çağdaş erdoğan - Profile on Academia.edu (original) (raw)

Papers by çağdaş erdoğan

Bu üründe yer alan bilgiler sadece lisanslı tıbbi çalışanlar için kaynak olarak sunulmuştur. Herh... more Bu üründe yer alan bilgiler sadece lisanslı tıbbi çalışanlar için kaynak olarak sunulmuştur. Herhangi bir konuda profesyonel tıbbi danışmanlık veya tıbbi tanı amacıyla kullanılmamalıdır. Akademisyen Kitabevi ve alıcı arasında herhangi bir şekilde doktor-hasta, terapist-hasta ve/ veya başka bir sağlık sunum hizmeti ilişkisi oluşturmaz. Bu ürün profesyonel tıbbi kararların eşleniği veya yedeği değildir. Akademisyen Kitabevi ve bağlı şirketleri, yazarları, katılımcıları, partnerleri ve sponsorları ürün bilgilerine dayalı olarak yapılan bütün uygulamalardan doğan, insanlarda ve cihazlarda yaralanma ve/veya hasarlardan sorumlu değildir. İlaçların veya başka kimyasalların reçete edildiği durumlarda, tavsiye edilen dozunu, ilacın uygulanacak süresi, yöntemi ve kontraendikasyonlarını belirlemek için, okuyucuya üretici tarafından her ilaca dair sunulan güncel ürün bilgisini kontrol etmesi tavsiye edilmektedir. Dozun ve hasta için en uygun tedavinin belirlenmesi, tedavi eden hekimin hastaya dair bilgi ve tecrübelerine dayanak oluşturması, hekimin kendi sorumluluğundadır. Akademisyen Kitabevi, üçüncü bir taraf tarafından yapılan ürüne dair değişiklikler, tekrar paketlemeler ve özelleştirmelerden sorumlu değildir.

The European Research Journal, Mar 4, 2022

Objectives: Duchenne and Becker muscular dystrophies (DMD/BMD) are muscle diseases that show X-li... more Objectives: Duchenne and Becker muscular dystrophies (DMD/BMD) are muscle diseases that show X-linked recessive inheritance. The disease occurs depending on large mutations, deletions/duplications, small mutations, point mutations and mid-intronic mutations of the gene encoding the protein called dystrophin. Therefore, in this study, we aimed to investigate the pathogenic variants of DMD in the affected family. Methods: A 23-year-old male who had weakness in the muscles, difficulty climbing the stairs, frequent falls at the age of seven was referred to the Medical Genetics department for an initial diagnosis of DMD/BMD. His siblings also suffered from similar symptoms. Therefore, eight individuals from the same family were included in the study. MLPA analysis was performed to evaluate deletion/duplication and variants of the DMD gene were evaluated by targeted NGS. Sophia DDM algorithms were used for the bioinformatics analysis of data, and the pathogenicity of the mutations was evaluated based on in silico prediction tools. Results: Allelic variants were identified in 8 individuals of the family including two suspected patients and six suspected obligatory carriers. NGS analysis revealed that proband and his nephew were hemizygous for pathogenic c.10018T > C (p.Cys3340Arg, C3340R) mutation and mother, two sisters and niece were carriers. Conclusions: C3340R mutation was first reported in a Taiwanese BMD patient among the 23 different pathologic changes. This variant identified as pathogenic because of being highly conserved cysteine substitution in the dystroglycan-binding domain of dystrophin. This study has the importance of reporting an infrequent pathogenic mutation, C3340R, in two patients and four suspected obligatory carriers of a Turkish family.

Medical Science and Discovery

Objective: Irritable bowel syndrome (IBS) is a chronic, functional disorder of the gastrointestin... more Objective: Irritable bowel syndrome (IBS) is a chronic, functional disorder of the gastrointestinal tract. Recent investigations have highlighted the potential involvement of inflammation, although the etiology of IBS remains unknown. This study aims to assess the connection between IBS and Monocyte/High-Density Lipoprotein (HDL) ratio (MHR), a new inflammatory marker. Material and Method: The study was conducted in the outpatient gastroenterology unit of a tertiary center between March-2021 and March-2022. Patients with IBS, according to the Rome IV criteria were examined retrospectively. Age- and sex-matched healthy controls were used to compute MHR and compare the results. Results: A total of 255 participants, 155 diagnosed with IBS and 100 in the control group, were included. The median (min-max) monocyte counts (cells/mm³) in the IBS and control groups were 380.0 (310.0-460.0) and 332.0 (232.0-449.3), respectively (p = 0.008). The median(min-max) HDL levels(mg/dl) in IBS and c...

