S M Zahid Hosen | The University of New South Wales (original) (raw)

Papers by S M Zahid Hosen

Kalanchoe pinnata (Family: Crassulaceae) is an important plant which has many traditional medicin... more Kalanchoe pinnata (Family: Crassulaceae) is an important plant which has many traditional medicinal uses. The main objective of this literature review was to give advance information for the drug discovery research for K. pinnata. It was found that this plant showed various pharmacological activities such as anthelmentic, immunosuppressive, wound healing, hepatoprotective, antinociceptive, anti-inflammatory and antidiabetic, nephroprotective, antioxidant activity, antimicrobial activity, analgesic, anticonvulsant, neuropharmacological and antipyretic. Anthelmentic activity was found due to the presence of tannins of the extract of K. pinnata and steroid glycosides such as bufadienolide showed wound healing activity. It was also found that the different flavonoids, polyphenols, triterpenoids and other chemical constituents of the plant were responsible for the antinociceptive, anti-inflammatory and antidiabetic properties. Quercetin had a marked protective effect on cadmium-induced n...

International Journal, 2012

Page 1. International Journal of Pharmacy Teaching & Practices 2012, Vol.3, Issue 1, 191-195.... more Page 1. International Journal of Pharmacy Teaching & Practices 2012, Vol.3, Issue 1, 191-195. 191 An Ontological Cluster on Bangladeshi and Indian Pharmaceutical Courses: Basics to Advances Dibyajyoti Saha*1, Subrata ...

Abstract: Cyclooxygenase-2 (COX-2) catalyzed synthesis of prostaglandin E2 and it associates with... more Abstract: Cyclooxygenase-2 (COX-2) catalyzed synthesis of prostaglandin E2 and it associates with tumor growth, infiltration, and metastasis in preclinical experiments. Known inhibitors against COX-2 exhibit toxicity. Therefore, it is of interest to screen natural compounds like flavanoids against COX-2. Molecular docking using 12 known flavanoids against COX-2 by FlexX and of ArgusLab were performed. All compounds showed a favourable binding energy of >-10 KJ/mol in FlexX and > -8 kcal/mol in ArgusLab. However, this data requires in vitro and in vivo verification for further consideration.

Journal of biomolecular structure & dynamics, 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the most cryptic pandemic outbreak ... more Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the most cryptic pandemic outbreak of the 21st century, has gripped more than 1.8 million people to death and infected almost eighty six million. As it is a new variant of SARS, there is no approved drug or vaccine available against this virus. This study aims to predict some promising cytotoxic T lymphocyte epitopes in the SARS-CoV-2 proteome utilizing immunoinformatic approaches. Firstly, we identified 21 epitopes from 7 different proteins of SARS-CoV-2 inducing immune response and checked for allergenicity and conservancy. Based on these factors, we selected the top three epitopes, namely KAYNVTQAF, ATSRTLSYY, and LTALRLCAY showing functional interactions with the maximum number of MHC alleles and no allergenicity. Secondly, the 3D model of selected epitopes and HLA-A*29:02 were built and Molecular Docking simulation was performed. Most interestingly, the best two epitopes predicted by docking are part of two different...

Mini-Reviews in Medicinal Chemistry, 2021

Ziziphus oenoplia Mill. (Family- Rhamnaceae) an important shrub, often found throughout the hot r... more Ziziphus oenoplia Mill. (Family- Rhamnaceae) an important shrub, often found throughout the hot regions of tropical Asia and northern Australia, is commonly well known as Jackal Jujube in English. It is a folk herbal medicine used as an abdominal pain killer and anti-diarrhoeal agent,. The review aims to provide up-to-date information on the vernacular information, botanical characterization, distribution, ethnopharmacological uses, pharmacological activities, and chemical constituents of Z. oenoplia for possible exploitation of treatment for various diseases and to suggest future investigations. This review was performed by studying online resources relating to Z. oenoplia and diverse resources, including scientific journals, books, and worldwide accepted databases from which information was assembled to accumulate significant information and relevant data at one place. Investigations on Z. oenoplia have been focused on its pharmacological activities, including its antimicrobial, a...

