zainab jassim | University of Baghdad (original) (raw)

Papers by zainab jassim

Iraqi Journal of Pharmacy

Article history: Background: The involvement of conventional animal testing to determine how medi... more Article history: Background: The involvement of conventional animal testing to determine how medications affect a biological system comes with many challenges. In the past few decades, A number of methods have emerged to accomplish these objectives, one of which is cell line creation technology which has dramatically increased the usefulness and efficiency of drug discovery research. Cell culture is the term used to describe the removal of cells from an animal or plant and their subsequent cultivation in a lab setting. The Caco-2 model is commonly used in the early stages of drug discovery to make decisions about permeability, absorption or both of tested chemicals. It is evident that novel 3D cell culture models offer enormous potential for disease modeling, medication's efficacy and safety assessment. However, the challenges provided by the inherent traits of Caco-2 cell variants and inter-laboratory methods have led to the development of irreducible data. Conclusion: These restrictions affect the extrapolation of findings from preclinical research to clinical investigations on drug-drug and herbal-drug interactions.

International Journal of Applied Pharmaceutics, 2017

Objective: The purpose of this study was to enhance the dissolution pattern of the practically wa... more Objective: The purpose of this study was to enhance the dissolution pattern of the practically water-insoluble diuretic drug, furosemide through its formulation into liquisolid tablets.Methods: A mathematical model was used to formulate four liquisolid powder systems using polyethylene glycol 400 as a non-volatile water miscible liquid vehicle. The liquid loading factors of the vehicle were used to calculate the optimum quantities of carrier (Avicel PH 102) and coating materials (Aerosil 200) needed to prepare acceptably flowing and compactible powder mixtures and (R) ratio used was 25. The liquisolid tablets were evaluated for weight variation, percent friability, hardness, content uniformity, disintegration time and in vitro drug release profile. Drug and the prepared systems were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and powder x-ray diffraction (PXRD) studies.Results: The enhanced dissolution rate due to the incr...

International Journal of Applied Pharmaceutics, 2021

Increasing requests for modified and personalized pharmaceutics and medical materials makes the i... more Increasing requests for modified and personalized pharmaceutics and medical materials makes the implementation of additive manufacturing increased rapidly in recent years. 3D printing has been involved numerous advantages in case of reduction in waste, flexibility in the design, and minimizing the high cost of intended products for bulk production of. Several of 3D printing technologies have been developed to fabricate novel solid dosage forms, including selective laser sintering, binder deposition, stereolithography, inkjet printing, extrusion-based printing, and fused deposition modeling. The selection of 3D printing techniques depends on their compatibility with the printed drug products. This review intent to provide a perspective on the incentives and possible applications of 3D printed pharmaceuticals, besides a practical viewpoint on how 3D printing could be included across the pharmaceutical field.

International Research Journal of Pharmacy, 2017

Dissolution of drug is the rate determining step for oral absorption of the poorly water soluble ... more Dissolution of drug is the rate determining step for oral absorption of the poorly water soluble drugs and solubility is the basic requirement for the absorption of the drug from GIT. The development of a soulful dissolution procedure for drug products with lower water solubility has been a provocation to both the pharmaceutical industry and the agencies that regulate them. This study demonstrates the systematic development o f a discriminatory dissolution method for clopidogrel bisulfate, a BCS class II drug exhibiting highly pH-dependent solubility. The method was developed by testing solubility of clopidogrel bisulfate in different concentrations of sodium lauryl sulfate. The results showed 900 ml of 0.1 N HCl and phosphate buffer pH 6.8 containing 1% SLS with a paddle speed of 50 rpm was selected as discriminative dissolution test conditions for clopidogrel bisulfate tablets. In conclusion surfactants and pH changes are very effective ways to increase solubility. The in vitro dissolution must serve as both a quality control tool and a potential surrogate marker of drug bioavailability and bioequivalence.