Neuro-Ophthalmology, Jan 29, 2013

In this study, we aimed to investigate habituation of pattern-reversal visually evoked potentials... more In this study, we aimed to investigate habituation of pattern-reversal visually evoked potentials (VEPs) in patients with relapsing remitting (RR) multiple sclerosis (MS). Twenty-one patients with this diagnosis and with a history of optic neuritis (ON), 29 such patients without a history of ON, and 25 normal controls were enrolled to study. One eye of each patient in the group with a history of ON and one eye of each subject in the control group was randomly selected. In the group with a past history of ON, the affected eye of the patients was selected in unilateral cases and the eye in which showed the greater latency delay of the P100 component in bilateral cases. P100 amplitudes were determined by visual inspection in 10 blocks of 512 responses and habituation was analysed as the percentage amplitude change between the 1st and 2nd-10th blocks. Amplitude of the P100 component of the VEP showed a significant clear-cut habituation after the first block in the control group but neither patient group showed a significant decrease in P100 amplitude. We conclude that our electrophysiological study has shown a lack of habituation in patients suffering from RR MS. This result could be important for the evaluation of visual system involvement in patients with MS, with or without a previous history of ON.

DergiPark (Istanbul University), Aug 19, 2022

To determine the clinical significance of gastrointestinal (GI) symptoms in mild hospitalized pat... more To determine the clinical significance of gastrointestinal (GI) symptoms in mild hospitalized patients with COVID-19 infection. Material and Method: This study included adult patients who were hospitalized with a confirmed diagnosis of COVID-19 infection. The demographical features, symptoms, clinical presentations, medical history, medications and clinical progress and outcomes were noted using data collection form by the clinicians. The effect of GI symptoms on clinical outcomes in patients with mild COVID-19 infection was statistically evaluated. Results: 307 patients were included to the study. 159 of patients (51.7%) had an at least one GI symptoms, 18.2% of those presented only GI symptoms while 21.2% only non-GI symptoms. 27% were asymptomatic at admission. The most common GI symptom was loss of appetite that presenting 16.9% patients. The second and third most common GI symptoms were diarrhea in 15% patients, nausea and loss of taste in 14% patients, respectively. There was no significant difference in laboratory parameters between GI and non-GI symptoms groups. When age, gender, smoking status, and comorbidities of patients with GI and non-GI symptoms groups were compared, there was no difference in mean age, gender, smokers, and comorbidities. In addition, the length of hospital stay (p=0.377), complete healing (p=0.372) and mortality (p=0.351) was similar in patients with GI and non-GI symptoms groups respectively. Early diagnosis of COVID-19 infection presenting with GI symptoms can help prevent infection spread. The majority of these symptoms were mild, and their presence was not associated with worse clinical outcomes.

Turkish Journal Of Neurology, Jan 6, 2022

Re cei ved/Ge lifl Ta ri hi: 22.06.2021 Ac cep ted/Ka bul Ta ri hi: 22.12.2021 İlk koronavirüs ol... more Re cei ved/Ge lifl Ta ri hi: 22.06.2021 Ac cep ted/Ka bul Ta ri hi: 22.12.2021 İlk koronavirüs olgusu ortaya çıktığından beri dünyanın çeşitli bölgelerinden Koronavirüs hastalığı-2019 (COVID-19) ile ilişkili nörolojik komplikasyonlar bildirilmektedir. Koronavirüs ile ilişkili Guillain-Barré sendromu (GBS) olguları bildirilse de ilişki halen net değildir ve kesin bir yargıya varmak için vaka sayısı yeterli değildir. Moleküler benzerlik GBS'deki istenmeyen immüniteyi ifade eden ilk hipotezlerdendir. Bu hipoteze göre immün sistemin patojenle veya başka şekilde aktiflenmesi ile oluşan antikorlar periferik sinirler ve spinal kökleri hedef alır. Patojenin doğrudan immün sistemi hedef aldığı direkt viral nörotoksisite kavramı üzerinde de durulmuştur.