Research Journal of Pharmacy and Technology, 2012

A clinically relevant drug-drug interaction (DDI) occurs when the effectiveness or toxicity of on... more A clinically relevant drug-drug interaction (DDI) occurs when the effectiveness or toxicity of one medication is altered by the administration of another medicine or a substance that is administered for medical purposes (to be distinguished from drug-food interactions). Adverse consequences of DDIs may result from either diminished therapeutic effect or toxicity. Among the various types of medical errors, the occurrence of adverse DDIs is one that is usually preventable. It is therefore essential that health professionals be able to evaluate the potential for DDIs and, when detected, to determine appropriate prevention or management strategies. In this study a patient drugs profile with multiple complicacies were evaluated for drug-drug interaction presence. Some drug-drug interactions were found moderate to severe level among the drugs taken by patient. Clopidogrel/Atorvastatin and Clopidogrel /proton-pump inhibitor interaction were the noticeable found- which should be taken in to...

Background: The prognosis of several malignancies is associated with blood groups ABOs, however, ... more Background: The prognosis of several malignancies is associated with blood groups ABOs, however, the mechanisms still remain unknown. The study was designed to explore the possible association among the esophageal cancer, as well as stomach, colon, rectum and liver cancer with blood groups ABO and Rh factors in Bangladeshi populations. Methods: The data of age, gender, ABO and Rh blood group type of cancer patients were collected from Chittagong medical college and from different oncologist chamber. The study sample consisted of 88 liver cancer,178 stomach cancer,125 colon cancer,45 rectum cancer,109 esophagus cancer and 1024 healthy male and female controls were assessed for the association with ABO blood groups. For statistical analysis, Chi-square test was used to assess the relationship between ABO blood groups and oral cancer, where the probability level was fixed at ≤0.05.Results: High incidence of stomach, rectum and liver cancer patients is associated with blood type A and...

The analgesic potential of Leea indica (Burm. f.) Merr., a Bangladeshi tribal medicinal plant was... more The analgesic potential of Leea indica (Burm. f.) Merr., a Bangladeshi tribal medicinal plant was studied for the first time. Despite the progress that has occured in recent years in the development of therapy, there is still a need for effective and potent analgesics, especially for the treatment of chronic pain. One of the most important analgesic drugs employed in clinical practice today continues to be the alkaloid morphine. Analgesic potential of L. indica was evaluated for centrally acting analgesic property using formalin induced licking response model and peripheral pharmacological actions using acetic acid-induced writhing test. In acetic acid-induced writhing test, ethanolic extracts at 200 mg/kg dose exhibited significant (p<0.05) reduction of writhing response in a dose dependent manner; in formalin induced licking response model a significant (p < 0.05 0.001) result was comparable to the standard drug diclofenac sodium. From the results it was concluded that both ...

The present research was conducted to investigate the analgesic activity of methanol extracts of ... more The present research was conducted to investigate the analgesic activity of methanol extracts of plants of Acorus calamus (Family: Acoraceae) and Oroxylum indicum (Family: Bignoniaceae). The analgesic activity of the methanolic extract of the Acorus calamus and Oroxylum indicum at the dose of 250 and 500 mg/kg body weight was evaluated against the standard drug Diclofenac sodium, at a dose of 25 mg/kg body weight. Adult swiss albino mice of either sex of five numbers in each group, was undertaken for study and evaluated by acetic acid induced writhing method. The methanol extract of Acorus calamus inhibited writhing reflex by 30.77% and 39.86% at the dose of 250 and 500 mg/kg body weight, respectively while the methanolic extract of Oroxylum indicum inhibited writhing reflex by 26.22% and 36.36% at the dose of 250 and 500 mg/kg body weight. The methanolic extract of Acorus calamus was found to be more active than Oroxylum indicum as a pain killer.

Kalanchoe pinnata (Family: Crassulaceae) is an important plant which has many traditional medicin... more Kalanchoe pinnata (Family: Crassulaceae) is an important plant which has many traditional medicinal uses. The main objective of this literature review was to give advance information for the drug discovery research for K. pinnata. It was found that this plant showed various pharmacological activities such as anthelmentic, immunosuppressive, wound healing, hepatoprotective, antinociceptive, anti-inflammatory and antidiabetic, nephroprotective, antioxidant activity, antimicrobial activity, analgesic, anticonvulsant, neuropharmacological and antipyretic. Anthelmentic activity was found due to the presence of tannins of the extract of K. pinnata and steroid glycosides such as bufadienolide showed wound healing activity. It was also found that the different flavonoids, polyphenols, triterpenoids and other chemical constituents of the plant were responsible for the antinociceptive, anti-inflammatory and antidiabetic properties. Quercetin had a marked protective effect on cadmium-induced n...

