brochure or technical assistance call:
REVISTA DE GASTROENTEROLOGIA DEL PERU
Lymphocytic colitis and microscopic enteritis are relatively common causes of chronic diarrhea an... more Lymphocytic colitis and microscopic enteritis are relatively common causes of chronic diarrhea and it is characterized by an intraepithelial lymphocytic infiltrate. There have been no previous reports of coexistence between these 2 pathologies. To describe histological and clinical characteristic in patients with coexistence of lymphocytic colitis and microscopic enteritis. All cases with simultaneous diagnosis of lymphocytic duodenosis and lymphocytic colitis were reevaluated during lapse time 2010-2016 in hospital Daniel Carrion. The slides were reviewed by 3 pathologists and clinical information was obtained from clinical records. Expression of CD3 and CD8 was detected in 6 cases by immunohistochemical assays. A total of 35 patients with coexistence of lymphocytic duodenitis and lymphocytic colitis were selected of the pathology archives, 80% were females, Anemia was identified in 28.5% of patients. Blastocysitis hominis infestation was identified in 31.8%. The mean intraepitheli...
i Acknowledgements I would like to express my sincere appreciation to clinical supervisor Dr. Pie... more i Acknowledgements I would like to express my sincere appreciation to clinical supervisor Dr. Pierre Vassallo for his encouragement throughout the course of this research. I would also like to express my gratitude to my academic supervisor Mr Jon Svensson for his guidance throughout the course. Special thanks go to Mrs Helen Gill, superintendent at Oxford MRI Centre for her continuous support and help throughout the preparation of this research. Last but not least, thanks is certainly due to Mr Frankie Zarb for his interest in the subject and Mr Liberato Camilleri for his help in statistics.
The complete study has been published elsewhere (Castillo et al. 2015) dx.
Poster: "ECR 2016 / B-0149 / Validation of a competence profile for MR radiographers using a... more Poster: "ECR 2016 / B-0149 / Validation of a competence profile for MR radiographers using a formal research process " by: " J. Castillo 1, C. J. Caruana1, P. S. Morgan2, C. Westbrook, A. Mizzi; 1Msida/MT, 2Nottingham/UK"
I would like to express my sincere appreciation to clinical supervisor Dr. Pierre Vassallo for hi... more I would like to express my sincere appreciation to clinical supervisor Dr. Pierre Vassallo for his encouragement throughout the course of this research. I would also like to express my gratitude to my academic supervisor Mr Jon Svensson for his guidance throughout the course. Special thanks go to Mrs Helen Gill, superintendent at Oxford MRI Centre for her continuous support and help throughout the preparation of this research. Last but not least, thanks is certainly due to Mr Frankie Zarb for his interest in the subject and Mr Liberato Camilleri for his help in statistics.
In this capstone project, I argue for the importance of incorporating the teaching of morals and ... more In this capstone project, I argue for the importance of incorporating the teaching of morals and ethics within the classroom. I ground this argument in a critical analysis of William Ayers’ Teaching Toward Freedom and a curriculum that links Ayers’ thesis with Dr. Martin Luther King Jr.’s Birmingham Letter. The review of Teaching Toward Freedom is designed to elicit why this is a critical book for the field of teacher education. In particular, the analysis focuses on Ayers’ development of a philosophical argument about the need for public school educators to commit to “moral” and “ethical action” within the curriculum. In developing his argument, Ayers grounds his thesis in the beauty of the arts, especially literature as the tool for “seeing” and “enacting” moral and ethical education. Then, borrowing from Ayers, I present a curriculum based upon Dr. King’s seminal work. I detail how this curriculum should be implemented and argue, in turn, how it will facilitate students’ efforts ...
