Ashish Diwan | The University of New South Wales (original) (raw)

Papers by Ashish Diwan

European Spine Journal, Sep 16, 2019

BMC Musculoskeletal Disorders, Aug 16, 2018

Frontiers in Surgery, Sep 21, 2022

Indian Journal of Orthopaedics, Apr 1, 2014

International Journal of Surgery Case Reports, Aug 1, 2023

Orthopaedic Proceedings, Sep 1, 2009

Introduction: Lumbar Total Disc Replacement (TDR) is an accepted treatment for recalcitrant Chron... more Introduction: Lumbar Total Disc Replacement (TDR) is an accepted treatment for recalcitrant Chronic Discogenic Low Back Pain. However, no studies have compared Lumbar TDR to non-operative intervention. The aim of this study was to investigate the two-year outcomes for con-current cohorts of chronic discogenic low back pain patients undergoing either Lumbar TDR or novel non-operative care. Methods: Data for the TDR cohort was from prospectively collected data of patients who had undergone Prodisc II lumbar TDR during August 2003 to December 2005. Two-year data for the non-operative cohort was collected prospectively from 880 sequential patients who underwent non-operative intervention between January to December 2005 and who met the inclusion and exclusion criteria. Inclusion criteria: age >20 and 6 months, had failed non-operative intervention. Exclusion criteria were: previous lumbar surgery, listhesis, facet disease, osteoporosis, pregnancy, red flag conditions, or poor command of English. Additional non-operative inclusion criteria were: attended a minimum of 3 non-operative sessions, completed the entry questionnaire. Novel non-operative care consisted of a cognition-driven motor relearning intervention, aimed at altering provocative movements and postures and reintegrating these alterations into daily life. Manual therapy and spinal injections were used as an adjunct where needed. Pre-treatment and two-year follow-up data for the following outcomes were collated from a modified NASS questionnaire: back/leg pain, activity limitation, and global perceived improvement. Data was expressed as mean difference with 95% confidence intervals for the difference between the means. Student-t test and paired student-t test were used to assess between group and within group differences. Results: 16 patients (9 males) were identified in the lumbar TDR cohort with median age 43 years (29–57) and median duration of symptoms of 3.5 years (0.5–24). 16 patients (9 males) were also identified in the non-operative cohort with median age of 42 years (24–61) and median duration of symptoms of 2.5 years (0.5–24). There were no cross-overs, however one patient in the TDR cohort had previously undergone the non-operative care regime. There were no significant pre-treatment differences observed in age, sex, duration of symptoms and back pain intensity between cohorts. However, significant pre-treatment differences were observed with 25% greater leg pain and 25% greater activity limitation score in the TDR cohort when compared to the non-operative cohort. Following Lumbar TDR the mean differences at two years for back pain, leg pain and activity limitation favoured improvements of 3.6(2 to 5.1) and 3.4(1.8 to 4.9) and 30.5%(19.2–41.8) respectively when compared to pre-treatment. Similar improvements were observed for the non-operative cohort with 5.0(3.7–6.3), 2.8 (0.7–5.0) and 20.9%(9.4–32.4) for back pain, leg pain and activity limitation respectively. 71% of Lumbar TDR patients and 67% of Non-operative patients reported their relief of symptoms as exceeding 60% at the two-year follow-up. Discussion: The data suggests that prior to treatment, patients undergoing lumbar TDR were worse off in activity limitation and leg pain than the non-operative cohort. However, improvements in back pain, leg pain, and activity limitation are clinically significant at two-year follow-up with either Prodisc II-L TDR or novel non-operative care for chronic discogenic low back pain patients. Clinically, it may be reasonable to offer patients with lesser leg pain intensity and activity limitation ongoing non-operative care. This level 3 evidence needs to be supported with more case cohorts or an otherwise ethically difficult to conduct RCT.

Introduction: Cranio-cervical instability (CCI) is a condition commonly found in patients with co... more Introduction: Cranio-cervical instability (CCI) is a condition commonly found in patients with connective tissue disorders such as Ehlers-Danlos Syndrome (EDS), leading to various symptoms. Assessing patients for surgical fusion as a treatment for CCI is challenging due to the complex nature of EDS-related symptoms. This study aimed to evaluate the role of pre-fusion Halo traction in alleviating symptoms and determining suitable candidates for fusion surgeries. Methods: A case series of 15 EDS patients with neurological symptoms underwent halo traction between 2019 and 2022. Patients completed a CCI Questionnaire before and after the traction, reporting symptoms related to headache, vision, hearing, equilibrium, and performance. Symptom groups were assigned scores based on patient responses, with one point for each affirmative answer. The scores were statistically analyzed using a paired t-test. Patients experiencing over 50% improvement in the majority of symptoms were considered f...