Medicinal Chemistry

Aims: One of the most important resources for the development of new drugs is a biologically acti... more Aims: One of the most important resources for the development of new drugs is a biologically active lead compound from natural sources. Biomedical researchers and pharmaceutical companies have a high interest in plant-derived molecules that can be used for drug development. Background: The collective knowledge of plants and their phytoconstituents would be of great benefit for the researchers involved in drug design. Therefore, we developed a unique and dynamic database GreenMolBD, to provide collective information of medicinal plants such as their individual profile, chemical constituents and pharmacological evidence, along with their plant parts and extract types based on different studies. Objective: We have also provided a complete profile of each compound, their physical, quantum, drug-likeliness, and toxicity properties (48 type’s descriptor) using in silico tools. Method: 1846 associated targets, related to individual compounds that are already explored in different studies, ...

Ayurvedic formulations were amalgamation of various herbs used to cure various lifestyle diseases... more Ayurvedic formulations were amalgamation of various herbs used to cure various lifestyle diseases. The secret of the natural health is based on the laws of ayurveda and on standardization of ayurvedic formulation that were well documented in the great treatises. These ayurvedic herbal formulations were processed under the most hygienic condition and were available in vacuum-sealed packaging in different quantities. Digestion is the mechanical and chemical breakdown of food into smaller components that were more easily absorbed into a blood stream, for instance. Digestion is a form of catabolism; a breakdown of large food molecules to smaller ones.The present study on ayurvedic formulation for digestive purpose will improve the motivation of the use of the medicinal herbs assets in the new form of formulation and also will serve as the research for new digestive ayurvedic formulation.The folk application of the herbs may be helpful for finding their proper pharmaceutical applications.

Drug Bank plays a vital role in the research of bioinformatics/chemo informatics. Drug bank is a ... more Drug Bank plays a vital role in the research of bioinformatics/chemo informatics. Drug bank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action information. Since its first release in the 2006, Drug Bank has been widely used to facilitate, in silico drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction and general pharmacological education. First drug bank was released in 2006 with version 1.0. Now it is successfully updated by the releasing of 2.0, 2.5 and 3.0 version. First released in 2006, Drug Bank has become widely used by pharmacists, medicinal chemists, pharmaceutical researchers, clinicians, educators and the general public. The database contains 6707 drug entries including 1436 FDA-approved small molecule drugs, 134 FDA-approved biotech (protein/peptide) drugs, 83 nutraceuticals and 5086 experimental drugs. Additionally, 4228 non-redundant protein (i....

The antioxidant activity of ethanolic extract of Cassia hirsuta (Family-Caesalpiniaceae) leaves h... more The antioxidant activity of ethanolic extract of Cassia hirsuta (Family-Caesalpiniaceae) leaves has been investigated in the present study. The antioxidant activity of the Cassia hirsuta leaves ethanolic extract was assessed by DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radical scavenging method. Extract showed significant DPPH free radical scavenging effect compared with standard antioxidant ascorbic acid. IC50 value of ascorbic acid and leaves extract was found 1.25 μg/ml and 200.96 μg/ml, respectively. The value of extract indicated significant antioxidant activity of the plant.

An in vitro thrombolytic model was used to check the clot lysis effect of four herbal extracts vi... more An in vitro thrombolytic model was used to check the clot lysis effect of four herbal extracts viz., Honey, Nigella sativa, Capsicum frutescens, Brassica oleracea, combination of Honey & Nigella sativa and Honey & Capsicum frutescens along with Streptokinase as a positive control and water as a negative control. And also brine shrimp lethality bio-assay was done using brine shrimp Nauplii and 5% of DMSO as a solvent for the ethanol extracts of Nigella sativa & Capsicum frutescens and Honey. Using an in vitro thrombolytic model, Honey, Nigella sativa, Capsicum frutescens, Brassica oleracea, combination of Honey & Nigella sativa and Honey & Capsicum frutescens showed 26.82%, 47.13%, 57.40%, 62.44%, 56.58% and 44.54% clot lysis effect respectively. From our study we found that Brassica oleracea, Capsicum frutescens, and combination of Honey & Nigella sativa showed significant % of clot lysis effect with reference to Streptokinase. Again from in vitro brine shrimp lethality bio-assay, w...