The Journal of Molecular Diagnostics
Neurotrophic tyrosine receptor kinase (NTRK1/2/3) gene fusions are oncogenic drivers in ∼0.3% of ... more Neurotrophic tyrosine receptor kinase (NTRK1/2/3) gene fusions are oncogenic drivers in ∼0.3% of solid tumors. High-quality testing to identify patients with NTRK fusion-positive tumors who could benefit from TRK inhibitors is recommended, but the current NTRK testing landscape, including next-generation sequencing (NGS), is fragmented and availability of assays varies widely. The analytical and clinical performance of four commonly available RNA-based NGS assays, Archer's FusionPlex Lung panel (AFL), Illumina's TruSight Oncology 500 (TSO500), as well as Thermo Fisher's Oncomine Precision Assay (OPA) and Oncomine Focus Assay (OFA) were evaluated. Experiments were conducted using contrived samples (formalin-fixed paraffin-embedded [FFPE] cell lines [n=3] and SeraSeq FFPE reference material [three lots]), NTRK fusion-negative clinical samples (n=30), and NTRK fusion-positive clinical samples (n=14) according to local assays. Estimated limit of detection varied across the four assays: 30-620 fusion copies for AFL (in cell lines), versus ∼30-290 copies for TSO500 and ∼1-28 copies for OFA and OPA. All assays showed 100% specificity for NTRK fusions detection, but QC pass rate was variable (AFL, 43%; TSO500, 77%; OFA, 83%). The NTRK fusion detection rate in QC-validated clinical samples was 100% for all assays. This comparison of the strengths and limitations of four RNA-based NGS assays will inform physicians and pathologists regarding optimal assay selection to support identification of patients with NTRK fusion-positive tumors.
Cancer Research, 2013
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Multiple Myeloma (MM)... more Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Multiple Myeloma (MM) is the second most common hematological malignancy. Despite the advances of therapeutic regimens over the last decade, nearly all patients eventually relapse, highlighting the need for additional therapeutic agents. Pim kinases, a family of serine/threonine kinase, are reported to be oncogenic and required for the maintenance of hematological malignancies. Here, consistent with previous reports, we show that Pim2 kinase expression is most highly elevated in MM. Importantly, shRNA knockdown of Pim2 leads to a significant inhibition of MM cell growth, suggesting that Pim2 is critical in maintaining MM malignancy. We developed a potent and specific small molecule inhibitor for the Pim kinases. Inhibition of Pim2 by this molecule suppresses MM cell growth. We find that Pim inhibitor treatment results in the suppression of cell proliferation, but not induction of apoptosis, in all MM cell lines tested. Further, we identified mTORC1 signaling, which is critical for cell proliferation, as significantly repressed by Pim2 inhibition. The two major mTORC1 downstream effectors: P70S6K and 4EBP1 are rapidly dephosphorylated upon Pim inhibitor treatment of MM cells. We are currently investigating the potential signaling modules that may mediate Pim2’s regulation on mTORC1 pathway. Taken together, our findings strongly support Pim2 as a promising therapeutic target in MM, given its distinct expression in MM and essential role in maintaining proliferation. Citation Format: Jing Lu, Tatiana Zavorotinskaya, Yumin Dai, Xiaohong Niu, Joseph Castillo, Janet Sim, Jianjun Yu, Kevin Shannon, Pablo Garcia. Pim2 is required for maintaining Multiple Myeloma cell proliferation through modulating mTORC1 pathway. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5194. doi:10.1158/1538-7445.AM2013-5194
Introduccion: Colitis linfocitica y enteritis microscopica son causas relativamente comunes de di... more Introduccion: Colitis linfocitica y enteritis microscopica son causas relativamente comunes de diarrea cronica y ambas se caracterizan por un infiltrado linfocitico intraepitelial. No existen reportes previos de la coexistencia de ambas entidades. Objetivo: Describir las caracteristicas clinicas e histologicas de los pacientes que presentan este diagnostico simultaneamente. Material y metodos: Se seleccionaron pacientes adultos con diarrea cronica que tuvieran biopsia simultanea de colon y duodeno tomados el mismo dia, durante los anos 2010-2016, en el Servicio de Gastroenterologia del Hospital Nacional Daniel Alcides Carrion. Se recopilo informacion clinica del archivo de historias. Las laminas fueron reevaluadas histologicamente por 3 patologos. Se realizo estudio inmunohistoquimico de linfocitos intraepiteliales para CD8 y CD3 en 6 casos. Resultados: De 63 pacientes con diarrea cronica y biopsia simultanea de duodeno y colon, se identifico un total de 35 pacientes (55,5%) con dia...
