Gabriel Domingo Vilallonga | UNSL Universidad Nacional de San Luis (original) (raw)

Papers by Gabriel Domingo Vilallonga

Research paper thumbnail of Temporal validation of extended workflow processes by means Petri Nets with Clocks

At present the business processes have temporary requirements within their specifications. Logist... more At present the business processes have temporary requirements within their specifications. Logistics, e-commerce, are examples of these, among others. The time involved in business processes is important regarding the interaction of the actors. The sound of the technology involved in building these processes plays a key role in assessing the risk of implementation. The possibility of having technologies with elements for such specifications is vital to accurately model of reality. Workflow (Wf) is the technology of wide acceptance and recognition that can improve business processes. The Wf architecture has the Interface 1, which lets you define process through its processes definition language (PDL), but has no elements to express temporary restrictions of this kind. Our works present a theoretical framework in which there is an extension of the grammar of the WPDL to allow the specification of time variable. It also establishes a correspondence between the PD and its underlying Petri Net with Clocks (PNwC) preserving its semantic. The correspondence is specified by means of the RAISE Specification Language (RSL). The correlation between these formalisms lets you define business process with temporary restrictions validated.

Research paper thumbnail of In Silico Laboratory Experiments using Statistical Model Checking: A new model of the Palytoxin-Induced Pump Channel as Case Study

IEEE/ACM Transactions on Computational Biology and Bioinformatics

Research paper thumbnail of Hypothesized diprotomeric enzyme complex supported by stochastic modelling of palytoxin-induced Na/K pump channels

Royal Society open science, 2018

The sodium-potassium pump (Na/K pump) is crucial for cell physiology. Despite great advances in t... more The sodium-potassium pump (Na/K pump) is crucial for cell physiology. Despite great advances in the understanding of this ionic pumping system, its mechanism is not completely understood. We propose the use of a statistical model checker to investigate palytoxin (PTX)-induced Na/K pump channels. We modelled a system of reactions representing transitions between the conformational substates of the channel with parameters, concentrations of the substates and reaction rates extracted from simulations reported in the literature, based on electrophysiological recordings in a whole-cell configuration. The model was implemented using the UPPAAL-SMC platform. Comparing simulations and probabilistic queries from stochastic system semantics with experimental data, it was possible to propose additional reactions to reproduce the single-channel dynamic. The probabilistic analyses and simulations suggest that the PTX-induced Na/K pump channel functions as a diprotomeric complex in which protein-...

Research paper thumbnail of Business process modeling using petri nets with clocks

Petri Nets are tools for the analysis and design of concurrent systems. There is a formal theory,... more Petri Nets are tools for the analysis and design of concurrent systems. There is a formal theory, which supports Petri Nets. We propose Petri Nets with Clocks which has a high expressive power in the concurrent and asynchronous process modeling and gives the possibility to model real time systems. The Petri Nets with Clocks are useful to model systems with temporal requirements via specification of clocks, using temporal invariants for the places and temporal conditions in the transitions. Also, we have developed an algorithm for the analysis of Petri Nets with Clocks. For the Business Processes Modeling, we propose to use Petri Nets with Clocks to formalize models, allowing to study the models through a quantitative and qualitative analysis. Petri Nets with Clocks includes additional temporal elements-clocks-, which are appropriate for the Business Processes Modeling and are not taken into consideration in the literature concerning the extensions of Petri Nets with time. Petri Nets with Clocks allows studying the structural properties of Business Processes Modeling. This study not only allows the simulation but also verifies formally the model. It is oriented to the verification and correction of errors in the modeling of the time variable en Business Processes.

Research paper thumbnail of Marco teórico para la traducción de procesos workflow extendido a redes de Petri con relojes

Resumen Workflow (Wf) es una de las tecnologías que habilita a la Reingeniería de Procesos de Neg... more Resumen Workflow (Wf) es una de las tecnologías que habilita a la Reingeniería de Procesos de Negocios (BPR), la cual ha probado ser el medio óptimo para el mejoramiento de los proceso de negocios.