BACKGROUND Routine check-ups for adolescent idiopathic scoliosis are critical to monitor progress... more BACKGROUND Routine check-ups for adolescent idiopathic scoliosis are critical to monitor progression and prescribe interventions. AIS is primarily screened via physical examination. If there are features of deformity, radiographs are necessary for diagnosis or follow-up, guiding further management, i.e., bracing corrections for moderate deformities and spine surgeries for severe deformities. However, this subjects children to repetitive radiation and routine practices can be disturbed. OBJECTIVE We aim to develop and prospectively validate an open mobile platform powered by validated deep learning models known as ScolioNets, for AIS severity and curve type classifications as well as progression identifications, to facilitate timely management of AIS with no extra radiation exposure. METHODS During the technology development stage, ScolioNets was trained and validated by 1780 back photos, consisting of heterogeneous severities and curve types. The ground truth (GT) labels for severit...

Frontiers in Bioengineering and Biotechnology, 2022

Intervertebral disc degeneration (IDD) is the main cause of low back pain, and little is known ab... more Intervertebral disc degeneration (IDD) is the main cause of low back pain, and little is known about its molecular and pathological mechanisms. According to reports, excessive compression is a high-risk factor for IDD; compressive stress can induce oxidative stress in nucleus pulposus (NP) cells during IDD progression that, in turn, promotes cell apoptosis and extracellular matrix (ECM) degradation. Currently, NP tissue engineering is considered a potential method for IDD treatment. However, after transplantation, NP cells may experience oxidative stress and induce apoptosis and ECM degradation due to compressive stress. Therefore, the development of strategies to protect NP cells under excessive compressive stress, including pretreatment of NP cells with antioxidants, has important clinical significance. Among the various antioxidants, bardoxolone methyl (BARD) is used to protect NP cells from damage caused by compressive stress. Our results showed that BARD can protect the viabili...

Introduction Intervertebral disc degeneration may cause chronic low back pain. Disc degeneration ... more Introduction Intervertebral disc degeneration may cause chronic low back pain. Disc degeneration is characterized by dysfunctional cells and a decrease in extra-cellular components. Bone marrow derived mononuclear cells are a heterogeneous cell population which contains mesenchymal stem cells. Transplantation of stem cells and progenitor cells may provide a new approach to treat disc degeneration, but it is unclear if transplanted cells can survive and differentiate in the non-vascularized disc. Methods Bone marrow was collected from syngeneic Sprague-Dawley rats and mononuclear cells were isolated. The cells were labelled with a fluorescence dye (Cell Tracker Orange) and suspended in PBS. 10–20μl of the cell suspension (1–2x10 5 cells/disc) was transplanted into coccygeal discs in 12 syngeneic rats. For each rat two discs were cell transplanted and one disc served as control. The rats were sacrificed after 0, 7, 14 or 21 days. For each time point the discs from one animal were save...

Journal of Orthopaedic Research, 2021

Extreme lateral interbody fusion allows for the insertion of a large-footprint interbody cage whi... more Extreme lateral interbody fusion allows for the insertion of a large-footprint interbody cage while maintaining the presence of natural stabilising ligaments and the facets. It is unclear how the load-distribution mechanisms through these structures alters with temporal changes in the bone graft. The aim of this research was to examine the effects of temporal bone graft changes on load-distribution among the cage, graft, and surrounding spinal structures using finite element analysis. Thoracolumbosacral spine computed tomography data from an asymptomatic male subject were segmented into anatomical regions of interest and digitally stitched to generate a surface mesh of the lumbar spine (L1-S1). The interbody cage was inserted into the L4-L5 region during surface meshing. A volumetric mesh was generated and imported into finite element software for pre-processing, running nonlinear static solves, and post-processing. Temporal stiffening was simulated in the graft region with unbonded (Soft Callus, Temporal Stage 1-3, Solid Graft) and bonded (Partial Fusion, Full Fusion) contact. In flexion and extension, cage stress reduced by 20% from the soft callus to solid graft state. Force on the graft was directly related to its stiffness, and load-share between the cage and graft improved with increasing graft stiffness, regardless of whether contact was fused with the endplates. Fused contact between the cage-graft complex and the adjacent endplates shifted load-distribution pathways from the ligaments and facets to the implant, however these changes did not extend to adjacent levels. These results suggest that once complete fusion is achieved, the existing load paths are seemingly diminished. This article is protected by copyright. All rights reserved.