Prasetyadi Mawardi | Sebelas Maret University (original) (raw)

Papers by Prasetyadi Mawardi

Bioscientia medicina, Jul 10, 2024

Clinical, Cosmetic and Investigational Dermatology

Cermin Dunia Kedokteran

Gangguan keseimbangan flora bakteri normal dalam vagina menyebabkan vaginosis bakterial. Vaginosi... more Gangguan keseimbangan flora bakteri normal dalam vagina menyebabkan vaginosis bakterial. Vaginosis bakterial dapat tidak menunjukkan gejala atau ditandai dengan adanya tubuh putih keabuan disertai bau amis. Skor Nugent merupakan standar emas untuk diagnosis. Penggunaan probiotik menunjukkan hasil memuaskan sehingga dipertimbangkan dalam manajemen bakterial vaginosis. Bacterial vaginosis is caused by disruption of normal bacterial flora balance in the vagina. This disease may show no symptoms; can be characterized by the presence of agrayish-white discharge accompanied by a fishy odor. Nugent score is the gold standard for diagnosis. The use of probiotics shows satisfactory results; and may be considered in the management of bacterial vaginosis.

Asian Journal of Healthy and Science

Introduction : Furunculosis is a skin inflammation of hair follicle which may become chronic and ... more Introduction : Furunculosis is a skin inflammation of hair follicle which may become chronic and recurrence. Plasmacytosis is a rare lymphoproliferative disorder involving skin and systemic organs. Here in we report a case of reccurent furunculosis with plasmacytosis treated with surgical excision. Case : A 57-years-old woman presented to our outpatient clinic with a recurrent lumps filled with pus on her left cheek since 2 years ago. Dermatological examination obtained a solitary nodule on the erythematous base skin filled with pus. Laboratory findings did not indicate the monoclonality of electrophoretic serum protein. Histopathological features of skin biopsy showed inflammatory cells aggregate in the perifollicular area consisting neutrophils, lymphocytes, monocytes, eosinophils, and plasma cells mainly in the dermal layer. The CD 138 immunostaining was positive, hence we diagnosed the patient with recurrent furunculosis with plasmacytosis. Surgical excision was conducted and no...

MEDICINUS

Pendahuluan: Re-emergence sifilis banyak ditemukan pada laki-laki homoseksual dengan infeksi HIV ... more Pendahuluan: Re-emergence sifilis banyak ditemukan pada laki-laki homoseksual dengan infeksi HIV positif. Perjalanan penyakit sifilis pada pasien dengan HIV lebih cepat dan berisiko tinggi menjadi neurosifilis. Koinfeksi sifilis dan human immunodeficiency virus (HIV) dikaitkan dengan penurunan CD4 dan peningkatan HIV-RNA. Perbaikan keduanya dikaitkan dengan terapi sifilis yang efektif, salah satunya dengan terapi doxycycline. Doxycycline memiliki efek antiinflamasi yang berhubungan dengan penurunan viral load serta peningkatan CD4 pada pasien positif HIV. Kasus: Laki-laki warga negara asing berusia 20 tahun dengan keluhan utama bintik merah tidak gatal pada sekujur tubuh yang muncul selama 2 hari disertai demam. Pasien sudah berobat namun belum tampak perbaikan. Riwayat berhubungan seksual sesama jenis dan bergonta-ganti pasangan lebih dari 10 kali dalam 10 tahun terakhir serta jarang menggunakan kondom. Regio generalisata tampak papul eritem multipel diskret berukuran miliar hingga...

Background: Occupational contact dermatitis is an inflammatory reaction caused by exposure to occ... more Background: Occupational contact dermatitis is an inflammatory reaction caused by exposure to occupational factors. Contact dermatitis due to plants or plant products are often found in clinical practice. Occupational contact dermatitis was common in traditional starch industry worker and palm sugar was the main ingredient of this industry. Palm sugar or Arenga pinnata Merr contain ingredients that potentially irritant and allergenic. Frequency and risk factors that affected the frequency of occupational contact dermatitis in traditional starch industry worker is unknown. Objective: To determine frequency and risk factors that affected the frequency of occupational contact dermatitis in traditional starch industry worker Methods: Analytic observational study with a cross-sectional design Results: Sixty nine subjects were include in this study, 82.6% are women. The mean age of subjects was 43.3 years old. Frequency of OCD on starch industral worker was 18.8%. In bivariate analysis, w...

Bioscientia medicina, Nov 12, 2023

Background: Recent studies have highlighted the possible role of vitamin D in atopic dermatitis (... more Background: Recent studies have highlighted the possible role of vitamin D in atopic dermatitis (AD) so that it can be used as therapeutical of AD. The aim of study to evaluate the effect of vitamin D supplementation as add-on therapy in adult patients with AD. Methods: Twenty-four adult patients with AD were included in a randomized, double-blind, placebo-controlled trial study. This study was conducted in Dr. Moewardi General Hospital Surakarta, Indonesia, from February to March 2023. Subjects were randomly assigned to oral cholecalciferol 5,000 IU/day versus placebo for 4 weeks and all subjects were given emollient. The severity of AD was evaluated by using scoring of atopic dermatitis (SCORAD) before and after the trial. Results: Compared to placebo, vitamin D supplementation for 1 month obtained clinically and statistically improvement in SCORAD score compare to control (-4.508 : 4.500, p= 0.000). Moreover, vitamin D supplementation had strong negative correlation to SCORAD score after the trial (r=-0.780, p= 0,000). There were no adverse effects in either group. and Conclusion: Clinical improvement was achieved after vitamin D supplementation as addon therapy in adult patients with AD.

Health and Medical Journal

Latar belakang: Efluvium telogen (ET) adalah kelainan pada rambut, ditandai dengan pelepasan ramb... more Latar belakang: Efluvium telogen (ET) adalah kelainan pada rambut, ditandai dengan pelepasan rambut telogen berlebihan tanpa adanya inflamasi. Salah satu faktor pencetusnya adalah systemic lupus erythematosus (SLE). Minoksidil topikal 2% adalah terapi pilihan yang bekerja dengan meningkatkan aliran darah dan oksigen ke folikel rambut. Antioksidan oral yang mengandung keratin (cynatine HNS) juga memperbaiki kesehatan rambut sehingga dapat diberikan sebagai terapi tambahan pada kasus ET. Kasus: Perempuan berusia 19 tahun dengan keluhan rambut rontok sejak 1 tahun yang lalu. Pasien mengeluhkan demam, ruam merah di wajah dan nyeri sendi 5 bulan lalu dengan hasil tes ANA >1/80, dsDNA positif lemah, Scl-70 positif lemah dan Ro-60 positif lemah. Pasien didiagnosis dengan SLE, diberikan terapi metilprednisolon tablet 48 mg/hari dan siklosporin tablet 100 mg/hari. Status dermatologis pada regio scalp tampak kerontokan rambut difus, pemeriksaan hair pull test positif dan pada pemeriksaan d...

Aktuelle Dermatologie

Introduction Condyloma acuminata (CA) is a sexually transmitted infection caused by the human pap... more Introduction Condyloma acuminata (CA) is a sexually transmitted infection caused by the human papillomavirus (HPV), and the recurrence rate is relatively high. A compromised immune system causes CA recurrence. The primary treatment goal is to eradicate the warts; however, the immunomodulatory combination therapy might reduce the recurrence rate, so it might enhance the healing process. Cimetidine is a histamine H2-receptor antagonist which might indicate immunomodulator activity. Aim This case report aimed to investigate the effectiveness of cimetidine as an immunomodulator agent against CA. Clinical cases Three patients visited dermatology and venerology outpatient clinic with multiple warts located on the external genital and perianal area. The examination described there were confluent cauliflower-like nodules. Besides, acetowhite examination showed positive reactions. Two patients were HIV-positve and one was negative. The lesions showed clinical improvement in all three patient...