The aim of this literature review was to provide advance research information for the future scie... more The aim of this literature review was to provide advance research information for the future scientists to discover new drug molecules from the medicinal plant, Moringa oleifera Lam. (Moringaceae). The plant provides a rich and rare combination of zeatin, quercetin, beta-sitosterol and kaempferol. In addition to its high nutritional value, Moringa oleifera Lam is very important for its medicinal value. Various parts of this plant such as leaves, roots, seed, bark, fruit, flowers and immature pods act as cardiac and circulatory stimulants, possess antitumor, antipyretic, anti-inflammatory, antiulcer, antispasmodic, diuretic, antihypertensive, cholesterol lowering, antioxidant, antidiabetic, hepatoprotective, antibacterial and antifungal activities, and are being employed for the treatment of different ailments in the indigenous system of medicine. This review gives the scientific information regarding pharmacological potentials of Moringa oleifera Lam. (Moringaceae). INTRODUCTION: Mo...

Computational Biology and Chemistry

Molecules

Inflammation plays an important role in different chronic diseases. Brominated indoles derived fr... more Inflammation plays an important role in different chronic diseases. Brominated indoles derived from the Australian marine mollusk Dicathais orbita (D. orbita) are of interest for their anti-inflammatory properties. This study evaluates the binding mechanism and potentiality of several brominated indoles (tyrindoxyl sulfate, tyrindoleninone, 6-bromoisatin, and 6,6′-dibromoindirubin) against inflammatory mediators cyclooxygenases-1/2 (COX-1/2) using molecular docking, followed by molecular dynamics simulation, along with physicochemical, drug-likeness, pharmacokinetic (pk), and toxicokinetic (tk) properties. Molecular docking identified that these indole compounds are anchored, with the main amino acid residues, positioned in the binding pocket of the COX-1/2, required for selective inhibition. Moreover, the molecular dynamics simulation based on root mean square deviation (RMSD), radius of gyration (Rg), solvent accessible surface area (SASA), and root mean square fluctuation (RMSF) ...

Kalanchoe pinnata (Family: Crassulaceae) is an important plant which has many traditional medicin... more Kalanchoe pinnata (Family: Crassulaceae) is an important plant which has many traditional medicinal uses. The main objective of this literature review was to give advance information for the drug discovery research for K. pinnata. It was found that this plant showed various pharmacological activities such as anthelmentic, immunosuppressive, wound healing, hepatoprotective, antinociceptive, anti-inflammatory and antidiabetic, nephroprotective, antioxidant activity, antimicrobial activity, analgesic, anticonvulsant, neuropharmacological and antipyretic. Anthelmentic activity was found due to the presence of tannins of the extract of K. pinnata and steroid glycosides such as bufadienolide showed wound healing activity. It was also found that the different flavonoids, polyphenols, triterpenoids and other chemical constituents of the plant were responsible for the antinociceptive, anti-inflammatory and antidiabetic properties. Quercetin had a marked protective effect on cadmium-induced n...

International Journal, 2012

Page 1. International Journal of Pharmacy Teaching & Practices 2012, Vol.3, Issue 1, 191-195.... more Page 1. International Journal of Pharmacy Teaching & Practices 2012, Vol.3, Issue 1, 191-195. 191 An Ontological Cluster on Bangladeshi and Indian Pharmaceutical Courses: Basics to Advances Dibyajyoti Saha*1, Subrata ...

Abstract: Cyclooxygenase-2 (COX-2) catalyzed synthesis of prostaglandin E2 and it associates with... more Abstract: Cyclooxygenase-2 (COX-2) catalyzed synthesis of prostaglandin E2 and it associates with tumor growth, infiltration, and metastasis in preclinical experiments. Known inhibitors against COX-2 exhibit toxicity. Therefore, it is of interest to screen natural compounds like flavanoids against COX-2. Molecular docking using 12 known flavanoids against COX-2 by FlexX and of ArgusLab were performed. All compounds showed a favourable binding energy of >-10 KJ/mol in FlexX and > -8 kcal/mol in ArgusLab. However, this data requires in vitro and in vivo verification for further consideration.

