ali Alkazzaz | University of Babylon (original) (raw)
Papers by ali Alkazzaz
BIO Web of Conferences
MicroRNAs are small non-coding RNAs that can regulate a variety of immune functions. MicroRNA146a... more MicroRNAs are small non-coding RNAs that can regulate a variety of immune functions. MicroRNA146a (miRNA-146a) is regarded as a crucial regulator of posttranscriptional gene expression, suggesting a role in autoimmune disorders. This study was performed to investigate association miRNAs-146a expression and its polymorphisms in patient with Rheumatoid arthritis. The current study includes 120 subjects classified into two main groups: 60 RA patients and 60 healthy controls. Quantitative expression of serum miRNA-146a, as well as its genotyping rs2910164 (C/G) were done to all subjects using real-time PCR and Tetra primer ARMS-PCR respectively. Serum miRNA-146a significantly over expressed in RA patients (fold change 2.59±1.18), compared to the controls (fold change 1.07±0.41), (P=< 0.0001).The receiver operating characteristics (ROC) curve was plotted to compare the expression efficiency of miR-146a showing high sensitivity 91.7 % and high specificity 91.1 %, AUC 0.95, (95% CI 0.91...
Annals of Tropical Medicine and Public Health, 2021
Rheumatoidarthritis is a long term disorder which is mostly affects the joints leading to joint s... more Rheumatoidarthritis is a long term disorder which is mostly affects the joints leading to joint swelling, stiffness& loss of function, mostly affects fingers& wrist. The risk of pregnancy complications is slightly higherfor women with rheumatoid arthritis than healthy women. The aim is to evaluate the rate of miscarriages in women with rheumatoid arthritis attending rheumatologic clinic at Marjan Hospital. The sample of women attending rheumatoid clinic was 1688, only 318 of them were with RA and 10 women were excluded as they receiving methotrexate during pregnancy. All those included in study were receiving folic acid, stop methotrexate and were diagnosed adopting ACR criteria 2010.Their age was between 15-50 years. They were compared to control group (300) attending obstetric department through the period of 12Dec 2016 to 12 Dec 2018. Those women evaluated through full history and physical examination including: age, parity, No. of miscarriages, family history of RA and laborator...
Article history: Received 19 September 2014 Received in revised form 19 November 2014 Accepted 29... more Article history: Received 19 September 2014 Received in revised form 19 November 2014 Accepted 29 November 2014 Available online 27 December 2014
Medical Journal of Babylon, 2013
Behcet’s disease is a vasculitis of unknown etiology, it is most prevalent in Mediterranean area,... more Behcet’s disease is a vasculitis of unknown etiology, it is most prevalent in Mediterranean area, the most serious problem is ocular involvement, and with the use of the immunosuppressive agents, ocular prognosis had significantly improved. The interferon 2 is a biological agent used for the treatment of viral hepatitis and renal cell carcinoma. It is used now for the treatment of Behcet’s disease, the mode of action of INF in Behcet’s disease is still unknown, it has many immuno -modulatory effects, such as enhancement of HLA class (I) antigen expression on the lymphoid cells, T and NK cell cyto-toxicity, and it diverts the T cell response. Forty patients had been studied through (2006 - 2008) in Merjan Teaching Hospital to compare the use of interferon 2 versus other immunosuppressive agents to show the difference especially in refractory eye problems and vascular involvement. Six to nine million units of interferon per week were given subcutaneously to (20) patients whom either...
Military Medical Science Letters
Medical Journal of Babylon, 2012
To evaluate the prevalence of ANCA antibodies in patients with systemic vasculitis and to compare... more To evaluate the prevalence of ANCA antibodies in patients with systemic vasculitis and to compare that to its prevalence in patients with different rheumatic diseases and in normal healthy control subjects. Fifty patients with systemic vasculitis and fifty patients with different rheumatic diseases and one hundred healthy control persons, have been tested for the presence of ANCA antibodies "Anti PR3" and "Anti MPO" by ELISA technique in central public health laboratory in Baghdad-Iraq. Seventeen patients out of fifty patients 34% with systemic vasculitis were found to be positive for ANCA antibodies ,nine patients were positive for c.ANCA " Anti-PR3 ", eight patients were positive for p.ANCA "Anti-MPO" and two patients were positive for both types with specificity of "99%" and sensitivity of 34%. All fifty patients with different rheumatic disease were negative for ANCA antibodies , and also the healthy control persons were negative...
