Landry Kablan | Universite Peleforo Gon Coulibaly (original) (raw)

Papers by Landry Kablan

Records of Natural Products, 2018

International Journal of Chemical Studies, 2018

The ethyl acetate extract from the stem bark of Alstonia boonei (Apocynaceae) were investigated f... more The ethyl acetate extract from the stem bark of Alstonia boonei (Apocynaceae) were investigated for highlight its cardiac glycosides components. This has leaded to the isolation and identification of two digitoxigenin derivative. The first one, Evomonoside, was known and the second one, 3b-O-[5(3,4-dihydroxy-5-methyltetrahydrofuran-2-yloxy)digitoxopyranosyl-2-yloxy]-5-en-14b -hydroxy-16b -acryloxydigitoxigenin, was new. Both compounds were isolated for the first time from A. boonei and their structures were established thanks to their spectral data (NMR, MS, IR and UV).

This QSAR study focused on a series of α-diaminophosphonates derived from Dapsone. Three models h... more This QSAR study focused on a series of α-diaminophosphonates derived from Dapsone. Three models have been obtained by taking into account both molecular descriptors and antifungal activities such as those of Aspergillus niger, Aspergillus foetidus and Fusarium oxysporum. Quantum chemistry methods were used at B3LYP/6-31G (d) calculation level to obtain the molecular descriptors. The statistical indicators of the first model which talk about Aspergillus niger activity are: the determination coefficient R2 = 0.976, the standard deviation S = 0.034, the Fischer test F = 80.857 and the correlation coefficient of the cross-validation Q2CV = 0.975. Those of the second model which highlight Aspergillus foetidus activity are: regression coefficient R2 = 0.946, standard deviation S = 0.041, Fischer test F = 35.353 and cross-validation correlation coefficient Q2CV = 0.943. The statistical indicators of the third model are: the determination coefficient R2 = 0.931, the standard deviation S = 0...

Morinda lucida (Rubiaceae) is a known medicinal plant used in traditional medicine in West Africa... more Morinda lucida (Rubiaceae) is a known medicinal plant used in traditional medicine in West Africa for the treatment of diseases and infections. The purpose of the present study was to investigate the chemical constituents of the stem barks of M. lucida from Côte d’Ivoire. The isolation of the compounds was carried out by a combination of silica gel column, sephadex gel filtration chromatography, preparative normal phase TLC and reverse-phase-C18 preparative TLC. The chemical structures were elucidated with the help of MS, 1D, 2D 1 H and 13 C NMR spectroscopic analysis, as well as the comparison of spectra data with that reported in the literature. The present phytochemical investigation led to the isolation and characterization of one new anthraquinone, 1,5,15trimethylmorindol (8) together with seven known anthraquinones, 3-hydroxy-2-hydroxymethyl-anthraquinone (1), damnacanthol (2), soranjidiol (3), rubiadin (4), damnacanthol-l-methyl ether (5), lucidin (6) and alizarin-1-methyl et...

Morinda lucida (Rubiaceae) is a plant used in West African’s traditional medicine for the treatme... more Morinda lucida (Rubiaceae) is a plant used in West African’s traditional medicine for the treatment of various diseases. The Phytochemical investigation of its stem barks led to the isolation of eight anthraquinone derivatives. Among these compounds, one is a new structure: 2-acetyl-1-hydroxyanthraquinone (8). The others were known from this plant: damnacanthal (1), 3-hydroxy-2-carbaldehyde-anthraquinone (2), 1-hydroxy-2-methyl-anthraquinone (3), nordamnacanthal (4), rubiadin-1-methyl ether (5), morindone (6), tectoquinone (7). Their structures were established according to their spectral data (NMR 1D and 2D, MS).

The essential oils (EOs) obtained by hydro-distillation of flowers and stems of Ageratum conyzoid... more The essential oils (EOs) obtained by hydro-distillation of flowers and stems of Ageratum conyzoides L. (Asteraceae) growing in Ivory Coast were investigated. The oils were analyzed and characterized by GC and GC–MS. Analyses of the EOs led to the identification and quantification of 48 constituents in the flower oil and 44 from the stem oil, respectively. Characterization of the EOs revealed the predominance of 6-demethoxyageratochromene or precocene I (flower: 58.8%, stem: 76.5%) and the sesquiterpene β-caryophyllene (flower: 15.2%, stem: 8.1%). Six of the identified compounds β-copaene, hexanal, trans-cadina-1(6),4-diene, α-calacorene, caryophylla-4(12),8(13)-diene-5-βol and 1,10-di-epi-cubenol are reported for the first time as constituents of A. conyzoides. Comparative analysis with data from Nigeria, Pakistan, Fiji and Brazil is reported. The antibacterial activity of EOs from of A. conyzoides was tested against seven bacteria. The inhibition zones and minimum inhibitory concen...

