D. Flores | Universidad Nacional de La Plata (original) (raw)

Papers by D. Flores

Epidemiology and Infection, 2013

We describe nine patients (eight aged &am... more We describe nine patients (eight aged <1 year) clinically diagnosed with pertussis yet laboratory-confirmed with Bordetella holmesii infections, a human pathogen normally isolated from blood. Most patients reported cough and cold symptoms. No death was reported. We report B. holmesii isolation in infants with respiratory symptoms in Argentina.

Computers & Chemical Engineering, 2008

Kinematic models for the settling of polydisperse solidliquid suspensions are based on the assump... more Kinematic models for the settling of polydisperse solidliquid suspensions are based on the assumption that the solid-fluid relative velocity for each solids species is an explicit function of the local solids concentrations. One such model, the Masliyah-Lockett-Bassoon (MLB) model, is employed herein to simulate continuous separation and classification of polydisperse suspensions. To this end, the well-established clarifier-thickener (CT) model for the continuous solid-liquid separation of suspensions is extended to a generalized clarifier-thickener (GCT). The new feature is that an arbitrary number of discharge streams (or products) is described by singular sink terms. The governing equation resulting from combining the GCT setup with the MLB hindered settling model is a strongly coupled system of nonlinear conservation laws that has a discontinuous flux and a new non-conservative transport term describing the singular sinks. A numerical algorithm for the solution of this equation is presented along with numerical examples. The model provides a complete description of the GCT unit including all critical design parameters, and predicts the composition of the overflow, underflow and discharge streams and the spatio-temporal evolution of the solids species concentrations inside the unit.

Epidemiology and Infection, 2013

We describe nine patients (eight aged <1 year) clinically diagnosed with pertussis yet laboratory... more We describe nine patients (eight aged <1 year) clinically diagnosed with pertussis yet laboratoryconfirmed with Bordetella holmesii infections, a human pathogen normally isolated from blood. Most patients reported cough and cold symptoms. No death was reported. We report B. holmesii isolation in infants with respiratory symptoms in Argentina.

Journal of Infection, 2009

Objectives: Pertussis continues causing significant morbidity and mortality worldwide. Although i... more Objectives: Pertussis continues causing significant morbidity and mortality worldwide. Although its epidemiology has been studied in many developed countries, the current pertussis situation in South America is scarcely known. This review summarizes the most important recent data concerning pertussis in a country of South America, Argentina. Methods: CDC criteria were used for pertussis diagnosis. Proportion of pertussis cases by age, immunization status, and immunization coverage rate evaluated at the Argentinean National Pertussis Reference Centers was reported. Bordetella pertussis isolates were characterized and compared with vaccine strains. Results: From 2002 to nowadays, a steady increase of pertussis cases was observed. Most of these cases correspond to patients younger than six months old that received less than three doses of vaccine. However, cases in adolescent and adults have also been detected. For this situation, which is not peculiar to Argentina, several explanations have been proposed. Among them, the inability of current vaccines to induce long-lasting immunity is the most widely accepted as a cause of pertussis resurgence. Furthermore, antigenic divergence between local clinical isolates and vaccine strains may have aggravated the effect of waning immunity.

Epidemiology and Infection, 2013

We describe nine patients (eight aged &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;am... more We describe nine patients (eight aged &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;1 year) clinically diagnosed with pertussis yet laboratory-confirmed with Bordetella holmesii infections, a human pathogen normally isolated from blood. Most patients reported cough and cold symptoms. No death was reported. We report B. holmesii isolation in infants with respiratory symptoms in Argentina.

Computers & Chemical Engineering, 2008

Kinematic models for the settling of polydisperse solidliquid suspensions are based on the assump... more Kinematic models for the settling of polydisperse solidliquid suspensions are based on the assumption that the solid-fluid relative velocity for each solids species is an explicit function of the local solids concentrations. One such model, the Masliyah-Lockett-Bassoon (MLB) model, is employed herein to simulate continuous separation and classification of polydisperse suspensions. To this end, the well-established clarifier-thickener (CT) model for the continuous solid-liquid separation of suspensions is extended to a generalized clarifier-thickener (GCT). The new feature is that an arbitrary number of discharge streams (or products) is described by singular sink terms. The governing equation resulting from combining the GCT setup with the MLB hindered settling model is a strongly coupled system of nonlinear conservation laws that has a discontinuous flux and a new non-conservative transport term describing the singular sinks. A numerical algorithm for the solution of this equation is presented along with numerical examples. The model provides a complete description of the GCT unit including all critical design parameters, and predicts the composition of the overflow, underflow and discharge streams and the spatio-temporal evolution of the solids species concentrations inside the unit.

Epidemiology and Infection, 2013

We describe nine patients (eight aged <1 year) clinically diagnosed with pertussis yet laboratory... more We describe nine patients (eight aged <1 year) clinically diagnosed with pertussis yet laboratoryconfirmed with Bordetella holmesii infections, a human pathogen normally isolated from blood. Most patients reported cough and cold symptoms. No death was reported. We report B. holmesii isolation in infants with respiratory symptoms in Argentina.

Journal of Infection, 2009

Objectives: Pertussis continues causing significant morbidity and mortality worldwide. Although i... more Objectives: Pertussis continues causing significant morbidity and mortality worldwide. Although its epidemiology has been studied in many developed countries, the current pertussis situation in South America is scarcely known. This review summarizes the most important recent data concerning pertussis in a country of South America, Argentina. Methods: CDC criteria were used for pertussis diagnosis. Proportion of pertussis cases by age, immunization status, and immunization coverage rate evaluated at the Argentinean National Pertussis Reference Centers was reported. Bordetella pertussis isolates were characterized and compared with vaccine strains. Results: From 2002 to nowadays, a steady increase of pertussis cases was observed. Most of these cases correspond to patients younger than six months old that received less than three doses of vaccine. However, cases in adolescent and adults have also been detected. For this situation, which is not peculiar to Argentina, several explanations have been proposed. Among them, the inability of current vaccines to induce long-lasting immunity is the most widely accepted as a cause of pertussis resurgence. Furthermore, antigenic divergence between local clinical isolates and vaccine strains may have aggravated the effect of waning immunity.