Research paper thumbnail of Temporal validation of extended workflow processes by means Petri Nets with Clocks

At present the business processes have temporary requirements within their specifications. Logist... more At present the business processes have temporary requirements within their specifications. Logistics, e-commerce, are examples of these, among others. The time involved in business processes is important regarding the interaction of the actors. The sound of the technology involved in building these processes plays a key role in assessing the risk of implementation. The possibility of having technologies with elements for such specifications is vital to accurately model of reality. Workflow (Wf) is the technology of wide acceptance and recognition that can improve business processes. The Wf architecture has the Interface 1, which lets you define process through its processes definition language (PDL), but has no elements to express temporary restrictions of this kind. Our works present a theoretical framework in which there is an extension of the grammar of the WPDL to allow the specification of time variable. It also establishes a correspondence between the PD and its underlying Petri Net with Clocks (PNwC) preserving its semantic. The correspondence is specified by means of the RAISE Specification Language (RSL). The correlation between these formalisms lets you define business process with temporary restrictions validated.

Research paper thumbnail of In Silico Laboratory Experiments using Statistical Model Checking: A new model of the Palytoxin-Induced Pump Channel as Case Study

IEEE/ACM Transactions on Computational Biology and Bioinformatics

Research paper thumbnail of Hypothesized diprotomeric enzyme complex supported by stochastic modelling of palytoxin-induced Na/K pump channels

Royal Society open science, 2018

The sodium-potassium pump (Na/K pump) is crucial for cell physiology. Despite great advances in t... more The sodium-potassium pump (Na/K pump) is crucial for cell physiology. Despite great advances in the understanding of this ionic pumping system, its mechanism is not completely understood. We propose the use of a statistical model checker to investigate palytoxin (PTX)-induced Na/K pump channels. We modelled a system of reactions representing transitions between the conformational substates of the channel with parameters, concentrations of the substates and reaction rates extracted from simulations reported in the literature, based on electrophysiological recordings in a whole-cell configuration. The model was implemented using the UPPAAL-SMC platform. Comparing simulations and probabilistic queries from stochastic system semantics with experimental data, it was possible to propose additional reactions to reproduce the single-channel dynamic. The probabilistic analyses and simulations suggest that the PTX-induced Na/K pump channel functions as a diprotomeric complex in which protein-...

Research paper thumbnail of Business process modeling using petri nets with clocks

Petri Nets are tools for the analysis and design of concurrent systems. There is a formal theory,... more Petri Nets are tools for the analysis and design of concurrent systems. There is a formal theory, which supports Petri Nets. We propose Petri Nets with Clocks which has a high expressive power in the concurrent and asynchronous process modeling and gives the possibility to model real time systems. The Petri Nets with Clocks are useful to model systems with temporal requirements via specification of clocks, using temporal invariants for the places and temporal conditions in the transitions. Also, we have developed an algorithm for the analysis of Petri Nets with Clocks. For the Business Processes Modeling, we propose to use Petri Nets with Clocks to formalize models, allowing to study the models through a quantitative and qualitative analysis. Petri Nets with Clocks includes additional temporal elements-clocks-, which are appropriate for the Business Processes Modeling and are not taken into consideration in the literature concerning the extensions of Petri Nets with time. Petri Nets with Clocks allows studying the structural properties of Business Processes Modeling. This study not only allows the simulation but also verifies formally the model. It is oriented to the verification and correction of errors in the modeling of the time variable en Business Processes.

Research paper thumbnail of Marco teórico para la traducción de procesos workflow extendido a redes de Petri con relojes

Resumen Workflow (Wf) es una de las tecnologías que habilita a la Reingeniería de Procesos de Neg... more Resumen Workflow (Wf) es una de las tecnologías que habilita a la Reingeniería de Procesos de Negocios (BPR), la cual ha probado ser el medio óptimo para el mejoramiento de los proceso de negocios.