Journal of Contemporary Medicine

Objective: To determine the clinical significance of gastrointestinal (GI) symptoms in mild hospi... more Objective: To determine the clinical significance of gastrointestinal (GI) symptoms in mild hospitalized patients with Covid-19 infection. Material and Methods: This study included adult patients who were hospitalized with a confirmed diagnosis of Covid-19 infection. The demographical features, symptoms, clinical presentations, medical history, medications and clinical progress and outcomes were noted using data collection form by the clinicians. The effect of GI symptoms on clinical outcomes in patients with mild Covid-19 infection was statistically evaluated. Results: 307 patients were included to the study. 159 of patients (51.7%) had an at least one GI symptoms, 18.2% of those presented only GI symptoms while 21.2% only non-GI symptoms. 27% were asymptomatic at admission. The most common GI symptom was loss of appetite that presenting 16.9% patients. The second and third most common GI symptoms were diarrhea in 15% patients, nausea and loss of taste in 14% patients, respectively...

Journal of Health Sciences and Medicine

Aim: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a serious c... more Aim: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a serious complication of ERCP. In this study, we aimed to compare the use of rectal indomethacin, pancreatic stenting or both techniques for prevention of PEP. Material and Method: Patients who underwent ERCP for the first time due to choledocholithiasis between January 2022 and June 2022 were retrospectively reviewed. The clinical findings, demographics, laboratory records, endoscopic intervention characteristics, whether rectal indomethacin was applied before the procedure, whether pancreatic stent was placed or not were evaluated. Results: A total of 367 patients who underwent ERCP for the first time were included in the study. The mean age was 61 (28-92) years and 53.4% were female. In 124 (33.8%) patients, involuntary guide-wire insertion into the pancreatic duct occurred during canulation. Pancreatic stent was placed in 82 (22.3%) of the patients. Rectal indomethacin was administered to 288 ...

Ordu Üniversitesi Hemşirelik Çalışmaları Dergisi

Amaç: Bu araştırma hemşirelik intörn öğrencilerinin COVID-19 şüphesi olan çocuk hasta ile ilgili ... more Amaç: Bu araştırma hemşirelik intörn öğrencilerinin COVID-19 şüphesi olan çocuk hasta ile ilgili verilen örnek vakada belirledikleri hemşirelik tanılarının incelenmesi amacıyla yürütülmüştür. Yöntem: Bu araştırma tanımlayıcı türdedir. Araştırmaya bir üniversitenin hemşirelik bölümüne devam eden ve Çocuk Sağlığı ve Hastalıkları Hemşireliği İntörn Uygulama dersine kayıtlı öğrenciler alınmıştır. Araştırmada örneklem seçimine gidilmemiş, derse kayıtlı 80 öğrencinin belirlediği toplam 446 adet hemşirelik tanısı incelenmiştir. Öğrencilerin belirledikleri hemşirelik tanıları araştırmacılar tarafından NANDA (North American Nursing Diagnosis Association) hemşirelik tanıları sınıflandırma sisteminde bulunup bulunmaması, tanı yapısının ve belirlenen tanılarının COVID-19 şüpheli çocuk hasta için uygunluğu açısından değerlendirilmiştir. Bulgular: Araştırmada her bir öğrenci ortalama 5.57±1.67 adet tanı belirlemiştir. Öğrencilerin belirledikleri tanıların; %76.90’ının NANDA sınıflandırma sistemin...

The European Research Journal

MRI Measures of Hippocampus in Mild Cognitive Impairment and Alzheimer Patients

Türk Nöroloji Dergisi, 2011

OBJECTIVE: In this study we aimed to compare the hippocampal volumes of patients diagnosed as Alz... more OBJECTIVE: In this study we aimed to compare the hippocampal volumes of patients diagnosed as Alzheimer's Disease (AD), Minimal Cognitive Impairment (MCI) and the healthy objects. We also tried to demonstrate whether there was a possible correlation between the cognitive tests and the hippocampal volumes. METHODS: Minimental State Examination, Adas-Cog and Global Deterioration Scale were administrated to the patients having Alzheimer's Disease (n=20). We also performed Minimental State Examination, and Adas-Cog to MCI patients (n=20) and Minimental State Examination to the healthy control group (n=18). Both right and left hippocampal volumes were measured by a three dimensioned Surf Driver programm with the support of cranial magnetic resonance imaging (MRI). RESULTS: Both right and left hippocampal volumes of the Alzheimer's Disease group were significantly smaller than the MCI and the control groups. Bilaterally hippocampal volumes of MCI group were also smaller than t...