Journal of biomolecular structure & dynamics, 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the most cryptic pandemic outbreak ... more Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the most cryptic pandemic outbreak of the 21st century, has gripped more than 1.8 million people to death and infected almost eighty six million. As it is a new variant of SARS, there is no approved drug or vaccine available against this virus. This study aims to predict some promising cytotoxic T lymphocyte epitopes in the SARS-CoV-2 proteome utilizing immunoinformatic approaches. Firstly, we identified 21 epitopes from 7 different proteins of SARS-CoV-2 inducing immune response and checked for allergenicity and conservancy. Based on these factors, we selected the top three epitopes, namely KAYNVTQAF, ATSRTLSYY, and LTALRLCAY showing functional interactions with the maximum number of MHC alleles and no allergenicity. Secondly, the 3D model of selected epitopes and HLA-A*29:02 were built and Molecular Docking simulation was performed. Most interestingly, the best two epitopes predicted by docking are part of two different...

Mini-Reviews in Medicinal Chemistry, 2021

Ziziphus oenoplia Mill. (Family- Rhamnaceae) an important shrub, often found throughout the hot r... more Ziziphus oenoplia Mill. (Family- Rhamnaceae) an important shrub, often found throughout the hot regions of tropical Asia and northern Australia, is commonly well known as Jackal Jujube in English. It is a folk herbal medicine used as an abdominal pain killer and anti-diarrhoeal agent,. The review aims to provide up-to-date information on the vernacular information, botanical characterization, distribution, ethnopharmacological uses, pharmacological activities, and chemical constituents of Z. oenoplia for possible exploitation of treatment for various diseases and to suggest future investigations. This review was performed by studying online resources relating to Z. oenoplia and diverse resources, including scientific journals, books, and worldwide accepted databases from which information was assembled to accumulate significant information and relevant data at one place. Investigations on Z. oenoplia have been focused on its pharmacological activities, including its antimicrobial, a...

Research Journal of Pharmacy and Technology, 2012

A clinically relevant drug-drug interaction (DDI) occurs when the effectiveness or toxicity of on... more A clinically relevant drug-drug interaction (DDI) occurs when the effectiveness or toxicity of one medication is altered by the administration of another medicine or a substance that is administered for medical purposes (to be distinguished from drug-food interactions). Adverse consequences of DDIs may result from either diminished therapeutic effect or toxicity. Among the various types of medical errors, the occurrence of adverse DDIs is one that is usually preventable. It is therefore essential that health professionals be able to evaluate the potential for DDIs and, when detected, to determine appropriate prevention or management strategies. In this study a patient drugs profile with multiple complicacies were evaluated for drug-drug interaction presence. Some drug-drug interactions were found moderate to severe level among the drugs taken by patient. Clopidogrel/Atorvastatin and Clopidogrel /proton-pump inhibitor interaction were the noticeable found- which should be taken in to...

Background: The prognosis of several malignancies is associated with blood groups ABOs, however, ... more Background: The prognosis of several malignancies is associated with blood groups ABOs, however, the mechanisms still remain unknown. The study was designed to explore the possible association among the esophageal cancer, as well as stomach, colon, rectum and liver cancer with blood groups ABO and Rh factors in Bangladeshi populations. Methods: The data of age, gender, ABO and Rh blood group type of cancer patients were collected from Chittagong medical college and from different oncologist chamber. The study sample consisted of 88 liver cancer,178 stomach cancer,125 colon cancer,45 rectum cancer,109 esophagus cancer and 1024 healthy male and female controls were assessed for the association with ABO blood groups. For statistical analysis, Chi-square test was used to assess the relationship between ABO blood groups and oral cancer, where the probability level was fixed at ≤0.05.Results: High incidence of stomach, rectum and liver cancer patients is associated with blood type A and...

The analgesic potential of Leea indica (Burm. f.) Merr., a Bangladeshi tribal medicinal plant was... more The analgesic potential of Leea indica (Burm. f.) Merr., a Bangladeshi tribal medicinal plant was studied for the first time. Despite the progress that has occured in recent years in the development of therapy, there is still a need for effective and potent analgesics, especially for the treatment of chronic pain. One of the most important analgesic drugs employed in clinical practice today continues to be the alkaloid morphine. Analgesic potential of L. indica was evaluated for centrally acting analgesic property using formalin induced licking response model and peripheral pharmacological actions using acetic acid-induced writhing test. In acetic acid-induced writhing test, ethanolic extracts at 200 mg/kg dose exhibited significant (p<0.05) reduction of writhing response in a dose dependent manner; in formalin induced licking response model a significant (p < 0.05 0.001) result was comparable to the standard drug diclofenac sodium. From the results it was concluded that both ...