Background: Osteoporosis presents to be a major public health problem because it is associated wi... more Background: Osteoporosis presents to be a major public health problem because it is associated with increased morbidity and mortality, particularly hip and vertebral fractures, which are a huge burden on the health system due to the high economic costs of those care fractures and disability derivatives they produce. Objectives: This study aims to determine relationships between osteoporosis and some factors (demographic factors, menstrual and obstetrical factors in females and life style). Materials and Methods: The study was carried out on 235 person, 150 of them had been referred to the Rheumatology-Rehabilitation unit in Marjan teaching hospital and considered them as a patients group and 85 of them were completely healthy people without any history of diseases and considered as healthy group. The risk factors were assessed from the patients’ interview and bone mineral density measurement had been done for each one of them. Results: The results of this study showed high significa...
Rheumatoid arthritis (RA) is a systemic disease, characterized by chronic inflammatory polyarthri... more Rheumatoid arthritis (RA) is a systemic disease, characterized by chronic inflammatory polyarthritis with extra articular complications. The prevalence is about 1% and more common in female than male. The aim of the study is early detection of left ventricle systolic dysfunction in rheumatoid arthritis (RA) patients by measuring global longitudinal strain, and mitral annular systolic velocity (S`). A Case control study enrolled 60 patients with RA (mean age 47.7 years) without history of cardiac disease and 40 healthy controls (mean age 44.5). All participants underwent trans thoracic echocardiography (TTE), tissue Doppler imaging (TDI) for assessment of mitral annular systolic velocity (S`), as well as left ventricle global longitudinal strain (GLS) using speckle tracking echocardiography (STE) technique. RA patients had shown lower mitral annular velocity S` in comparison with control (9.60±1.61 vs 10.72±1.17; p value <0.001), also RA patient had shown lower negative left ventr...
Advances in Life Science and Technology, 2014
Behcet’s disease (BD) is multi systemic inflammatory disorder of unknown cause, it characterized ... more Behcet’s disease (BD) is multi systemic inflammatory disorder of unknown cause, it characterized by recurrent oral and genital ulcer, skin lesion and uveitis. The etiopathogensis of Behcet’s Disease had long been postulated, possibility that immunological abnormalities induced by microbial pathogens in genetically susceptible individual are important in the pathogenesis. There was no positive association between eye involvement, arteritis and HLA5 tissue typing and positive pethergy test .The HLA5 was positive in 62% of patients with Behcet’s disease in Iraqi patients. Endothelial nitric oxide synthase is synthesized by arginine oxidation, it is one of nitric oxide synthase family, this enzyme has three isoform tow constitutive (neuronal NOS include nNOS and NOS-I)and one inducible NOS (Inos, nos-II), endotheline enzyme responsible of generate small amount of nitrous oxide, The eNOS gene is located on chromosome 7q35-36. 33 Iraqi patients with Behcet’s disease compared with the same...
Journal of Natural Sciences Research, 2013
Background: Pulmonary arterial hypertension (PAH) is now the most frequent cause of death in syst... more Background: Pulmonary arterial hypertension (PAH) is now the most frequent cause of death in systemic sclerosis (SSc). Aims: The aims of the present study were to evaluate the prevalence of pulmonary arterial hypertension (PAH) and predictors in SSc among Iraqi patients. Materials and Methods: A cross-sectional study conducted on 56 patients with SSc diagnosed according to the criteria developed by the American College of Rheumatology. Baseline characteristics [age, sex, body mass index (BMI), duration of SSc, type of SSc, duration of Raynaud’s phenomenon, and presence of telangiectasia] were documented. Antiscleroderma 70 (anti-SCL70) and anticentromere antibodies were measured. Doppler echocardiography was done to diagnose PAH. A risk score was obtained from 7 criteria, namely: Anti-Centromere Ab, Limited disease type, short duration of Raynaud's phenomena (<2.5 years), older age group (40+ years), absence of Telangiectasia, female gender, and absence of anti SCL70 Ab. Re...
