Alejandro Alfaro | Universidad Nacional Mayor de San Marcos (original) (raw)
Papers by Alejandro Alfaro
Socioeconomic disparities and the genomic landscape of gastric cancer, 2024
The genomic characteristics of Peruvian patients with gastric adenocarcinoma from diverse socioec... more The genomic characteristics of Peruvian patients with gastric adenocarcinoma from diverse socioeconomic backgrounds were examined in consideration of the possibility that patients from different socioeconomic backgrounds may be exposed to different risk factors. We conducted a prospective pilot study in two Peruvian cities (Lima and Ica). This study enrolled 15 patients from low socioeconomic status (LSES) and 15 patients from medium/high socioeconomic status (MHSES). The genomic profiling of gastric adenocarcinoma samples was done through the FoundationOne CDx platform. We compared the genomic characteristics and the need for targeted therapy and immunotherapy between LSES and MHSES. The genes with higher rates of alterations were TP53 (73.3% vs. 50.0%, P = 0.2635); CDH1 (26.7% vs. 28.6%, P = 1); CDKN2A (20.0% vs. 28.6%, P = 1); KRAS (33.3% vs. 7.1%, P = 0.1686); ARID1A (20.0% vs. 14.3%, P = 1); MLL2 (13.3% vs. 21.4%, P = 1) and SOX9 (33.3% vs. 0.0%, P = 0.0421) in LSES versus HMSES, respectively. There was no significant difference in tumor mutational burden (P = 0.377) or microsatellite status (P = 1). The LSES group had a higher need for targeted therapy or immunotherapy according to gene involvement and alterations. A significant genomic difference exists among patients with gastric adenocarcinoma of different socioeconomic status, which may result in a different need for targeted therapy and immunotherapy.
European Journal of Hospital Pharmacy: Science and Practice, 2013
Results 8 MW patients were included, their average age was 72 years old (rank: 51-82), of which 5... more Results 8 MW patients were included, their average age was 72 years old (rank: 51-82), of which 50% were male. The symptoms with which patients presented before commencing treatment included: asthenia (100%), anorexia, peripheral neuropathy (37.5%), anaemia (25%), hyperviscosity syndrome (62.5%); 40% of patients required a session of plasmapheresis. Various treatment regimens were used: Two of the patients commenced treatment with fludarabine, one started with cladribine and two with chlorambucil. Patients with fludarabine had a good response and in the other three cases the response was quite low; as a result, treatment was changed to weekly rituximab until the symptoms stopped and the IgM decreased. Three of the patients started treatment with weekly rituximab with a good response in two of the cases and one had a low response so the treatment was changed to rituximab with cladribine. All patients except one who is currently receiving rituximab and cladribine have had relapses after the first treatment. They were treated with weekly rituximab until the symptoms stopped, except in two of the cases, who currently continue with maintenance rituximab every two and three months respectively. As regards tolerance and adverse reactions, neutropenia appeared in just one patient treated with chlorambucil, the treatments were well tolerated by the remaining patients. Conclusions Various drugs are used for the treatment of MW: chlorambucil, fludarabine, cladribine and rituximab, alone or in combination. The treatment regimen the most commonly used, especially if weekly rituximab, especially for those patients that have had relapses with other treatments. Weekly rituximab is a treatment with a good response rate and is well tolerated. No conflict of interest. Use of BotUlinUm toxin type A in polAnd: systemAtic Review And QUestionnAiRe sURvey
Revista Peruana de Medicina Experimental y Salud Pública, 2006
ThereisapaucityofHIVautopsydatafromSouthAmericaandnonethatdocumentthepostmortemfindingsinpatients... more ThereisapaucityofHIVautopsydatafromSouthAmericaandnonethatdocumentthepostmortemfindingsinpatients� with HIV/AIDS in Peru. Objectives: The purpose of this autopsy study was to determine the spectrum of opportunistic infections and the causes of mortality in HIV-positive patients at a public hospital in Lima. Material and methods: Clinico-epidemiological information regarding HIV infection in Peru is also reviewed. Sixteen HIV-related hospital post- mortems, performed between 1999-2004, were included in this retrospective analysis. Results: The primary cause of death was established in 12 patients: one died of neoplasia and 11 of infectious diseases, including 3 from pulmonary infection, 7 from disseminated infection, and 2 from central nervous system infection (one case had dual pathology). Opportunisticinfectionswereidentifiedin�14�cases,�comprisingcytomegalovirus,�histoplasmosis,�cryptococcosis,�toxo- plasmosis, Pneumocystis pneumonia, aspergillosis, tuberculosis, varicella zoster ...
Dermatol. peru, 2006
La queratosis actínica es una lesión premaligna cuyo riesgo de degeneración neoplásica se calcula... more La queratosis actínica es una lesión premaligna cuyo riesgo de degeneración neoplásica se calcula en 10 a 20%, algunos autores han señalado que la presencia de un fondo inflamatorio facilitaría la progresión a cáncer y por lo tanto la alteraciones de genes involucrados en ...
https://www.dermatologiaperuana.pe/assets/uploads/revista\_qYa0\_v29\_n1.pdf#page=42, 2019
La esporotricosis es una micosis subcutánea causada por microrganismos dimorfos del genero Sporot... more La esporotricosis es una micosis subcutánea causada por microrganismos dimorfos del genero Sporothrix. Se presenta el caso
de una paciente mujer de 20 años, que presenta una placa eritematosa con múltiples ulceras en sacabocado en la espalda,
además se describen los hallazgos en los exámenes realizados que permitieron llegar al diagnóstico e instaurar el tratamiento
apropiado.
Critical Reviews in Oncology/Hematology
Anales de la Facultad de Medicina, 2013
Se presenta el caso clínico de un paciente varón de 58 años, natural de Junín, que ingresó por Em... more Se presenta el caso clínico de un paciente varón de 58 años, natural de Junín, que ingresó por Emergencia, referido de un hospital provincial por un cuadro de obstrucción intestinal, con un tiempo de enfermedad de 7 días, caracterizado por dolor abdominal tipo cólico difuso, náuseas y vómitos y distensión abdominal. Por dos meses presentaba dolor abdominal intermitente intenso, 3 a 4 episodios por mes, que cedía en forma espontánea, pero progresivamente aumentó su frecuencia y se asoció con ingesta de alimentos, disminuyó el apetito y perdió peso aproximadamente 6 a 7 kilos; no presentaba antecedentes patológicos ni quirúrgicos de importancia. Durante su hospitalización en nuestro nosocomio se obtuvo una tomografía (TAC) abdominal que mostró la presencia de dos tumoraciones, una en colon ascendente y otra en región retroperitoneal, que fueron extraídas en cirugía electiva. El resultado de la anatomía patológica fue adenocarcinoma bien diferenciado de colon y liposarcoma dediferencia...
Anales De La Facultad De Medicina, Apr 1, 2013
Folia Dermatol Peru, Dec 1, 2000
Pathology - Research and Practice, 2006
There is a paucity of HIV autopsy data from South America and none that document the postmortem f... more There is a paucity of HIV autopsy data from South America and none that document the postmortem findings in patients with HIV/AIDS in Peru. The purpose of this autopsy study was to determine the spectrum of opportunistic infections and the causes of mortality in HIV-positive patients at a public hospital in Lima. Clinico-epidemiological information regarding HIV infection in Peru is also reviewed. Sixteen HIV-related hospital postmortems, performed between 1999 and 2004, were included in this retrospective analysis. The primary cause of death was established in 12 patients: one died of neoplasia and 11 of infectious diseases, including 3 from pulmonary infection, 7 from disseminated infection, and 2 from central nervous system infection (one case had dual pathology). Opportunistic infections were identified in 14 cases, comprising cytomegalovirus, histoplasmosis, cryptococcosis, toxoplasmosis, Pneumocystis pneumonia, aspergillosis, tuberculosis, varicella zoster virus, and cryptosporidiosis. Fourteen patients had at least one AIDS-related disease that had been neither clinically suspected nor diagnosed premortem. Moreover, 82% of the diagnoses considered to be of important clinical significance had not been suspected antemortem. The spectrum and frequency of certain opportunistic infections differed from other South American autopsy studies, highlighting the importance of performing HIV/AIDS postmortems in resource-limited countries where locally specific disease patterns may be observed.
Rev Peru Med Exp …, 2006
Existen pocos estudios que reporten datos acerca de autopsias de pacientes con VIH en Sudamérica ... more Existen pocos estudios que reporten datos acerca de autopsias de pacientes con VIH en Sudamérica y ninguno que documente los resultados post mórtem en los pacientes con VIH/SIDA en el Perú. Objetivos: Determinar el espectro de las infecciones oportunistas y las causas de mortalidad en pacientes VIH-positivos en un hospital público en Lima. Asimismo, se revisa la información clínico-epidemiológica con respecto a la infección con VIH en el Perú. Materiales y métodos: Se incluyeron en este análisis retrospectivo, 16 autopsias relacionadas con VIH del Hospital Dos de Mayo, realizadas entre 1999-2004. Resultados: La causa primaria de la muerte fue establecida en 12 pacientes: uno murió de neoplasia y 11 de enfermedades infecciosas, incluyendo tres con infección pulmonar, siete con infección diseminada, y dos con infección del sistema nervioso central (un caso presentó patología dual). Las infecciones oportunistas fueron identificadas en 14 casos, incluyendo citomegalovirus, histoplasmosis, criptococcosis, toxoplasmosis, neumonía por Pneumocistis, aspergilosis, tuberculosis, virus de la varicela-zoster y criptosporidiosis. Catorce pacientes tenían por lo menos una enfermedad relacionada con el SIDA que no había sido sospechada clínicamente ni diagnosticada antes de la muerte. Por otra parte, 82% de los diagnósticos considerados de significancia clínica importante, no habían sido sospechados antes de la muerte. Conclusiones: El espectro y la frecuencia de ciertas infecciones oportunistas reportadas en el presente estudio lo diferencia de otros estudios de autopsias realizados en Sudamérica; destacando la importancia de realizar necropsias en VIH/SIDA en países de recursos limitados, con el fin de observar los patrones locales específicos de la enfermedad.
Anales De La Facultad De Medicina, Apr 1, 2013
Resumen Se presenta el caso clínico de un paciente varón de 58 años, natural de Junín, que ingres... more Resumen Se presenta el caso clínico de un paciente varón de 58 años, natural de Junín, que ingresó por Emergencia, referido de un hospital provincial por un cuadro de obstrucción intestinal, con un tiempo de enfermedad de 7 días, caracterizado por dolor abdominal tipo cólico difuso, náuseas y vómitos y distensión abdominal. Por dos meses presentaba dolor abdominal intermitente intenso, 3 a 4 episodios por mes, que cedía en forma espontánea, pero progresivamente aumentó su frecuencia y se asoció con ingesta de alimentos, disminuyó el apetito y perdió peso aproximadamente 6 a 7 kilos; no presentaba antecedentes patológicos ni quirúrgicos de importancia. Durante su hospitalización en nuestro nosocomio se obtuvo una tomografía (TAC) abdominal que mostró la presencia de dos tumoraciones, una en colon ascendente y otra en región retroperitoneal, que fueron extraídas en cirugía electiva. El resultado de la anatomía patológica fue adenocarcinoma bien diferenciado de colon y liposarcoma dediferenciado del tumor retroperitoneal; ambos presentaron bordes quirúrgicos libres de neoplasia. La coincidencia de ambas patologías no ha sido descrita en la literatura médica. Palabras clave: Cáncer de colon, liposarcoma de colon, obstrucción intestinal. Abstract This is a case report of a 58 year-old male born in Junin. Patient was referred to the emergency room from a rural hospital and was admitted with the diagnosis of intestinal obstruction. He had colicky type diffuse abdominal pain, abdominal distention, nausea and vomiting for 7 days. He had presented abdominal pain off and on for the past 2 months. Pain was severe at least 3 to 4 times a week, improved spontaneously but returned with increased frequency, exacerbated by food ingestion, and associated with decreased appetite and 6 to 7 kg weight loss. Patient did not have any significant past medical or surgical history. During hospitalization abdominal CT showed two tumors, one in the ascending colon and the other in the retroperitoneal region. These were surgically removed. Pathology result reported well differentiated colon adenocarcinoma and dedifferentiated liposarcoma, both with surgical borders clean of neoplasia. Simultaneous finding of these tumors has not been described in the medical literature.
Anales De La Facultad De Medicina, Apr 1, 2013
Resumen Se presenta el caso clínico de un paciente varón de 58 años, natural de Junín, que ingres... more Resumen Se presenta el caso clínico de un paciente varón de 58 años, natural de Junín, que ingresó por Emergencia, referido de un hospital provincial por un cuadro de obstrucción intestinal, con un tiempo de enfermedad de 7 días, caracterizado por dolor abdominal tipo cólico difuso, náuseas y vómitos y distensión abdominal. Por dos meses presentaba dolor abdominal intermitente intenso, 3 a 4 episodios por mes, que cedía en forma espontánea, pero progresivamente aumentó su frecuencia y se asoció con ingesta de alimentos, disminuyó el apetito y perdió peso aproximadamente 6 a 7 kilos; no presentaba antecedentes patológicos ni quirúrgicos de importancia. Durante su hospitalización en nuestro nosocomio se obtuvo una tomografía (TAC) abdominal que mostró la presencia de dos tumoraciones, una en colon ascendente y otra en región retroperitoneal, que fueron extraídas en cirugía electiva. El resultado de la anatomía patológica fue adenocarcinoma bien diferenciado de colon y liposarcoma dediferenciado del tumor retroperitoneal; ambos presentaron bordes quirúrgicos libres de neoplasia. La coincidencia de ambas patologías no ha sido descrita en la literatura médica. Palabras clave: Cáncer de colon, liposarcoma de colon, obstrucción intestinal. Abstract This is a case report of a 58 year-old male born in Junin. Patient was referred to the emergency room from a rural hospital and was admitted with the diagnosis of intestinal obstruction. He had colicky type diffuse abdominal pain, abdominal distention, nausea and vomiting for 7 days. He had presented abdominal pain off and on for the past 2 months. Pain was severe at least 3 to 4 times a week, improved spontaneously but returned with increased frequency, exacerbated by food ingestion, and associated with decreased appetite and 6 to 7 kg weight loss. Patient did not have any significant past medical or surgical history. During hospitalization abdominal CT showed two tumors, one in the ascending colon and the other in the retroperitoneal region. These were surgically removed. Pathology result reported well differentiated colon adenocarcinoma and dedifferentiated liposarcoma, both with surgical borders clean of neoplasia. Simultaneous finding of these tumors has not been described in the medical literature.
Reporte de Caso: TIROIDITIS DE HASHIMOTO ASOCIADA A TIROIDITIS SUBAGUDA, 2016
We report the case of a 52-year-old who female, who presented a cervical mass thyroid-dependent, ... more We report the case of a 52-year-old who female, who presented a cervical mass thyroid-dependent, whose pathological anatomic study demonstrated Hashimoto's thyroiditis with a subacute inflammatory component.
The finding of these two entities are not described in Anglo-American literature being the first case to be reported.
Socioeconomic disparities and the genomic landscape of gastric cancer, 2024
The genomic characteristics of Peruvian patients with gastric adenocarcinoma from diverse socioec... more The genomic characteristics of Peruvian patients with gastric adenocarcinoma from diverse socioeconomic backgrounds were examined in consideration of the possibility that patients from different socioeconomic backgrounds may be exposed to different risk factors. We conducted a prospective pilot study in two Peruvian cities (Lima and Ica). This study enrolled 15 patients from low socioeconomic status (LSES) and 15 patients from medium/high socioeconomic status (MHSES). The genomic profiling of gastric adenocarcinoma samples was done through the FoundationOne CDx platform. We compared the genomic characteristics and the need for targeted therapy and immunotherapy between LSES and MHSES. The genes with higher rates of alterations were TP53 (73.3% vs. 50.0%, P = 0.2635); CDH1 (26.7% vs. 28.6%, P = 1); CDKN2A (20.0% vs. 28.6%, P = 1); KRAS (33.3% vs. 7.1%, P = 0.1686); ARID1A (20.0% vs. 14.3%, P = 1); MLL2 (13.3% vs. 21.4%, P = 1) and SOX9 (33.3% vs. 0.0%, P = 0.0421) in LSES versus HMSES, respectively. There was no significant difference in tumor mutational burden (P = 0.377) or microsatellite status (P = 1). The LSES group had a higher need for targeted therapy or immunotherapy according to gene involvement and alterations. A significant genomic difference exists among patients with gastric adenocarcinoma of different socioeconomic status, which may result in a different need for targeted therapy and immunotherapy.
European Journal of Hospital Pharmacy: Science and Practice, 2013
Results 8 MW patients were included, their average age was 72 years old (rank: 51-82), of which 5... more Results 8 MW patients were included, their average age was 72 years old (rank: 51-82), of which 50% were male. The symptoms with which patients presented before commencing treatment included: asthenia (100%), anorexia, peripheral neuropathy (37.5%), anaemia (25%), hyperviscosity syndrome (62.5%); 40% of patients required a session of plasmapheresis. Various treatment regimens were used: Two of the patients commenced treatment with fludarabine, one started with cladribine and two with chlorambucil. Patients with fludarabine had a good response and in the other three cases the response was quite low; as a result, treatment was changed to weekly rituximab until the symptoms stopped and the IgM decreased. Three of the patients started treatment with weekly rituximab with a good response in two of the cases and one had a low response so the treatment was changed to rituximab with cladribine. All patients except one who is currently receiving rituximab and cladribine have had relapses after the first treatment. They were treated with weekly rituximab until the symptoms stopped, except in two of the cases, who currently continue with maintenance rituximab every two and three months respectively. As regards tolerance and adverse reactions, neutropenia appeared in just one patient treated with chlorambucil, the treatments were well tolerated by the remaining patients. Conclusions Various drugs are used for the treatment of MW: chlorambucil, fludarabine, cladribine and rituximab, alone or in combination. The treatment regimen the most commonly used, especially if weekly rituximab, especially for those patients that have had relapses with other treatments. Weekly rituximab is a treatment with a good response rate and is well tolerated. No conflict of interest. Use of BotUlinUm toxin type A in polAnd: systemAtic Review And QUestionnAiRe sURvey
Revista Peruana de Medicina Experimental y Salud Pública, 2006
ThereisapaucityofHIVautopsydatafromSouthAmericaandnonethatdocumentthepostmortemfindingsinpatients... more ThereisapaucityofHIVautopsydatafromSouthAmericaandnonethatdocumentthepostmortemfindingsinpatients� with HIV/AIDS in Peru. Objectives: The purpose of this autopsy study was to determine the spectrum of opportunistic infections and the causes of mortality in HIV-positive patients at a public hospital in Lima. Material and methods: Clinico-epidemiological information regarding HIV infection in Peru is also reviewed. Sixteen HIV-related hospital post- mortems, performed between 1999-2004, were included in this retrospective analysis. Results: The primary cause of death was established in 12 patients: one died of neoplasia and 11 of infectious diseases, including 3 from pulmonary infection, 7 from disseminated infection, and 2 from central nervous system infection (one case had dual pathology). Opportunisticinfectionswereidentifiedin�14�cases,�comprisingcytomegalovirus,�histoplasmosis,�cryptococcosis,�toxo- plasmosis, Pneumocystis pneumonia, aspergillosis, tuberculosis, varicella zoster ...
Dermatol. peru, 2006
La queratosis actínica es una lesión premaligna cuyo riesgo de degeneración neoplásica se calcula... more La queratosis actínica es una lesión premaligna cuyo riesgo de degeneración neoplásica se calcula en 10 a 20%, algunos autores han señalado que la presencia de un fondo inflamatorio facilitaría la progresión a cáncer y por lo tanto la alteraciones de genes involucrados en ...
https://www.dermatologiaperuana.pe/assets/uploads/revista\_qYa0\_v29\_n1.pdf#page=42, 2019
La esporotricosis es una micosis subcutánea causada por microrganismos dimorfos del genero Sporot... more La esporotricosis es una micosis subcutánea causada por microrganismos dimorfos del genero Sporothrix. Se presenta el caso
de una paciente mujer de 20 años, que presenta una placa eritematosa con múltiples ulceras en sacabocado en la espalda,
además se describen los hallazgos en los exámenes realizados que permitieron llegar al diagnóstico e instaurar el tratamiento
apropiado.
Critical Reviews in Oncology/Hematology
Anales de la Facultad de Medicina, 2013
Se presenta el caso clínico de un paciente varón de 58 años, natural de Junín, que ingresó por Em... more Se presenta el caso clínico de un paciente varón de 58 años, natural de Junín, que ingresó por Emergencia, referido de un hospital provincial por un cuadro de obstrucción intestinal, con un tiempo de enfermedad de 7 días, caracterizado por dolor abdominal tipo cólico difuso, náuseas y vómitos y distensión abdominal. Por dos meses presentaba dolor abdominal intermitente intenso, 3 a 4 episodios por mes, que cedía en forma espontánea, pero progresivamente aumentó su frecuencia y se asoció con ingesta de alimentos, disminuyó el apetito y perdió peso aproximadamente 6 a 7 kilos; no presentaba antecedentes patológicos ni quirúrgicos de importancia. Durante su hospitalización en nuestro nosocomio se obtuvo una tomografía (TAC) abdominal que mostró la presencia de dos tumoraciones, una en colon ascendente y otra en región retroperitoneal, que fueron extraídas en cirugía electiva. El resultado de la anatomía patológica fue adenocarcinoma bien diferenciado de colon y liposarcoma dediferencia...
Anales De La Facultad De Medicina, Apr 1, 2013
Folia Dermatol Peru, Dec 1, 2000
Pathology - Research and Practice, 2006
There is a paucity of HIV autopsy data from South America and none that document the postmortem f... more There is a paucity of HIV autopsy data from South America and none that document the postmortem findings in patients with HIV/AIDS in Peru. The purpose of this autopsy study was to determine the spectrum of opportunistic infections and the causes of mortality in HIV-positive patients at a public hospital in Lima. Clinico-epidemiological information regarding HIV infection in Peru is also reviewed. Sixteen HIV-related hospital postmortems, performed between 1999 and 2004, were included in this retrospective analysis. The primary cause of death was established in 12 patients: one died of neoplasia and 11 of infectious diseases, including 3 from pulmonary infection, 7 from disseminated infection, and 2 from central nervous system infection (one case had dual pathology). Opportunistic infections were identified in 14 cases, comprising cytomegalovirus, histoplasmosis, cryptococcosis, toxoplasmosis, Pneumocystis pneumonia, aspergillosis, tuberculosis, varicella zoster virus, and cryptosporidiosis. Fourteen patients had at least one AIDS-related disease that had been neither clinically suspected nor diagnosed premortem. Moreover, 82% of the diagnoses considered to be of important clinical significance had not been suspected antemortem. The spectrum and frequency of certain opportunistic infections differed from other South American autopsy studies, highlighting the importance of performing HIV/AIDS postmortems in resource-limited countries where locally specific disease patterns may be observed.
Rev Peru Med Exp …, 2006
Existen pocos estudios que reporten datos acerca de autopsias de pacientes con VIH en Sudamérica ... more Existen pocos estudios que reporten datos acerca de autopsias de pacientes con VIH en Sudamérica y ninguno que documente los resultados post mórtem en los pacientes con VIH/SIDA en el Perú. Objetivos: Determinar el espectro de las infecciones oportunistas y las causas de mortalidad en pacientes VIH-positivos en un hospital público en Lima. Asimismo, se revisa la información clínico-epidemiológica con respecto a la infección con VIH en el Perú. Materiales y métodos: Se incluyeron en este análisis retrospectivo, 16 autopsias relacionadas con VIH del Hospital Dos de Mayo, realizadas entre 1999-2004. Resultados: La causa primaria de la muerte fue establecida en 12 pacientes: uno murió de neoplasia y 11 de enfermedades infecciosas, incluyendo tres con infección pulmonar, siete con infección diseminada, y dos con infección del sistema nervioso central (un caso presentó patología dual). Las infecciones oportunistas fueron identificadas en 14 casos, incluyendo citomegalovirus, histoplasmosis, criptococcosis, toxoplasmosis, neumonía por Pneumocistis, aspergilosis, tuberculosis, virus de la varicela-zoster y criptosporidiosis. Catorce pacientes tenían por lo menos una enfermedad relacionada con el SIDA que no había sido sospechada clínicamente ni diagnosticada antes de la muerte. Por otra parte, 82% de los diagnósticos considerados de significancia clínica importante, no habían sido sospechados antes de la muerte. Conclusiones: El espectro y la frecuencia de ciertas infecciones oportunistas reportadas en el presente estudio lo diferencia de otros estudios de autopsias realizados en Sudamérica; destacando la importancia de realizar necropsias en VIH/SIDA en países de recursos limitados, con el fin de observar los patrones locales específicos de la enfermedad.
Anales De La Facultad De Medicina, Apr 1, 2013
Resumen Se presenta el caso clínico de un paciente varón de 58 años, natural de Junín, que ingres... more Resumen Se presenta el caso clínico de un paciente varón de 58 años, natural de Junín, que ingresó por Emergencia, referido de un hospital provincial por un cuadro de obstrucción intestinal, con un tiempo de enfermedad de 7 días, caracterizado por dolor abdominal tipo cólico difuso, náuseas y vómitos y distensión abdominal. Por dos meses presentaba dolor abdominal intermitente intenso, 3 a 4 episodios por mes, que cedía en forma espontánea, pero progresivamente aumentó su frecuencia y se asoció con ingesta de alimentos, disminuyó el apetito y perdió peso aproximadamente 6 a 7 kilos; no presentaba antecedentes patológicos ni quirúrgicos de importancia. Durante su hospitalización en nuestro nosocomio se obtuvo una tomografía (TAC) abdominal que mostró la presencia de dos tumoraciones, una en colon ascendente y otra en región retroperitoneal, que fueron extraídas en cirugía electiva. El resultado de la anatomía patológica fue adenocarcinoma bien diferenciado de colon y liposarcoma dediferenciado del tumor retroperitoneal; ambos presentaron bordes quirúrgicos libres de neoplasia. La coincidencia de ambas patologías no ha sido descrita en la literatura médica. Palabras clave: Cáncer de colon, liposarcoma de colon, obstrucción intestinal. Abstract This is a case report of a 58 year-old male born in Junin. Patient was referred to the emergency room from a rural hospital and was admitted with the diagnosis of intestinal obstruction. He had colicky type diffuse abdominal pain, abdominal distention, nausea and vomiting for 7 days. He had presented abdominal pain off and on for the past 2 months. Pain was severe at least 3 to 4 times a week, improved spontaneously but returned with increased frequency, exacerbated by food ingestion, and associated with decreased appetite and 6 to 7 kg weight loss. Patient did not have any significant past medical or surgical history. During hospitalization abdominal CT showed two tumors, one in the ascending colon and the other in the retroperitoneal region. These were surgically removed. Pathology result reported well differentiated colon adenocarcinoma and dedifferentiated liposarcoma, both with surgical borders clean of neoplasia. Simultaneous finding of these tumors has not been described in the medical literature.
Anales De La Facultad De Medicina, Apr 1, 2013
Resumen Se presenta el caso clínico de un paciente varón de 58 años, natural de Junín, que ingres... more Resumen Se presenta el caso clínico de un paciente varón de 58 años, natural de Junín, que ingresó por Emergencia, referido de un hospital provincial por un cuadro de obstrucción intestinal, con un tiempo de enfermedad de 7 días, caracterizado por dolor abdominal tipo cólico difuso, náuseas y vómitos y distensión abdominal. Por dos meses presentaba dolor abdominal intermitente intenso, 3 a 4 episodios por mes, que cedía en forma espontánea, pero progresivamente aumentó su frecuencia y se asoció con ingesta de alimentos, disminuyó el apetito y perdió peso aproximadamente 6 a 7 kilos; no presentaba antecedentes patológicos ni quirúrgicos de importancia. Durante su hospitalización en nuestro nosocomio se obtuvo una tomografía (TAC) abdominal que mostró la presencia de dos tumoraciones, una en colon ascendente y otra en región retroperitoneal, que fueron extraídas en cirugía electiva. El resultado de la anatomía patológica fue adenocarcinoma bien diferenciado de colon y liposarcoma dediferenciado del tumor retroperitoneal; ambos presentaron bordes quirúrgicos libres de neoplasia. La coincidencia de ambas patologías no ha sido descrita en la literatura médica. Palabras clave: Cáncer de colon, liposarcoma de colon, obstrucción intestinal. Abstract This is a case report of a 58 year-old male born in Junin. Patient was referred to the emergency room from a rural hospital and was admitted with the diagnosis of intestinal obstruction. He had colicky type diffuse abdominal pain, abdominal distention, nausea and vomiting for 7 days. He had presented abdominal pain off and on for the past 2 months. Pain was severe at least 3 to 4 times a week, improved spontaneously but returned with increased frequency, exacerbated by food ingestion, and associated with decreased appetite and 6 to 7 kg weight loss. Patient did not have any significant past medical or surgical history. During hospitalization abdominal CT showed two tumors, one in the ascending colon and the other in the retroperitoneal region. These were surgically removed. Pathology result reported well differentiated colon adenocarcinoma and dedifferentiated liposarcoma, both with surgical borders clean of neoplasia. Simultaneous finding of these tumors has not been described in the medical literature.
Reporte de Caso: TIROIDITIS DE HASHIMOTO ASOCIADA A TIROIDITIS SUBAGUDA, 2016
We report the case of a 52-year-old who female, who presented a cervical mass thyroid-dependent, ... more We report the case of a 52-year-old who female, who presented a cervical mass thyroid-dependent, whose pathological anatomic study demonstrated Hashimoto's thyroiditis with a subacute inflammatory component.
The finding of these two entities are not described in Anglo-American literature being the first case to be reported.