The present research was conducted to investigate the analgesic activity of methanol extracts of ... more The present research was conducted to investigate the analgesic activity of methanol extracts of plants of Acorus calamus (Family: Acoraceae) and Oroxylum indicum (Family: Bignoniaceae). The analgesic activity of the methanolic extract of the Acorus calamus and Oroxylum indicum at the dose of 250 and 500 mg/kg body weight was evaluated against the standard drug Diclofenac sodium, at a dose of 25 mg/kg body weight. Adult swiss albino mice of either sex of five numbers in each group, was undertaken for study and evaluated by acetic acid induced writhing method. The methanol extract of Acorus calamus inhibited writhing reflex by 30.77% and 39.86% at the dose of 250 and 500 mg/kg body weight, respectively while the methanolic extract of Oroxylum indicum inhibited writhing reflex by 26.22% and 36.36% at the dose of 250 and 500 mg/kg body weight. The methanolic extract of Acorus calamus was found to be more active than Oroxylum indicum as a pain killer.

Kalanchoe pinnata (Family: Crassulaceae) is an important plant which has many traditional medicin... more Kalanchoe pinnata (Family: Crassulaceae) is an important plant which has many traditional medicinal uses. The main objective of this literature review was to give advance information for the drug discovery research for K. pinnata. It was found that this plant showed various pharmacological activities such as anthelmentic, immunosuppressive, wound healing, hepatoprotective, antinociceptive, anti-inflammatory and antidiabetic, nephroprotective, antioxidant activity, antimicrobial activity, analgesic, anticonvulsant, neuropharmacological and antipyretic. Anthelmentic activity was found due to the presence of tannins of the extract of K. pinnata and steroid glycosides such as bufadienolide showed wound healing activity. It was also found that the different flavonoids, polyphenols, triterpenoids and other chemical constituents of the plant were responsible for the antinociceptive, anti-inflammatory and antidiabetic properties. Quercetin had a marked protective effect on cadmium-induced n...

Medicinal Chemistry

Aims: One of the most important resources for the development of new drugs is a biologically acti... more Aims: One of the most important resources for the development of new drugs is a biologically active lead compound from natural sources. Biomedical researchers and pharmaceutical companies have a high interest in plant-derived molecules that can be used for drug development. Background: The collective knowledge of plants and their phytoconstituents would be of great benefit for the researchers involved in drug design. Therefore, we developed a unique and dynamic database GreenMolBD, to provide collective information of medicinal plants such as their individual profile, chemical constituents and pharmacological evidence, along with their plant parts and extract types based on different studies. Objective: We have also provided a complete profile of each compound, their physical, quantum, drug-likeliness, and toxicity properties (48 type’s descriptor) using in silico tools. Method: 1846 associated targets, related to individual compounds that are already explored in different studies, ...

Ayurvedic formulations were amalgamation of various herbs used to cure various lifestyle diseases... more Ayurvedic formulations were amalgamation of various herbs used to cure various lifestyle diseases. The secret of the natural health is based on the laws of ayurveda and on standardization of ayurvedic formulation that were well documented in the great treatises. These ayurvedic herbal formulations were processed under the most hygienic condition and were available in vacuum-sealed packaging in different quantities. Digestion is the mechanical and chemical breakdown of food into smaller components that were more easily absorbed into a blood stream, for instance. Digestion is a form of catabolism; a breakdown of large food molecules to smaller ones.The present study on ayurvedic formulation for digestive purpose will improve the motivation of the use of the medicinal herbs assets in the new form of formulation and also will serve as the research for new digestive ayurvedic formulation.The folk application of the herbs may be helpful for finding their proper pharmaceutical applications.

