LAURA ADAMO | Università degli studi di Pavia (original) (raw)

Papers by LAURA ADAMO

Research paper thumbnail of Pathologic placental lesions in early and late fetal growth restriction

Acta Obstetricia et Gynecologica Scandinavica, 2019

Introduction: The purpose of the study was to evaluate the differences in individual histopatholo... more Introduction: The purpose of the study was to evaluate the differences in individual histopathologic placental lesions in pregnancies complicated by early-onset (<32 weeks at diagnosis) and late-onset (≥32 weeks at diagnosis) fetal growth restriction (FGR). Material and methods: A cohort study of 440 singleton pregnancies complicated by FGR, diagnosed according to standard ultrasonographic criteria, followed up and delivered at the same institution between 2010 and 2016. Placental lesions were classified according to the Amsterdam Placental Workshop Consensus Criteria.

Research paper thumbnail of Fetal Micro and Macroglossia: Defining Normal Fetal Tongue Size

Journal of Ultrasound in Medicine

OBJECTIVES Abnormal fetal tongue size is a phenotypic feature of various syndromes including Beck... more OBJECTIVES Abnormal fetal tongue size is a phenotypic feature of various syndromes including Beckwith-Wiedemann, Pierre-Robin, oromandibular limb hypoplasia, chromosomal aberrations, etc. Current data regarding normal fetal tongue size are limited. Hence, micro/macroglossia are subjectively determined. The aim of the study was to construct a contemporary fetal tongue nomogram and to assess its clinical contribution. METHODS A prospective cross-sectional study was performed in well dated, low risk, singleton pregnancies. Fetal tongues were measured by 5 trained sonographers. Highest quality images were selected. Intra- and interobserver variability was assessed. Tongue length, width, area, and circumference 1st to 99th centiles were calculated for each gestational week. Based on the normal tongue size charts, we created a Tongue Centile Calculator. RESULTS Over 18 months, 664 tongue measurements were performed. A cubic polynomial regression model best described the correlation between tongue size and gestational age. The correlation coefficient (r2 ) was 0.934, 0.932, 0.925, and 0.953 for tongue length, width, area, and circumference, respectively (P < .001). Intra- and interobserver variability had high interclass correlation coefficients (>0.9). Using the new charts, we were able to identify 2 cases of macroglossia, subsequently diagnosed with Beckwith-Wiedemann, and 4 cases of microglossia, 3 associated with Pierre-Robin sequence, and 1 associated with persistent buccopharyngeal membrane. CONCLUSIONS We present novel fetal tongue size charts from 13 to 40 weeks of gestation. Clinical application of these nomograms may be beneficial in the prenatal diagnosis of syndromes or malformations associated with abnormal fetal tongue size.

Research paper thumbnail of The fetal stomach throughout gestation: Normal charts and clinical implication

Prenatal Diagnosis, 2021

To construct a nomogram of fetal stomach, and to prospectively determine the clinical value of st... more To construct a nomogram of fetal stomach, and to prospectively determine the clinical value of stomach measurement in pathological cases.

Research paper thumbnail of Brief History of Intrapartum Ultrasonography

Research paper thumbnail of Prenatal Diagnosis of Jeune Syndrome by Whole‐Exome Sequencing in a Case With Mild Skeletal Changes

Journal of Ultrasound in Medicine, 2020

Research paper thumbnail of From screening chromosomal anomalies to early diagnosis of fetal malformations

Current Opinion in Obstetrics and Gynecology, 2020

Purpose of review The aim of this review is to understand why and how to improve the detection ra... more Purpose of review The aim of this review is to understand why and how to improve the detection rate of the fetal anomalies in the first trimester. Recent findings The role of the first trimester is evolving from aneuploid and basic anatomical screening to a necessary tool to identifying early fetal malformations. In the past 20 years, several studies were conducted to assess the detection rate of anomalies in the first trimester, and despite the improvement in the diagnoses of spina bifida and cleft lip, many anomalies detectable in the first trimester are still being diagnosed in the second trimester scan. Analyzing the factors that improve the detection rate can show the reason why, even in recent years, only 50% of the anomalies are diagnosed in the first trimester. Summary Thanks to the improvement in the ultrasound technology, the fetus can be thoroughly studied even in early gestation and it is, therefore, indispensable to increase the detection rate of the anomalies diagnosable from the first trimester. The sonographer's utmost attention should be applied to all pregnancies, not only in high-risk patients, and new protocols based on the mid trimester scan are needed to spread the concept of first trimester anatomical scan.