International Journal Of Medical Science And Clinical Research Studies

Background. Achatina fulica (A. fulica) snail slime was well known having many advantages especia... more Background. Achatina fulica (A. fulica) snail slime was well known having many advantages especially as moisturizer and antimicrobial, but enzymatic antioxidant properties have not been studied yet. Objective. This study aimed to find the enzymatic antioxidant properties of snail slime extract and to find photoprotective potency in sunburn. Method. This research was an experimental test using randomized post-test only control group design using 75 male BALB/c mice were divided into 15 groups. There were an untreated group, 4 groups were given various doses of snail slime extract topically, 5 groups were irradiated with UVA 30J/cm2 and 5 groups were irradiated with UVB 200mJ/cm2. Skin biopsy were performed 24 hours after irradiated to be analyzed for enzymatic antioxidants properties of SOD, CAT and GPX, and also histologic changes. Data analysis were conducted with one-way ANOVA and followed by post hoc LSD with SPSS 26. Results. A. fulica snail slime contained enzymatic antioxidant...

Annals of the Romanian Society for Cell Biology, Mar 1, 2021

Berkala Ilmu Kesehatan Kulit dan Kelamin, Nov 30, 2022

Background: Condyloma acuminatum (CA) or genital warts is sexually transmitted infection resultin... more Background: Condyloma acuminatum (CA) or genital warts is sexually transmitted infection resulting from Human papillomavirus (HPV). It is estimated that CA occurs in >80% of reproductive age in many countries, with the most common types being low risk types HPV 6 and 11, but sometimes could be combined with high-risk types are HPV 16, 18. Gen E6 is an oncoprotein that cooperates with E7 to provide a suitable environment for viral DNA replication and inhibits cellular apoptotic processes. The E6 gene has characteristic properties as a p53 tumor suppressor protein. Purpose: To analyse the high-risk types HPV 16 and 18 in CA patients. Methods: This study was a cross-sectional, observational analytic study that assessed data collection concurrently over time. Specimens were patients diagnosed with condyloma acuminatum, biopsies were performed, and immunohistochemical (IHC) staining was also performed to examine E6 of high risk types HPV 16 and 18. The sampling technique used sequential sampling, and the inclusion criteria included patients who came to our hospital for treatment. Result: Twenty patients with CA were include in this study consist of 11 male and 9 female, meanwhile 9 subjects in homosexual group and 11 subjects in heterosexual group. Based on IHC examination 33% cases were detected of high-risk types HPV 16 and 18 especially among homosexual group. According to t-test obtained significant result of highrisk types and low-risk types of HPV from IHC staining (p=0.038). Conclusion: Condyloma acuminatum is a sexually transmitted infection that commonly caused by low-risk types HPV 6 and 11, but this study showed high risk types HPV16 and 18 also found in MSM (Male Sex with Male) patients with CA, so that it is necessary to be aware of the possibility of transformation to malignancy.

Langerhans cell histiocytosis (HSL) or histiocytosis X, eosinophilic granuloma, letterer siwe dis... more Langerhans cell histiocytosis (HSL) or histiocytosis X, eosinophilic granuloma, letterer siwe disease, hand schuller christian disease and hashimoto pritzker disease is a disorder caused by the accumulation and proliferation of langerhans cells in various organs of the body that causes tissue damage. The highest prevalence of HSL occurs in children less than 3 years old, with a ratio of 2:1 for boys and girls. The classic appearance of skin manifestations is an eruption resembling seborrheic dermatitis in the folds, axillae, scalp, retroauricular and trunk areas. The appearance of the lesion is yellow to brownish red papules, purpuric and crusted papules that can occur together with erosion. Histopathological examination with staining with S100 or cluster of differentiation 1a (CD1a) revealed Langerhans cell infiltration. The results of immunohistochemistry with IHC S-100 staining, CD1a showed a picture of Langerhans cells and histiocytes. The purpose of this paper is to study the h...

MEDICINUS

Latar belakang: Acne vulgaris (AV) merupakan penyakit inflamasi kronis pada unit pilosebasea deng... more Latar belakang: Acne vulgaris (AV) merupakan penyakit inflamasi kronis pada unit pilosebasea dengan manifestasi klinis berupa komedo terbuka dan tertutup, papul, pustul dan nodul. Terapi AV umumnya melibatkan lebih dari satu obat dikarenakan patogenesis AV yang multifaktorial. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian astaxanthin oral 4 mg sebagai terapi adjuvan AV terhadap penurunan kadar serum tumor necrosis factor alpha (TNF-α) yang merupakan salah satu penanda inflamasi. Metode: Penelitian ini merupakan penelitian double-blind randomized controlled trial. Sampel berjumlah 34 pasien AV derajat ringan dan sedang (skor Global Acne Grading System/GAGS 1-30) yang diobati dengan kombinasi tretinoin 0,025% dan clindamycin phosphate 1,2%. Pada kelompok perlakuan ditambahkan terapi dengan astaxanthin sementara pada kelompok kontrol diberikan plasebo berisi laktulosa selama 4 minggu. Hasil pretest dan posttest pada kedua kelompok dianalisis secara statistik meng...

Developing a Global Pandemic Exit Strategy and Framework for Global Health Security

Cermin Dunia Kedokteran, Mar 1, 2021

Latar belakang: Melasma adalah hiperpigmentasi wajah pada wanita di area yang sering terpapar sin... more Latar belakang: Melasma adalah hiperpigmentasi wajah pada wanita di area yang sering terpapar sinar matahari, bersifat kronik kambuhan. Saat ini formula Kligman masih menjadi pilihan terapi efektif tetapi mempunyai efek samping terutama pada pemakaian jangka lama. Kombinasi terapi asam traneksamat, nikotinamid, dan microneedling merupakan terapi alternatif yang aman dan efektif untuk jangka lama. Tujuan: Untuk mengetahui keberhasilan terapi kombinasi topikal krim asam traneksamat 3%, nikotinamid 3%, dan microneedling dalam menurunkan skor MASI dan indeks melanin pasien melasma. Kasus: Dua pasien perempuan umur 45 dan 44 tahun dengan keluhan utama bercak hitam di wajah. Pasien 1 dengan melasma tipe campuran dan pasien 2 dengan melasma tipe epidermal. Pasien diterapi topikal menggunakan krim kombinasi asam traneksamat 3% dan nikotinamid 3% dengan microneedling. Microneedling dilakukan pada minggu ke-0, ke-4, dan ke-8. Evaluasi terapi saat minggu ke-0, 4, 8, dan 12, dengan skor MASI dan indeks melanin menggunakan Mexameter®. Hasil: Terdapat penurunan nilai skor MASI dan indeks melanin. Simpulan: Terapi kombinasi krim asam traneksamat 3%, nikotinamid 3%, dan microneedling dapat menurunkan skor MASI dan indeks melanin.

Cermin Dunia Kedokteran, Apr 1, 2019

Clinical, Cosmetic and Investigational Dermatology, Mar 1, 2022

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute severe cutaneous ad... more Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute severe cutaneous adverse reactions commonly caused by medication. Precise evaluation of disease severity in initial setting must be obtained to start appropriate treatment. Neutrophil and lymphocyte ratio (NLR) plays a role in displaying inflammatory reaction while eosinophils count (EC) influences immunological dysregulation including the proliferation of cytotoxic cells in early onset of SJS/TEN. Objective: To evaluate whether NLR and EC serve as prognostic markers of disease severity in patients with SJS/TEN using SCORTEN. Methods: A single center study with retrospective study included SJS/TEN patients at Dr. Moewardi General Hospital Surakarta in January 1st 2018-December 31st 2020. The required laboratory data was assessed at the beginning of the patient's admission through medical records. The significance analysis were performed using one-way ANOVA and Spearman while the receiver-operator curve were used to evaluate the prognostic value of variables for severity in SJS/TEN patients. Results: The total sample in this study was 24 patients with majority female (58%) and range from 25 to >50 years (54%). The results demonstrated of significant difference and positively correlated between NLR and EC with severity of SJS/TEN (p<0.01; r>0.05). The specificity and sensitivity of 51%;61% and 70%;60%, respectively. Conclusion: NLR and EC can be used as prognosticators of severity in SJS/TEN while further research on other inflammatory markers with increased number of samples and study centers are needed to provide more actual data.

Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences, Nov 22, 2021

Bioscientia medicina, Jul 10, 2024

Clinical, Cosmetic and Investigational Dermatology

Cermin Dunia Kedokteran

Gangguan keseimbangan flora bakteri normal dalam vagina menyebabkan vaginosis bakterial. Vaginosi... more Gangguan keseimbangan flora bakteri normal dalam vagina menyebabkan vaginosis bakterial. Vaginosis bakterial dapat tidak menunjukkan gejala atau ditandai dengan adanya tubuh putih keabuan disertai bau amis. Skor Nugent merupakan standar emas untuk diagnosis. Penggunaan probiotik menunjukkan hasil memuaskan sehingga dipertimbangkan dalam manajemen bakterial vaginosis. Bacterial vaginosis is caused by disruption of normal bacterial flora balance in the vagina. This disease may show no symptoms; can be characterized by the presence of agrayish-white discharge accompanied by a fishy odor. Nugent score is the gold standard for diagnosis. The use of probiotics shows satisfactory results; and may be considered in the management of bacterial vaginosis.

Asian Journal of Healthy and Science

Introduction : Furunculosis is a skin inflammation of hair follicle which may become chronic and ... more Introduction : Furunculosis is a skin inflammation of hair follicle which may become chronic and recurrence. Plasmacytosis is a rare lymphoproliferative disorder involving skin and systemic organs. Here in we report a case of reccurent furunculosis with plasmacytosis treated with surgical excision. Case : A 57-years-old woman presented to our outpatient clinic with a recurrent lumps filled with pus on her left cheek since 2 years ago. Dermatological examination obtained a solitary nodule on the erythematous base skin filled with pus. Laboratory findings did not indicate the monoclonality of electrophoretic serum protein. Histopathological features of skin biopsy showed inflammatory cells aggregate in the perifollicular area consisting neutrophils, lymphocytes, monocytes, eosinophils, and plasma cells mainly in the dermal layer. The CD 138 immunostaining was positive, hence we diagnosed the patient with recurrent furunculosis with plasmacytosis. Surgical excision was conducted and no...

MEDICINUS

Pendahuluan: Re-emergence sifilis banyak ditemukan pada laki-laki homoseksual dengan infeksi HIV ... more Pendahuluan: Re-emergence sifilis banyak ditemukan pada laki-laki homoseksual dengan infeksi HIV positif. Perjalanan penyakit sifilis pada pasien dengan HIV lebih cepat dan berisiko tinggi menjadi neurosifilis. Koinfeksi sifilis dan human immunodeficiency virus (HIV) dikaitkan dengan penurunan CD4 dan peningkatan HIV-RNA. Perbaikan keduanya dikaitkan dengan terapi sifilis yang efektif, salah satunya dengan terapi doxycycline. Doxycycline memiliki efek antiinflamasi yang berhubungan dengan penurunan viral load serta peningkatan CD4 pada pasien positif HIV. Kasus: Laki-laki warga negara asing berusia 20 tahun dengan keluhan utama bintik merah tidak gatal pada sekujur tubuh yang muncul selama 2 hari disertai demam. Pasien sudah berobat namun belum tampak perbaikan. Riwayat berhubungan seksual sesama jenis dan bergonta-ganti pasangan lebih dari 10 kali dalam 10 tahun terakhir serta jarang menggunakan kondom. Regio generalisata tampak papul eritem multipel diskret berukuran miliar hingga...

Background: Occupational contact dermatitis is an inflammatory reaction caused by exposure to occ... more Background: Occupational contact dermatitis is an inflammatory reaction caused by exposure to occupational factors. Contact dermatitis due to plants or plant products are often found in clinical practice. Occupational contact dermatitis was common in traditional starch industry worker and palm sugar was the main ingredient of this industry. Palm sugar or Arenga pinnata Merr contain ingredients that potentially irritant and allergenic. Frequency and risk factors that affected the frequency of occupational contact dermatitis in traditional starch industry worker is unknown. Objective: To determine frequency and risk factors that affected the frequency of occupational contact dermatitis in traditional starch industry worker Methods: Analytic observational study with a cross-sectional design Results: Sixty nine subjects were include in this study, 82.6% are women. The mean age of subjects was 43.3 years old. Frequency of OCD on starch industral worker was 18.8%. In bivariate analysis, w...

Bioscientia medicina, Nov 12, 2023

Background: Recent studies have highlighted the possible role of vitamin D in atopic dermatitis (... more Background: Recent studies have highlighted the possible role of vitamin D in atopic dermatitis (AD) so that it can be used as therapeutical of AD. The aim of study to evaluate the effect of vitamin D supplementation as add-on therapy in adult patients with AD. Methods: Twenty-four adult patients with AD were included in a randomized, double-blind, placebo-controlled trial study. This study was conducted in Dr. Moewardi General Hospital Surakarta, Indonesia, from February to March 2023. Subjects were randomly assigned to oral cholecalciferol 5,000 IU/day versus placebo for 4 weeks and all subjects were given emollient. The severity of AD was evaluated by using scoring of atopic dermatitis (SCORAD) before and after the trial. Results: Compared to placebo, vitamin D supplementation for 1 month obtained clinically and statistically improvement in SCORAD score compare to control (-4.508 : 4.500, p= 0.000). Moreover, vitamin D supplementation had strong negative correlation to SCORAD score after the trial (r=-0.780, p= 0,000). There were no adverse effects in either group. and Conclusion: Clinical improvement was achieved after vitamin D supplementation as addon therapy in adult patients with AD.

Health and Medical Journal

Latar belakang: Efluvium telogen (ET) adalah kelainan pada rambut, ditandai dengan pelepasan ramb... more Latar belakang: Efluvium telogen (ET) adalah kelainan pada rambut, ditandai dengan pelepasan rambut telogen berlebihan tanpa adanya inflamasi. Salah satu faktor pencetusnya adalah systemic lupus erythematosus (SLE). Minoksidil topikal 2% adalah terapi pilihan yang bekerja dengan meningkatkan aliran darah dan oksigen ke folikel rambut. Antioksidan oral yang mengandung keratin (cynatine HNS) juga memperbaiki kesehatan rambut sehingga dapat diberikan sebagai terapi tambahan pada kasus ET. Kasus: Perempuan berusia 19 tahun dengan keluhan rambut rontok sejak 1 tahun yang lalu. Pasien mengeluhkan demam, ruam merah di wajah dan nyeri sendi 5 bulan lalu dengan hasil tes ANA >1/80, dsDNA positif lemah, Scl-70 positif lemah dan Ro-60 positif lemah. Pasien didiagnosis dengan SLE, diberikan terapi metilprednisolon tablet 48 mg/hari dan siklosporin tablet 100 mg/hari. Status dermatologis pada regio scalp tampak kerontokan rambut difus, pemeriksaan hair pull test positif dan pada pemeriksaan d...

Aktuelle Dermatologie

Introduction Condyloma acuminata (CA) is a sexually transmitted infection caused by the human pap... more Introduction Condyloma acuminata (CA) is a sexually transmitted infection caused by the human papillomavirus (HPV), and the recurrence rate is relatively high. A compromised immune system causes CA recurrence. The primary treatment goal is to eradicate the warts; however, the immunomodulatory combination therapy might reduce the recurrence rate, so it might enhance the healing process. Cimetidine is a histamine H2-receptor antagonist which might indicate immunomodulator activity. Aim This case report aimed to investigate the effectiveness of cimetidine as an immunomodulator agent against CA. Clinical cases Three patients visited dermatology and venerology outpatient clinic with multiple warts located on the external genital and perianal area. The examination described there were confluent cauliflower-like nodules. Besides, acetowhite examination showed positive reactions. Two patients were HIV-positve and one was negative. The lesions showed clinical improvement in all three patient...