Cancer Immunology Research
Indonesian Journal of Electrical Engineering and Computer Science
Whenever a broadcast transmitter is on-air, it is required to be tended by licensed broadcast tec... more Whenever a broadcast transmitter is on-air, it is required to be tended by licensed broadcast technicians. Technicians periodically monitor the transmitter performance, record the supply voltage and current at the last stage of the power amplifier and keeps a copy for at least two years. Also recorded are the times the transmitter is turned ON and OFF as well as the times the transmitter shuts down and returns back to air. This paper proposes a system to remotely tend analog transmitters in one central monitoring station. The remote tending of several transmitters in one location is made possible through internet connection. However, the challenge in the proposed system is in the gathering of transmitter data. A prototype of the system was constructed and tested in an FM broadcast transmitter. Test results on the prototype performance show that the proposed system can effectively be used to remotely monitor, record data and control the status of analog broadcast transmitters. The pr...
Indonesian Journal of Electrical Engineering and Computer Science
Once broadcast transmitters are put into operation, regulatory bodies in different countries requ... more Once broadcast transmitters are put into operation, regulatory bodies in different countries require the equipment to be monitored, data logged and controlled. Normally, transmitter personnel turn ON the transmitter at the start of the broadcasting activities, and turn it OFF at the end of the activities. They also regularly record the transmitter meter readings on output power, voltage and current as long as the transmitter is on-air. These data must be logged and saved for future references. These procedures are done by transmitter personnel manually. With the advent of internet technology, this paper presents a system to remotely monitor, gather and record meter readings, and a provision to control the turning ON/OFF as well as to adjust the output power of a number of digital transmitters. All these procedures are done in one central location. The system was implemented and then tested using a digital television transmitter. Results of the tests show that the developed system ca...
Experimental and Molecular Therapeutics
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru
Lymphocytic colitis and microscopic enteritis are relatively common causes of chronic diarrhea an... more Lymphocytic colitis and microscopic enteritis are relatively common causes of chronic diarrhea and it is characterized by an intraepithelial lymphocytic infiltrate. There have been no previous reports of coexistence between these 2 pathologies. To describe histological and clinical characteristic in patients with coexistence of lymphocytic colitis and microscopic enteritis. All cases with simultaneous diagnosis of lymphocytic duodenosis and lymphocytic colitis were reevaluated during lapse time 2010-2016 in hospital Daniel Carrion. The slides were reviewed by 3 pathologists and clinical information was obtained from clinical records. Expression of CD3 and CD8 was detected in 6 cases by immunohistochemical assays. A total of 35 patients with coexistence of lymphocytic duodenitis and lymphocytic colitis were selected of the pathology archives, 80% were females, Anemia was identified in 28.5% of patients. Blastocysitis hominis infestation was identified in 31.8%. The mean intraepitheli...
Genes & nutrition, 2017
A large number of genome-wide association studies, transferability studies, and candidate gene st... more A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with common human obesity. The mounting evidence suggests that these obesity gene variants interact with multiple environmental factors and increase susceptibility to this complex metabolic disease. The objective of this review article is to provide concise and updated information on energy balance, heritability of body weight, origins of gene variants, and gene-nutrient interactions in relation to human obesity. It is proposed that knowledge of these related topics will provide valuable insight for future preventative lifestyle intervention using targeted nutritional and medicinal therapies.
Gene, Jan 5, 2017
It is generally accepted that the selection of gene variants during human evolution optimized ene... more It is generally accepted that the selection of gene variants during human evolution optimized energy metabolism that now interacts with our obesogenic environment to increase the prevalence of obesity. The purpose of this study was to perform a global evolutionary and metabolic analysis of human obesity gene risk variants (110 human obesity genes with 127 nearest gene risk variants) identified using genome-wide association studies (GWAS) to enhance our knowledge of early and late genotypes. As a result of determining the mean frequency of these obesity gene risk variants in 13 available populations from around the world our results provide evidence for the early selection of ancestral risk variants (defined as selection before migration from Africa) and late selection of derived risk variants (defined as selection after migration from Africa). Our results also provide novel information for association of these obesity genes or encoded proteins with diverse metabolic pathways and oth...
Metal Finishing
Recycling rinsewaters with Ion Exchange has long been known to reduce waste discharge. Convention... more Recycling rinsewaters with Ion Exchange has long been known to reduce waste discharge. Conventional Ion Exchange systems, however, produce large volumes of regenerant waste, making evaporation expensive. The 786 series Rinsewater Recycling Systems from Hydromatix reduce regenerant waste by 98%, making ZERO Discharge feasible. For brochure or technical assistance call: