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Papers by Haitham Lateef Abdulhadi

Research paper thumbnail of Effect of Salvia officinalis and Zingiber officinaler Extracts on Some Physiological and Biochemical Parameters of Mice

Journal for Research in Applied Sciences and Biotechnology, Feb 5, 2023

Research paper thumbnail of Ganoderma Lucidum Attenuates and Prevents CCL4-INDUCED Hepatic and Renal Damage in Sprague -Dawley Rats

Ganoderma lucidum (G. lucidum) is considered to be a medicinal mushroom and it is widely used as ... more Ganoderma lucidum (G. lucidum) is considered to be a medicinal mushroom and it is widely used as anti-oxidants to prevent or treat of different types of diseases including cancer, cardiovascular disease and renal dysfunction. This study aimed to indicate whether G. lucidum could attenuate oxidative stress and prevent Hepatorenal damage. CCl4 was used to induce oxidative stress in adult male of Sprague-Dawley rats (about 8-weeks old, 200-220g weight). Adult rats were randomly divided into four equal groups A, B, C and D. Group A was determined as a control one, group B received daily oral dose of Ganoderma Extract, (600 mg/kg/bw) for 12 weeks, while groups C and D received 0.1ml\100g b.w. of CCl4 (50% in olive oil) via the intraperitoneal route twice a week for 12 weeks, followed by daily oral dose of GAN extract, (600 mg/kg/bw). Blood samples were later collected for biochemical analysis. Liver and Renal Function Tests, such as ALT (alanine transaminase), ALP (alkaline phosphatase) and AST (aspartate aminotransferase), uric acid, creatinine and urea were determined. The current study is also determined the antioxidant enzyme activity, such as malondialdehyde (MDA), catalase (CAT), glutathione (GSH), superoxide dismutase (SOD) and H2O2 induced by CCl4. The results demonstrated that G. lucidum can significantly prevent the CCl4 induced liver and kidney damage.

Research paper thumbnail of The Function of Melatonin Hormone in the Reorganization of the Impact of the Oxidative Stress Induced by Bisphenol a in Hyperlipidemia Along with Diabetes in Serum of Rats

Annals of Tropical Medicine and Public Health, 2020

Environmental pollution had been a reality of life for several centuries however it became a true... more Environmental pollution had been a reality of life for several centuries however it became a true drawback since the beginning of the commercial revolution. Environmental contaminants are shown to induce ROS generation in each intra-and animate thing areas of cells or people resulting in cell death and tissue injury. Chemicals that induce effects by uncomfortable endocrine systems or mimicking endocrine mediators are jointly delineated as endocrine disrupting compounds (EDCs). Bisphenol A, (BPA) (2, 2-bis (4-hydroxyphenyl) propane) is one in every of the world's highest production volume compounds. It a phenolic compound and is wide utilized in the assembly of resins and polycarbonate plastics. Earlier, it's been shown that BPA induced oxidative stress in numerous tissues in human and rats. This study investigates the results of Bisphenol A pollution on Lipids profile, glucose level, antioxidants and therefore the potential pollution protection by melatonin in experimental. The rats received ten mg/kg of internal secretion pursued by 50 mg/kg of Bisphenol A 3 days per week for 6 incontestable increase triglycerides, total cholesterol, LDL and VLDL, illustrate important in cluster treated with BPA for three and 6 weeks cluster. These were related to the enlarged in lipid peroxidation and cut inhibitor glutathione, superoxide dismutase, enzyme activity and increase in malondialdehyde levels. The protection by internal secretion was determined in connection with the rejuvenation of all oxidative parameters within the blood serum, suggesting that internal secretion is employed for management of many diseases, like avoirdupois, diabetes, cancer, and immune and cardiac disorders. It will recapture ROS by its antioxidant qualities and raise antioxidant enzyme activities.

Research paper thumbnail of Punicalagin protects against the development of pancreatic injury and insulitis in rats with induced T1DM by reducing inflammation and oxidative stress

Molecular and Cellular Biochemistry

Research paper thumbnail of Histological Alterations in Leukocytes of Patients suffering Leukemia by Scanning Electron Microscope

Aim of study:Leukemia is known as cancer of white blood cells. This research was performed to enl... more Aim of study:Leukemia is known as cancer of white blood cells. This research was performed to enlighten the ultra-structural changes that occur in leukocytes of the patients who are diagnosed of leukemia in Basra, Iraq. Materials and Methods:Blood was withdrawn from 15 leukemic children who reported to Basra Hospital in the years 20122015. The samples taken were examined by a transmission electron microscopy. Results:The result shows that there were immature leukocytes present with a varied structure as compared to their normal structure. Adherence phenomenon was observed in this group of leukocytes. Conclusions:There was a shift in the rates of leukemia seen in young children in the past couple of years that suggested a strong link between low level radiation (LLR) exposure and leukemia. Key word: Leukemia, Leukocyte, Ultra structural INTRODUCTION Basra is known to be the second largest city of Iraq. Being the second largest city, faces a large chunk of air pollution. It has faced ...

Research paper thumbnail of Evaluation of Antioxidant and Antimicrobial Activities of Torularhodin

Advanced Science Letters, 2012

Research paper thumbnail of Cardioameliorative effect of punicalagin against streptozotocin-induced apoptosis, redox imbalance, metabolic changes and inflammation

Egyptian Journal of Basic and Applied Sciences, 2015

View related articles View Crossmark data Citing articles: 1 View citing articles Full Length Art... more View related articles View Crossmark data Citing articles: 1 View citing articles Full Length Article Cardioameliorative effect of punicalagin against streptozotocin-induced apoptosis, redox imbalance, metabolic changes and inflammation

Research paper thumbnail of Histological Alterations in Leukocytes of Patients suffering Leukemia by Scanning Electron Microscope

Aim of study:Leukemia is known as cancer of white blood cells. This research was performed to enl... more Aim of study:Leukemia is known as cancer of white blood cells. This research was performed to enlighten the ultra-structural changes that occur in leukocytes of the patients who are diagnosed of leukemia in Basra, Iraq. Materials and Methods:Blood was withdrawn from 15 leukemic children who reported to Basra Hospital in the years 2012-2015. The samples taken were examined by a transmission electron microscopy. Results:The result shows that there were immature leukocytes present with a varied structure as compared to their normal structure. Adherence phenomenon was observed in this group of leukocytes. Conclusions:There was a shift in the rates of leukemia seen in young children in the past couple of years that suggested a strong link between low level radiation (LLR) exposure and leukemia.

Research paper thumbnail of Evaluation of Antioxidant and Antimicrobial Activities of Euphorbia terracina L. from Deltaic Mediterranean Coast, Egypt

The importance of medicinal plants and traditional health systems in solving the health care prob... more The importance of medicinal plants and traditional health systems in solving the health care problems of the world is gaining increasing attention. The main aim of this study is to evaluate antimicrobial and antioxidant activities of Euphorbia terracina L. (family Euphorbiaceae) is short-lived perennial herb, up to 80 cm tall. It was collected from northern sector of Nile Delta at the period of May 2015. Different extracts of Euphorbia terracina, were screened for their antimicrobial activity against nine pathogenic bacterial and one fungal strain using filter paper disc assay. The antimicrobial activity was significantly variable according to the solvent used. Hexane extract was found to be the most effective against most tested organisms followed by methanol extract showed the inhibitory activities against Proteus vulgaris (inhibition zones = 9.3 mm), Petroleum ether and ethyl acetate extracts exhibited most antimicrobial against Staphylococcus aureus (inhibition zone = 10 mm, each). Antioxidant activity was screened using DPPH scavenging activity. Ethyl acetate extract was found to be the most effective (IC50 = 1.23 mg/mL). Preliminary phytochemical screening on methanol extract showed variations in active secondary compounds. Saponins were found to be the richest one in this regard (39.17±1.3 mg/g D.W.) and total phenolics were estimated 22.11±0.9 mg/g D.W.

Research paper thumbnail of Cardioameliorative effect of punicalagin against streptozotocin-induced apoptosis, redox imbalance, metabolic changes and inflammation

e g y p t i a n j o u r n a l o f b a s i c a n d a p p l i e d s c i e n c e s , 2015

The effect of punicalagin on metabolic risks, oxidative stress, inflammation, cardiac apopto-sis ... more The effect of punicalagin on metabolic risks, oxidative stress, inflammation, cardiac apopto-sis and histopathological alterations in experimentally induced diabetes was addressed. Diabetes was induced in male rats by a single injection of streptozotocin (STZ; 40 mg/kg, i.p.), and then punicalagin (1 mg/kg) was i.p. administered every other day for 15 days. The diabetic rats treated with punicalagin exhibited ameliorated hyperglycemia and HbA1c; improved insulin levels, HOMA-IR levels and lipid profiles; and normalized levels of IL-1b, IL-6 and TNF-α. Punicalagin also reduced the increase in the MDA and H2O2 levels; normalized the levels of GSH, SOD and CAT in the heart; and improved serum markers of heart function including the levels of tro-ponin T level and CK-MB and LDH activities. Histopathological examinations of heart sections match these results, confirming the beneficial effect of punicalagin. It also modulated cardiomyocyte apoptosis via enhanced Bcl-2 expression; blocked the increases in P53, Bax and caspases-3, 8 and 9; and ameliorated DNA damage in the heart. The current results suggest that punicalagin protected the heart against apoptosis, necrosis, inflammation and DNA damage by improving the redox state, suppressing caspases and P53 and increasing Bcl-2. In conclusion , punicalagin possesses strong therapeutic potential in treating and regulating diabetes and attenuating its associated complications in the heart.

Research paper thumbnail of Effect of Salvia officinalis and Zingiber officinaler Extracts on Some Physiological and Biochemical Parameters of Mice

Journal for Research in Applied Sciences and Biotechnology, Feb 5, 2023

Research paper thumbnail of Ganoderma Lucidum Attenuates and Prevents CCL4-INDUCED Hepatic and Renal Damage in Sprague -Dawley Rats

Ganoderma lucidum (G. lucidum) is considered to be a medicinal mushroom and it is widely used as ... more Ganoderma lucidum (G. lucidum) is considered to be a medicinal mushroom and it is widely used as anti-oxidants to prevent or treat of different types of diseases including cancer, cardiovascular disease and renal dysfunction. This study aimed to indicate whether G. lucidum could attenuate oxidative stress and prevent Hepatorenal damage. CCl4 was used to induce oxidative stress in adult male of Sprague-Dawley rats (about 8-weeks old, 200-220g weight). Adult rats were randomly divided into four equal groups A, B, C and D. Group A was determined as a control one, group B received daily oral dose of Ganoderma Extract, (600 mg/kg/bw) for 12 weeks, while groups C and D received 0.1ml\100g b.w. of CCl4 (50% in olive oil) via the intraperitoneal route twice a week for 12 weeks, followed by daily oral dose of GAN extract, (600 mg/kg/bw). Blood samples were later collected for biochemical analysis. Liver and Renal Function Tests, such as ALT (alanine transaminase), ALP (alkaline phosphatase) and AST (aspartate aminotransferase), uric acid, creatinine and urea were determined. The current study is also determined the antioxidant enzyme activity, such as malondialdehyde (MDA), catalase (CAT), glutathione (GSH), superoxide dismutase (SOD) and H2O2 induced by CCl4. The results demonstrated that G. lucidum can significantly prevent the CCl4 induced liver and kidney damage.

