Saverio Cinti | Università Politecnica delle Marche, Italy (original) (raw)
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Papers by Saverio Cinti
Redox biology, Oct 1, 2021
Langenbeck's Archives of Surgery, Feb 24, 2023
bioRxiv (Cold Spring Harbor Laboratory), Jan 20, 2020
Trends in Endocrinology and Metabolism, Sep 1, 2018
Adipocytes are lipid-rich parenchymal cells contained in a very plastic organ, whose composition ... more Adipocytes are lipid-rich parenchymal cells contained in a very plastic organ, whose composition can undergo striking physiologic changes. In standard conditions the organ contains white and brown adipocytes which play opposite roles: lipid storage to meet metabolic requirements and lipid burning for thermogenesis, respectively. During chronic cold exposure, white adipocytes transdifferentiate to brown, to increase thermogenesis, whereas in conditions of chronic positive energy balance brown adipocytes transdifferentiate to white, to increase energy stores. During pregnancy, lactation, and post-lactation, subcutaneous white adipocytes convert to milk-producing glands formed by lipid-rich elements that can be defined as pink adipocytes. Recent fate-mapping data support the conversion of pink to brown adipocytes and the reversible conversion of brown adipocytes to myoepithelial cells of alveoli.
Biochimica Et Biophysica Acta - Molecular And Cell Biology Of Lipids, May 1, 2013
Proceedings of the National Academy of Sciences of the United States of America, Mar 15, 2004
The FASEB Journal, May 5, 2009
Pediatric and adolescent medicine, Apr 16, 2015
Italian journal of anatomy and embryology, 2015
Springer eBooks, 2018
The brownish areas of the adipose organ are constituted of brown adipose tissue (BAT). The lower ... more The brownish areas of the adipose organ are constituted of brown adipose tissue (BAT). The lower right panel of this plate shows the color and gross appearance of white and brown fat. This last is a lobular tissue in which the parenchymal cell is a multilocular roundish cell with a central nucleus, called brown adipocyte. The vacuoles are made up of triglycerides. These same molecules are stored in white adipocytes, which are mainly unilocular.
The FASEB Journal, Dec 23, 2019
Italian journal of anatomy and embryology, 2017
Italian journal of anatomy and embryology, 2016
Journal of Lipid Research, 2023
Experimental Cell Research, Jul 1, 1985
Biology of the Cell, 1989
The distribution of the uncoupling protein (UCP) in brown adipocyte mitochondria of the hibernant... more The distribution of the uncoupling protein (UCP) in brown adipocyte mitochondria of the hibernant Muscardinus avellanarius was obtained by ultrastructural immunocytochemistry. In both cryosections and sections of Lowicryl‐embedded material UCP was localized in the mitochondrial cristae of brown adipocytes, but not in liver mitochondria. It should now be possible to easily identify the morphology of cells committed to BAT differentiation in the tissue as well as in cell culture.
Endocrinology, Oct 30, 2017
Redox biology, Oct 1, 2021
Langenbeck's Archives of Surgery, Feb 24, 2023
bioRxiv (Cold Spring Harbor Laboratory), Jan 20, 2020
Trends in Endocrinology and Metabolism, Sep 1, 2018
Adipocytes are lipid-rich parenchymal cells contained in a very plastic organ, whose composition ... more Adipocytes are lipid-rich parenchymal cells contained in a very plastic organ, whose composition can undergo striking physiologic changes. In standard conditions the organ contains white and brown adipocytes which play opposite roles: lipid storage to meet metabolic requirements and lipid burning for thermogenesis, respectively. During chronic cold exposure, white adipocytes transdifferentiate to brown, to increase thermogenesis, whereas in conditions of chronic positive energy balance brown adipocytes transdifferentiate to white, to increase energy stores. During pregnancy, lactation, and post-lactation, subcutaneous white adipocytes convert to milk-producing glands formed by lipid-rich elements that can be defined as pink adipocytes. Recent fate-mapping data support the conversion of pink to brown adipocytes and the reversible conversion of brown adipocytes to myoepithelial cells of alveoli.
Biochimica Et Biophysica Acta - Molecular And Cell Biology Of Lipids, May 1, 2013
Proceedings of the National Academy of Sciences of the United States of America, Mar 15, 2004
The FASEB Journal, May 5, 2009
Pediatric and adolescent medicine, Apr 16, 2015
Italian journal of anatomy and embryology, 2015
Springer eBooks, 2018
The brownish areas of the adipose organ are constituted of brown adipose tissue (BAT). The lower ... more The brownish areas of the adipose organ are constituted of brown adipose tissue (BAT). The lower right panel of this plate shows the color and gross appearance of white and brown fat. This last is a lobular tissue in which the parenchymal cell is a multilocular roundish cell with a central nucleus, called brown adipocyte. The vacuoles are made up of triglycerides. These same molecules are stored in white adipocytes, which are mainly unilocular.
The FASEB Journal, Dec 23, 2019
Italian journal of anatomy and embryology, 2017
Italian journal of anatomy and embryology, 2016
Journal of Lipid Research, 2023
Experimental Cell Research, Jul 1, 1985
Biology of the Cell, 1989
The distribution of the uncoupling protein (UCP) in brown adipocyte mitochondria of the hibernant... more The distribution of the uncoupling protein (UCP) in brown adipocyte mitochondria of the hibernant Muscardinus avellanarius was obtained by ultrastructural immunocytochemistry. In both cryosections and sections of Lowicryl‐embedded material UCP was localized in the mitochondrial cristae of brown adipocytes, but not in liver mitochondria. It should now be possible to easily identify the morphology of cells committed to BAT differentiation in the tissue as well as in cell culture.
Endocrinology, Oct 30, 2017