Proceedings of The 2nd International Conference on Research in Education, 2019

The aim of this study is to determine the attitudes of the sports science faculty students with p... more The aim of this study is to determine the attitudes of the sports science faculty students with pedagogical formation training towards the teaching profession and to make a comparison based on some characteristics. The research was conducted as a survey model. The research group was comprised of 353 students, who were attending to the Faculty of Sports Sciences in Erciyes University during 2018-2019 education year and who received pedagogical formation training. The research data were collected using the "Attitude Scale for the Profession of Physical Education Teaching". SPSS program was used in the analysis of the data. According to the results of the study, the attitudes of the sports science faculty students with pedagogical formation training towards the profession of teaching were determined to be at "medium level". Additionally, there was statistically no significant difference in the attitudes of the students in the research group towards the teaching profession concerning variables such as gender, age, active participation in sports, grade point average, and grade levels; but there was a statistically significant difference concerning the department and sport branch.

AMAC: Bu calismada Turkiye`nin Denizli ilindeki epilepsi prevalansinin degerlendirilmesi ve Turki... more AMAC: Bu calismada Turkiye`nin Denizli ilindeki epilepsi prevalansinin degerlendirilmesi ve Turkiye`nin diger sehirlerinde ve dunyanin degisik bolgelerinde yapilan diger prevalans calismalari ile karsilastirilmasi amaclandi.YONTEMLER: Bu amacla 4666 kisi calismaya dahil edildi. Oncelikle bu kisiler yuz yuze gorusme ile bir sorgulama formu doldurdu. Nobeti olabilecegi dusunulen olgular klinisyenler tarafindan degerlendirildi ve tumune EEG uygulandi.BULGULAR: Elde edilen prevalans degeri, Turkiye de benzer sorgulama formu ile yapilan diger calismalara gore daha dusuk saptandi. Bu durum Denizli ilinde egitim ve gelismislik duzeyinin diger calismalarda taranan illere gore daha yuksek olmasi ile aciklanabilir. Diger taraftan dunya genelindeki calismalar ile karsilastirildiginda, elde ettigimiz sonuclar gelismekte olan ulkelerin sonuclarina benzerdi.SONUC: Denizli de epilepsi prevalansi 5.7/1000 idi. Hastalik baslangici ilk dekadda daha sikti.

Purpose: In this study we aimed to evaluate the prevalence of epilepsy in Denizli, a city of Turk... more Purpose: In this study we aimed to evaluate the prevalence of epilepsy in Denizli, a city of Turkey, and to compare it with both studies from the world and Turkey. Methods: With this purpose 4666 people were included to the study. Primarily they filled a questionnaire form face to face. The ones suggested to have seizure were evaluated by clinicians and EEG was performed. Results: The prevalence of epilepsy was found 5.7 /1000 in Denizli. The beginning of the disease was more frequent in the first two decades. Conclusion: This prevalence value was lesser than the ones using the same questionnaire in Turkey suggesting a higher educational grade and development in Denizli. On the other hand when compared worldwide, the results were similar to the ones observed in the developing countries. Pam Med J 2012;5(3):110-114

Journal of Education and Research in Nursing, 2020

Aim: To determine the nurses, who are working in neonatal intensive care, knowledge about cluster... more Aim: To determine the nurses, who are working in neonatal intensive care, knowledge about clustered care and the affecting factors. Methods: 93 neonatal nurses were included in the study. In the collection of the study data, The demographic features form and The knowledge level form clustered care were used. Results: The rate of nurses who receiving training for neonatal intensive care from the was 67.7%, and the rate of those receiving training on the individualized developmental care of the newborn is 21.5%. Nurses who received training for individualized developmental care and neonatal intensive care, had a high education level and had a long working period in NICU, had higher knowledge level scores for collective care. As a result, the education level of the nurses working in the neonatal intensive care unit, the experience and the trainings they have received in the NICU affect the information about clustered care that plays a critical role in the care of the newborn and is used frequently by the nurses. For this reason, it is thought that the education needs of nurses working in neonatal intensive care units will be determined and their knowledge regarding collective care will increase with the trainings provided.

