George Pappas-Gogos | University of Ioannina/Greece (original) (raw)

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Papers by George Pappas-Gogos

Journal of surgical case reports, Mar 1, 2022

Journal of Clinical Medicine, Apr 23, 2022

Techniques in Coloproctology, 2008

Current Oncology, Mar 7, 2023

Current Oncology, Apr 25, 2023

Journal of Trauma and Acute Care Surgery

BACKGROUND Accurate preoperative risk assessment in emergency laparotomy (EL) is valuable for inf... more BACKGROUND Accurate preoperative risk assessment in emergency laparotomy (EL) is valuable for informed decision making and rational use of resources. Available risk prediction tools have not been validated adequately across diverse health care settings. Herein, we report a comparative external validation of four widely cited prognostic models. METHODS A multicenter cohort was prospectively composed of consecutive patients undergoing EL in 11 Greek hospitals from January 2020 to May 2021 using the National Emergency Laparotomy Audit (NELA) inclusion criteria. Thirty-day mortality risk predictions were calculated using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP), NELA, Portsmouth Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (P-POSSUM), and Predictive Optimal Trees in Emergency Surgery Risk tools. Surgeons' assessment of postoperative mortality using predefined cutoffs was recorded, and a su...

Biomarkers in Medicine, 2020

Frontiers in Oncology

Intestinal metaplasia of the stomach (IM) is considered a pre-cancerous lesion and is a potential... more Intestinal metaplasia of the stomach (IM) is considered a pre-cancerous lesion and is a potential precursor to adenocarcinoma. Metabolic syndrome (MetS) has been associated with lesions to the gastrointestinal tract such as the risk of developing Barett esophagus. Vascular endothelial growth factor and leptin have been associated with either gastrointestinal tract carcinogenesis or MetS. In this context, this study was designed to analyze plasma levels of VEGF and leptin in patients with IM and MetS. Four groups of 137 participants (a control group and three patient groups, IM, MetS and IM- MetS) were created. Inclusion criteria for the presence of IM were endoscopic findings and histological confirmation, while for MetS the ATP III and IDF guidelines. Levels of plasma vascular endothelial growth factor (VEGF) and leptin (Leptin) were determined. VEGF levels were increased in IM (IM vs Control, p=0,011) and IM-MetS groups (IM-MetS vs Control, p <0.001 and IM-MetS vs MetS, p=0.001...

World Journal of Surgery

Background Emergency laparotomy (EL) is accompanied by high post-operative morbidity and mortalit... more Background Emergency laparotomy (EL) is accompanied by high post-operative morbidity and mortality which varies significantly between countries and populations. The aim of this study is to report outcomes of emergency laparotomy in Greece and to compare them with the results of the National Emergency Laparotomy Audit (NELA). Methods This is a multicentre prospective cohort study undertaken between 01.2019 and 05.2020 including consecutive patients subjected to EL in 11 Greek hospitals. EL was defined according to NELA criteria. Demographics, clinical variables, and post-operative outcomes were prospectively registered in an online database. Multivariable logistic regression analysis was used to identify independent predictors of post-operative mortality. Results There were 633 patients, 53.9% males, ASA class III/IV 43.6%, older than 65 years 58.6%. The most common operations were small bowel resection (20.5%), peptic ulcer repair (12.0%), adhesiolysis (11.8%) and Hartmann’s procedu...

Journal of Surgical Case Reports, 2022

Intussusception in adults is rare, and the clinical symptoms of intussusception are subtle, makin... more Intussusception in adults is rare, and the clinical symptoms of intussusception are subtle, making the diagnosis quite challenging. Gastrointestinal lipomas are rare benign tumors and are essentially adipose growths, most frequently found within the small intestine wall or mesentery. Limited up-to-date evidence exists regarding such lipomas. Intussusception due to a gastrointestinal lipoma constitutes an infrequent clinical entity, and the diagnosis of duodenal lipoma mainly depends on endoscopy examination, supplemented by computed tomography and magnetic resonance imaging. The present report describes a case of jejunal intussusception in an adult with a history of intermittent colicky abdominal pain located in the left upper quadrant over the last month. Contrast-enhanced computed tomography of the abdomen showed the typical target sign of a small intestinal intussusception along the left upper quadrant and a well-defined, low-density tumor in the intussusception. Exploratory lapa...