Drug Bank plays a vital role in the research of bioinformatics/chemo informatics. Drug bank is a ... more Drug Bank plays a vital role in the research of bioinformatics/chemo informatics. Drug bank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action information. Since its first release in the 2006, Drug Bank has been widely used to facilitate, in silico drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction and general pharmacological education. First drug bank was released in 2006 with version 1.0. Now it is successfully updated by the releasing of 2.0, 2.5 and 3.0 version. First released in 2006, Drug Bank has become widely used by pharmacists, medicinal chemists, pharmaceutical researchers, clinicians, educators and the general public. The database contains 6707 drug entries including 1436 FDA-approved small molecule drugs, 134 FDA-approved biotech (protein/peptide) drugs, 83 nutraceuticals and 5086 experimental drugs. Additionally, 4228 non-redundant protein (i....

The antioxidant activity of ethanolic extract of Cassia hirsuta (Family-Caesalpiniaceae) leaves h... more The antioxidant activity of ethanolic extract of Cassia hirsuta (Family-Caesalpiniaceae) leaves has been investigated in the present study. The antioxidant activity of the Cassia hirsuta leaves ethanolic extract was assessed by DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radical scavenging method. Extract showed significant DPPH free radical scavenging effect compared with standard antioxidant ascorbic acid. IC50 value of ascorbic acid and leaves extract was found 1.25 μg/ml and 200.96 μg/ml, respectively. The value of extract indicated significant antioxidant activity of the plant.

An in vitro thrombolytic model was used to check the clot lysis effect of four herbal extracts vi... more An in vitro thrombolytic model was used to check the clot lysis effect of four herbal extracts viz., Honey, Nigella sativa, Capsicum frutescens, Brassica oleracea, combination of Honey & Nigella sativa and Honey & Capsicum frutescens along with Streptokinase as a positive control and water as a negative control. And also brine shrimp lethality bio-assay was done using brine shrimp Nauplii and 5% of DMSO as a solvent for the ethanol extracts of Nigella sativa & Capsicum frutescens and Honey. Using an in vitro thrombolytic model, Honey, Nigella sativa, Capsicum frutescens, Brassica oleracea, combination of Honey & Nigella sativa and Honey & Capsicum frutescens showed 26.82%, 47.13%, 57.40%, 62.44%, 56.58% and 44.54% clot lysis effect respectively. From our study we found that Brassica oleracea, Capsicum frutescens, and combination of Honey & Nigella sativa showed significant % of clot lysis effect with reference to Streptokinase. Again from in vitro brine shrimp lethality bio-assay, w...

The aim of this literature review was to provide advance research information for the future scie... more The aim of this literature review was to provide advance research information for the future scientists to discover new drug molecules from the medicinal plant, Moringa oleifera Lam. (Moringaceae). The plant provides a rich and rare combination of zeatin, quercetin, beta-sitosterol and kaempferol. In addition to its high nutritional value, Moringa oleifera Lam is very important for its medicinal value. Various parts of this plant such as leaves, roots, seed, bark, fruit, flowers and immature pods act as cardiac and circulatory stimulants, possess antitumor, antipyretic, anti-inflammatory, antiulcer, antispasmodic, diuretic, antihypertensive, cholesterol lowering, antioxidant, antidiabetic, hepatoprotective, antibacterial and antifungal activities, and are being employed for the treatment of different ailments in the indigenous system of medicine. This review gives the scientific information regarding pharmacological potentials of Moringa oleifera Lam. (Moringaceae). INTRODUCTION: Mo...

Computational Biology and Chemistry

Molecules

Inflammation plays an important role in different chronic diseases. Brominated indoles derived fr... more Inflammation plays an important role in different chronic diseases. Brominated indoles derived from the Australian marine mollusk Dicathais orbita (D. orbita) are of interest for their anti-inflammatory properties. This study evaluates the binding mechanism and potentiality of several brominated indoles (tyrindoxyl sulfate, tyrindoleninone, 6-bromoisatin, and 6,6′-dibromoindirubin) against inflammatory mediators cyclooxygenases-1/2 (COX-1/2) using molecular docking, followed by molecular dynamics simulation, along with physicochemical, drug-likeness, pharmacokinetic (pk), and toxicokinetic (tk) properties. Molecular docking identified that these indole compounds are anchored, with the main amino acid residues, positioned in the binding pocket of the COX-1/2, required for selective inhibition. Moreover, the molecular dynamics simulation based on root mean square deviation (RMSD), radius of gyration (Rg), solvent accessible surface area (SASA), and root mean square fluctuation (RMSF) ...