Research paper thumbnail of OC01.04: Determination of the normal fetal conus medullaris level throughout pregnancy by a novel three‐dimensional rendering technique

Ultrasound in Obstetrics & Gynecology, 2021

Research paper thumbnail of Pathologic placental lesions in early and late fetal growth restriction

Acta Obstetricia et Gynecologica Scandinavica, 2019

Introduction: The purpose of the study was to evaluate the differences in individual histopatholo... more Introduction: The purpose of the study was to evaluate the differences in individual histopathologic placental lesions in pregnancies complicated by early-onset (<32 weeks at diagnosis) and late-onset (≥32 weeks at diagnosis) fetal growth restriction (FGR). Material and methods: A cohort study of 440 singleton pregnancies complicated by FGR, diagnosed according to standard ultrasonographic criteria, followed up and delivered at the same institution between 2010 and 2016. Placental lesions were classified according to the Amsterdam Placental Workshop Consensus Criteria.

Research paper thumbnail of Fetal Micro and Macroglossia: Defining Normal Fetal Tongue Size

Journal of Ultrasound in Medicine

OBJECTIVES Abnormal fetal tongue size is a phenotypic feature of various syndromes including Beck... more OBJECTIVES Abnormal fetal tongue size is a phenotypic feature of various syndromes including Beckwith-Wiedemann, Pierre-Robin, oromandibular limb hypoplasia, chromosomal aberrations, etc. Current data regarding normal fetal tongue size are limited. Hence, micro/macroglossia are subjectively determined. The aim of the study was to construct a contemporary fetal tongue nomogram and to assess its clinical contribution. METHODS A prospective cross-sectional study was performed in well dated, low risk, singleton pregnancies. Fetal tongues were measured by 5 trained sonographers. Highest quality images were selected. Intra- and interobserver variability was assessed. Tongue length, width, area, and circumference 1st to 99th centiles were calculated for each gestational week. Based on the normal tongue size charts, we created a Tongue Centile Calculator. RESULTS Over 18 months, 664 tongue measurements were performed. A cubic polynomial regression model best described the correlation between tongue size and gestational age. The correlation coefficient (r2 ) was 0.934, 0.932, 0.925, and 0.953 for tongue length, width, area, and circumference, respectively (P < .001). Intra- and interobserver variability had high interclass correlation coefficients (>0.9). Using the new charts, we were able to identify 2 cases of macroglossia, subsequently diagnosed with Beckwith-Wiedemann, and 4 cases of microglossia, 3 associated with Pierre-Robin sequence, and 1 associated with persistent buccopharyngeal membrane. CONCLUSIONS We present novel fetal tongue size charts from 13 to 40 weeks of gestation. Clinical application of these nomograms may be beneficial in the prenatal diagnosis of syndromes or malformations associated with abnormal fetal tongue size.

Research paper thumbnail of The fetal stomach throughout gestation: Normal charts and clinical implication

Prenatal Diagnosis, 2021

To construct a nomogram of fetal stomach, and to prospectively determine the clinical value of st... more To construct a nomogram of fetal stomach, and to prospectively determine the clinical value of stomach measurement in pathological cases.

Research paper thumbnail of Brief History of Intrapartum Ultrasonography

Research paper thumbnail of Prenatal Diagnosis of Jeune Syndrome by Whole‐Exome Sequencing in a Case With Mild Skeletal Changes

Journal of Ultrasound in Medicine, 2020

Research paper thumbnail of From screening chromosomal anomalies to early diagnosis of fetal malformations

Current Opinion in Obstetrics and Gynecology, 2020

Purpose of review The aim of this review is to understand why and how to improve the detection ra... more Purpose of review The aim of this review is to understand why and how to improve the detection rate of the fetal anomalies in the first trimester. Recent findings The role of the first trimester is evolving from aneuploid and basic anatomical screening to a necessary tool to identifying early fetal malformations. In the past 20 years, several studies were conducted to assess the detection rate of anomalies in the first trimester, and despite the improvement in the diagnoses of spina bifida and cleft lip, many anomalies detectable in the first trimester are still being diagnosed in the second trimester scan. Analyzing the factors that improve the detection rate can show the reason why, even in recent years, only 50% of the anomalies are diagnosed in the first trimester. Summary Thanks to the improvement in the ultrasound technology, the fetus can be thoroughly studied even in early gestation and it is, therefore, indispensable to increase the detection rate of the anomalies diagnosable from the first trimester. The sonographer's utmost attention should be applied to all pregnancies, not only in high-risk patients, and new protocols based on the mid trimester scan are needed to spread the concept of first trimester anatomical scan.

Research paper thumbnail of OC01.04: Determination of the normal fetal conus medullaris level throughout pregnancy by a novel three‐dimensional rendering technique

Ultrasound in Obstetrics & Gynecology, 2021