Annals of Translational Medicine, 2020

Σκοπός: Ο ορθοκολικός καρκίνος, καθώς και η χειρουργικές επεμβάσεις που αφορούν στο παχύ έντερο κ... more Σκοπός: Ο ορθοκολικός καρκίνος, καθώς και η χειρουργικές επεμβάσεις που αφορούν στο παχύ έντερο και στο ορθό σχετίζονται με αυξημένο οξειδωτικό στρες μέσω διαφορετικών μηχανισμών. Στην παρούσα μελέτη, αξιολογήθηκαν και συγκρίθηκαν τα επίπεδα διαφορετικών δεικτών οξειδωτικού στρες σε ασθενείς με ορθοκολικό καρκίνο που υποβλήθηκαν σε χειρουργική επέμβαση με λαπαροσκοπική ή ανοιχτή προσπέλαση.Υλικό/Μέθοδοι: Εξήντα ασθενείς με καρκίνο του παχέος εντέρου τυχαιοποιήθηκαν σε δύο ομάδες, την ομάδα της λαπαροσκοπικής (ΑΠ) και την ομάδα της ανοικτής προσπέλασης (ΑΠ). Η λιπιδιακή υπεροξείδωση, η οξείδωση των πρωτεϊνών, η οξείδωση του RNA και οι βλάβες από δραστικές μορφές αζώτου διερευνήθηκαν μέσω προσδιορισμού των 8-ισοπροστανίων (8-epiPGF2a), των καρβονυλίων (PC), της 8-υδροξυγουανοσίνης (8-OHG) και της 3-νιτροτυροσίνης (3-ΝΤ) αντίστοιχα, στο πλάσμα των ασθενών. Σκοπός ήταν η ανάλυση και η σύγκριση των επιπέδων των δεικτών του οξειδωτικού στρες σε διαφορετικές χρονικές περιόδους και μεταξύ τ...

The American Surgeon, 2007

Unresectable obstructing rectal cancer with synchronous hepatic metastases is usually a fatal dis... more Unresectable obstructing rectal cancer with synchronous hepatic metastases is usually a fatal disease. This prospective study was scheduled to treat this difficult condition using a multimodal curative strategy combined with a two-stage surgical treatment. Patients with T4N2 or N3M1 rectal cancer and hepatic metastases underwent a two-stage surgical treatment; in the first stage, a decompressing colostomy plus radiofrequency ablation (RFA) in liver metastases. In the second stage, a colectomy was done with stoma closing and resection of superficial necrotic hepatic tumors, plus repetition of RFA in recurrent or new hepatic tumors. Four patients were included, with 1 to 8 (total 20) hepatic metastases, each <5 cm in diameter. In the first stage, two patients were operated on by open approach and two laparoscopically. All hepatic tumors were treated by RFA to produce at least a 1-cm tumor-free margin. After chemoradiation of the rectal tumor, the second stage of surgical treatment ...

Gastroenterology research, 2018

Double pylorus is a rare endoscopic finding that has been reported in 0.001% to 0.4% of upper gas... more Double pylorus is a rare endoscopic finding that has been reported in 0.001% to 0.4% of upper gastrointestinal endoscopies and can be either congenital or acquired. Acquired double pylorus is usually an uncommon complication of peptic ulcer that erodes and creates a fistula between the duodenal bulb and the prepyloric antrum. We describe a case of a 67-year-old man who experienced mild epigastric pain and dyspepsia over the last 6 months. The patient periodically took nonsteroidal anti-inflammatory drugs (NSAIDs) due to joint pain. Esophagogastroduodenoscopy revealed gastritis and a double pylorus. An accessory channel connected the lesser curvature of the prepyloric antrum to the duodenal bulb and the endoscope was able to be passed through both of the ducts. The Helicobacter pylori quick test proved positive. Two years later, a follow-up endoscopy showed that fistula fused with normal pylorus and there was a single large opening.

International journal of surgery case reports, 2018

De Garengeot hernia is defined as femoral hernia containing appendix. An acute appendicitis in a ... more De Garengeot hernia is defined as femoral hernia containing appendix. An acute appendicitis in a femoral hernia is a extremely unusual surgical finding and occurs in 0.08%-0.013% of all cases. We report the case of an elderly woman, who presented with a typical clinical image of incarcerated femoral hernia and underwent open surgery. An infrainguinal incision was performed and after the dissection of hernia sac, an acute appendicitis within femoral hernia was revealed. Subsequently, appendectomy and hernioplasty were performed. Acute appendicitis within femoral hernia should be included in differential diagnosis of patients presenting with clinical signs of an incarcerated femoral hernia and prompt surgical treatment is essential in order to avoid severe complications.