International Journal Of Medical Science And Clinical Research Studies

Background. Achatina fulica (A. fulica) snail slime was well known having many advantages especia... more Background. Achatina fulica (A. fulica) snail slime was well known having many advantages especially as moisturizer and antimicrobial, but enzymatic antioxidant properties have not been studied yet. Objective. This study aimed to find the enzymatic antioxidant properties of snail slime extract and to find photoprotective potency in sunburn. Method. This research was an experimental test using randomized post-test only control group design using 75 male BALB/c mice were divided into 15 groups. There were an untreated group, 4 groups were given various doses of snail slime extract topically, 5 groups were irradiated with UVA 30J/cm2 and 5 groups were irradiated with UVB 200mJ/cm2. Skin biopsy were performed 24 hours after irradiated to be analyzed for enzymatic antioxidants properties of SOD, CAT and GPX, and also histologic changes. Data analysis were conducted with one-way ANOVA and followed by post hoc LSD with SPSS 26. Results. A. fulica snail slime contained enzymatic antioxidant...

Annals of the Romanian Society for Cell Biology, Mar 1, 2021

Berkala Ilmu Kesehatan Kulit dan Kelamin, Nov 30, 2022

Background: Condyloma acuminatum (CA) or genital warts is sexually transmitted infection resultin... more Background: Condyloma acuminatum (CA) or genital warts is sexually transmitted infection resulting from Human papillomavirus (HPV). It is estimated that CA occurs in >80% of reproductive age in many countries, with the most common types being low risk types HPV 6 and 11, but sometimes could be combined with high-risk types are HPV 16, 18. Gen E6 is an oncoprotein that cooperates with E7 to provide a suitable environment for viral DNA replication and inhibits cellular apoptotic processes. The E6 gene has characteristic properties as a p53 tumor suppressor protein. Purpose: To analyse the high-risk types HPV 16 and 18 in CA patients. Methods: This study was a cross-sectional, observational analytic study that assessed data collection concurrently over time. Specimens were patients diagnosed with condyloma acuminatum, biopsies were performed, and immunohistochemical (IHC) staining was also performed to examine E6 of high risk types HPV 16 and 18. The sampling technique used sequential sampling, and the inclusion criteria included patients who came to our hospital for treatment. Result: Twenty patients with CA were include in this study consist of 11 male and 9 female, meanwhile 9 subjects in homosexual group and 11 subjects in heterosexual group. Based on IHC examination 33% cases were detected of high-risk types HPV 16 and 18 especially among homosexual group. According to t-test obtained significant result of highrisk types and low-risk types of HPV from IHC staining (p=0.038). Conclusion: Condyloma acuminatum is a sexually transmitted infection that commonly caused by low-risk types HPV 6 and 11, but this study showed high risk types HPV16 and 18 also found in MSM (Male Sex with Male) patients with CA, so that it is necessary to be aware of the possibility of transformation to malignancy.

Langerhans cell histiocytosis (HSL) or histiocytosis X, eosinophilic granuloma, letterer siwe dis... more Langerhans cell histiocytosis (HSL) or histiocytosis X, eosinophilic granuloma, letterer siwe disease, hand schuller christian disease and hashimoto pritzker disease is a disorder caused by the accumulation and proliferation of langerhans cells in various organs of the body that causes tissue damage. The highest prevalence of HSL occurs in children less than 3 years old, with a ratio of 2:1 for boys and girls. The classic appearance of skin manifestations is an eruption resembling seborrheic dermatitis in the folds, axillae, scalp, retroauricular and trunk areas. The appearance of the lesion is yellow to brownish red papules, purpuric and crusted papules that can occur together with erosion. Histopathological examination with staining with S100 or cluster of differentiation 1a (CD1a) revealed Langerhans cell infiltration. The results of immunohistochemistry with IHC S-100 staining, CD1a showed a picture of Langerhans cells and histiocytes. The purpose of this paper is to study the h...

MEDICINUS

Latar belakang: Acne vulgaris (AV) merupakan penyakit inflamasi kronis pada unit pilosebasea deng... more Latar belakang: Acne vulgaris (AV) merupakan penyakit inflamasi kronis pada unit pilosebasea dengan manifestasi klinis berupa komedo terbuka dan tertutup, papul, pustul dan nodul. Terapi AV umumnya melibatkan lebih dari satu obat dikarenakan patogenesis AV yang multifaktorial. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian astaxanthin oral 4 mg sebagai terapi adjuvan AV terhadap penurunan kadar serum tumor necrosis factor alpha (TNF-α) yang merupakan salah satu penanda inflamasi. Metode: Penelitian ini merupakan penelitian double-blind randomized controlled trial. Sampel berjumlah 34 pasien AV derajat ringan dan sedang (skor Global Acne Grading System/GAGS 1-30) yang diobati dengan kombinasi tretinoin 0,025% dan clindamycin phosphate 1,2%. Pada kelompok perlakuan ditambahkan terapi dengan astaxanthin sementara pada kelompok kontrol diberikan plasebo berisi laktulosa selama 4 minggu. Hasil pretest dan posttest pada kedua kelompok dianalisis secara statistik meng...

Developing a Global Pandemic Exit Strategy and Framework for Global Health Security

Cermin Dunia Kedokteran, Mar 1, 2021

Latar belakang: Melasma adalah hiperpigmentasi wajah pada wanita di area yang sering terpapar sin... more Latar belakang: Melasma adalah hiperpigmentasi wajah pada wanita di area yang sering terpapar sinar matahari, bersifat kronik kambuhan. Saat ini formula Kligman masih menjadi pilihan terapi efektif tetapi mempunyai efek samping terutama pada pemakaian jangka lama. Kombinasi terapi asam traneksamat, nikotinamid, dan microneedling merupakan terapi alternatif yang aman dan efektif untuk jangka lama. Tujuan: Untuk mengetahui keberhasilan terapi kombinasi topikal krim asam traneksamat 3%, nikotinamid 3%, dan microneedling dalam menurunkan skor MASI dan indeks melanin pasien melasma. Kasus: Dua pasien perempuan umur 45 dan 44 tahun dengan keluhan utama bercak hitam di wajah. Pasien 1 dengan melasma tipe campuran dan pasien 2 dengan melasma tipe epidermal. Pasien diterapi topikal menggunakan krim kombinasi asam traneksamat 3% dan nikotinamid 3% dengan microneedling. Microneedling dilakukan pada minggu ke-0, ke-4, dan ke-8. Evaluasi terapi saat minggu ke-0, 4, 8, dan 12, dengan skor MASI dan indeks melanin menggunakan Mexameter®. Hasil: Terdapat penurunan nilai skor MASI dan indeks melanin. Simpulan: Terapi kombinasi krim asam traneksamat 3%, nikotinamid 3%, dan microneedling dapat menurunkan skor MASI dan indeks melanin.

Cermin Dunia Kedokteran, Apr 1, 2019

Clinical, Cosmetic and Investigational Dermatology, Mar 1, 2022

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute severe cutaneous ad... more Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute severe cutaneous adverse reactions commonly caused by medication. Precise evaluation of disease severity in initial setting must be obtained to start appropriate treatment. Neutrophil and lymphocyte ratio (NLR) plays a role in displaying inflammatory reaction while eosinophils count (EC) influences immunological dysregulation including the proliferation of cytotoxic cells in early onset of SJS/TEN. Objective: To evaluate whether NLR and EC serve as prognostic markers of disease severity in patients with SJS/TEN using SCORTEN. Methods: A single center study with retrospective study included SJS/TEN patients at Dr. Moewardi General Hospital Surakarta in January 1st 2018-December 31st 2020. The required laboratory data was assessed at the beginning of the patient's admission through medical records. The significance analysis were performed using one-way ANOVA and Spearman while the receiver-operator curve were used to evaluate the prognostic value of variables for severity in SJS/TEN patients. Results: The total sample in this study was 24 patients with majority female (58%) and range from 25 to >50 years (54%). The results demonstrated of significant difference and positively correlated between NLR and EC with severity of SJS/TEN (p<0.01; r>0.05). The specificity and sensitivity of 51%;61% and 70%;60%, respectively. Conclusion: NLR and EC can be used as prognosticators of severity in SJS/TEN while further research on other inflammatory markers with increased number of samples and study centers are needed to provide more actual data.

Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences, Nov 22, 2021