Amina Tucak | University of Sarajevo (original) (raw)
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Institute of Biophysics, Chinese Academy of Sciences
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Animal testing has shown unsatisfaction when it comes to examination of hepato-neuro-and cardioto... more Animal testing has shown unsatisfaction when it comes to examination of hepato-neuro-and cardiotoxicity, as well as in the development of new therapies, while use of in vitro model systems is limited by unavailability of human tissues. For this reason, use of human embryonic stem cells (hESC) as unlimited source for producing differentiated somatic progeny, represents a great medical advance. Induced pluripotent stem cells (iPSC) represent a new type of stem cells that occur by reprogramming of genomes of adult stem cells, such as dermal fibroblasts into a pluripotent state. These cells have many similarities with embryonic stem cells, and their reprogramming requests transcription factors OCT4, SOX2, and KLF4. IPSC are characterized by the ability of recovery and differentiation into different cell types such as-cells, hepatocytes, cardiomyocytes, hematopoietic cells, which opens the door to the new methods of treatment of many diseases especially in the field of personalized regenerative medicine. This paperwork contains future trends and possibilities of using iPSC's in regenerative personalized medicine, and with great certainty we can say that the discovery of the same has brought a revolutionary changes to medicine, and that these cells will soon be used not only for modeling of various diseases, but also for treating diseases and finding and testing new drugs that will help to improve the quality of life in many patients.
Transdermal drug delivery offers a number of advantages including sustained release, improved pat... more Transdermal drug delivery offers a number of advantages including sustained release, improved patient compliance, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. However, only few medications can be delivered through the transdermal route in therapeutic amounts. NSAIDs are consisted of a group of drugs that are widely used, but their use by oral or transdermal system is limited due to a number of side effects. Therefore, NSAIDs are ideal candidates for delivery via microneedles, a relatively new method of drug delivery. A new concept was introduced known as microneedles and these could be used to effectively deliver drugs using micron-sized needles in a minimally invasive and painless manner. Microneedles can be used to enhance transdermal drug delivery and they can be fabricated in different forms.
Animal testing has shown unsatisfaction when it comes to examination of hepato-neuro-and cardioto... more Animal testing has shown unsatisfaction when it comes to examination of hepato-neuro-and cardiotoxicity, as well as in the development of new therapies, while use of in vitro model systems is limited by unavailability of human tissues. For this reason, use of human embryonic stem cells (hESC) as unlimited source for producing differentiated somatic progeny, represents a great medical advance. Induced pluripotent stem cells (iPSC) represent a new type of stem cells that occur by reprogramming of genomes of adult stem cells, such as dermal fibroblasts into a pluripotent state. These cells have many similarities with embryonic stem cells, and their reprogramming requests transcription factors OCT4, SOX2, and KLF4. IPSC are characterized by the ability of recovery and differentiation into different cell types such as-cells, hepatocytes, cardiomyocytes, hematopoietic cells, which opens the door to the new methods of treatment of many diseases especially in the field of personalized regenerative medicine. This paperwork contains future trends and possibilities of using iPSC's in regenerative personalized medicine, and with great certainty we can say that the discovery of the same has brought a revolutionary changes to medicine, and that these cells will soon be used not only for modeling of various diseases, but also for treating diseases and finding and testing new drugs that will help to improve the quality of life in many patients.
Transdermal drug delivery offers a number of advantages including sustained release, improved pat... more Transdermal drug delivery offers a number of advantages including sustained release, improved patient compliance, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. However, only few medications can be delivered through the transdermal route in therapeutic amounts. NSAIDs are consisted of a group of drugs that are widely used, but their use by oral or transdermal system is limited due to a number of side effects. Therefore, NSAIDs are ideal candidates for delivery via microneedles, a relatively new method of drug delivery. A new concept was introduced known as microneedles and these could be used to effectively deliver drugs using micron-sized needles in a minimally invasive and painless manner. Microneedles can be used to enhance transdermal drug delivery and they can be fabricated in different forms.