Iraqi postgraduate Medical Journal, 2013
ABSTRACT: BACKGROUND : The incidence of rheumatoid arthritis[RA] varies from country to another w... more ABSTRACT: BACKGROUND : The incidence of rheumatoid arthritis[RA] varies from country to another which not depend on genetic bases alone but can explained by environmental exposure and genetic and environmental interaction, area of military conflict ,there was stress induced pathway that elevates the risk for rheumatoid arthritis, in Iraq rheumatoid was 1% of population in 1975. OBJECTIVE: To evaluate incidence of RA in Babylon –Iraq from 2001-2011 PATIENTS AND METHODS: This study was done to examine the incidence of RA in Babylon between 2001-2011 by Retrospective cohort study in Merjan Teaching Hospital ,Rheumatology unit .Data included sex .birth year ,residency and latex test , from 2001 to 2011.All patients were diagnosed as Rheumatoid Arthritis according to American College of Rheumatology ACR 1987revised criteria of RA .the numbers of patients of RA who were received DMRADs included methotrxate therapy were recorded each year and incidence of each year was found then t...
Background: There are scarce data on disease characteristics and severity of coronavirus 2019 (CO... more Background: There are scarce data on disease characteristics and severity of coronavirus 2019 (COVID-19) among Iraqi patients with rheumatic diseases (RDs). In this study, we aimed to report the disease characteristics and variables associated with COVID-19 outcome among patients with RDs. Methods: Between October 2020 and April 2021, rheumatic diseases (RDs) patients with COVID-19 were registered from different centres in Iraq. The patient's demographics, rheumatological history, COVID-19 symptoms, severity, and management, if any, their disease progress and outcome have been assessed. Binary logistic regression analysis was performed to determine predictors of disease severity. Results: 253 patients were included in the study, and most were females. The commonest rheumatic disease was rheumatoid arthritis (RA), followed by systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS) (95, 52 and 20 patients respectively). It has been found that 50.6% of patients had mild COVID-19, and 49.4% had moderate disease; 18% of patients required oxygen support, no patient was treated in hospital, and there was no reported death. Patients with moderate COVID-19 had significantly higher age than mild type (p= 0.022); with more BMI (p=0.03), more in the number of comorbidities (p<0.001), more steroids users (p=0.012), higher steroid dose (P=0.034), had longer steroid duration, longer duration of conventional disease-modifying antirheumatic drugs (cDMARDs) (p=0.018), and biologic Diseasemodifying Antirheumatic Drug (bDMARDs) in months (p=0.025). Increasing body mass index (BMI), duration of biological DMARDs use, and an increasing number of comorbidities were significant independent factors that increase the risk of having more severe COVID-19, (p<0.05). Gorial et al.: COVID-19 patients with rheumatic diseases IN PRESS Conclusion: COVID-19 infection rheumatic patients tend to have mild-moderate disease course; BMI, duration of biological DMARDs use, and many comorbidities were significant independent factors that increase the risk of having more severe COVID-19.
Medical Journal of Babylon, 2014
Objectives: To identifying effect of body mass index and physical activities on risk of osteoporo... more Objectives: To identifying effect of body mass index and physical activities on risk of osteoporosis in Babylon governorate. Methods: A descriptive cross-sectional study carried out during the period from December 2012 till the end of March 2013. Data were collected by the researcher depending on the direct interview with the participants using especial questionnaire, was constructed for the purpose of the study, consisted of five parts: the first part was concerned with the socio-demographic characteristics, second part was physical activities levels, third part was about obstetric-gynecological history of female, fourth part measured body mass index, fifth part dealt with Medical history and family which consist of Chronic diseases, Medications used, Certain features and Family history. The study sample was (312), (281) females and (31)males. Results: The results indicated that the prevalence rate of osteoporosis in this study was 25.6%. The higher percentage of osteoporosis (26.7...
Journal of Natural Sciences Research, 2015
Osteoporosis is a condition of skeletal fragility due to progressive loss of bone mass. It occurs... more Osteoporosis is a condition of skeletal fragility due to progressive loss of bone mass. It occurs in the elderly of both sexes but is most pronounced in postmenopausal women . The aim of this study was to assess the efficacy of Thyme in treatment of postmenopausal women with osteoporosis and compare it's effect with Calcium plus Vitamin D3 . Forty postmenopausal women with osteoporosis were randomly divided into two groups( each group include twenty women) .The duration of treatment was 6 months . First group was given Thyme capsule 500mg twice daily, second group was given Calcium plus Vitamin D3(Calcium 600mg plus Vitamin D3 500 I.U.) once daily .The following parameters were measured for two groups at baseline and at 6 months intervals bone mineral density(BMD) and t score except ESR and serum ionized calcium were measured at baseline and at 2 months interval . There were a significant increase in BMD, t score in group treated with Thyme after 6 months as compared with baseli...
Osteoporosis is a chronic, progressive disease of multifactorial etiology characterized by low bo... more Osteoporosis is a chronic, progressive disease of multifactorial etiology characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility. The disease often does not become clinically apparent until a fracture occurs . It occurs in the elderly of both sexes but is most pronounced in postmenopausal women .The aim of this study was to assess the efficacy of sodium alendronate plus Thyme in treatment of postmenopausal women with osteoporosis and compare it's effect with Sodium alendronate alone . Forty postmenopausal women with osteoporosis were randomly divided into two groups( each group include twenty women) .The duration of treatment was 6 months . First group was given Sodium alendronate 70mg weekly and Thyme capsule 500mg twice daily, second group was given Sodium alendronate 70mg once weekly .The following parameters were measured for two groups at baseline and at 6 months intervals bone mineral density(BMD) an...
Indian Journal of Public Health Research & Development
Expert Review of Clinical Immunology
JOURNAL OF UNIVERSITY OF BABYLON for pure and applied sciences
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinica... more Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation. SLE can affect all organs and the involvement of major organs can be life threatening. This study aimed to determine the relationship of Epidermal Growth Factor (EGF) and Cortisol hormone on SLE Disease. This study was carried out on (70) study sample, (36) were patients and (34) control. SLE disease had significant association between study groups and sex of patients with SEE disease were 16 times more likely to be female. There were significant mean differences of Epidermal growth factor and Cortisol Hormones by study groups
BIO Web of Conferences
MicroRNAs are small non-coding RNAs that can regulate a variety of immune functions. MicroRNA146a... more MicroRNAs are small non-coding RNAs that can regulate a variety of immune functions. MicroRNA146a (miRNA-146a) is regarded as a crucial regulator of posttranscriptional gene expression, suggesting a role in autoimmune disorders. This study was performed to investigate association miRNAs-146a expression and its polymorphisms in patient with Rheumatoid arthritis. The current study includes 120 subjects classified into two main groups: 60 RA patients and 60 healthy controls. Quantitative expression of serum miRNA-146a, as well as its genotyping rs2910164 (C/G) were done to all subjects using real-time PCR and Tetra primer ARMS-PCR respectively. Serum miRNA-146a significantly over expressed in RA patients (fold change 2.59±1.18), compared to the controls (fold change 1.07±0.41), (P=< 0.0001).The receiver operating characteristics (ROC) curve was plotted to compare the expression efficiency of miR-146a showing high sensitivity 91.7 % and high specificity 91.1 %, AUC 0.95, (95% CI 0.91...
Annals of Tropical Medicine and Public Health, 2021
Rheumatoidarthritis is a long term disorder which is mostly affects the joints leading to joint s... more Rheumatoidarthritis is a long term disorder which is mostly affects the joints leading to joint swelling, stiffness& loss of function, mostly affects fingers& wrist. The risk of pregnancy complications is slightly higherfor women with rheumatoid arthritis than healthy women. The aim is to evaluate the rate of miscarriages in women with rheumatoid arthritis attending rheumatologic clinic at Marjan Hospital. The sample of women attending rheumatoid clinic was 1688, only 318 of them were with RA and 10 women were excluded as they receiving methotrexate during pregnancy. All those included in study were receiving folic acid, stop methotrexate and were diagnosed adopting ACR criteria 2010.Their age was between 15-50 years. They were compared to control group (300) attending obstetric department through the period of 12Dec 2016 to 12 Dec 2018. Those women evaluated through full history and physical examination including: age, parity, No. of miscarriages, family history of RA and laborator...