Research paper thumbnail of The Function of Melatonin Hormone in the Reorganization of the Impact of the Oxidative Stress Induced by Bisphenol a in Hyperlipidemia Along with Diabetes in Serum of Rats

Annals of Tropical Medicine and Public Health, 2020

Environmental pollution had been a reality of life for several centuries however it became a true... more Environmental pollution had been a reality of life for several centuries however it became a true drawback since the beginning of the commercial revolution. Environmental contaminants are shown to induce ROS generation in each intra-and animate thing areas of cells or people resulting in cell death and tissue injury. Chemicals that induce effects by uncomfortable endocrine systems or mimicking endocrine mediators are jointly delineated as endocrine disrupting compounds (EDCs). Bisphenol A, (BPA) (2, 2-bis (4-hydroxyphenyl) propane) is one in every of the world's highest production volume compounds. It a phenolic compound and is wide utilized in the assembly of resins and polycarbonate plastics. Earlier, it's been shown that BPA induced oxidative stress in numerous tissues in human and rats. This study investigates the results of Bisphenol A pollution on Lipids profile, glucose level, antioxidants and therefore the potential pollution protection by melatonin in experimental. The rats received ten mg/kg of internal secretion pursued by 50 mg/kg of Bisphenol A 3 days per week for 6 incontestable increase triglycerides, total cholesterol, LDL and VLDL, illustrate important in cluster treated with BPA for three and 6 weeks cluster. These were related to the enlarged in lipid peroxidation and cut inhibitor glutathione, superoxide dismutase, enzyme activity and increase in malondialdehyde levels. The protection by internal secretion was determined in connection with the rejuvenation of all oxidative parameters within the blood serum, suggesting that internal secretion is employed for management of many diseases, like avoirdupois, diabetes, cancer, and immune and cardiac disorders. It will recapture ROS by its antioxidant qualities and raise antioxidant enzyme activities.

Research paper thumbnail of Punicalagin protects against the development of pancreatic injury and insulitis in rats with induced T1DM by reducing inflammation and oxidative stress

Molecular and Cellular Biochemistry

Research paper thumbnail of Histological Alterations in Leukocytes of Patients suffering Leukemia by Scanning Electron Microscope

Aim of study:Leukemia is known as cancer of white blood cells. This research was performed to enl... more Aim of study:Leukemia is known as cancer of white blood cells. This research was performed to enlighten the ultra-structural changes that occur in leukocytes of the patients who are diagnosed of leukemia in Basra, Iraq. Materials and Methods:Blood was withdrawn from 15 leukemic children who reported to Basra Hospital in the years 20122015. The samples taken were examined by a transmission electron microscopy. Results:The result shows that there were immature leukocytes present with a varied structure as compared to their normal structure. Adherence phenomenon was observed in this group of leukocytes. Conclusions:There was a shift in the rates of leukemia seen in young children in the past couple of years that suggested a strong link between low level radiation (LLR) exposure and leukemia. Key word: Leukemia, Leukocyte, Ultra structural INTRODUCTION Basra is known to be the second largest city of Iraq. Being the second largest city, faces a large chunk of air pollution. It has faced ...

Research paper thumbnail of Evaluation of Antioxidant and Antimicrobial Activities of Torularhodin

Advanced Science Letters, 2012

Research paper thumbnail of Cardioameliorative effect of punicalagin against streptozotocin-induced apoptosis, redox imbalance, metabolic changes and inflammation

Egyptian Journal of Basic and Applied Sciences, 2015

View related articles View Crossmark data Citing articles: 1 View citing articles Full Length Art... more View related articles View Crossmark data Citing articles: 1 View citing articles Full Length Article Cardioameliorative effect of punicalagin against streptozotocin-induced apoptosis, redox imbalance, metabolic changes and inflammation

Research paper thumbnail of Histological Alterations in Leukocytes of Patients suffering Leukemia by Scanning Electron Microscope

Aim of study:Leukemia is known as cancer of white blood cells. This research was performed to enl... more Aim of study:Leukemia is known as cancer of white blood cells. This research was performed to enlighten the ultra-structural changes that occur in leukocytes of the patients who are diagnosed of leukemia in Basra, Iraq. Materials and Methods:Blood was withdrawn from 15 leukemic children who reported to Basra Hospital in the years 2012-2015. The samples taken were examined by a transmission electron microscopy. Results:The result shows that there were immature leukocytes present with a varied structure as compared to their normal structure. Adherence phenomenon was observed in this group of leukocytes. Conclusions:There was a shift in the rates of leukemia seen in young children in the past couple of years that suggested a strong link between low level radiation (LLR) exposure and leukemia.

Research paper thumbnail of Evaluation of Antioxidant and Antimicrobial Activities of Euphorbia terracina L. from Deltaic Mediterranean Coast, Egypt

The importance of medicinal plants and traditional health systems in solving the health care prob... more The importance of medicinal plants and traditional health systems in solving the health care problems of the world is gaining increasing attention. The main aim of this study is to evaluate antimicrobial and antioxidant activities of Euphorbia terracina L. (family Euphorbiaceae) is short-lived perennial herb, up to 80 cm tall. It was collected from northern sector of Nile Delta at the period of May 2015. Different extracts of Euphorbia terracina, were screened for their antimicrobial activity against nine pathogenic bacterial and one fungal strain using filter paper disc assay. The antimicrobial activity was significantly variable according to the solvent used. Hexane extract was found to be the most effective against most tested organisms followed by methanol extract showed the inhibitory activities against Proteus vulgaris (inhibition zones = 9.3 mm), Petroleum ether and ethyl acetate extracts exhibited most antimicrobial against Staphylococcus aureus (inhibition zone = 10 mm, each). Antioxidant activity was screened using DPPH scavenging activity. Ethyl acetate extract was found to be the most effective (IC50 = 1.23 mg/mL). Preliminary phytochemical screening on methanol extract showed variations in active secondary compounds. Saponins were found to be the richest one in this regard (39.17±1.3 mg/g D.W.) and total phenolics were estimated 22.11±0.9 mg/g D.W.

Research paper thumbnail of Cardioameliorative effect of punicalagin against streptozotocin-induced apoptosis, redox imbalance, metabolic changes and inflammation

e g y p t i a n j o u r n a l o f b a s i c a n d a p p l i e d s c i e n c e s , 2015

The effect of punicalagin on metabolic risks, oxidative stress, inflammation, cardiac apopto-sis ... more The effect of punicalagin on metabolic risks, oxidative stress, inflammation, cardiac apopto-sis and histopathological alterations in experimentally induced diabetes was addressed. Diabetes was induced in male rats by a single injection of streptozotocin (STZ; 40 mg/kg, i.p.), and then punicalagin (1 mg/kg) was i.p. administered every other day for 15 days. The diabetic rats treated with punicalagin exhibited ameliorated hyperglycemia and HbA1c; improved insulin levels, HOMA-IR levels and lipid profiles; and normalized levels of IL-1b, IL-6 and TNF-α. Punicalagin also reduced the increase in the MDA and H2O2 levels; normalized the levels of GSH, SOD and CAT in the heart; and improved serum markers of heart function including the levels of tro-ponin T level and CK-MB and LDH activities. Histopathological examinations of heart sections match these results, confirming the beneficial effect of punicalagin. It also modulated cardiomyocyte apoptosis via enhanced Bcl-2 expression; blocked the increases in P53, Bax and caspases-3, 8 and 9; and ameliorated DNA damage in the heart. The current results suggest that punicalagin protected the heart against apoptosis, necrosis, inflammation and DNA damage by improving the redox state, suppressing caspases and P53 and increasing Bcl-2. In conclusion , punicalagin possesses strong therapeutic potential in treating and regulating diabetes and attenuating its associated complications in the heart.