Intensive and Critical Care Nursing, 2019

Objective: The aim of this study was to evaluate the effectiveness of the maternal voice in reduc... more Objective: The aim of this study was to evaluate the effectiveness of the maternal voice in reducing pain during painful procedures in children between one and three years old receiving treatment in paediatric intensive care unit. Design and methods: This research was designed as a randomised controlled experimental study. Sixty children were randomised into two groups, the maternal-voice group and the controls. The children in the maternal-voice group listened to the maternal voice during the procedure. Although questionnaire forms were used to determine the descriptive characteristics of infants, the Face, Legs, Activity, Cry, Consolability (FLACC) pain assessment scale was used to evaluate pain level. Heart rate and oxygen saturation were also measured. Results: There were significant differences in the pain, heart rate and oxygen saturation levels between the maternal-voice and control groups. Pain levels and heart rates of the children in the experimental group during and after the painful procedures were much lower, and their oxygen saturations were higher than those of the children in the control group. Practic implications: Distraction methods, such as listening to the maternal voice, should be used as a nursing intervention to reduce pain and decrease heart rate and increaseoxygen saturation in children during painful procedures in the paediatric intensive care unit. The maternal voice is recommended as a helpful option in cases when a pain control method is required. Future research needs to explore different interventional practices.

Journal of Pediatric Nursing, 2018

Sudden infant death syndrome is the most common cause of death during the post-neonatal period. F... more Sudden infant death syndrome is the most common cause of death during the post-neonatal period. Factors such as sleeping position, bed sharing, pillow use, smoking during pregnancy and the breastfeeding period constitute risk factors for sudden infant death syndrome. This study aims to identify the risky behaviors of mothers with infants that may put their children at risk for sudden infant death syndrome. Design and methods: This is a cross-sectional, descriptive study. Data were collected using a questionnaire that was developed by the researchers. The questionnaire was filled out by 456 mothers who applied to the family health center between October 2014 and January 2015. Results: The greatest risk factor is the infant's sleeping position. A total of 77.9% of the mothers put their babies in bed in a non-supine position; 65.8% used a pillow when they put their babies in bed, 52.9% used a soft mattress, and 28.5% shared their beds with their babies. Prone sleeping was more likely to occur when smoke was present in the home or a pillow was used. Conclusion: Nurses should notify families of the risky behaviors that can cause sudden infant death syndrome and plan appropriate nursing care.

Therapeutics and clinical risk management, 2018

Data regarding lacosamide treatment as an adjunctive therapy in patients representative of a foca... more Data regarding lacosamide treatment as an adjunctive therapy in patients representative of a focal-onset epilepsy population including those with and without intellectual/developmental disorders (IDDs) are limited. To evaluate the retention rates of lacosamide in focal-onset epilepsy patients with and without IDD. We retrospectively reviewed all consecutive electronic and paper medical records of patients diagnosed with focal-onset epilepsy who were treated with lacosamide in two tertiary epilepsy centers. One hundred and thirty-six patients who met the inclusion criteria were studied. Number of patients with IDD was 46 (33.8%). Median lacosamide dose was 300 mg/day. A total of 39 patients (28.7%) experienced side effects, and 22 of them (16.2%) discontinued lacosamide. The 1-, 2-, and 3-year retention rates of lacosamide in patients with IDD were 68%, 62%, and 53%, respectively. Kaplan-Meier survival analysis showed that the retention rates were significantly lower in patients with...

The Journal of Spinal Cord Medicine, 2007

Case report: A 25-year-old man with Behc ¸et's disease was admitted because of weakness of the lo... more Case report: A 25-year-old man with Behc ¸et's disease was admitted because of weakness of the lower limbs and difficulty in urination. He had received a rabies vaccination 2 months previous because he had been bitten by a dog. Findings: Clinical and laboratory findings supported acute transverse myelitis. A hyperintense lesion and expansion at the level of conus medullaris was detected on spinal magnetic resonance imaging. Although neurologic involvement is one of the main causes of mortality and morbidity in Behc ¸et's disease, the factors that aggravate the involvement of the nervous system are still unclear. Vaccination may have been the factor that had activated autoimmune mechanisms in this case. To our knowledge, involvement of the conus medullaris in Behc ¸et's disease after rabies vaccination has not been reported.

Neuro-Ophthalmology, 2013