Article history: Received 19 September 2014 Received in revised form 19 November 2014 Accepted 29... more Article history: Received 19 September 2014 Received in revised form 19 November 2014 Accepted 29 November 2014 Available online 27 December 2014
Medical Journal of Babylon, 2013
Behcet’s disease is a vasculitis of unknown etiology, it is most prevalent in Mediterranean area,... more Behcet’s disease is a vasculitis of unknown etiology, it is most prevalent in Mediterranean area, the most serious problem is ocular involvement, and with the use of the immunosuppressive agents, ocular prognosis had significantly improved. The interferon 2 is a biological agent used for the treatment of viral hepatitis and renal cell carcinoma. It is used now for the treatment of Behcet’s disease, the mode of action of INF in Behcet’s disease is still unknown, it has many immuno -modulatory effects, such as enhancement of HLA class (I) antigen expression on the lymphoid cells, T and NK cell cyto-toxicity, and it diverts the T cell response. Forty patients had been studied through (2006 - 2008) in Merjan Teaching Hospital to compare the use of interferon 2 versus other immunosuppressive agents to show the difference especially in refractory eye problems and vascular involvement. Six to nine million units of interferon per week were given subcutaneously to (20) patients whom either...
Military Medical Science Letters
Medical Journal of Babylon, 2012
To evaluate the prevalence of ANCA antibodies in patients with systemic vasculitis and to compare... more To evaluate the prevalence of ANCA antibodies in patients with systemic vasculitis and to compare that to its prevalence in patients with different rheumatic diseases and in normal healthy control subjects. Fifty patients with systemic vasculitis and fifty patients with different rheumatic diseases and one hundred healthy control persons, have been tested for the presence of ANCA antibodies "Anti PR3" and "Anti MPO" by ELISA technique in central public health laboratory in Baghdad-Iraq. Seventeen patients out of fifty patients 34% with systemic vasculitis were found to be positive for ANCA antibodies ,nine patients were positive for c.ANCA " Anti-PR3 ", eight patients were positive for p.ANCA "Anti-MPO" and two patients were positive for both types with specificity of "99%" and sensitivity of 34%. All fifty patients with different rheumatic disease were negative for ANCA antibodies , and also the healthy control persons were negative...
Background: Osteoporosis presents to be a major public health problem because it is associated wi... more Background: Osteoporosis presents to be a major public health problem because it is associated with increased morbidity and mortality, particularly hip and vertebral fractures, which are a huge burden on the health system due to the high economic costs of those care fractures and disability derivatives they produce. Objectives: This study aims to determine relationships between osteoporosis and some factors (demographic factors, menstrual and obstetrical factors in females and life style). Materials and Methods: The study was carried out on 235 person, 150 of them had been referred to the Rheumatology-Rehabilitation unit in Marjan teaching hospital and considered them as a patients group and 85 of them were completely healthy people without any history of diseases and considered as healthy group. The risk factors were assessed from the patients’ interview and bone mineral density measurement had been done for each one of them. Results: The results of this study showed high significa...
Rheumatoid arthritis (RA) is a systemic disease, characterized by chronic inflammatory polyarthri... more Rheumatoid arthritis (RA) is a systemic disease, characterized by chronic inflammatory polyarthritis with extra articular complications. The prevalence is about 1% and more common in female than male. The aim of the study is early detection of left ventricle systolic dysfunction in rheumatoid arthritis (RA) patients by measuring global longitudinal strain, and mitral annular systolic velocity (S`). A Case control study enrolled 60 patients with RA (mean age 47.7 years) without history of cardiac disease and 40 healthy controls (mean age 44.5). All participants underwent trans thoracic echocardiography (TTE), tissue Doppler imaging (TDI) for assessment of mitral annular systolic velocity (S`), as well as left ventricle global longitudinal strain (GLS) using speckle tracking echocardiography (STE) technique. RA patients had shown lower mitral annular velocity S` in comparison with control (9.60±1.61 vs 10.72±1.17; p value <0.001), also RA patient had shown lower negative left ventr...