Drug Invention Today, 2018

Journal of Pharmacy Research, 2018

Background: Fast dissolving oral drug delivery system is solid dosage form which disintegrates or... more Background: Fast dissolving oral drug delivery system is solid dosage form which disintegrates or dissolves within second when placed in the mouth without need of water or chewing. In present investigation, an attempt has been made to develop oral fast dissolving film of calcium channel blocker lacidipine. Method: Five formulas were prepared by solvent casting method using HPMC (METOLOSE)® as a film forming polymer and evaluated for their physical characteristics such as thickness, weight variation, folding endurance, drug content, disintegration time and in vitro drug release. The compatibility of the drug in the formulation was confirmed by FTIR and DSC studies. Result and Conclusion: The optimized formula F1 showed minimum in vitro disintegration time of 25 second and highest dissolution rate 97.3% in 10 minutes with good mechanical properties. Based on overall results, the conclusion that lacidipine was successfully prepared as oral fast dissolving film with accepted properties.

Objective: The present study aims to enhance the dissolution rate of a poorly water-soluble drug,... more Objective: The present study aims to enhance the dissolution rate of a poorly water-soluble drug, clopidogrel bisulfate by the preparation of the nanoparticles. Methods: Nanoparticles of clopidogrel were produced by antisolvent-precepitation method using different stabilizers at drug :stabilizer ratio 1:2 alone and in combination and characterized for particle size, drug entrapment efficiency (DEE), dissolution testing, scanning electron microscopy imaging (SEM) and atomic force microscopy (AFM). Lyophilized nanoparticles were compressed into tablets by direct compression method and evaluated by different methods. Compatibility studies (Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) ), and powder x-ray diffraction (PXRD) were also done. Results: Through this study, the particle size was ranged from 5.29 to 480 nm and %DEE was ranged from 83% to 97%. Amongst all formulations F13,stabilized with PVPK-30 and PVA, showed complete dissolution (...

Journal Of Advanced Pharmacy Education And Research

Asian Journal of Pharmaceutical and Clinical Research

Objective: The aim of the present work was to formulate and evaluate fast dissolving film contain... more Objective: The aim of the present work was to formulate and evaluate fast dissolving film containing lornoxicam.Materials and Methods: To prepare the film, hydroxypropyl methylcellulose E5 and polyvinyl alcohol (PVA) were used as film-forming polymers by solvent casting method. Glycerine was used as plasticizer, aspartame, and mannitol as sweetener. All prepared films were evaluated for its weight variation, disintegration time, thickness, drug content, pH, dissolution study, and folding endurance. The drug-excipients compatibility study was done using differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR).Results: Satisfactory results obtained when PVA was used as film-forming polymer, and the drug was dispersed in the polymer solution using poloxamer 407 as a solubilizing agent. Formulation F2 is considered as the optimized formulation as it showed good folding endurance (>300), faster disintegration rate (30 s), and maximum in vitro drug release (87%) wi...

Asian Journal of Pharmaceutical and Clinical Research

Objective: Emulgels as topical dosage form recently gains an interest represent a combination of ... more Objective: Emulgels as topical dosage form recently gains an interest represent a combination of gels and emulsions in united form. Metronidazole is an antimicrobial and anti-inflammatory drug, as the first topical therapy approved for rosacea; metronidazole has remained a cornerstone of rosacea management. Methods: Emulgel formulations of metronidazole benzoate were prepared using two types of gelling agents, Carbopol 940 and hydroxypropyl methylcellulose, the influence of type and concentration of them on the release of metronidazole benzoate was investigated. The prepared formulations were evaluated on the basis of pH, spreadability, viscosity, drug content, in vitro release, and compatibility studies. Results: All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. Conclusion: The best formulation (F4) prepared using Carbopol 940 as gelling agent showed the highest drug release through 5 h.

Objective: The present study aims to enhance the dissolution rate of a poorly water-soluble drug,... more Objective: The present study aims to enhance the dissolution rate of a poorly water-soluble drug, clopidogrel bisulfate by the preparation of the nanoparticles.

Iraqi Journal of Pharmacy

Article history: Background: The involvement of conventional animal testing to determine how medi... more Article history: Background: The involvement of conventional animal testing to determine how medications affect a biological system comes with many challenges. In the past few decades, A number of methods have emerged to accomplish these objectives, one of which is cell line creation technology which has dramatically increased the usefulness and efficiency of drug discovery research. Cell culture is the term used to describe the removal of cells from an animal or plant and their subsequent cultivation in a lab setting. The Caco-2 model is commonly used in the early stages of drug discovery to make decisions about permeability, absorption or both of tested chemicals. It is evident that novel 3D cell culture models offer enormous potential for disease modeling, medication's efficacy and safety assessment. However, the challenges provided by the inherent traits of Caco-2 cell variants and inter-laboratory methods have led to the development of irreducible data. Conclusion: These restrictions affect the extrapolation of findings from preclinical research to clinical investigations on drug-drug and herbal-drug interactions.

International Journal of Applied Pharmaceutics, 2017

Objective: The purpose of this study was to enhance the dissolution pattern of the practically wa... more Objective: The purpose of this study was to enhance the dissolution pattern of the practically water-insoluble diuretic drug, furosemide through its formulation into liquisolid tablets.Methods: A mathematical model was used to formulate four liquisolid powder systems using polyethylene glycol 400 as a non-volatile water miscible liquid vehicle. The liquid loading factors of the vehicle were used to calculate the optimum quantities of carrier (Avicel PH 102) and coating materials (Aerosil 200) needed to prepare acceptably flowing and compactible powder mixtures and (R) ratio used was 25. The liquisolid tablets were evaluated for weight variation, percent friability, hardness, content uniformity, disintegration time and in vitro drug release profile. Drug and the prepared systems were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and powder x-ray diffraction (PXRD) studies.Results: The enhanced dissolution rate due to the incr...

International Journal of Applied Pharmaceutics, 2021

Increasing requests for modified and personalized pharmaceutics and medical materials makes the i... more Increasing requests for modified and personalized pharmaceutics and medical materials makes the implementation of additive manufacturing increased rapidly in recent years. 3D printing has been involved numerous advantages in case of reduction in waste, flexibility in the design, and minimizing the high cost of intended products for bulk production of. Several of 3D printing technologies have been developed to fabricate novel solid dosage forms, including selective laser sintering, binder deposition, stereolithography, inkjet printing, extrusion-based printing, and fused deposition modeling. The selection of 3D printing techniques depends on their compatibility with the printed drug products. This review intent to provide a perspective on the incentives and possible applications of 3D printed pharmaceuticals, besides a practical viewpoint on how 3D printing could be included across the pharmaceutical field.

International Research Journal of Pharmacy, 2017

Dissolution of drug is the rate determining step for oral absorption of the poorly water soluble ... more Dissolution of drug is the rate determining step for oral absorption of the poorly water soluble drugs and solubility is the basic requirement for the absorption of the drug from GIT. The development of a soulful dissolution procedure for drug products with lower water solubility has been a provocation to both the pharmaceutical industry and the agencies that regulate them. This study demonstrates the systematic development o f a discriminatory dissolution method for clopidogrel bisulfate, a BCS class II drug exhibiting highly pH-dependent solubility. The method was developed by testing solubility of clopidogrel bisulfate in different concentrations of sodium lauryl sulfate. The results showed 900 ml of 0.1 N HCl and phosphate buffer pH 6.8 containing 1% SLS with a paddle speed of 50 rpm was selected as discriminative dissolution test conditions for clopidogrel bisulfate tablets. In conclusion surfactants and pH changes are very effective ways to increase solubility. The in vitro dissolution must serve as both a quality control tool and a potential surrogate marker of drug bioavailability and bioequivalence.