Black hair suffers from a lipid deficiency, either on the surface with a decrease in sebaceous se... more Black hair suffers from a lipid deficiency, either on the surface with a decrease in sebaceous secretion or in depth with a lack of covalent bonds between the lipids and the cuticular cells. The result is a porous cuticle, a dull, rough hair that is difficult to untangle and breaks easily. The aim of this study was to evaluate properties of oils extracted from Cocos nucifera and Elaeis guineensis intended for the formulation of shampoos for black hair. Physicochemical and rheological analyses were carried out. Both oils showed a refractive index of 1.45 and melting points of 28 °C and 30 °C for coconut oil and palm kernel oil, respectively. The relative densities, moisture contents, saponification indexes, peroxide values, unsaponifiable matter contents, para-anisidine values were relatively similar while iodine and acid values were different. Both oils are rich in lauric, oleic and linoleic acids. These oils exhibited a Newtonian behavior and a dominant elastic nature after their m...

Molecules, 2021

The chemical variability and the in vitro anti-inflammatory activity of the leaf essential oil fr... more The chemical variability and the in vitro anti-inflammatory activity of the leaf essential oil from Ivorian Isolona dewevrei were investigated for the first time. Forty-seven oil samples were analyzed using a combination of CC, GC(RI), GC-MS and 13C-NMR, thus leading to the identification of 113 constituents (90.8–98.9%). As the main components varied drastically from sample to sample, the 47 oil compositions were submitted to hierarchical cluster and principal components analyses. Three distinct groups, each divided into two subgroups, were evidenced. Subgroup I−A was dominated by (Z)-β-ocimene, β-eudesmol, germacrene D and (E)-β-ocimene, while (10βH)-1β,8β-oxido-cadina-4-ene, santalenone, trans-α-bergamotene and trans-β-bergamotene were the main compounds of Subgroup I−B. The prevalent constituents of Subgroup II−A were germacrene B, (E)-β-caryophyllene, (5αH,10βMe)-6,12-oxido-elema-1,3,6,11(12)-tetraene and γ-elemene. Subgroup II−B displayed germacrene B, germacrene D and (Z)-β-o...

Chemical Science International Journal

This theoretical study of chemical reactivity was conducted using the method of the Density Funct... more This theoretical study of chemical reactivity was conducted using the method of the Density Functional Theory (DFT), with B3LYP/6-311G (d, p) as calculation level. A series of five (05) Schiff bases derived from 4.4 '-diaminodiphenylsulfone (Dapsone) was concerned and allowed to predict the chemical reactivity of these compounds. Molecular geometries and electronic properties such as the energies of the frontier molecular orbitals (HOMO and LUMO), ionization potential (I), and

GSC Biological and Pharmaceutical Sciences

Our work was based on the study of aqueous and hydroethanol extracts from the leaves of Amaranthu... more Our work was based on the study of aqueous and hydroethanol extracts from the leaves of Amaranthus hybridus L. (Amaranthaceae), Corchorus olitorius L. (Tiliaceae) and Hibiscus sabdariffa L. (Malvaceae), and decoction. This work presents for the first time the phytochemical screening and the antioxidant activity of extracts of leaves of these three plants coming from the Côte d’Ivoire. Phytochemical analysis of these extracts revealed the presence of polyphenols and alkaloids in the three leaves. The total phenolic content of the extracts showed variations, between 13.22 and 90.89 mg GAE/g. The hydroethanol extract (90.89 mg GAE/g) and decoction of C. olitorius (57.89 mg GAE/g) had the most elevated contents. The evaluation of the reducing power with DPPH method revealed that the hydroethanol extract of C. olitorius was the most active (IC50 = 45.58 µg/mL). This result was in agreement with that obtained by FRAP method.

Journal of Materials Physics and Chemistry

International Journal of Research -GRANTHAALAYAH

The objective of this study is to search families of chemical compounds and to evaluate subacute ... more The objective of this study is to search families of chemical compounds and to evaluate subacute toxicity of decoction of Landolphia owariensis liana bark on wistar rat. To identify the family compound chemical staining reactions and / or precipitation was used. Subacute toxicity study was conducted using OECD method 404. 15 rats of both sexes were divided into five groups. They were received for each lot, distilled water (control), 50, 300, 2000 and 5000 mg/kg body weight of decoction every 24 hours orally for 28 days (OECD 404). Body weights, hematological, biochemical and histological parameters of the liver and kidneys were analyzed. The results of phytochemical screening showed that the decoction of L. owariensis contains sterols, polyterpenes, polyphenols and flavonoids. It is rich in chemical substances with antioxidant properties (polyphenols and flavonoids). For toxicity assessment, no significant changes in body weight between control and treated groups and no physiologica...

SDRP Journal of Computational Chemistry & Molecular Modelling

Journal of Essential Oil Bearing Plants

IRA-International Journal of Applied Sciences (ISSN 2455-4499)

This QSAR study, which involved a series of Azetidinones derived from…