Advances in Life Science and Technology, 2014
Behcet’s disease (BD) is multi systemic inflammatory disorder of unknown cause, it characterized ... more Behcet’s disease (BD) is multi systemic inflammatory disorder of unknown cause, it characterized by recurrent oral and genital ulcer, skin lesion and uveitis. The etiopathogensis of Behcet’s Disease had long been postulated, possibility that immunological abnormalities induced by microbial pathogens in genetically susceptible individual are important in the pathogenesis. There was no positive association between eye involvement, arteritis and HLA5 tissue typing and positive pethergy test .The HLA5 was positive in 62% of patients with Behcet’s disease in Iraqi patients. Endothelial nitric oxide synthase is synthesized by arginine oxidation, it is one of nitric oxide synthase family, this enzyme has three isoform tow constitutive (neuronal NOS include nNOS and NOS-I)and one inducible NOS (Inos, nos-II), endotheline enzyme responsible of generate small amount of nitrous oxide, The eNOS gene is located on chromosome 7q35-36. 33 Iraqi patients with Behcet’s disease compared with the same...
Journal of Natural Sciences Research, 2013
Background: Pulmonary arterial hypertension (PAH) is now the most frequent cause of death in syst... more Background: Pulmonary arterial hypertension (PAH) is now the most frequent cause of death in systemic sclerosis (SSc). Aims: The aims of the present study were to evaluate the prevalence of pulmonary arterial hypertension (PAH) and predictors in SSc among Iraqi patients. Materials and Methods: A cross-sectional study conducted on 56 patients with SSc diagnosed according to the criteria developed by the American College of Rheumatology. Baseline characteristics [age, sex, body mass index (BMI), duration of SSc, type of SSc, duration of Raynaud’s phenomenon, and presence of telangiectasia] were documented. Antiscleroderma 70 (anti-SCL70) and anticentromere antibodies were measured. Doppler echocardiography was done to diagnose PAH. A risk score was obtained from 7 criteria, namely: Anti-Centromere Ab, Limited disease type, short duration of Raynaud's phenomena (<2.5 years), older age group (40+ years), absence of Telangiectasia, female gender, and absence of anti SCL70 Ab. Re...
Iraqi postgraduate Medical Journal, 2013
ABSTRACT: BACKGROUND : The incidence of rheumatoid arthritis[RA] varies from country to another w... more ABSTRACT: BACKGROUND : The incidence of rheumatoid arthritis[RA] varies from country to another which not depend on genetic bases alone but can explained by environmental exposure and genetic and environmental interaction, area of military conflict ,there was stress induced pathway that elevates the risk for rheumatoid arthritis, in Iraq rheumatoid was 1% of population in 1975. OBJECTIVE: To evaluate incidence of RA in Babylon –Iraq from 2001-2011 PATIENTS AND METHODS: This study was done to examine the incidence of RA in Babylon between 2001-2011 by Retrospective cohort study in Merjan Teaching Hospital ,Rheumatology unit .Data included sex .birth year ,residency and latex test , from 2001 to 2011.All patients were diagnosed as Rheumatoid Arthritis according to American College of Rheumatology ACR 1987revised criteria of RA .the numbers of patients of RA who were received DMRADs included methotrxate therapy were recorded each year and incidence of each year was found then t...
Background: There are scarce data on disease characteristics and severity of coronavirus 2019 (CO... more Background: There are scarce data on disease characteristics and severity of coronavirus 2019 (COVID-19) among Iraqi patients with rheumatic diseases (RDs). In this study, we aimed to report the disease characteristics and variables associated with COVID-19 outcome among patients with RDs. Methods: Between October 2020 and April 2021, rheumatic diseases (RDs) patients with COVID-19 were registered from different centres in Iraq. The patient's demographics, rheumatological history, COVID-19 symptoms, severity, and management, if any, their disease progress and outcome have been assessed. Binary logistic regression analysis was performed to determine predictors of disease severity. Results: 253 patients were included in the study, and most were females. The commonest rheumatic disease was rheumatoid arthritis (RA), followed by systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS) (95, 52 and 20 patients respectively). It has been found that 50.6% of patients had mild COVID-19, and 49.4% had moderate disease; 18% of patients required oxygen support, no patient was treated in hospital, and there was no reported death. Patients with moderate COVID-19 had significantly higher age than mild type (p= 0.022); with more BMI (p=0.03), more in the number of comorbidities (p<0.001), more steroids users (p=0.012), higher steroid dose (P=0.034), had longer steroid duration, longer duration of conventional disease-modifying antirheumatic drugs (cDMARDs) (p=0.018), and biologic Diseasemodifying Antirheumatic Drug (bDMARDs) in months (p=0.025). Increasing body mass index (BMI), duration of biological DMARDs use, and an increasing number of comorbidities were significant independent factors that increase the risk of having more severe COVID-19, (p<0.05). Gorial et al.: COVID-19 patients with rheumatic diseases IN PRESS Conclusion: COVID-19 infection rheumatic patients tend to have mild-moderate disease course; BMI, duration of biological DMARDs use, and many comorbidities were significant independent factors that increase the risk of having more severe COVID-19.