Drug Invention Today, 2018

Journal of Pharmacy Research, 2018

Background: Fast dissolving oral drug delivery system is solid dosage form which disintegrates or... more Background: Fast dissolving oral drug delivery system is solid dosage form which disintegrates or dissolves within second when placed in the mouth without need of water or chewing. In present investigation, an attempt has been made to develop oral fast dissolving film of calcium channel blocker lacidipine. Method: Five formulas were prepared by solvent casting method using HPMC (METOLOSE)® as a film forming polymer and evaluated for their physical characteristics such as thickness, weight variation, folding endurance, drug content, disintegration time and in vitro drug release. The compatibility of the drug in the formulation was confirmed by FTIR and DSC studies. Result and Conclusion: The optimized formula F1 showed minimum in vitro disintegration time of 25 second and highest dissolution rate 97.3% in 10 minutes with good mechanical properties. Based on overall results, the conclusion that lacidipine was successfully prepared as oral fast dissolving film with accepted properties.

Objective: The present study aims to enhance the dissolution rate of a poorly water-soluble drug,... more Objective: The present study aims to enhance the dissolution rate of a poorly water-soluble drug, clopidogrel bisulfate by the preparation of the nanoparticles. Methods: Nanoparticles of clopidogrel were produced by antisolvent-precepitation method using different stabilizers at drug :stabilizer ratio 1:2 alone and in combination and characterized for particle size, drug entrapment efficiency (DEE), dissolution testing, scanning electron microscopy imaging (SEM) and atomic force microscopy (AFM). Lyophilized nanoparticles were compressed into tablets by direct compression method and evaluated by different methods. Compatibility studies (Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) ), and powder x-ray diffraction (PXRD) were also done. Results: Through this study, the particle size was ranged from 5.29 to 480 nm and %DEE was ranged from 83% to 97%. Amongst all formulations F13,stabilized with PVPK-30 and PVA, showed complete dissolution (...

Journal Of Advanced Pharmacy Education And Research

Asian Journal of Pharmaceutical and Clinical Research

Objective: The aim of the present work was to formulate and evaluate fast dissolving film contain... more Objective: The aim of the present work was to formulate and evaluate fast dissolving film containing lornoxicam.Materials and Methods: To prepare the film, hydroxypropyl methylcellulose E5 and polyvinyl alcohol (PVA) were used as film-forming polymers by solvent casting method. Glycerine was used as plasticizer, aspartame, and mannitol as sweetener. All prepared films were evaluated for its weight variation, disintegration time, thickness, drug content, pH, dissolution study, and folding endurance. The drug-excipients compatibility study was done using differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR).Results: Satisfactory results obtained when PVA was used as film-forming polymer, and the drug was dispersed in the polymer solution using poloxamer 407 as a solubilizing agent. Formulation F2 is considered as the optimized formulation as it showed good folding endurance (>300), faster disintegration rate (30 s), and maximum in vitro drug release (87%) wi...

Asian Journal of Pharmaceutical and Clinical Research

Objective: Emulgels as topical dosage form recently gains an interest represent a combination of ... more Objective: Emulgels as topical dosage form recently gains an interest represent a combination of gels and emulsions in united form. Metronidazole is an antimicrobial and anti-inflammatory drug, as the first topical therapy approved for rosacea; metronidazole has remained a cornerstone of rosacea management. Methods: Emulgel formulations of metronidazole benzoate were prepared using two types of gelling agents, Carbopol 940 and hydroxypropyl methylcellulose, the influence of type and concentration of them on the release of metronidazole benzoate was investigated. The prepared formulations were evaluated on the basis of pH, spreadability, viscosity, drug content, in vitro release, and compatibility studies. Results: All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. Conclusion: The best formulation (F4) prepared using Carbopol 940 as gelling agent showed the highest drug release through 5 h.

Objective: The present study aims to enhance the dissolution rate of a poorly water-soluble drug,... more Objective: The present study aims to enhance the dissolution rate of a poorly water-soluble drug, clopidogrel bisulfate by the preparation of the nanoparticles.