Medical Journal of Babylon, 2014
Objectives: To identifying effect of body mass index and physical activities on risk of osteoporo... more Objectives: To identifying effect of body mass index and physical activities on risk of osteoporosis in Babylon governorate. Methods: A descriptive cross-sectional study carried out during the period from December 2012 till the end of March 2013. Data were collected by the researcher depending on the direct interview with the participants using especial questionnaire, was constructed for the purpose of the study, consisted of five parts: the first part was concerned with the socio-demographic characteristics, second part was physical activities levels, third part was about obstetric-gynecological history of female, fourth part measured body mass index, fifth part dealt with Medical history and family which consist of Chronic diseases, Medications used, Certain features and Family history. The study sample was (312), (281) females and (31)males. Results: The results indicated that the prevalence rate of osteoporosis in this study was 25.6%. The higher percentage of osteoporosis (26.7...
Journal of Natural Sciences Research, 2015
Osteoporosis is a condition of skeletal fragility due to progressive loss of bone mass. It occurs... more Osteoporosis is a condition of skeletal fragility due to progressive loss of bone mass. It occurs in the elderly of both sexes but is most pronounced in postmenopausal women . The aim of this study was to assess the efficacy of Thyme in treatment of postmenopausal women with osteoporosis and compare it's effect with Calcium plus Vitamin D3 . Forty postmenopausal women with osteoporosis were randomly divided into two groups( each group include twenty women) .The duration of treatment was 6 months . First group was given Thyme capsule 500mg twice daily, second group was given Calcium plus Vitamin D3(Calcium 600mg plus Vitamin D3 500 I.U.) once daily .The following parameters were measured for two groups at baseline and at 6 months intervals bone mineral density(BMD) and t score except ESR and serum ionized calcium were measured at baseline and at 2 months interval . There were a significant increase in BMD, t score in group treated with Thyme after 6 months as compared with baseli...
Osteoporosis is a chronic, progressive disease of multifactorial etiology characterized by low bo... more Osteoporosis is a chronic, progressive disease of multifactorial etiology characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility. The disease often does not become clinically apparent until a fracture occurs . It occurs in the elderly of both sexes but is most pronounced in postmenopausal women .The aim of this study was to assess the efficacy of sodium alendronate plus Thyme in treatment of postmenopausal women with osteoporosis and compare it's effect with Sodium alendronate alone . Forty postmenopausal women with osteoporosis were randomly divided into two groups( each group include twenty women) .The duration of treatment was 6 months . First group was given Sodium alendronate 70mg weekly and Thyme capsule 500mg twice daily, second group was given Sodium alendronate 70mg once weekly .The following parameters were measured for two groups at baseline and at 6 months intervals bone mineral density(BMD) an...
Indian Journal of Public Health Research & Development
Expert Review of Clinical Immunology
JOURNAL OF UNIVERSITY OF BABYLON for pure and applied sciences
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinica... more Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation. SLE can affect all organs and the involvement of major organs can be life threatening. This study aimed to determine the relationship of Epidermal Growth Factor (EGF) and Cortisol hormone on SLE Disease. This study was carried out on (70) study sample, (36) were patients and (34) control. SLE disease had significant association between study groups and sex of patients with SEE disease were 16 times more likely to be female. There were significant mean differences of Epidermal growth factor and Cortisol Hormones by study groups